scholarly journals Impact of the serum and blood biomarkers on the severity and survival of the COVID-19 infected patients with dementia

2021 ◽  
Author(s):  
Duygu Aydemir ◽  
Nuriye Nuray Ulusu
Keyword(s):  
Elderly Population ◽  
The Elderly ◽  
Serum Biochemistry ◽  
C Reactive Protein ◽  
Distribution Width ◽  
Reactive Protein ◽  
Dementia Patients ◽  
Disease Mortality ◽  
Laboratory Biomarkers ◽  
Blood Data

Abstract Aim Elderly population is categorized as a risk group for COVID-19 infection and dementia is the major cause of disability in elderly individuals and affects 70% of the elderly population. In this study, we evaluated blood and serum biomarkers of the patients with dementia infected by COVID-19 to evaluate possible indicators of the severity of COVID-19 infection. Methods Laboratory biomarkers of 11 dementia patients between the ages 85-96 infected by COVID-19 have been used for this study. Serum biochemistry and blood data of survived six patients were compared with the five patients who died because of COVID-19 to evaluate biomarkers correlated with COVID-19 severity and disease mortality. Results Fibrinogen, d-dimer, C-reactive protein (CRP), P, and Mg levels increased in the deceased dementia patients compared to the survived ones. Glucose, blood urea nitrogen (BUN), alanine transaminase (ALT), aspartate aminotransferase (AST), troponin, lactate, and procalcitonin levels significantly decreased in the deceased patients compared to the survived ones infected by COVID-19. %NEU, %LYM, MONO, %MONO, EOS, %EOS, %BASO, MPV, PT, INR, hematocrit (HCT), hemoglobin (Hb), total Hb, red blood cells (RBC), PDW, and ferritin levels decreased in the deceased patients compared to the healthy ones, where red cell distribution width (RDW), prothrombin time (PT), WBC and NEU levels significantly increased in the deceased patients infected by COVID-19. Conclusion Changes in the serum biochemistry and blood markers are correlated with COVID-19 infection severity and mortality that can be used to the prediction of disease progression in dementia patients.

scholarly journals Lipid Management in the Elderly Population

2021 ◽  
Vol 3 (1) ◽  
pp. 60-63
Author(s):  
Micheli Ito Gimenes Pires ◽  
Thaise de Araujo Wrubleski ◽  
Gustavo Lenci Marques
Keyword(s):  
Elderly Population ◽  
Cholesterol Absorption ◽  
The Elderly ◽  
Population Ageing ◽  
Blood Levels ◽  
C Reactive Protein ◽  
First Line ◽  
Intestinal Cholesterol Absorption ◽  
Lipid Management ◽  
Reactive Protein

Considering that deaths from cardiovascular disease have been increasing in proportion to population ageing, prevention and treatment of dyslipidemia in elderly people is essential to avoid such outcome. Some biomarkers, albeit with limitations, have shown effectiveness in predicting cardiovascular events. Among them, blood levels of C-reactive protein, Lipoprotein A and, especially, coronary artery calcium. Dyslipidemia management primarily includes changes in lifestyle, such as physical activity, diet and smoking cessation. However, in elderly, drug therapy may be necessary, with statins being the first line treatment. In addition, therapies with drugs that decrease intestinal cholesterol absorption or increase LDL absorption by the liver, for example, have shown benefit when added to conventional therapy. Therefore, this review aims to contemplate some aspects of dyslipidemia in the elderly population, since appropriate management of such condition can significantly avoid undesirable outcomes.

Relationship of C-Reactive Protein to Risk of Cardiovascular Disease in the Elderly

1997 ◽  
Vol 17 (6) ◽  
pp. 1121-1127 ◽  
Author(s):  
Russell P. Tracy ◽  
Rozenn N. Lemaitre ◽  
Bruce M. Psaty ◽  
Diane G. Ives ◽  
Rhobert W. Evans ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
The Elderly ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Relationship Of

scholarly journals FRI0420 ASSOCIATION BETWEEN RED BLOOD CELLS DISTRIBUTION WIDTH AND CARDIOVASCULAR RISK IN OSTEOARTHRITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 808.2-808
Author(s):  
N. Hammam ◽  
G. Salem ◽  
D. Fouad ◽  
S. Rashad
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Functional Limitations ◽  
Functional Limitation ◽  
C Reactive Protein ◽  
Cvd Risk Factors ◽  
Cvd Risk ◽  
Distribution Width ◽  
Reactive Protein ◽  
Lipid Panel

Background:Osteoarthritis (OA) is the most common joint disease that results in patient’s morbidity and disabilities. There is strong evidence that OA is a significant risk factor for cardiovascular disease (CVD). Red cell distribution width (RDW) blood test is a measure of the variation in red blood cell volume and size. Elevated RDW has recently been found to correlate with CVD risk in patients with and without heart disease and autoimmune diseases. RDW may be a marker for factors driving CVS risk.Objectives:: To investigate whether RDW can serve as a potential parameter for indicating cardiovascular risk in OA patients.Methods:A subsample of 819 OA patients was extracted from 2003-2006 National Health & Nutrition Examination Survey in a cross-sectional study. 63.7% of them were females. Their mean age was 66.4 ± 14.1 yrs. Demographic, medical data, inflammatory markers & lipid panel were obtained. Only patients with Haemoglobin>12 mg/dl were included. Functional limitations were assessed using a physical function questionnaire.Results:Elevated levels of RDW were associated with CVD risk factors in OA patients. 532 (65.8%) OA patients had functional limitations, while 78 (9.5%) and 63 (7.6%) known to have heart attacks or stroke ever. Mean RDW was 12.9±1.1fL. There was a positive significant correlation between RDW & CVD risk factors including body mass index (r=0.17, p<0.001), C-reactive protein (r=0.29, p<0.001), serum uric acid (r=0.12, p<0.001), and functional limitation (0.16, p<0.001). No significant association between RDW & lipid panel was found. In multiple regression analysis controlling for age, sex as covariates, body mass index (β =0.02, 95%CI: 0.01, 0.03, p=0.002), C-reactive protein (β =0.35, 95%CI: 0.26, 0.45, p<0.001), and functional limitation (β =0.18, 95%CI: 0.13, 0.35, p=0.03).Conclusion:In addition to known CVD risk in OA patients, elevated RDW levels should prompt physicians to aggressively screen and treat their patients for modifiable CVS risk factors, in addition to OA.Disclosure of Interests:None declared

scholarly journals Correlation of High Sensitive C Reactive Protein Levels as Inflammation Marker with Red Blood Cell Distribution Width Value in Regular Hemodialysis Patients at H. Adam Malik General Hospital

2021 ◽  
Vol 8 (7) ◽  
pp. 14-27
Author(s):  
Anwar Sholeh ◽  
Alwi Thamrin Nasution ◽  
Radar Radius Tarigan
Keyword(s):  
General Hospital ◽  
Pearson Correlation ◽  
Cell Distribution ◽  
C Reactive Protein ◽  
Distribution Width ◽  
Reactive Protein ◽  
Pearson Correlation Analysis ◽  
The Relationship ◽  
Red Blood Cell Distribution ◽  
Regular Hemodialysis

Background: Chronic kidney disease (CKD) is characterized by structural and functional disorder of the kidney with irreversible and gradual characteristics with one of the modalities of renal replacement therapy such as hemodialysis (HD). The role of inflammation in HD patients by uremic toxin and dialysis can be assessed by the marker of High Sensitive C Reactive Protein (HsCRP). Several studies have examined the relationship between HsCRP and red cell distribution width (RDW) in regular HD patients which leads to increase patient morbidity and mortality, but until now, there has been no study in Indonesia regarding the correlation between HsCRP and RDW in regular HD patients. This study aims to determine the correlation HsCRP as a marker of inflammation and RDW values in regular HD patients. Methods: This is a cross-sectional study in Regular HD patients at Dialysis Unit-H. Adam Malik General Hospital. A total of 20 subjects were included. Bivariate and multivariate analysis was conducted to analyze the relationship of HsCRP, ureum, creatinin, hemoglobin, and eGFR to RDW. Results: There were 20 Regular HD patients analyzed. The proportion of patients with increased RDW was 80%. In pearson correlation test, there is a strong correlation between HsCRP and RDW (r= 0.667, p<0.001). Discussion: Majority of regular HD patients at H. Adam Malik General Hospital were assessed with increased RDW. Pearson correlation analysis revealed HsCRP was significantly associated with RDW. Conclusion: Increased RDW was found in 80% of regular HD patients at H. Adam malik General Hospital. From pearson correlation analysis, we found HsCRP was significantly associated with RDW. Keywords: inflammation, high sensitive c reactive protein, red blood cell distribution width, regular hemodialysis.

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