Efficacy And Renal Safety of Febuxostat In Management of Gout And Chronic Kidney Disease: A Retrospective Study

Abstract Background: Elevated serum urate levels are associated with renal deterioration of chronic kidney disease (CKD). Whether urate-lowering treatment with febuxostat can improve renal function or attenuate the decline of the estimated glomerular filtration rate (eGFR) is controversial. The current study sought to explore efficacy and renal safety of febuxostat in gout patients with CKD and explore factors correlated with target serum urate (sUA).Methods: The current study was a single-center retrospective study comprising male gout patients with CKD. sUA, the rate of sUA < 360 µmol/L and renal safety were analyzed in subjects who had been treated with febuxostat for more than 44 weeks. Factors correlated with target sUA were explored by logistic regression analysis. Results: A total of 87 patients who had been diagnosed with gout and CKD met the inclusion criteria for the study. Twenty-five (28.73%) patients presented with stage 2 CKD, 58 (66.67%) were diagnosed with stage 3 CKD and 4 (4.60%) were diagnosed with stage 4 CKD. Analysis of sUA level showed a significant reduction at week 44~ (598.22 ± 95.11 µmol/L vs. 429.76 ± 123.45 μmol/L; P < 0.05), and the RAT increased to 34.50%. eGFR level of all patients was 52.37 ± 11.74 ml/min/1.73cm2 at baseline and 56.51 ± 15.01 ml/min/1.73cm2 at week 44~ (P < 0.05). The findings showed improvement of eGFR level in different stages of CKD, mainly in stage 3 CKD patients (P < 0.05). After stratification based on risk factors of hypertension, diabetic mellitus, hyperlipidemia and the usage of Non-Steroidal Anti-inflammatory Drugs (NSAIDs), the findings showed that eGFR levels of patients with ≤ 1 risk factors showed significant improvement (P < 0.05). Logistic regression analysis indicated that baseline sUA level and acute arthritis were correlated with the RAT in gout and CKD patients treated with febuxostat.Conclusions: In this retrospective study, febuxostat demonstrated effective and renal safety in gout patients with CKD. Baseline sUA level and acute arthritis may affect achieving of target sUA.

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Risk and protective factors for cats with naturally occurring chronic kidney disease

Journal of Feline Medicine and Surgery ◽

10.1177/1098612x15625453 ◽

2016 ◽

Vol 19 (4) ◽

pp. 358-363 ◽

Cited By ~ 2

Author(s):

Kakanang Piyarungsri ◽

Rosama Pusoonthornthum

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Logistic Regression ◽

Regression Analysis ◽

Kidney Disease ◽

Protective Factors ◽

Logistic Regression Analysis ◽

Backward Elimination ◽

Naturally Occurring ◽

Significant Disease

Objectives Chronic kidney disease (CKD) is a significant disease in cats. Identifying risk and protective factors may help to prevent this significant disease. Methods An age-matched case-control study was performed to determine the risk factors in cats with naturally occurring CKD. Twenty-nine clinically normal cats aged ⩾5 years and 101 cats with naturally occurring CKD were studied. Risk factors were determined by interviewing cat owners from the Small Animal Hospital, Faculty of Veterinary Science, Chulalongkorn University, and veterinary hospitals in the Bangkok Metropolitan area, through questionnaires completed between June 2004 and November 2014. Univariable and multivariable analyses were performed using two independent proportional test methods and logistic regression analysis with backward elimination. Results Male sex (odd ratios [OR] 2.80, 95% confidence interval [CI] 1.02–8.87; P = 0.02), tap water (OR 3.43, 95% CI 1.08–11.45; P = 0.03) and an outdoor lifestyle (OR 3.77, 95% CI 1.03–17.99; P = 0.04) were associated with an increased risk for CKD. Commercial dry cat food (OR 0.06, 95% CI 0.02–0.17; P = 0.00), filtered water (OR 0.13, 95% CI 0.03–0.52; P = 0.01) and an indoor lifestyle (OR 0.28, 95% CI 0.07–0.98; P = 0.02) were associated with a decreased risk. Logistic regression analysis using backward elimination demonstrated that cats fed commercial dry cat food (OR 0.042, 95% CI 0.01–0.17; P = 0.00) had a decreased risk for CKD compared with cats on other types of diet. Conclusions and relevance Multivariable analysis found only feeding commercial dry cat food to be significant, suggesting that commercial dry cat food may be a potential protective factor for CKD in cats.

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The association between NAFLD and risk of chronic kidney disease: a cross-sectional study

Therapeutic Advances in Chronic Disease ◽

10.1177/20406223211048649 ◽

2021 ◽

Vol 12 ◽

pp. 204062232110486

Author(s):

Ying Cao ◽

You Deng ◽

Jingjing Wang ◽

Hong Zhao ◽

Jingyu Zhang ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Logistic Regression ◽

Regression Analysis ◽

Kidney Disease ◽

Liver Fibrosis ◽

Logistic Regression Analysis ◽

Abdominal Ultrasonography ◽

Cross Sectional ◽

Nonalcoholic Fatty Liver ◽

Nafld Fibrosis Score

Objective: The aim of this study was to evaluate the association between nonalcoholic fatty liver disease (NAFLD) and NAFLD with different comorbidities and risk of chronic kidney disease (CKD) and abnormal albuminuria. Materials and Methods: A total of 3872 Chinese individuals excluding those with hepatitis B or C infection and absence of alcohol abuse were included in the study. NAFLD was diagnosed by abdominal ultrasonography. The liver fibrosis was assessed by NAFLD fibrosis score (NFS) and fibrosis-4 index (FIB-4). CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2 and/or abnormal albuminuria (urinary albumin-to-creatinine ratio ⩾ 3 mg/mmol). The logistic regression analysis was performed to examine the association between NAFLD and NAFLD with different comorbidities and risk of CKD. Results: The prevalence of CKD and abnormal albuminuria was higher in individuals with NAFLD than in those without NAFLD (15.8% vs 11.9%, p < 0.001; 14.8% vs 11.0%, p < 0.001). Logistic regression analysis demonstrated that NAFLD was risk factor of CKD. Notably, after adjustment for sex, age, and DM, NAFLD was associated with 1.31-fold higher risk of prevalent CKD ⩾ 1 ( p < 0.05). NAFLD individuals with elder age, DM, obesity, hypertension, MetS, and advanced liver fibrosis had higher risks of both prevalent CKD and abnormal albuminuria than those without comorbidities. Conclusions: NAFLD and NAFLD with traditional comorbidities are strongly associated with risk of prevalence of CKD and abnormal albuminuria. Patients with NAFLD especially those with coexisting comorbidities were recommended to carefully access the development of CKD.

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Risk Factors of Atrial Arrhythmia in Patients With Liver Cirrhosis: A Retrospective Study

Frontiers in Cardiovascular Medicine ◽

10.3389/fcvm.2021.704073 ◽

2021 ◽

Vol 8 ◽

Author(s):

Xiya Lu ◽

Zhijing Wang ◽

Liu Yang ◽

Changqing Yang ◽

Meiyi Song

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Liver Cirrhosis ◽

Retrospective Study ◽

Logistic Regression Analysis ◽

Multiple Logistic Regression Analysis ◽

Multivariate Logistic Regression Analysis ◽

Clinical Information ◽

Atrial Arrhythmia

Background and Objectives: Liver cirrhosis is known to be associated with atrial arrhythmia. However, the risk factors for atrial arrhythmia in patients with liver cirrhosis remain unclear. This retrospective study aimed to investigate the risk factors for atrial arrhythmia in patients with liver cirrhosis.Methods: In the present study, we collected data from 135 patients with liver cirrhosis who were admitted to the Department of Gastroenterology at Shanghai Tongji Hospital. We examined the clinical information recorded, with the aim of identifying the risk factors for atrial arrhythmia in patients with liver cirrhosis. Multiple logistic regression analysis was used to screen for significant factors differentiating liver cirrhosis patients with atrial arrhythmia from those without atrial arrhythmia.Results: The data showed that there were seven significantly different factors that distinguished the group with atrial arrhythmia from the group without atrial arrhythmia. The seven factors were age, white blood cell count (WBC), albumin (ALB), serum Na+, B-type natriuretic peptide (BNP), ascites, and Child-Pugh score. The results of multivariate logistic regression analysis suggested that age (β = 0.094, OR = 1.098, 95% CI 1.039–1.161, P = 0.001) and ascites (β =1.354, OR = 3.874, 95% CI 1.202–12.483, P = 0.023) were significantly associated with atrial arrhythmia.Conclusion: In the present study, age and ascites were confirmed to be risk factors associated with atrial arrhythmia in patients with liver cirrhosis.

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Cardiovascular Risk Factors in Pre-dialysis Chronic Kidney Disease patients of Nepal

Journal of Advances in Internal Medicine ◽

10.3126/jaim.v9i2.32813 ◽

2020 ◽

Vol 9 (2) ◽

pp. 47-53

Author(s):

Kashyap Dahal ◽

A. Baral ◽

K.K. Sah ◽

J.R. Shrestha ◽

A. Niraula ◽

...

Keyword(s):

Risk Factors ◽

Chronic Kidney Disease ◽

Logistic Regression ◽

Regression Analysis ◽

Kidney Disease ◽

Multiple Logistic Regression Analysis ◽

Multiple Logistic Regression ◽

Cvd Risk Factors ◽

Cvd Risk ◽

Traditional Risk Factors

Background and Aims: Cardiovascular disease (CVD) is the commonest cause of morbidity and mortality in patients with chronic kidney disease (CKD) due to increased prevalence of traditional and nontraditional CVD risk factors. Our study aimed to evaluate these risk factors in pre-dialysis Nepalese CKD patients. Methods: This was a cross-sectional study conducted in Department of Nephrology, Bir hospital. Total 100 consecutive pre-dialysis CKD patients were enrolled. Ten traditional and six nontraditional CVD risk factors were analyzed and compared between CKD stages. Descriptive statistics was used to illustrate the socio-demographic and clinical characteristics, chi square test for categorical variables and multiple logistic regression analysis was done to determine the risk factors of CVD in CKD patients. p-value<0.05 was considered to be statistically significant. Results: Mean patient age was 52.03}13.64 years with majority (60%) of the patients being male. Comparison of traditional risk factors in different stages depicted similar trend except for old age in Stage 3 CKD (p=0.002). Anemia (p<0.001), hyperphosphatemia (p=0.01), hyperparathyroidism (p<0.01) and cumulative nontraditional risk factors were significantly higher (p=0.01) in stage 5 CKD. The predicted CVD events by Framingham risk score showed high risk in 37% with no significant difference among the stages. Multiple logistic regression analysis showed increased body mass index, low serum albumin and increased serum phosphate as the three significant predictors for left ventricular hypertrophy. Conclusion: Our study shows that the CVD risk factors were prevailing along the various stages of CKD. The occurrence of non-traditional risk factors increased with increasing stage of CKD.

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Serum uric acid is associated with coronary artery calcification in early chronic kidney disease: a cross-sectional study

BMC Nephrology ◽

10.1186/s12882-021-02463-2 ◽

2021 ◽

Vol 22 (1) ◽

Author(s):

Miyeun Han ◽

Hyunsuk Kim ◽

Hyo Jin Kim ◽

Eunjeong Kang ◽

Yong-Soo Kim ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Logistic Regression ◽

Uric Acid ◽

Regression Analysis ◽

Risk Factor ◽

Coronary Artery ◽

Kidney Disease ◽

Logistic Regression Analysis ◽

Coronary Artery Calcification ◽

Cross Sectional

Abstract Background Although uric acid (UA) is regarded as a risk factor for cardiovascular disease, whether UA is an independent risk factor contributing to coronary artery calcification in chronic kidney disease (CKD) is not well known. We evaluated whether UA level is associated with coronary artery calcium (CAC) score in a predialysis CKD cohort. Methods A total of 1,350 subjects who underwent coronary computed tomography as part of the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease were analysed. We conducted a logistic regression analysis to evaluate the association between UA and the presence of CAC. Results CAC was detected in 705 (52.2 %) patients, and the level of UA was significantly higher in CAC > 0 patients. UA showed a positive relationship with CAC > 0 in age- and sex-adjusted logistic regression analysis (Odds ratio (OR) 1.11, 95 % confidence interval (CI) 1.04–1.19, P = 0.003). However, UA showed no association with CAC > 0 in multivariate analysis. Further analysis showed that UA showed a positive association with CAC > 0 only in estimated glomerual filtration rate (eGFR) > 60 ml/min/1.73 m2 (OR 1.23, 95 % CI 1.02–1.49, P = 0.036) but not in eGFR 30–59 ml/min/1.73 m2 (OR 0.92, 95 % CI 0.78–1.08, P = 0.309) or < 30 ml/min/1.73 m2 (OR 0.92, 95 % CI 0.79–1.08, P = 0.426). Conclusions UA level was significantly associated with CAC in early CKD, but not in advanced CKD.

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Association of lipid accumulation product with chronic kidney disease in Chinese community adults: a report from the REACTION study

Lipids in Health and Disease ◽

10.1186/s12944-021-01569-8 ◽

2021 ◽

Vol 20 (1) ◽

Author(s):

Pijun Yan ◽

Yong Xu ◽

Ying Miao ◽

Qian Tang ◽

Yuru Wu ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Logistic Regression ◽

Regression Analysis ◽

Kidney Disease ◽

Logistic Regression Analysis ◽

Lipid Accumulation ◽

Community Dwelling ◽

Chinese Community ◽

Lipid Accumulation Product ◽

Male Subjects

Abstract Background Limited studies regarding the correlation of lipid accumulation product (LAP) with a decreased estimated glomerular filtration rate (eGFR) have yielded conflicting findings, and no report has demonstrated the relationship of LAP with chronic kidney disease (CKD), defined as the presence of albuminuria and/or a decreased eGFR. The purpose of this study was to estimate the possible correlation of LAP with CKD prevalence in Chinese community adults. Method In this cross-sectional study, LAP level of 7202 participants (age ≥ 40 years) was determined, and its possible association with CKD was evaluated by a multiple logistic regression model. Results Compared with subjects with non-CKD, non-albuminuria, and high eGFR, LAP levels significantly increased in female not male subjects with CKD, albuminuria, and low eGFR, respectively (all P < 0.001). The univariate logistic regression analysis revealed that LAP level of female not male subjects were significantly and positively associated with the prevalence of CKD (P < 0.001). The multivariate logistic regression analysis showed that the risk of CKD prevalence in female not male subjects progressively increased across LAP quartiles (P for trend < 0.01), and the risk of CKD prevalence of subjects in Q4 significantly increased compared to those in Q1 after adjustment for potential confounding factors in Models 4 (odds ratio [OR]: 1.382, 95% confidence intervals [CI] 1.002–1.906, P < 0.05). Stratified analysis revealed positive associations of LAP quartiles with risk of CKD prevalence in people with the following characteristics: women, older, overweight, with hypertension, normal glucose tolerance, appropriate low-density lipoprotein cholesterol, nonsmokers, nondrinkers, and no cardiovascular disease events. Conclusions High LAP levels might be significantly associated with risk of CKD prevalence in community-dwelling Chinese female adults, which may inform both public health recommendations and clinical practice.

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MIF associated with pulmonary hypertension susceptibility and severity in non-dialysis Chronic kidney disease patients

European Journal of Inflammation ◽

10.1177/2058739220961191 ◽

2020 ◽

Vol 18 ◽

pp. 205873922096119

Author(s):

Jianhua Wu ◽

Naifeng Guo ◽

Xiaolan Chen

Keyword(s):

Chronic Kidney Disease ◽

Pulmonary Hypertension ◽

Logistic Regression ◽

Regression Analysis ◽

Kidney Disease ◽

Logistic Regression Analysis ◽

Multivariate Logistic Regression Analysis ◽

Control Group ◽

Stage 4 ◽

Stage 1

Pulmonary hypertension (PAH) is one of the more serious complications of Chronic kidney disease (CKD), and its exact pathogenesis has not been clarified. As an upstream proinflammatory factor, macrophage migration inhibitor (MIF) is involved in the occurrence and development of many diseases. This study aimed to detect the relationship between serum MIF and PAH in non-dialysis CKD patients. A total of 382 non-dialysis CKD patients were enrolled in this study. Bio-Plex cytokine assay was used to detect MIF. CKD patients were divided into the PAH group and non-PAH group according to echocardiographic results. Relative risk was determined by logistic regression analysis. The pulmonary artery pressure in the CKD group was higher than that in the control group ( p < 0.01). Pulmonary arterial pressure was higher in stage 4 to 5 CKD patients than in Stage 1 to 3 CKD patients ( p < 0. 01), and the incidence of PAH was also increased ( p < 0. 01). MIF in the CKD group were higher than in the control group ( p < 0.05). MIF in CKD patients with PAH were higher than those without PAH ( p < 0.05). Multivariate logistic regression analysis showed that MIF is correlated with PAH (OR = 10.745; 95% CI 2.288–89.447, p < 0.05). PAH is common in non-dialysis CKD patients, and with the deterioration of kidney disease, the incidence of PAH is gradually increased, indicating that MIF plays an important role in the development of PAH in CKD patients.

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Serum Uric Acid is Associated with Coronary Artery Calcification in Early Chronic Kidney Disease: A Cross-Sectional Study

10.21203/rs.3.rs-221660/v1 ◽

2021 ◽

Author(s):

Miyeun Han ◽

Hyunsuk Kim ◽

Hyo Jin Kim ◽

Eunjeong Kang ◽

Yong-Soo Kim ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Logistic Regression ◽

Uric Acid ◽

Regression Analysis ◽

Risk Factor ◽

Coronary Artery ◽

Kidney Disease ◽

Logistic Regression Analysis ◽

Coronary Artery Calcification ◽

Cross Sectional

Abstract Background: Although uric acid (UA) is regarded as a risk factor for cardiovascular disease, whether UA is an independent risk factor contributing to coronary artery calcification in chronic kidney disease (CKD) is not well known. We evaluated whether UA level is associated with coronary artery calcium (CAC) score in a predialysis CKD cohort.Methods: A total of 1,350 subjects who underwent coronary computed tomography as part of the KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease were analysed. We conducted a logistic regression analysis to evaluate the association between UA and the presence of CAC.Results: CAC was detected in 705 (52.2%) patients, and the level of UA was significantly higher in CAC>0 patients. UA showed a positive relationship with CAC >0 in age- and sex-adjusted logistic regression analysis (Odds ratio (OR) 1.11, 95% confidence interval (CI) 1.04-1.19, P = 0.003). However, UA showed no association with CAC>0 in multivariate analysis. Further analysis showed that UA showed a positive association with CAC>0 only in estimated glomerual filtration rate (eGFR) > 60 ml/min/1.73 m2 (OR 1.23, 95% CI 1.02-1.49, P = 0.036) but not in eGFR 30–59 ml/min/1.73 m2 (OR 0.92, 95% CI 0.78-1.08, P = 0.309) or <30 ml/min/1.73 m2 (OR 0.92, 95% CI 0.79-1.08, P = 0.426). Conclusions: UA level was significantly associated with CAC in early CKD, but not in advanced CKD.

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Dietary intake, anthropometric measurements, biochemistry profile and their associations with chronic kidney disease and diabetes mellitus

Journal of Nutritional Science ◽

10.1017/jns.2020.38 ◽

2020 ◽

Vol 9 ◽

Author(s):

Emily de S. Ferreira ◽

Luciana S. da Silva ◽

Glauce D. da Costa ◽

Tiago R. Moreira ◽

Luíza D. Borges ◽

...

Keyword(s):

Diabetes Mellitus ◽

Chronic Kidney Disease ◽

Logistic Regression ◽

Regression Analysis ◽

Kidney Disease ◽

Dietary Intake ◽

Logistic Regression Analysis ◽

Multiple Logistic Regression Analysis ◽

Anthropometric Measurements ◽

Biochemical Profile

Abstract The chronic kidney disease (CKD) and diabetes mellitus (DM) are considered a serious public health problem. The objective was investigating the association of DM with the anthropometric measures, biochemical profile and dietary intake in patients with CKD. Is a cross-sectional study done in 2017, with 51 patients previously diagnosed with CKD. We collect socio-demographic, lifestyle variables, anthropometric measurements, biochemical profile and dietary intake. We using the Kolmogorov–Smirnov test, followed by Pearson's χ2 test and Student's t test. Data were analysed using several multivariable logistic regression models, including the socio-demographic, anthropometric, dietary intake and biochemical variable. Variables with P ≤ 0⋅20 in the univariate analyses were selected and kept in the block in the simple and multiple logistic regression analysis, to determine the differences between the categories and the factors associated with the presence of DM or not, remaining in the model final, only the significant variables (P ≤ 0⋅05). Each variable was adjusted for all other variables included in the univariate analysis. The strength of the association was assessed by the odds ratio and 95% confidence intervals (CI). The multivariate logistic regression analysis evidenced that the increase of 1 cm in waist circumference and 1 mg/dl in VLDL-c values increases the chance of DM, respectively, by 8⋅4% (OR 1⋅076; P 0⋅05) and 8⋅8% (OR 1⋅102; P 0⋅01). In contrast, an increase of 1 mg/dl in total cholesterol decreases the chance of developing DM by 3⋅1% (OR 0⋅965; P 0⋅01), that is, it becomes a protective factor. The present study identified the associations between overweight, dietary intake and biochemical tests.

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Risk factors for tissue expander infection in scar reconstruction: a retrospective cohort study of 2374 consecutive cases

Burns & Trauma ◽

10.1093/burnst/tkaa037 ◽

2020 ◽

Vol 8 ◽

Author(s):

Chen Dong ◽

Minhui Zhu ◽

Luguang Huang ◽

Wei Liu ◽

Hengxin Liu ◽

...

Keyword(s):

Risk Factors ◽

Logistic Regression ◽

Regression Analysis ◽

Treatment Failure ◽

Logistic Regression Analysis ◽

Disease Duration ◽

Multivariate Logistic Regression Analysis ◽

Tissue Expansion ◽

Multivariate Logistic Regression ◽

Hematoma Evacuation

Abstract Background Tissue expansion is used for scar reconstruction owing to its excellent clinical outcomes; however, the complications that emerge from tissue expansion hinder repair. Infection is considered a major complication of tissue expansion. This study aimed to analyze the perioperative risk factors for expander infection. Methods A large, retrospective, single-institution observational study was carried out over a 10-year period. The study enrolled consecutive patients who had undergone tissue expansion for scar reconstruction. Demographics, etiological data, expander-related characteristics and postoperative infection were assessed. Univariate and multivariate logistic regression analysis were performed to identify risk factors for expander infection. In addition, we conducted a sensitivity analysis for treatment failure caused by infection as an outcome. Results A total of 2374 expanders and 148 cases of expander infection were assessed. Treatment failure caused by infection occurred in 14 expanders. Multivariate logistic regression analysis identified that disease duration of ≤1 year (odds ratio (OR), 2.07; p < 0.001), larger volume of expander (200–400 ml vs <200 ml; OR, 1.74; p = 0.032; >400 ml vs <200 ml; OR, 1.76; p = 0.049), limb location (OR, 2.22; p = 0.023) and hematoma evacuation (OR, 2.17; p = 0.049) were associated with a high likelihood of expander infection. Disease duration of ≤1 year (OR, 3.88; p = 0.015) and hematoma evacuation (OR, 10.35; p = 0.001) were so related to high risk of treatment failure. Conclusions The rate of expander infection in patients undergoing scar reconstruction was 6.2%. Disease duration of <1 year, expander volume of >200 ml, limb location and postoperative hematoma evacuation were independent risk factors for expander infection.

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