scholarly journals Analysis of the Safety and Pregnant Outcomes of Fertility-Sparing Surgery in Ovarian Malignant Sex Cord-Stromal Tumors: A Multicenter Retrospective Study

2021 ◽  
Author(s):  
Junting Li ◽  
Ran Chu ◽  
Gang Chen ◽  
Yuanming Shen ◽  
Yanhui Lou ◽  
...  
Keyword(s):  
Risk Factors ◽  
Regression Analysis ◽  
High Risk ◽  
Stromal Tumors ◽  
High Risk Factors ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Stage Ia ◽  
Staging Surgery ◽  
Sex Cord Stromal Tumors

Abstract Background: To assess the difference in survival between fertility-sparing surgery (FSS) and radical surgery (RS) and explore pregnant outcomes after FSS in stage I malignant sex cord-stromal tumors (MSCSTs).Methods: We performed a multicenter retrospective cohort study on patients who were diagnosed with stage IA or IC MSCSTs. Inverse Probability of Treatment Weighting was performed between the FSS and RS groups. The Chi-square test and Kaplan-Meier method were used to compare the categorical variables and disease-free survival (DFS). The binary logistic regression analysis and Cox proportional hazards regression analysis were used to identify high-risk factors related to DFS and pregnancy.Results: A total of 107 patients were included, of whom 54 (50.5%) women underwent FSS, and 53 (49.5%) women underwent RS. After IPTW, 208 patients were obtained, and all of the covariates were well balanced. After a median follow-up time of 50 months (range 7-156 months), there was no significant difference of DFS between the two groups in both unweighted cohort (P=0.969) or weighted cohort (P=0.792). In the weighted cohort, stage IC (P=0.014), tumor diameter >8 cm (P=0.003), incomplete staging surgery (P=0.003) and no adjuvant chemotherapy (P <0.001) were 4 high-risk factors associated with a shorter DFS. Among 14 patients who had pregnancy desire, 11 (78.6%) women conceived successfully, and the live birth rate was 76.9%. In univariate analysis, only adjuvant chemotherapy (P=0.009) was associated with infertility.Conclusions: On the premise of complete staging surgery, FSS is safe and feasible in stage IA and IC MSCSTs with satisfactory reproductive outcomes.

scholarly journals Ovarian Steroid Cell Tumor (Not Otherwise Specified): A Case Report of Ovarian Hyperandrogenism

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Hadjkacem Faten ◽  
Ghorbel Dorra ◽  
Charfi Slim ◽  
Safi Wajdi ◽  
Charfi Nadia ◽  
...  
Keyword(s):  
Transvaginal Ultrasound ◽  
Cell Tumor ◽  
Ovarian Mass ◽  
Stromal Tumors ◽  
Not Otherwise Specified ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Steroid Cell Tumor ◽  
Ovarian Hyperandrogenism ◽  
Sex Cord Stromal Tumors

Steroid cell tumors (SCTs) (not otherwise specified (NOS)) are rare sex cord-stromal tumors of the ovary. These are associated with hormonal disturbances resulting in menstrual bleeding patterns and androgenic effects. We report the case of a 36-year-old female presented with hirsutism, signs of virilization, and elevated androgen levels. Transvaginal ultrasound showed a solid-appearing right ovarian mass. She underwent fertility-sparing surgery with a laparoscopic left oophorectomy. Histological examination showed a benign steroid cell tumor, NOS. These tumors often small can then present a problem of positive diagnosis responsible for a delay in the diagnosis.

scholarly journals The effect of fertility-sparing surgery on sexuality and global quality of life in women with malignant ovarian germ cell and sex cord stromal tumors: an analysis of the CORSETT database of the AGO study group

2021 ◽  
Author(s):  
Annette Hasenburg ◽  
Hellmut Plett ◽  
Bernhard Krämer ◽  
Elena Braicu ◽  
Bastian Czogalla ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Study Group ◽  
Sexually Active ◽  
Stromal Tumors ◽  
Fertility Sparing Surgery ◽  
Global Quality ◽  
Fertility Sparing ◽  
Global Quality Of Life ◽  
Sex Cord Stromal Tumors

Abstract Purpose Malignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST) are ovarian neoplasms that affect disproportionally young women. Little is known about the impact of surgical and adjuvant management of these patient’s sexual life. This study investigated the effect of fertility-sparing surgery on sexual activity and global quality of life (gQoL) in women with MOGCT and SCST. Methods CORSETT was an observational, multicenter, mixed retrospective/prospective cohort study of the AGO study group. Women of any age who had been diagnosed with MOGCTs and SCSTs between 2001 and 2011 were asked to complete the Sexual Activity Questionnaire (SAQ) and the EORTC QLQ-C30. Results In total, 355 patients were included. Of these, 152 patients with confirmed histological diagnosis had completed the questionnaires. A total of 106 patients were diagnosed with SCST and 46 with MOGCT. Totally, 83 women (55%) were sexually active. After fertility-sparing surgery, patients had a 2.6 fold higher probability for being sexually active than after non-fertility-conserving treatment (unadjusted odds ratio (OR) 2.6, p = 0.01). After adjustment for age, time since diagnosis, FIGO stage, histology and phase of disease, the OR dropped to 1.8 (p = 0.22). Of the sexually active patients, 35 (42%) reported high levels of discomfort during intercourse; 38% after fertility-sparing; and 58% after non-fertility-sparing surgery (adjusted OR 2.8, p = 0.18). Women with fertility-conserving treatment reported a significantly better global QoL (Fadj 2.1, 6.2 points difference, p = 0.03) but not more pleasure during intercourse than women without fertility-sparing surgery (Fadj 0.4, p = 0.52). Conclusion Fertility preserving approaches should be offered to every patient, when oncologically acceptable.

scholarly journals Fertility sparing surgery for ovarian sex cord stromal tumors: a nine case series

2018 ◽  
Vol 31 ◽  
Author(s):  
Montassar Ghalleb ◽  
Hatem Bouzaiene ◽  
Sarah Sghaier ◽  
Hanen Bouaziz ◽  
Monia Hechiche ◽  
...  
Keyword(s):  
Case Series ◽  
Stromal Tumors ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Sex Cord Stromal Tumors

Safety of Fertility-Sparing Surgery for Premenopausal Women With Sex Cord-Stromal Tumors Confined to the Ovary

2017 ◽  
Vol 27 (9) ◽  
pp. 1826-1832 ◽  
Author(s):  
Dimitrios Nasioudis ◽  
Melissa K. Frey ◽  
Eloise Chapman-Davis ◽  
Steven S. Witkin ◽  
Kevin Holcomb
Keyword(s):  
Overall Survival ◽  
Tumor Resection ◽  
Premenopausal Women ◽  
Population Based ◽  
Cancer Specific Survival ◽  
Stromal Tumors ◽  
Fertility Sparing Surgery ◽  
Fertility Sparing ◽  
Definitive Surgery ◽  
Sex Cord Stromal Tumors

ObjectiveThe aim of this retrospective population-based study was to investigate the oncologic safety of fertility-sparing surgery (FSS) for premenopausal women with malignant sex cord-stromal tumors (SCSTs) confined to the ovary.MethodsA cohort of women aged 18 to 49 years and diagnosed with a stage I malignant SCST between 1984 and 2013 was drawn from the National Cancer Institute's Surveillance, Epidemiology, and End Results database. Based on site-specific surgery codes, women who had FSS, defined as unilateral oophorectomy/tumor resection without hysterectomy, and definite surgery were identified. Cancer-specific survival and overall survival were evaluated after generation of Kaplan-Meier curves, whereas comparisons between the 2 groups were made with the log-rank test.ResultsA total of 255 women who met the inclusion criteria were identified; 161 (63.1%) underwent FSS whereas 94 (36.9%) had definitive surgery (bilateral salpingo-oophorectomy and hysterectomy). Median follow-up was 104 months. Cancer-specific survival (P= 0.015) but not overall survival (P= 0.76) was superior for women who had definite surgery.ConclusionsIn this retrospective population-based cohort of premenopausal women with SCSTs confined to the ovary, FSS was associated only with a worse long-term cancer-specific survival compared with definitive surgery. Women undergoing FSS for early stage SCSTs should be extensively counseled and closely monitored.

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