scholarly journals Oxidative stress in myocardial infarction-does it correlate with the cardiac marker troponin?

2021 ◽  
Vol 8 (3) ◽  
pp. 190-192
Author(s):  
Pallavi R ◽  
Prabha S P ◽  
Sumina Cherian ◽  
Venugopal K ◽  
Geetha A
Keyword(s):  
Oxidative Stress ◽  
Myocardial Infarction ◽  
Heart Attack ◽  
Significant Positive Correlation ◽  
Troponin I ◽  
Healthy Controls ◽  
Healthy Individuals ◽  
Cardiac Marker ◽  
Positive Correlation ◽  
Significant Difference

A myocardial infarction (MI), often known as a heart attack, occurs when blood supply to a region of the heart is reduced or stopped, resulting in heart muscle damage. One of the elemental mechanisms responsible for the development of myocardial infarction is oxidative stress. The study aims to assess the Oxidative stress and Troponin I levels in patients with myocardial infarction (MI) and compare them with the level of these parameters in healthy controls. An attempt has been made to find if there is any correlation between oxidative stress and Troponin I levels in patients with myocardial infarction.The Cardiac marker Troponin I and the marker of oxidative stress malondialdehyde were estimated in 30 patients with myocardial infarction and 30 healthy individuals who acted as controls. A statistically significant difference was observed between Troponin I and MDA in patients with MI as compared with controls. A significant positive correlation was also observed between MDA and Troponin I levels. In our study there wasa significant positive correlation between oxidative stress and Troponin I. Further studies with a larger number of subjects will be needed to find if oxidative stress plays a role in the pathogenesis of myocardial infarction.

Correlation between DJ-1 levels in the cerebrospinal fluid and the progression of disabilities in multiple sclerosis patients

2008 ◽  
Vol 14 (8) ◽  
pp. 1056-1060 ◽  
Author(s):  
M Hirotani ◽  
C Maita ◽  
M Niino ◽  
SM Iguchi-Ariga ◽  
S Hamada ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Healthy Subjects ◽  
Significant Positive Correlation ◽  
Healthy Controls ◽  
Significant Difference ◽  
Relapsing Remitting ◽  
Multiple Sclerosis Patients

Objectives DJ-1 plays a key role in the anti-oxidative stress function. Increasing evidence supports the role of oxidative stress in the pathogenesis of multiple sclerosis (MS). The aim of this study was to investigate whether the DJ-1 levels were increased in patients with MS and to examine its association with the progression of MS. Methods Quantitative immunoblot assays were performed to evaluate the DJ-1 level in serum and cerebrospinal fluid (CSF) collected from relapsing–remitting patients with MS ( n = 29), disease controls subjects ( n = 14), and healthy subjects ( n = 44). Results No significant difference was observed in the serum DJ-1 level among the patients with MS, disease controls, and healthy controls. However, the CSF DJ-1 levels were significantly higher in the patients with MS than in the disease control subjects ( P < 0.0001). A significant positive correlation was also found between the CSF DJ-1 levels and the Multiple Sclerosis Severity Score ( P < 0.005, r = 0.501). Conclusions These results show that the CSF DJ-1 levels are significantly increased in the CSF of patients with MS and that the CSF DJ-1 levels may be associated with the disease progression of MS. Therefore, DJ-1 possibly plays an important role in the pathogenesis of MS.

Increased plasma kynurenine and its relationship to neopterin and tryptophan in Tourette's syndrome

1996 ◽  
Vol 26 (4) ◽  
pp. 857-862 ◽  
Author(s):  
H. Rickards ◽  
S. M. Dursun ◽  
G. Farrar ◽  
T. Betts ◽  
J. A. Corbett ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Negative Correlation ◽  
Plasma Levels ◽  
Significant Positive Correlation ◽  
Significant Negative Correlation ◽  
Healthy Controls ◽  
Positive Correlation ◽  
Control Value ◽  
Cellular Immune ◽  
Patient Value

SynopsisFasting plasma levels of tryptophan, kynurenine and the pteridines, neopterin and tetrahydrobiopterin were measured in seven patients with Gilles de la Tourette syndrome (GTS) and 10 healthy controls. Plasma kynurenine was significantly elevated in the GTS patients. The lowest patient value was higher than the highest control value. Values for tryptophan, neopterin and tetrahydrobiopterin were similar in TS patients and controls. However, in TS patients only, there was a significant negative correlation between tryptophan and neopterin and a significant positive correlation between kynurenine and neopterin when controlling for tryptophan. This finding indicates that activation of cellular immune processes is a possible explanation for the rise in plasma kynurenine.

scholarly journals A Circulating Exosome RNA Signature Is a Potential Diagnostic Marker for Pancreatic Cancer, a Systematic Study

Cancers ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 2565
Author(s):  
Yixing Wu ◽  
Hongmei Zeng ◽  
Qing Yu ◽  
Huatian Huang ◽  
Beatrice Fervers ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Chronic Pancreatitis ◽  
Early Detection ◽  
Validation Dataset ◽  
Healthy Controls ◽  
Rna Seq ◽  
Healthy Individuals ◽  
Kras Mutations ◽  
Significant Difference ◽  
Rna Signature

Several exosome proteins, miRNAs and KRAS mutations have been investigated in the hope of carrying out the early detection of pancreatic cancer with high sensitivity and specificity, but they have proven to be insufficient. Exosome RNAs, however, have not been extensively evaluated in the diagnosis of pancreatic cancer. The purpose of this study was to investigate the potential of circulating exosome RNAs in pancreatic cancer detection. By retrieving RNA-seq data from publicly accessed databases, differential expression and random-effects meta-analyses were performed. The results showed that pancreatic cancer had a distinct circulating exosome RNA signature in healthy individuals, and that the top 10 candidate exosome RNAs could distinguish patients from healthy individuals with an area under the curve (AUC) of 1.0. Three (HIST2H2AA3, LUZP6 and HLA-DRA) of the 10 genes in exosomes had similar differential patterns to those in tumor tissues based on RNA-seq data. In the validation dataset, the levels of these three genes in exosomes displayed good performance in distinguishing cancer from both chronic pancreatitis (AUC = 0.815) and healthy controls (AUC = 0.8558), whereas a slight difference existed between chronic pancreatitis and healthy controls (AUC = 0.586). Of the three genes, the level of HIST2H2AA3 was positively associated with KRAS status. However, there was no significant difference in the levels of the three genes across the disease stages (stages I–IV). These findings indicate that circulating exosome RNAs have a potential early detection value in pancreatic cancer, and that a distinct exosome RNA signature exists in distinguishing pancreatic cancer from healthy individuals.

scholarly journals Immature Platelet Fraction as a Non-Invasive Marker for Esophageal Varices

2021 ◽  
pp. 55-64
Author(s):  
Alyaa Marzouk Soliman ◽  
Sherief Mohamed Abd-Elsalam ◽  
Amal Saeid ALBendary ◽  
Osama El. Sayed Negm
Keyword(s):  
Esophageal Varices ◽  
Significant Positive Correlation ◽  
Oesophageal Varices ◽  
P Value ◽  
Positive Correlation ◽  
Non Invasive ◽  
Immature Platelet Fraction ◽  
Significant Difference ◽  
Cirrhotic Patients ◽  
Group 1

Background: All cirrhotic patients should be screened for oesophageal varices (OV) at the time of diagnosis. The development of a non-invasive method for the detection of OV is a vital issue in subjects with cirrhosis to decrease the need for invasive endoscopic procedures that can be costly. This work aimed to evaluate immature platelet fraction (IPF) as a non-invasive marker and predictor of OV. Methods: This cross-sectional study was carried out on 80 cirrhotic patients with esophageal varices diagnosed by upper endoscopy. They were divided into Group (1): 40 patients with cirrhosis with esophageal varices and Group (2): 40 patients with cirrhosis and without esophageal varices. All patients were subjected to the complete history taking, physical examination, routine laboratory investigations (Complete blood count, IPF, C-reactive protein, Liver and kidney function tests, Bone marrow aspiration for some cases, Ascetic sample analysis when applicable), Pelvic-Abdominal ultrasonography, Child Pugh score assessment, Upper GIT endoscopy. Results: There was a significant difference between the studied groups regarding IPF (p<0.001). At cutoff >12 IPF had (AUC= 0.993) with sensitivity of 97.5% and specificity of 97.5% for detection of esophageal varices. There was a significant negative correlation between IPF and platelets count (p- value < 0.001). There was a significant positive correlation between IPF and Child Pugh score (p- value <0.001). There was a highly significant positive correlation between IPF and CRP (p value <0.001). There was significant difference between the two groups as regards splenic longitudinal diameter (p<0.001). As regards platelet count, there was a significant difference between the two groups (p<0.001). It was significantly lower in Group 1. Conclusions: IPF is elevated in cirrhotic patients with naive esophageal varices than in cirrhotic patients without varices. IPF could be used as a noninvasive, easy to measure method for detection of the presence of esophageal varices at a cutoff level of >12.

scholarly journals Correlation of adverse childhood experiences with psychiatric disorders and aggressiveness in adulthood

2010 ◽  
Vol 67 (8) ◽  
pp. 653-658 ◽  
Author(s):  
Ljiljana Samardzic ◽  
Gordana Nikolic ◽  
Grozdanko Grbesa ◽  
Maja Simonovic ◽  
Tatjana Milenkovic
Keyword(s):  
Psychiatric Disorders ◽  
Adverse Childhood Experiences ◽  
Psychotic Disorders ◽  
Psychiatric Patients ◽  
Statistical Significance ◽  
Healthy Individuals ◽  
Childhood Experiences ◽  
Positive Correlation ◽  
Adverse Childhood ◽  
Significant Difference

Background/Aim. Consequences of individual adverse childhood experiences for adult mental health have been precisely studied during past decades. The focus of past research was mainly on childhood maltreatment and neglect. The aim of this paper was to determine association between multiple adverse childhood experiences and psychiatric disorders, as well as their correlation to the degree and type of aggressiveness in adult psychiatric patients. Methods. One hundred and thirteen psychiatric outpatients were divided into three diagnostic groups: psychotics, non-psychotics and alcoholics and compared with fourty healthy individuals. Adverse childhood experiences data were gathered retrospectively, using the Adverse childhood experiences questionnaire and explanatory interview. Aggressiveness was assessed using Buss-Perry Aggression Questionnaire. The Student's t test, ANOVA and correlational analysis were used for evaluation of statistical significance of differences among the groups. A value p < 0.05 was considered statistically significant. Results. Our results showed that the mean number of adverse childhood experiences in each group of psychiatric patients, as well as in the whole group of patients, was statistically significantly higher than in the group of healthy individuals (p < 0.001); there was a statistically significant difference in score of physical aggressiveness between the patients exposed to adverse childhood experiences and those who were not exposed to them (p < 0.05); scores of physical aggressiveness were in positive correlation with the number of adverse childhood experiences (p < 0.05). The highest mean score of adverse childhood experiences was evidenced in the group of patients with psychotic disorders. Conclusion. Multiple adverse childhood experiences are significantly associated with psychotic disorders, nonpsychotic disorders and alcohol dependence in adulthood and their presence is important morbidity risk factor for psychiatric disorders. They are in positive correlation with physical aggressiveness of the patients from these diagnostic groups.

A new biopsy technique for sampling subcutaneous fat in cattle

1972 ◽  
Vol 12 (58) ◽  
pp. 460 ◽  
Author(s):  
DG Saville ◽  
WS Gilbert ◽  
JM Wright
Keyword(s):  
Local Anaesthetic ◽  
Small Area ◽  
Significant Positive Correlation ◽  
Subcutaneous Fat ◽  
Pesticide Level ◽  
Positive Correlation ◽  
Biopsy Technique ◽  
Significant Difference ◽  
Mesenteric Fat

A technique is described for the rapid biopsy sampling of subcutaneous fat in cattle. The technique involves freezing and folding back a small area of skin to allow removal of the underlying fat. The advantages of this technique are that it is rapid, animals do not have to be placed under general or local anaesthetic, no suturing is required and there is little disturbance to the animal. No significant difference in pesticide level was found between subcutaneous, peri-renal, and mesenteric fat, but a significant positive correlation (r = 0.82) was found between combined DDE and DDT levels in biopsy and carcase subcutaneous samples. This indicated that the residues measured from biopsy samples in this experiment were a good indication to levels in the rest of the animal.

scholarly journals Multicenter Clinical and Analytical Evaluation of the AxSYM Troponin-I Immunoassay to Assist in the Diagnosis of Myocardial Infarction

1999 ◽  
Vol 45 (2) ◽  
pp. 206-212 ◽  
Author(s):  
Fred S Apple ◽  
Andrew J Maturen ◽  
Richard E Mullins ◽  
Pennell C Painter ◽  
Melissa S Pessin-Minsley ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Muscle Injury ◽  
Troponin I ◽  
Dynamic Range ◽  
Chronic Renal Disease ◽  
Noncardiac Surgery ◽  
Minimum Detectable Concentration ◽  
Healthy Individuals ◽  
Detectable Concentration ◽  
Serial Samples

Abstract We evaluated the AxSYM troponin I (cTnI) immunoassay for assisting in the detection of acute myocardial infarction (AMI). At four sites, the total imprecision (CV) over 20 days was 6.3–10.2%. The minimum detectable concentration was 0.14 ± 0.05 μg/L. Comparison of cTnI measurements between the AxSYM and Stratus (n = 406) over the dynamic range of the AxSYM assay demonstrated good correlation, r = 0.881, with a proportional bias: AxSYM cTnI = 3.50(Stratus cTnI) − 1.10. The confidence intervals (95%) for the slope and intercept were 3.39–3.64 and −1.32 to −0.95, respectively. The expected cTnI concentration in healthy individuals was ≤0.5 μg/L, whereas the ROC curve-determined cutoff for AMI was 2.0 μg/L. This gave a diagnostic sensitivity of 91.8% and specificity of 92.4% when tested in serial samples collected within 24 h of admission in 633 patients presenting with chest pain, of which 122 had an AMI. The concordances of the AxSYM cTnI with the Stratus cTnI, OPUS cTnI, and Access cTnI were 95.3%, 95.1%, and 94.3%, respectively, from patients with suspected AMI. The AxSYM cTnI demonstrated excellent clinical specificity, ≥96%, in skeletal muscle injury, chronic renal disease, and same-day noncardiac surgery patients.

scholarly journals Serum complement (C3, C4) levels in patients with acute myocardial infarction and angina pectoris

2008 ◽  
Vol 33 (3) ◽  
pp. 98-102 ◽  
Author(s):  
ASM Giasuddin ◽  
Jamila M ElMahdawi ◽  
Fakhri M ElHassadi
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Angina Pectoris ◽  
Acute Phase ◽  
Significant Positive Correlation ◽  
Complement C3 ◽  
Serum Complement ◽  
Positive Correlation ◽  
Control Subjects

Serum complement (C3, C4) levels in Libyan patients with acute myocardial infarction (AMI; 31 patients) and angina pectoris (AP; 11 patients) at the 1st day and 7th day of attack were estimated. A group of 26 healthy Libyans were taken as control subjects (CS). Serum C3 and C4 levels (mean ± SD, mg/dl) were elevated at the 1st day in AMI as well as AP patients (C3 → AMI1: 154.0 ± 28.5, AP1: 152.0 ± 45.0, CS: 132.0 ± 8.0, ANOVA: p=0.0072; C4→ AMI1: 38 ± 13, AP1: 37 ± 17, CS: 29 ± 6, ANOVA: p=0.0160). No significant differences for the elevated C3 and C4 levels at the 1st day were observed between the two diseases groups (AMI1 vs AP1 → C3: p=0.879, C4: p=0.818). At the 7th day, C3 and C4 levels were further elevated in AMI, while they remained at the similar elevated levels in AP (C3 → AMI 7: 173.1 ± 28.0, AP 7: 149.0 ± 41.0, CS: 132.0 ± 8.0, ANOVA: p=0.0000; C4 → AMI 7: 46.0 ± 7.0, AP 7: 36.0 ± 15.0, CS: 29.0 ± 6.0, ANOVA: p=0.0000). Again, no significance differences for the raised C3 and C4 levels at the 7th day was observed between AMI and AP patients (AMI 7 vs AP 7 → C3: P=0.059, C4: p=0.06). The C3 elevation showed significant positive correlation in AMI group (r=0.522, p=0.003) while it was insignificant in AP patients (r=0.037, p=0.915). Regarding C4 levels, it was significantly correlated in AMI (r=0.483, p=0.006), and in AP, although it was positively correlated (r=0.656, P=0.028) the observed difference was not significant (t=0.29, p=0.778). In conclusion, serum C3 and C4 levels were more profoundly elevated in AMI compared to AP patients suggestive of an acute phase and inflammatory response.DOI = 10.3329/bmrcb.v33i3.1141Bangladesh Med Res Counc Bull 2007; 33: 98-102

THE EFFECT OF SENSORIMOTOR RHYTHM ENHANCING NEUROFEEDBACK ON POWER OF ADJACENT FREQUENCY BANDS

2012 ◽  
Vol 24 (04) ◽  
pp. 307-312 ◽  
Author(s):  
Majid Ghoshuni ◽  
Mohammad Firoozabadi ◽  
Mohammad Ali Khalilzadeh ◽  
Mohammad Reza Hashemi Golpayegani
Keyword(s):  
Cognitive Functions ◽  
Significant Positive Correlation ◽  
Healthy Individuals ◽  
Neurofeedback Training ◽  
Frequency Bands ◽  
Positive Correlation ◽  
Sensorimotor Rhythm ◽  
The Given

Sensorimotor rhythm (SMR) neurofeedback training (NFT) has an important role in improvement of cognitive functions in both clinical and healthy individuals. It is very possible that in SMR NFT adjacent frequency bands, such as alpha and beta1, be affected by SMR enhancing neurofeedback. Therefore, the adjacent frequency bands, in addition to SMR, may be associated with the improvement of the cognitive functions. Eight sessions of NFT were applied to healthy individuals to enhance their SMR activity. In order to investigate the effect of SMR enhancing neurofeedback on the power of adjacent frequency bands, correlation between the change in SMR activity and the change in alpha or beta1 activity was computed. The results revealed that there is a highly significant positive correlation between the change in SMR and beta1 activities. The given outcome suggests that during SMR NFT, the effect of both SMR and beta1 be considered together on the improvement of the cognitive functions.

scholarly journals Evaluation of Systemic Antioxidant Level and Oxidative Stress In Relation to Lifestyle and Disease Progression in Asthmatic Patients/ Evaluacija nivoa antioksidanasa i oksidativnog stresa u sistemu u odnosu na životni stil i progresiju bolesti kod obolelih od astme

2016 ◽  
Vol 35 (1) ◽  
pp. 55-62 ◽  
Author(s):  
Abhay Singh Yadav ◽  
Manisha Saini
Keyword(s):  
Oxidative Stress ◽  
Catalase Activity ◽  
Healthy Individuals ◽  
Asthmatic Patients ◽  
Reducing Ability ◽  
Significant Difference ◽  
Severity Of The Disease ◽  
Student’S T ◽  
Plasma Antioxidant ◽  
Post Hoc

SummaryAsthma is a chronic disorder of the airways. Oxidative stress is an important part of asthma pathogenesis. It plays a crucial role in exacerbating the disease, as well as an important consequence of airways inflammation.Aim: The present study was undertaken to investigate the lipid peroxidation and catalase activity in serum and antioxidant level in plasma of asthmatic patients and their association with lifestyle and severity of the disease.Methods: A total of 210 subjects, 120 asthmatics and 90 healthy controls matched in respect to age, sex, lifestyle and socioeconomic status, were chosen randomly for the present study. The samples were analyzed for MDA concentration and catalase activity in serum and ferric reducing ability of plasma (FRAP). Statistical analysis was done using unpaired Student’s t-test, ANOVA with Duncan post hoc test and Pearson coefficient of correlation.Results: The serum MDA was found to be significantly higher in the asthmatics as compared to healthy individuals (p<0.01) while catalase activity in serum and antioxidant level of the plasma were markedly lower in the asthmatics as compared to healthy individuals (p<0.01). A significant difference was observed in serum MDA, catalase activity and plasma antioxidant level among the patients in relation to the severity of disease. There was a marked increase in the serum MDA in the patients with longer duration of the disease (p<0.05).Conclusion: The oxidant-antioxidant imbalance occurs in asthma leading to oxidative stress and is an important part of the asthma pathogenesis.

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