scholarly journals Aerobic exercise capacity is maintained over a 5-year period in mild-to-moderate chronic kidney disease: a longitudinal study

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Helena Wallin ◽  
Eva Jansson ◽  
Carin Wallquist ◽  
Britta Hylander Rössner ◽  
Stefan H. Jacobson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Chronic Kidney Disease ◽  
Heart Rate ◽  
Renal Function ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Activity Level ◽  
Peak Heart Rate ◽  
Aerobic Exercise Capacity ◽  
Over Time

Abstract Background Aerobic exercise capacity is reduced in non-dialysis chronic kidney disease (CKD), but the magnitude of changes in exercise capacity over time is less known. Our main hypothesis was that aerobic ExCap would decline over 5 years in individuals with mild-to-moderate CKD along with a decline in renal function. A secondary hypothesis was that such a decline in ExCap would be associated with a decline in muscle strength, cardiovascular function and physical activity. Methods We performed a 5-year-prospective study on individuals with mild-to-moderate CKD, who were closely monitored at a nephrology clinic. Fiftytwo individuals with CKD stage 2–3 and 54 age- and sex-matched healthy controls were included. Peak workload was assessed through a maximal cycle exercise test. Muscle strength and lean body mass, cardiac function, vascular stiffness, self-reported physical activity level, renal function and haemoglobin level were evaluated. Tests were repeated after 5 years. Statistical analysis of longitudinal data was performed using linear mixed models. Results Exercise capacity did not change significantly over time in either the CKD group or controls, although the absolute workloads were significantly lower in the CKD group. Only in a CKD subgroup reporting low physical activity at baseline, exercise capacity declined. Renal function decreased in both groups, with a larger decline in CKD (p = 0.05 between groups). Peak heart rate, haemoglobin level, handgrip strength, lean body mass and cardiovascular function did not decrease significantly over time in CKD individuals. Conclusions On a group level, aerobic exercise capacity and peak heart rate were maintained over 5 years in patients with well-controlled mild-to-moderate CKD, despite a slight reduction in glomerular filtration rate. In line with the maintained exercise capacity, cardiovascular and muscular function were also preserved. In individuals with mild-to-moderate CKD, physical activity level at baseline seems to have a predictive value for exercise capacity at follow-up.

scholarly journals Aerobic exercise capacity is maintained over a 5-year period in mild-to-moderate chronic kidney disease: A longitudinal study

2020 ◽  
Author(s):  
Helena Wallin ◽  
Eva Jansson ◽  
Carin Wallquist ◽  
Britta Hylander Rössner ◽  
Stefan H Jacobson ◽  
...  
Keyword(s):  
Physical Activity ◽  
Chronic Kidney Disease ◽  
Heart Rate ◽  
Renal Function ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Activity Level ◽  
Peak Heart Rate ◽  
Aerobic Exercise Capacity ◽  
Over Time

Abstract Background: Aerobic exercise capacity is reduced in non-dialysis chronic kidney disease (CKD), but little is known about the magnitude of changes in exercise capacity over time. Our main hypothesis was that aerobic ExCap would decline over 5 years in individuals with mild-to-moderate CKD along with a decline in renal function. A secondary hypothesis was that such a decline in ExCap would be associated with a decline in muscle strength, cardiovascular function and physical activity. Methods: We performed a 5-year-prospective study on individuals with mild-to-moderate CKD, who were closely monitored at a nephrology clinic. Fiftytwo individuals with CKD stage 2–3 and 54 age- and sex-matched healthy controls were included. Peak workload was assessed through a maximal cycle exercise test. Muscle strength and lean body mass, cardiac function, vascular stiffness, self-reported physical activity level, renal function and haemoglobin level were evaluated. Tests were repeated after 5 years. Statistical analysis of longitudinal data was performed using linear mixed models.Results: Exercise capacity did not change significantly over time in either the CKD group or controls, although the absolute workloads were significantly lower in the CKD group. Only in a CKD subgroup reporting low physical activity at baseline, exercise capacity declined. Renal function decreased in both groups, with a faster decline in CKD (p = 0.05 between groups). Peak heart rate, haemoglobin level, handgrip strength, lean body mass and cardiovascular function did not decrease significantly over time in CKD individuals. Conclusions: On a group level, aerobic exercise capacity and peak heart rate were maintained over 5 years in patients with well-controlled mild-to-moderate CKD, despite a slight reduction in glomerular filtration rate, mirroring the lack of progression of cardiovascular and muscular dysfunction in this group. In patients with mild-to-moderate CKD, physical activity level at baseline seems to have a predictive value for exercise capacity at follow-up.

scholarly journals Aerobic exercise capacity is maintained over a 5-year period in mild-to-moderate chronic kidney disease: A longitudinal study

2019 ◽  
Author(s):  
Helena Wallin ◽  
Eva Jansson ◽  
Carin Wallquist ◽  
Britta Hylander Rössner ◽  
Stefan H Jacobson ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Heart Rate ◽  
Renal Function ◽  
Kidney Disease ◽  
Haemoglobin Level ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Peak Heart Rate ◽  
Aerobic Exercise Capacity ◽  
Over Time

Abstract Background: Aerobic exercise capacity is reduced in non-dialysis chronic kidney disease (CKD), but little is known about the magnitude of changes in exercise capacity over time. In a 5-year-prospective study, we evaluated exercise capacity and known determinants of exercise capacity in patients with mild-to-moderate CKD attending a specialist nephrology clinic. Methods: We included 52 individuals with CKD stage 2–3 and 54 age- and sex-matched healthy controls. Peak workload was assessed through a maximal cycle exercise test. Muscle strength and lean body mass, cardiac function, vascular stiffness, renal function and haemoglobin level were evaluated. Tests were repeated after 5 years. Statistical analysis of longitudinal data was performed using linear mixed models. Results: Exercise capacity did not change significantly over time in either CKD individuals or controls, although the absolute workload levels were significantly lower in CKD individuals. Renal function decreased in both groups, with a faster decline in CKD (p = 0.05 between groups). Peak heart rate, haemoglobin level, handgrip strength, lean body mass and cardiovascular function did not decrease significantly over time in CKD individuals. Physical activity level increased over 5 years only in the CKD group. Conclusions: Aerobic exercise capacity and peak heart rate are maintained over 5 years in a group of patients with well-controlled CKD grade 2–3, despite a slight reduction in glomerular filtration rate, mirroring the lack of progression of cardiovascular and muscular dysfunction in this group.

scholarly journals Physical activity is associated with improved aerobic exercise capacity over time in adults with congenital heart disease

2013 ◽  
Vol 168 (5) ◽  
pp. 4685-4691 ◽  
Author(s):  
Ana Ubeda Tikkanen ◽  
Alexander R. Opotowsky ◽  
Ami B. Bhatt ◽  
Michael J. Landzberg ◽  
Jonathan Rhodes
Keyword(s):  
Physical Activity ◽  
Congenital Heart Disease ◽  
Heart Disease ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Congenital Heart ◽  
Aerobic Exercise Capacity ◽  
Over Time

Aerobic Exercise Capacity In Mild-to-moderate Chronic Kidney Disease Is Maintained Over A 5 Year-period

2018 ◽  
Vol 50 (5S) ◽  
pp. 359
Author(s):  
Helena Wallin ◽  
Anette Rickenlund ◽  
Maria E. Eriksson ◽  
Eva Jansson ◽  
Carin Wallquist ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Aerobic Exercise Capacity ◽  
Moderate Chronic Kidney Disease

Postural balance and physical activity in daily life (PADL) in physically independent older adults with different levels of aerobic exercise capacity

2012 ◽  
Vol 55 (2) ◽  
pp. 480-485 ◽  
Author(s):  
Daniela Hayashi ◽  
Cristiane G. Gonçalves ◽  
Rodolfo B. Parreira ◽  
Karen B.P. Fernandes ◽  
Denilson C. Teixeira ◽  
...  
Keyword(s):  
Physical Activity ◽  
Older Adults ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Postural Balance ◽  
Daily Life ◽  
Aerobic Exercise Capacity ◽  
Different Levels

Effects of Physical Activity and Aerobic Exercise Capacity on Aortic Stiffness in Patients With Untreated Hypertension

2009 ◽  
Vol 39 (2) ◽  
pp. 52 ◽  
Author(s):  
Sang-Hoon Na ◽  
Yong-Seok Kim ◽  
Jun-Ho Bae ◽  
Deuk-Young Nah ◽  
Young-Kwon Kim ◽  
...  
Keyword(s):  
Physical Activity ◽  
Aerobic Exercise ◽  
Exercise Capacity ◽  
Aortic Stiffness ◽  
Aerobic Exercise Capacity ◽  
Untreated Hypertension

scholarly journals Decreased Aerobic Exercise Capacity After Long-Term Remission From Cushing Syndrome: Exploration of Mechanisms

2019 ◽  
Vol 105 (4) ◽  
pp. e1408-e1418 ◽  
Author(s):  
Sean H P P Roerink ◽  
Matthew S Cocks ◽  
Margreet A E M Wagenmakers ◽  
Raffaella P Rodighiero ◽  
Juliette A Strauss ◽  
...  
Keyword(s):  
Aerobic Exercise ◽  
Protein Content ◽  
Exercise Capacity ◽  
Muscle Fiber ◽  
Cushing Syndrome ◽  
Activity Level ◽  
Control Individual ◽  
Mitochondrial Content ◽  
Cross Sectional ◽  
Aerobic Exercise Capacity

Abstract Background Although major improvements are achieved after cure of Cushing syndrome (CS), fatigue and decreased quality of life persist. This is the first study to measure aerobic exercise capacity in patients in remission of CS for more than 4 years in comparison with matched controls, and to investigate whether the reduction in exercise capacity is related to alterations in muscle tissue. Methods Seventeen patients were included. A control individual, matched for sex, estrogen status, age, body mass index, smoking, ethnicity, and physical activity level was recruited for each patient. Maximal aerobic capacity (VO2peak) was assessed during incremental bicycle exercise to exhaustion. In 8 individually matched patients and controls, a percutaneous muscle biopsy was obtained and measures were made of cross-sectional areas, capillarization, and oxphos complex IV (COXIV) protein content as an indicator of mitochondrial content. Furthermore, protein content of endothelial nitric oxide synthase (eNOS) and eNOS phosphorylated on serine1177 and of the NAD(P)H-oxidase subunits NOX2, p47phox, and p67phox were measured in the microvascular endothelial layer. Findings Patients showed a lower mean VO2peak (SD) (28.0 [7.0] vs 34.8 [7.9] ml O2/kg bw/min, P < .01), maximal workload (SD) (176 [49] vs 212 [67] watt, P = .01), and oxygen pulse (SD) (12.0 [3.7] vs 14.8 [4.2] ml/beat, P < .01) at VO2peak. No differences were seen in muscle fiber type–specific cross-sectional area, capillarization measures, mitochondrial content, and protein content of eNOS, eNOS-P-ser1177, NOX2, p47phox, and p67phox. Interpretation Because differences in muscle fiber and microvascular outcome measures are not statistically significant, we hypothesize that cardiac dysfunction, seen in active CS, persists during remission and limits blood supply to muscles.

Maximal Oxygen Uptake and Daily Physical Activity in 7- to 12-Year-Old Boys

1993 ◽  
Vol 5 (4) ◽  
pp. 357-366 ◽  
Author(s):  
Hazzaa M. Al-Hazzaa ◽  
Mohammed A. Sulaiman
Keyword(s):  
Physical Activity ◽  
Heart Rate ◽  
Oxygen Uptake ◽  
Maximal Oxygen Uptake ◽  
Open Circuit ◽  
Daily Physical Activity ◽  
Activity Level ◽  
Activity Levels ◽  
School Time ◽  
The Relationship

The present study examined the relationship between maximal oxygen uptake (V̇O2max) and daily physical activity in a group of 7- to 12-year-old boys. V̇O2max was assessed through the incremental treadmill test using an open circuit system. Physical activity level was obtained from heart rate telemetry outside of school time for 8 hrs during weekdays and during 40 min of physical education classes. The findings indicated that the absolute value of V̇O2max increased with age, while relative to body weight it remained almost the same across age, with a mean of 48.4 ml · kg−1 · min−1. Moreover, heart rate telemetry showed that the boys spent a limited amount of time on activities that raise the heart rate to a level above 160 bpm (an average of 1.9%). In addition, V̇O2max was found to be significantly related to the percentage of time spent at activity levels at or above a heart rate of 140 bpm, but not with activity levels at or above a heart rate of 160 bpm.

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