scholarly journals Patients with IVF complicated by moderate-to-critical OHSS experience increased thrombosis,GDM and neonatal NICU admission but slightly shorter gestation compared with matched IVF counterparts: A retrospective Chinese cohort study

2020 ◽  
Author(s):  
Linli Hu ◽  
Rui Xie ◽  
Mengying Wang ◽  
Yingpu Sun
Keyword(s):  
Live Birth ◽  
Ovarian Hyperstimulation Syndrome ◽  
Incidence Rates ◽  
Obstetric Complications ◽  
Neonatal Outcomes ◽  
Premature Delivery ◽  
Control Group ◽  
Hypertensive Disorder ◽  
Ovarian Hyperstimulation ◽  
Neonatal Complications

Abstract Background : Ovarian hyperstimulation syndrome (OHSS) is a common disease during controlled ovarian hyperstimulation treatment. However, the obstetrics and neonatal outcomes of these group of patients are barely known. The aim of this study was to explore the effects of late moderate-to-critical ovarian hyperstimulation syndrome (OHSS) on obstetric and neonatal outcomes. Methods: This is a prospective observational study including 17,537 patients after IVF/ICSI-fresh embryo transfer (ET) from June 2012 to July 2016, after meeting the inclusion and exclusion criteria, of whom 7064 eligible patients were diagnosed with clinical pregnancy. Finally, 6356 patients were allocated to the control group, and 385 patients who were hospitalized and treated at the center for late moderate-to-critical OHSS were allocated to the OHSS group. Results: The live birth delivery rate did not significantly differ between the OHSS and the macthed control groups, and the incidence rates of the obstetric complications venous thrombosis (VT), gestational diabetes mellitus (GDM), neonatal complications and the numbers of neonates admitted to the NICU were significantly higher in the OHSS group than that in the macthed control group. The duration of gestation was significantly higher in the macthed control group than that in the OHSS group. Conclusions: Late moderate-to-critical OHSS could reduce gestational time, increase obstetric complications and neonatal complications. However, the incidence rates of live birth rate, premature delivery, miscarriage, early abortion, hypertensive disorder of pregnancy (HDP), Placenta previa (PP), Intrahepatic cholestasis of pregnancy (ICP), average neonatal weight and LBW did not statistically significant difference between the two groups.

scholarly journals Patients with IVF complicated by moderate-to-critical OHSS experience increased thrombosis, GDM and neonatal NICU admission but slightly shorter gestation compared with matched IVF counterparts: A retrospective Chinese cohort study

2020 ◽  
Author(s):  
Linli Hu ◽  
Rui Xie ◽  
Mengying Wang ◽  
Yingpu Sun
Keyword(s):  
Live Birth ◽  
Ovarian Hyperstimulation Syndrome ◽  
Matched Control ◽  
Incidence Rates ◽  
Obstetric Complications ◽  
Neonatal Outcomes ◽  
Control Group ◽  
Ovarian Hyperstimulation ◽  
Matched Control Group ◽  
Neonatal Complications

Abstract Background: Ovarian hyperstimulation syndrome (OHSS) is a common disease during controlled ovarian hyperstimulation treatment. However, the obstetrics and neonatal outcomes of these group of patients are barely known. The aim of this study was to explore the effects of late moderate-to-critical ovarian hyperstimulation syndrome (OHSS) on obstetric and neonatal outcomes.Methods: This prospective observational study included 17,537 patients who underwent IVF/ICSI-fresh embryo transfer (ET) between June 2012 and July 2016 and met the inclusion and exclusion criteria, including 7064 eligible patients diagnosed with clinical pregnancy. Finally, 6356 patients were allocated to the control group, and 385 patients who were hospitalized and treated at the center for late moderate-to-critical OHSS were allocated to the OHSS group.Results: The duration of gestation in the matched control group was significantly higher than that in the OHSS group. The live birth delivery rate did not significantly differ between the OHSS and the matched control groups, and the incidence rates of the obstetric complications venous thrombosis (VT) and gestational diabetes mellitus (GDM), neonatal complications and the numbers of neonates admitted to the NICU in the OHSS group were significantly higher than those in the matched control group. Conclusions: Late moderate-to-critical OHSS could reduce the gestational time and increase obstetric complications and neonatal complications. However, the live birth rate and incidence rates of premature delivery, miscarriage, early abortion, hypertensive disorder of pregnancy (HDP), placenta previa (PP), intrahepatic cholestasis of pregnancy (ICP), average neonatal weight and LBW did not statistically significant differ between the two groups.

scholarly journals Perinatal outcomes in women with in vitro fertilization pregnancies hospitalized for late moderate-to-critical ovarian hyperstimulation syndrome: A prospective observational study

2020 ◽  
Author(s):  
Linli Hu ◽  
Rui Xie ◽  
Mengying Wang ◽  
Yingpu Sun
Keyword(s):  
Observational Study ◽  
Live Birth ◽  
Ovarian Hyperstimulation Syndrome ◽  
Prospective Observational Study ◽  
Incidence Rates ◽  
Obstetric Complications ◽  
Neonatal Outcomes ◽  
Premature Delivery ◽  
Complication Rates ◽  
Ovarian Hyperstimulation

Abstract Background Ovarian hyperstimulation syndrome (OHSS) is a common disease during controlled ovarian hyperstimulation treatment. However, the obstetrics and neonatal outcomes of these group of patients are barely known. The aim of this study was to explore the effects of late moderate-to-critical ovarian hyperstimulation syndrome (OHSS) on obstetric and neonatal outcomes. Methods This is a prospective observational study including 17,537 patients after IVF/ICSI-fresh embryo transfer (ET) from June 2012 to July 2016, after meeting the inclusion and exclusion criteria, of whom 7064 eligible patients were diagnosed with clinical pregnancy. Finally, 6356 patients were allocated to the control group, and 385 patients who were hospitalized and treated at the center for late moderate-to-critical OHSS were allocated to the OHSS group. Results The live birth delivery and neonatal complication rates did not significantly differ between the OHSS and control groups, and the incidence rates of the obstetric complications venous thrombosis (VT) and gestational diabetes mellitus (GDM) were significantly higher in the OHSS group. Conclusions Late moderate-to-critical OHSS could reduce gestational time, increase obstetric complications and neonatal complications. However, the incidence rates of live birth rate, premature delivery, miscarriage, early abortion, PIH, PP, ICP, average neonatal weight and LBW did not statistically significant difference between the two groups.

scholarly journals Patients with IVF complicated by moderate-to-critical OHSS experience increased thrombosis,GDM and neonatal NICU admission but slightly shorter gestation compared with matched IVF counterparts: A retrospective Chinese cohort study

2020 ◽  
Author(s):  
Linli Hu ◽  
Rui Xie ◽  
Mengying Wang ◽  
Yingpu Sun
Keyword(s):  
Live Birth ◽  
Birth Rate ◽  
Matched Control ◽  
Live Birth Rate ◽  
Incidence Rates ◽  
Obstetric Complications ◽  
Control Group ◽  
Ovarian Hyperstimulation ◽  
Matched Control Group ◽  
Neonatal Complications

Abstract Background: Ovarian hyperstimulation syndrome (OHSS) is a common disease during controlled ovarian hyperstimulation treatment. However, the obstetric and neonatal outcomes of this group of patients are unknown. The aim of this study was to explore the effects of late moderate-to-critical OHSS on obstetric and neonatal outcomes.Methods: This prospective observational study included 17,537 patients who underwent IVF/ICSI-fresh embryo transfer (ET) between June 2012 and July 2016 and met the inclusion criteria, including 7,064 eligible patients diagnosed with clinical pregnancy. Ultimately, 6,356 patients were allocated to the control group, and 385 patients who were hospitalized and treated at the center for late moderate-to-critical OHSS were allocated to the OHSS group. Then, propensity score matching analysis was performed, matching nine maternal baseline covariates and the number of multiple gestations; 385 patients with late moderate-to-critical OHSS were compared with a matched control group of 1,540 patients. The primary outcomes were the live birth rate, preterm delivery rate, miscarriage rate, gestational age at birth (weeks), obstetric complications and neonatal complications.Results: The duration of gestation in the matched control group was significantly higher than that in the OHSS group. The live birth delivery rate did not significantly differ between the OHSS and matched control groups. The incidence rates of the obstetric complications venous thrombosis (VT) and gestational diabetes mellitus (GDM), neonatal complications and the number of neonates admitted to the NICU were significantly higher in the OHSS group than in the matched control group.Conclusions: Pregnant women undergoing IVF with fresh ET whose course is complicated by late moderate-to-critical OHSS appear to experience shortened gestation and increased obstetrical and neonatal complications compared with matched controls whose course is not complicated by OHSS. However, the live birth rate, average neonatal weight, and incidence rates of premature delivery, miscarriage, early abortion, hypertensive disorder of pregnancy (HDP), placenta previa (PP), intrahepatic cholestasis of pregnancy (ICP), and low neonatal birth weight (LBW) did not differ significantly between the two groups.

scholarly journals Patients with IVF complicated by moderate-to-critical OHSS experience increased thrombosis,GDM and neonatal NICU admission but slightly shorter gestation compared with matched IVF counterparts: A retrospective Chinese cohort study

2020 ◽  
Author(s):  
Linli Hu ◽  
Rui Xie ◽  
Mengying Wang ◽  
Yingpu Sun
Keyword(s):  
Live Birth ◽  
Ovarian Hyperstimulation Syndrome ◽  
Birth Rate ◽  
Matched Control ◽  
Live Birth Rate ◽  
Incidence Rates ◽  
Obstetric Complications ◽  
Control Group ◽  
Ovarian Hyperstimulation ◽  
Matched Control Group

Abstract Background: Ovarian hyperstimulation syndrome (OHSS) is a common disease during controlled ovarian hyperstimulation treatment. However, the obstetrics and neonatal outcomes of these group of patients are barely known. The aim of this study was to explore the effects of late moderate-to-critical ovarian hyperstimulation syndrome (OHSS) on obstetric and neonatal outcomes.Methods: This prospective observational study included 17,537 patients who underwent IVF/ICSI-fresh embryo transfer (ET) between June 2012 and July 2016 and met the inclusion and exclusion criteria, including 7064 eligible patients diagnosed with clinical pregnancy. Finally, 6356 patients were allocated to the control group, and 385 patients who were hospitalized and treated at the center for late moderate-to-critical OHSS were allocated to the OHSS group. Then, propensity score matching analysis was performed, with matching of nine maternal baseline covariates and the number of multiple gestations. 385 patients of late moderate-to-critical OHSS and compared with a matched control group of 1540 patients. The primary outcomes were live birth rate, preterm delivery rate, miscarriage rate, gestational age at birth (weeks), obstetric complications and neonatal complications.Results: The duration of gestation in the matched control group was significantly higher than that in the OHSS group. The live birth delivery rate did not significantly differ between the OHSS and the matched control groups, and the incidence rates of the obstetric complications venous thrombosis (VT) and gestational diabetes mellitus (GDM), neonatal complications and the numbers of neonates admitted to the NICU in the OHSS group were significantly higher than those in the matched control group.Conclusions: Pregnant women undergoing IVF-ET fresh transplantation will shorten the gestational time and increase obstetric complications and neonatal complications because of Late moderate-to-critical OHSS. However, the live birth rate and incidence rates of premature delivery, miscarriage, early abortion, hypertensive disorder of pregnancy (HDP), placenta previa (PP), intrahepatic cholestasis of pregnancy (ICP), average neonatal weight and LBW did not statistically significant differ between the two groups.

scholarly journals Patients with IVF complicated by moderate-to-critical OHSS experience increased thrombosis, GDM and neonatal NICU admission but slightly shorter gestation compared with matched IVF counterparts: A retrospective Chinese cohort study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Linli Hu ◽  
Rui Xie ◽  
Mengying Wang ◽  
Yingpu Sun
Keyword(s):  
Live Birth ◽  
Birth Rate ◽  
Matched Control ◽  
Live Birth Rate ◽  
Incidence Rates ◽  
Obstetric Complications ◽  
Control Group ◽  
Ovarian Hyperstimulation ◽  
Matched Control Group ◽  
Neonatal Complications

Abstract Background Ovarian hyperstimulation syndrome (OHSS) is a common disease during controlled ovarian hyperstimulation treatment. However, the obstetric and neonatal outcomes of this group of patients are unknown. The aim of this study was to explore the effects of late moderate-to-critical OHSS on obstetric and neonatal outcomes. Methods This prospective observational study included 17,537 patients who underwent IVF/ICSI-fresh embryo transfer (ET) between June 2012 and July 2016 and met the inclusion criteria, including 7,064 eligible patients diagnosed with clinical pregnancy. Ultimately, 6,356 patients were allocated to the control group, and 385 patients who were hospitalized and treated at the center for late moderate-to-critical OHSS were allocated to the OHSS group. Then, propensity score matching analysis was performed, matching nine maternal baseline covariates and the number of multiple gestations; 385 patients with late moderate-to-critical OHSS were compared with a matched control group of 1,540 patients. The primary outcomes were the live birth rate, preterm delivery rate, miscarriage rate, gestational age at birth (weeks), obstetric complications and neonatal complications. Results The duration of gestation in the matched control group was significantly higher than that in the OHSS group. The live birth delivery rate did not significantly differ between the OHSS and matched control groups. The incidence rates of the obstetric complications venous thrombosis (VT) and gestational diabetes mellitus (GDM), neonatal complications and the number of neonates admitted to the NICU were significantly higher in the OHSS group than in the matched control group. Conclusions Pregnant women undergoing IVF with fresh ET whose course is complicated by late moderate-to-critical OHSS appear to experience shortened gestation and increased obstetrical and neonatal complications compared with matched controls whose course is not complicated by OHSS. However, the live birth rate, average neonatal weight, and incidence rates of premature delivery, miscarriage, early abortion, hypertensive disorder of pregnancy (HDP), placenta previa (PP), intrahepatic cholestasis of pregnancy (ICP), and low neonatal birth weight (LBW) did not differ significantly between the two groups.

scholarly journals Scoping review of coronavirus case series (SARS-CoV, MERS-CoV and SARS-CoV-2) and their obstetric and neonatal results

2020 ◽  
Vol 33 (5) ◽  
pp. 313-326 ◽  
Author(s):  
Noelia Rodríguez-Blanco ◽  
Irene Vegara-Lopez ◽  
Loreto Aleo-Giner ◽  
José Tuells ◽  
Keyword(s):  
Pregnant Women ◽  
Scoping Review ◽  
Clinical Characteristics ◽  
Case Series ◽  
Obstetric Complications ◽  
Neonatal Outcomes ◽  
Premature Delivery ◽  
Neonatal Complications ◽  
Information Center ◽  
Bibliographic Search

Background. The appearance of new infectious diseases, such as COVID-19, poses a challenge in monitoring pregnancy and preventing obstetric and neonatal complications. A scoping review has the objective to review the information available in pregnant women infected with the MERS-CoV, SARSCoV, SARS-CoV-2 coronaviruses to assess the similarities in terms of and differences in the clinical characteristics of the mothers and neonatal outcomes. Methods. We carried out a bibliographic search (scoping review) according to the PRISMA guidelines between March and April 2020 in the MEDLINE, SciELO, and CUIDEN databases and the Elsevier COVID-19 Information Center. Results. We analyzed 20 articles with a total of 102 cases. 9 of MERS-CoV, 14 of SARS-CoV and 79 of SARS-CoV-2. Fever (75.5%) and pneumonia (73.5%) were the most frequent symptoms in infected pregnant women. The most frequent obstetric complications were the threat of premature delivery (23.5%) and caesarean section (74.5%). No vertical transmission was documented in any of the infants. Conclusions. All three coronaviruses produce pneumonia with very similar symptoms, being milder in the case of SARSCoV2. Despite documented obstetric complications, neonatal outcomes are mostly favorable. Increased knowledge is needed to improve and prevent obstetric and neonatal complications from these infections in pregnant women.

scholarly journals Reproductive Outcomes of Women with Polycystic Ovarian Syndrome Following In-Vitro Fertilization — A Meta-Analysis and Systematic Review

2019 ◽  
Vol 01 (04) ◽  
pp. 193-201
Author(s):  
I-Ferne Tan ◽  
Audrey J. R. Lim ◽  
Inthrani R. Indran ◽  
Michael S. Kramer ◽  
Eu-Leong Yong
Keyword(s):  
Live Birth ◽  
Ovarian Hyperstimulation Syndrome ◽  
Birth Rate ◽  
Meta Analysis ◽  
Live Birth Rate ◽  
Ovarian Hyperstimulation ◽  
Vitro Fertilization ◽  
Ivf Outcomes ◽  
Ovarian Syndrome

Background: Polycystic ovarian syndrome (PCOS) is a common cause of infertility in women. In-vitro fertilization (IVF) is required in 20–30% of women with PCOS trying to conceive. This is associated with increased risk of multiple gestation and ovarian hyperstimulation syndrome. Improvements in IVF techniques, safety standards, and the increased use of frozen embryos in recent years have lead to improved outcomes for women with PCOS. We performed a systematic review and meta-analysis to compare these outcomes with women without PCOS. Search Methods: A search of PubMed, EMBASE, the Cochrane Central Register of clinical trials, and Scopus databases for all articles published until November 16th, 2017 identified 21 studies comparing IVF outcomes in PCOS and non-PCOS women. Inclusion criteria were Rotterdam criteria PCOS, comparable IVF regimes, immediate IVF outcomes, and pregnancy outcomes. Studies were excluded if the control group included any PCOS criteria, donor oocytes, or in-vitro maturation. Outcomes: No difference was observed in live birth rate per cycle in women with vs. without PCOS (RR [Formula: see text] 1.01 [0.89, 1.16]; [Formula: see text] 82%), but the live birth rate per first cycle in PCOS cycles (RR [Formula: see text] 0.93 [0.88, 0.99]) was slightly lower. There was also no difference in the clinical pregnancy rate (RR 1.02 [0.89, 1.17]) or biochemical pregnancy rate (RR 1.03 [0.99, 1.08]) observed between the two groups. PCOS was associated with a significantly higher number of oocytes retrieved (mean difference [Formula: see text] 3.6; 95% CI [2.8, 4.4]), risk of miscarriage (RR 2.90 [2.09, 4.02]), and risk of ovarian hyperstimulation syndrome (RR 3.42 [2.28, 5.13]) per cycle. Conclusion: Despite a widespread perception of poor reproductive potential, women with PCOS experience IVF outcomes similar to those without PCOS. Although there is a slightly lower live birth rate during their first stimulation cycle, success rates are similar after multiple cycles. PCOS is associated with a higher risk of ovarian hyperstimulation syndrome. Further studies are required to mitigate this risk.

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