scholarly journals Myocardial Infarction as An Independent Predictor of Intramyocardial Hemorrhage in Acute Reperfused Myocardial Ischemic Rats

2021 ◽  
Author(s):  
Rui Xia ◽  
Tong Zhu ◽  
Yu Zhang ◽  
Bo He ◽  
Yushu Chen ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Significant Positive Correlation ◽  
T2 Mapping ◽  
Critical Factor ◽  
Myocardial Edema ◽  
Myocardial Tissue ◽  
Experimental Sample ◽  
Positive Correlation ◽  
Infarction Size ◽  
Custom Made

Abstract Background: In the previous studies, hemorrhage occurred only with the largest infarctions and studies confirmed a moderate correlation between the extent of necrosis and hemorrhage, but the extent of infarction size of these studies was limited. This study was to find the correlations between intramyocardial hemorrhage (IMH), myocardial infarction (MI), and myocardial edema (ME) from days 2 to 7 in a 7.0T MR scanner.Methods: The different degrees of myocardial ischemia were induced by occluding different sections of the proximal left anterior descending coronary artery (1–3 mm under the left auricle). T2*-mapping, T2-mapping and late gadolinium enhancement (LGE) sequences were performed on a 7.0T MR system at day 2 and 7. T2*- and T2-maps were calculated using a custom-made software. All areas were expressed as a percentage of the whole myocardial tissue of the left ventricle. The rats were divided into two groups based on the T2* results; MI with IMH was referred to as the +IMH group, while MI without IMH was referred to as the –IMH group.Results: The final experimental sample consisted of 25 rats in the +IMH group and 10 rats in the –IMH group. For the +IMH group. On day 2, There was a significant positive correlation between IMH size and MI size (r = 0.677, P<0.01), and a positive correlation between IMH size and ME size (r = 0.552, P<0.01). On day 7, There was a significant positive correlation between IMH size and MI size (r = 0.711, P<0.01), while no correlation was found between IMH size and ME size (r = 0.429, P = 0.097). Conclusions: Infarction size prior to reperfusion is a critical factor in determining whether a MI is hemorrhagic or non-hemorrhagic in rats.

Assessment of myocardial edema and area at risk in a rat model of myocardial infarction with a faster T2 mapping method

2015 ◽  
Vol 56 (9) ◽  
pp. 1085-1090 ◽  
Author(s):  
Rui Xia ◽  
Xi Lu ◽  
Bing Zhang ◽  
Yuqing Wang ◽  
Jichun Liao ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
At Risk ◽  
Rat Model ◽  
T2 Mapping ◽  
Myocardial Edema ◽  
Mapping Method ◽  
Area At Risk

scholarly journals Serum complement (C3, C4) levels in patients with acute myocardial infarction and angina pectoris

2008 ◽  
Vol 33 (3) ◽  
pp. 98-102 ◽  
Author(s):  
ASM Giasuddin ◽  
Jamila M ElMahdawi ◽  
Fakhri M ElHassadi
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Angina Pectoris ◽  
Acute Phase ◽  
Significant Positive Correlation ◽  
Complement C3 ◽  
Serum Complement ◽  
Positive Correlation ◽  
Control Subjects

Serum complement (C3, C4) levels in Libyan patients with acute myocardial infarction (AMI; 31 patients) and angina pectoris (AP; 11 patients) at the 1st day and 7th day of attack were estimated. A group of 26 healthy Libyans were taken as control subjects (CS). Serum C3 and C4 levels (mean ± SD, mg/dl) were elevated at the 1st day in AMI as well as AP patients (C3 → AMI1: 154.0 ± 28.5, AP1: 152.0 ± 45.0, CS: 132.0 ± 8.0, ANOVA: p=0.0072; C4→ AMI1: 38 ± 13, AP1: 37 ± 17, CS: 29 ± 6, ANOVA: p=0.0160). No significant differences for the elevated C3 and C4 levels at the 1st day were observed between the two diseases groups (AMI1 vs AP1 → C3: p=0.879, C4: p=0.818). At the 7th day, C3 and C4 levels were further elevated in AMI, while they remained at the similar elevated levels in AP (C3 → AMI 7: 173.1 ± 28.0, AP 7: 149.0 ± 41.0, CS: 132.0 ± 8.0, ANOVA: p=0.0000; C4 → AMI 7: 46.0 ± 7.0, AP 7: 36.0 ± 15.0, CS: 29.0 ± 6.0, ANOVA: p=0.0000). Again, no significance differences for the raised C3 and C4 levels at the 7th day was observed between AMI and AP patients (AMI 7 vs AP 7 → C3: P=0.059, C4: p=0.06). The C3 elevation showed significant positive correlation in AMI group (r=0.522, p=0.003) while it was insignificant in AP patients (r=0.037, p=0.915). Regarding C4 levels, it was significantly correlated in AMI (r=0.483, p=0.006), and in AP, although it was positively correlated (r=0.656, P=0.028) the observed difference was not significant (t=0.29, p=0.778). In conclusion, serum C3 and C4 levels were more profoundly elevated in AMI compared to AP patients suggestive of an acute phase and inflammatory response.DOI = 10.3329/bmrcb.v33i3.1141Bangladesh Med Res Counc Bull 2007; 33: 98-102

scholarly journals Serial native T1- and T2-mapping to quantitatively monitor resorption of myocardial edema following acute myocardial infarction

2015 ◽  
Vol 17 (S1) ◽  
Author(s):  
Enver Tahir ◽  
Martin R Sinn ◽  
Ulf K Radunski ◽  
Dennis Säring ◽  
Christian Stehning ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
T2 Mapping ◽  
Myocardial Edema ◽  
Native T1 ◽  
T1 And T2

scholarly journals Serial T2-mapping to quantitatively monitor resorption of myocardial edema following acute myocardial infarction

2013 ◽  
Vol 15 (S1) ◽  
Author(s):  
Gunnar Lund ◽  
Kai Muellerleile ◽  
Peter Bannas ◽  
Julia Cuerlis ◽  
Dominik Barz ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
T2 Mapping ◽  
Myocardial Edema

scholarly journals T2 Versus T2* MRI Mapping in the Knee Articular Cartilage at 1.5 Tesla and 3 Tesla

2018 ◽  
Vol 5 (1) ◽  
pp. 119-129 ◽  
Author(s):  
Mokhtar Mars ◽  
Zeineb Tbini ◽  
Souha Gharbi ◽  
Mouna Chelli Bouaziz ◽  
Fethi Ladeb
Keyword(s):  
Articular Cartilage ◽  
Negative Correlation ◽  
Significant Positive Correlation ◽  
T2 Mapping ◽  
Relaxation Times ◽  
Significant Negative Correlation ◽  
3 Tesla ◽  
T2 Relaxation ◽  
Positive Correlation ◽  
T2 Mri

Background: Recently, several studies have shown that T2 and T2* MRI parametric mapping are sensitive to structural and biochemical changes in the extracellular cartilage matrix. The objective of this study was to assess, compare and correlate quantitative T2 and T2* relaxation time of the knee articular cartilage at 1.5 Tesla (T) and 3 Tesla. Methods: Thirty-eight symptomatic patients with knee articular cartilage disease and forty-one asymptomatic volunteers were prospectively included in the study. Knee MRI examination was performed by 3 T and 1.5 T scanner. Multi-Echo Spin-Echo (MESE) and Multi-Echo Gradient Echo (MEGE) sequences were used to determine T2* and T2 maps. T2 and T2* relaxation times values were measured in three Regions Of Itnterest (ROI) on knee articular cartilage using mono-exponential analysis fitting algorithm. Results: There was a significant difference between volunteers and patients for T2 and T2* relaxation times values at 1.5 T and 3 T (p<0.05). The comparison between magnetic fields has shown lower T2 and T2* relaxation times at 3 T compared to 1.5 T. Pearson’s correlation analysis between T2 and T2* at 1.5T revealed a significant positive correlation for volunteers (r=0.245, p = 0.01) and a significant negative correlation for patients (0.016, p = 0.018). At 3T, there was a significant positive correlation between T2 and T2* for volunteers (r=0.076) and patients (r=0.165). The correlation of T2 and T2* between 1.5 T and 3T showed a significant negative correlation (r=-0.087, p = 0.01). Conclusion: T2* mapping may be used for the diagnosis of knee articular cartilage osteoarthritis with the advantage of relatively short scanning time, higher SNR, shorter echo times and the non-effect of the stimulated echo compared to T2 mapping.

scholarly journals Oxidative stress in myocardial infarction-does it correlate with the cardiac marker troponin?

2021 ◽  
Vol 8 (3) ◽  
pp. 190-192
Author(s):  
Pallavi R ◽  
Prabha S P ◽  
Sumina Cherian ◽  
Venugopal K ◽  
Geetha A
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Heart Attack ◽  
Significant Positive Correlation ◽  
Troponin I ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Cardiac Marker ◽  
Positive Correlation ◽  
Significant Difference

A myocardial infarction (MI), often known as a heart attack, occurs when blood supply to a region of the heart is reduced or stopped, resulting in heart muscle damage. One of the elemental mechanisms responsible for the development of myocardial infarction is oxidative stress. The study aims to assess the Oxidative stress and Troponin I levels in patients with myocardial infarction (MI) and compare them with the level of these parameters in healthy controls. An attempt has been made to find if there is any correlation between oxidative stress and Troponin I levels in patients with myocardial infarction.The Cardiac marker Troponin I and the marker of oxidative stress malondialdehyde were estimated in 30 patients with myocardial infarction and 30 healthy individuals who acted as controls. A statistically significant difference was observed between Troponin I and MDA in patients with MI as compared with controls. A significant positive correlation was also observed between MDA and Troponin I levels. In our study there wasa significant positive correlation between oxidative stress and Troponin I. Further studies with a larger number of subjects will be needed to find if oxidative stress plays a role in the pathogenesis of myocardial infarction.

Quantitative T2 mapping for detecting myocardial edema after reperfusion of myocardial infarction: validation and comparison with T2-weighted images

2013 ◽  
Vol 29 (S1) ◽  
pp. 65-72 ◽  
Author(s):  
Chul Hwan Park ◽  
Eui-Young Choi ◽  
Hyuck Moon Kwon ◽  
Bum Kee Hong ◽  
Byoung Kwon Lee ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
T2 Mapping ◽  
Myocardial Edema ◽  
T2 Weighted Images
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