The effect of fertility-sparing surgery on sexuality and global quality of life in women with malignant ovarian germ cell and sex cord stromal tumors: an analysis of the CORSETT database of the AGO study group

Abstract Purpose Malignant ovarian germ cell (MOGCT) and sex cord stromal tumors (SCST) are ovarian neoplasms that affect disproportionally young women. Little is known about the impact of surgical and adjuvant management of these patient’s sexual life. This study investigated the effect of fertility-sparing surgery on sexual activity and global quality of life (gQoL) in women with MOGCT and SCST. Methods CORSETT was an observational, multicenter, mixed retrospective/prospective cohort study of the AGO study group. Women of any age who had been diagnosed with MOGCTs and SCSTs between 2001 and 2011 were asked to complete the Sexual Activity Questionnaire (SAQ) and the EORTC QLQ-C30. Results In total, 355 patients were included. Of these, 152 patients with confirmed histological diagnosis had completed the questionnaires. A total of 106 patients were diagnosed with SCST and 46 with MOGCT. Totally, 83 women (55%) were sexually active. After fertility-sparing surgery, patients had a 2.6 fold higher probability for being sexually active than after non-fertility-conserving treatment (unadjusted odds ratio (OR) 2.6, p = 0.01). After adjustment for age, time since diagnosis, FIGO stage, histology and phase of disease, the OR dropped to 1.8 (p = 0.22). Of the sexually active patients, 35 (42%) reported high levels of discomfort during intercourse; 38% after fertility-sparing; and 58% after non-fertility-sparing surgery (adjusted OR 2.8, p = 0.18). Women with fertility-conserving treatment reported a significantly better global QoL (Fadj 2.1, 6.2 points difference, p = 0.03) but not more pleasure during intercourse than women without fertility-sparing surgery (Fadj 0.4, p = 0.52). Conclusion Fertility preserving approaches should be offered to every patient, when oncologically acceptable.

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Measurement of Quality of Life VII. Statistical Covariation and Global Quality of Life Data: The Method of Weight-Modified Linear Regression

The Scientific World JOURNAL ◽

10.1100/tsw.2003.89 ◽

2003 ◽

Vol 3 ◽

pp. 1020-1029 ◽

Cited By ~ 3

Author(s):

Soren Ventegodt ◽

Joav Merrick

Keyword(s):

Quality Of Life ◽

Linear Regression ◽

Scientific Community ◽

Population Studies ◽

Life Data ◽

Global Quality ◽

Global Quality Of Life ◽

Psychometric Measures ◽

Exact Size

Existing standard statistical procedures do not seem to fulfill the needs of the researcher in global quality-of-life (QOL) research, because the most interesting question seems to be the exact size of statistical covariations. A method is necessary if we are to isolate the most important factors connected to quality of life among the thousands of possible factors in life. We have developed a new procedure we call �weight-modified linear regression�. Unfortunately as demonstrated in the discussion, the procedure is not totally without problems and weaknesses. In spite of the critique, we believe the procedure to be valid for the purpose of estimating the size of the covariation in population studies including psychometric measures of global quality of life. As we need to be certain that the procedure is valid, we hereby invite the scientific community to give us further critique of the method and suggestions for its improvement.

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Fertility Related Quality of Life in Primary Infertile Couples: A Comparative Study from Eastern India

International Journal of Indian Psychology ◽

10.25215/0501.062 ◽

2017 ◽

Vol 5 (1) ◽

Author(s):

Swarnali Bose ◽

Bharati Roy

Keyword(s):

Quality Of Life ◽

Infertile Couple ◽

Psychological Burden ◽

Primary Infertility ◽

Global Quality ◽

Global Quality Of Life ◽

The Family ◽

Related Quality ◽

Written Informed Consent

Fertility is considered as a marital responsibility in most the communities and a kind of social respectability for couples. The societal and parental pressures for propagation of the family name can also place a psychological burden on the infertile couple and may significantly affect quality of life. The present study aimed to investigate the gender differences in fertility related quality of life in primary infertility. 30 couples with primary infertility were recruited for the study after a written informed consent. Hindi version of FertiQoL was applied to all participants. Males had significantly better emotional, relational, social and global quality of life (QoL) as compared to females. Tolerability to infertility related problems was significantly better in females compared to males. This study found that primary infertility has extensive negative repercussions on the QOL of women as compared to males.

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Variety of activity: Relationship with health status, demographic variables and global quality of life

Psychology Health & Medicine ◽

10.1080/135485099106180 ◽

1999 ◽

Vol 4 (3) ◽

pp. 241-254 ◽

Cited By ~ 8

Author(s):

M. E. Hyland ◽

S. C. Sodergren ◽

S. J. Singh

Keyword(s):

Quality Of Life ◽

Health Status ◽

Demographic Variables ◽

Activity Relationship ◽

Global Quality ◽

Global Quality Of Life

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Trend of global quality of life in localized or metastatic prostate cancer patients after treatment

Urological Science ◽

10.1016/j.urols.2016.05.196 ◽

2016 ◽

Vol 27 (2) ◽

pp. S53-S54

Author(s):

Yao-Lin Kao ◽

Yuh-Shyan Tsai ◽

Zong-Ying Lin ◽

Chien-Hui Ou ◽

Wen-Horng Yang ◽

...

Keyword(s):

Quality Of Life ◽

Prostate Cancer ◽

Cancer Patients ◽

Metastatic Prostate Cancer ◽

Global Quality ◽

Global Quality Of Life

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Quality of life in persons living with HIV–AIDS in three healthcare institutions of Cali, Colombia

Colombia Medica ◽

10.25100/cm.v41i3.706 ◽

2010 ◽

pp. 206-214 ◽

Cited By ~ 5

Author(s):

Claudia Patricia Valencia ◽

Gladys Eugenia Canaval ◽

Diana Marín ◽

Carmen J. Portillo

Keyword(s):

Quality Of Life ◽

Health Insurance ◽

Antiretroviral Therapy ◽

Satisfaction With Life ◽

Pearson Correlation ◽

Global Quality ◽

Persons Living With Hiv ◽

Global Quality Of Life ◽

Hiv Aids

Antecedents: The Human Immunodeficiency Virus is currently considered a chronic disease; hence, quality of life is an important goal for those suffering the disease or living with someone afflicted by the virus. Objectives: We sought to measure the quality of life in individuals living with acquired immunodeficiency syndrome virus and establish its relationship with socio-demographic and clinical variables. Methods: This is a cross-sectional, descriptive study with a sample of 137 HIV-infected individuals attending three healthcare institutions in the city of Cali, Colombia. Quality of life was measured via the HIV/AIDS-Targeted Quality of Life (HAT-QoL) instrument. The descriptive analyses included mean and standard deviation calculations. To determine the candidate variables, we used the student t test and the Pearson correlation. The response variable in the multiple linear regression was the score for quality of life. Results: Some 27% of the sample were women and 3% were transgender; the mean age of the sample was 35 + 10.2 years; 88% had some type of health insurance; 27% had been diagnosed with AIDS, and 64% were taking antiretroviral medications at the time of the study. Quality of life was measured through a standard scale with scores from 0 to 100. Participants’ global quality of life mean was 59 + 17.8. The quality-of-life dimensions with the highest scores were sexual function, satisfaction with the healthcare provider, and satisfaction with life. The highest quality-of-life scores were obtained by participants who received antiretroviral therapy, had health insurance, lower symptoms of depression, low frequency and intensity of symptoms, and no prior reports of sexual abuse. Eight variables explained 53% of the variability of the global quality of life. Conclusions: Those receiving antiretroviral therapy and who report fewer symptoms best perceived their quality of life. Implications for practice: Healthcare providers, especially nursing professional face a challenge in caring to alleviate symptoms and contribute to improving the quality of life of their patients.

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Ovarian Steroid Cell Tumor (Not Otherwise Specified): A Case Report of Ovarian Hyperandrogenism

Case Reports in Oncological Medicine ◽

10.1155/2020/6970823 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Hadjkacem Faten ◽

Ghorbel Dorra ◽

Charfi Slim ◽

Safi Wajdi ◽

Charfi Nadia ◽

...

Keyword(s):

Transvaginal Ultrasound ◽

Cell Tumor ◽

Ovarian Mass ◽

Stromal Tumors ◽

Not Otherwise Specified ◽

Fertility Sparing Surgery ◽

Fertility Sparing ◽

Steroid Cell Tumor ◽

Ovarian Hyperandrogenism ◽

Sex Cord Stromal Tumors

Steroid cell tumors (SCTs) (not otherwise specified (NOS)) are rare sex cord-stromal tumors of the ovary. These are associated with hormonal disturbances resulting in menstrual bleeding patterns and androgenic effects. We report the case of a 36-year-old female presented with hirsutism, signs of virilization, and elevated androgen levels. Transvaginal ultrasound showed a solid-appearing right ovarian mass. She underwent fertility-sparing surgery with a laparoscopic left oophorectomy. Histological examination showed a benign steroid cell tumor, NOS. These tumors often small can then present a problem of positive diagnosis responsible for a delay in the diagnosis.

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Quality of Life After Transhiatal Compared With Extended Transthoracic Resection for Adenocarcinoma of the Esophagus

Journal of Clinical Oncology ◽

10.1200/jco.2004.11.102 ◽

2004 ◽

Vol 22 (20) ◽

pp. 4202-4208 ◽

Cited By ~ 119

Author(s):

A.G.E.M. de Boer ◽

J.J.B. van Lanschot ◽

J.W. van Sandick ◽

J.B.F. Hulscher ◽

P.F.M. Stalmeier ◽

...

Keyword(s):

Quality Of Life ◽

Psychological Symptoms ◽

Well Being ◽

Physical Symptoms ◽

Activity Level ◽

Gradual Improvement ◽

Global Quality ◽

Global Quality Of Life ◽

Generic Quality

PurposeTo assess 3 years of quality of life in patients with esophageal cancer in a randomized trial comparing limited transhiatal resection with extended transthoracic resection.Patients and MethodsQuality-of-life questionnaires were sent at baseline and at 5 weeks; 3, 6, 9, and 12 months; and 1.5, 2, 2.5, and 3 years after surgery. Physical and psychological symptoms, activity level, and global quality of life were assessed with the disease-specific Rotterdam Symptom Checklist. Generic quality of life was measured with the Medical Outcomes Study Short Form-20.ResultsA total of 199 patients participated. Physical symptoms and activity level declined after the operation and gradually returned toward baseline within the first year (P < .01). Psychological well-being consistently improved after baseline (P < .01), whereas global quality of life showed a small initial decline followed by continuous gradual improvement (P < .01). Quality of life stabilized in the second and third year. Three months after the operation, patients in the transhiatal esophagectomy group (n = 96) reported fewer physical symptoms (P = .01) and better activity levels (P < .01) than patients in the transthoracic group (n = 103), but no differences were found at any other measurement point. For psychological symptoms and global quality of life, no differences were found at any follow-up measurement. A similar pattern was found for generic quality of life.ConclusionNo lasting differences in quality of life of patients who underwent either transhiatal or transthoracic resection were found. Compared with baseline, quality of life declined after the operation but was restored within a year in both groups.

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A cognitive–existential intervention to improve existential and global quality of life in cancer patients: A pilot study

Palliative & Supportive Care ◽

10.1017/s147895151400073x ◽

2014 ◽

Vol 13 (4) ◽

pp. 981-990 ◽

Cited By ~ 10

Author(s):

Pierre Gagnon ◽

Lise Fillion ◽

Marie-Anik Robitaille ◽

Michèle Girard ◽

François Tardif ◽

...

Keyword(s):

Quality Of Life ◽

Pilot Study ◽

Usual Care ◽

Cancer Patients ◽

Group Intervention ◽

Usual Condition ◽

Global Quality ◽

Global Quality Of Life ◽

The Individual

AbstractObjective:We developed a specific cognitive–existential intervention to improve existential distress in nonmetastatic cancer patients. The present study reports the feasibility of implementing and evaluating this intervention, which involved 12 weekly sessions in both individual and group formats, and explores the efficacy of the intervention on existential and global quality of life (QoL) measures.Method:Some 33 nonmetastatic cancer patients were randomized between the group intervention, the individual intervention, and the usual condition of care. Evaluation of the intervention on the existential and global QoL of patients was performed using the existential well-being subscale and the global scale of the McGill Quality of Life (MQoL) Questionnaire.Results:All participants agreed that their participation in the program helped them deal with their illness and their personal life. Some 88.9% of participants agreed that this program should be proposed for all cancer patients, and 94.5% agreed that this intervention helped them to reflect on the meaning of their life. At post-intervention, both existential and psychological QoL improved in the group intervention versus usual care (p = 0.086 and 0.077, respectively). At the three-month follow-up, global and psychological QoL improved in the individual intervention versus usual care (p = 0.056 and 0.047, respectively).Significance of results:This pilot study confirms the relevance of the intervention and the feasibility of the recruitment and randomization processes. The data strongly suggest a potential efficacy of the intervention for existential and global quality of life, which will have to be confirmed in a larger study.

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