scholarly journals Asymptomatic Malaria And Glycemic Control Among Type 2 Diabetes Mellitus Patients In A Rural Tertiary Health Facility In Ido- Ekiti, Southwestern Nigeria- A Cross Sectional Study.

2021 ◽  
Author(s):  
Azeez Oyemomi Ibrahim ◽  
Tosin Anthony Agbesanwa ◽  
Segun Mathew Agboola ◽  
Olabode Muftau Shabi ◽  
Adewumi Oluwaserimi Ajetunmobi ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Poor Glycemic Control ◽  
Asymptomatic Malaria ◽  
Malaria Parasitaemia ◽  
Southwestern Nigeria ◽  
Cross Sectional

Abstract Background: : Despite the high burden of Asymptomatic Malaria and Type 2 diabetes mellitus in sub-Saharan African, limited data exist regarding their co-occurrence and its associated clinical impacts of asymptomatic malaria parasitaemia on Type 2 diabetes mellitus in rural setting. The purpose of this study is to determine the prevalence of glycemic control and asymptomatic malaria parasitaemia; and to investigate the influence of socio-demographic characteristics and asymptomatic malaria parasitaemia on glycemic control among patients with Type 2 diabetes mellitus.Methods: Hospital-based cross-sectional study was conducted on 150 T2DM patients at Federal Teaching Hospital, Ido-Ekiti, SouthWestern Nigeria, between April and September 2019. Systematic random sampling technique was adopted to recruit the respondents. Socio-demographic data were obtained using a semi- structured interviewer administered questionnaire and clinical files. Venous blood samples were collected and processed for glycosylated haemoglobin sugar estimation and malaria parasite detection by microscopy. Data were analyzed using SPSS version 20.0. Multivariate logistic regression analysis was used to identify the influence of asymptomatic malaria parasitaemia and the socio-demographic profile on glycemic control.Results: The mean age, mean glycemic control and mean parasite density of the respondents were 64.8±11.1 years, 6.9±2.1% and 1123.4±433.8 respectively. The prevalence of poor glycemic control and asymptomatic malaria parasitaemia were 30.0% and 14.0% respectively. Old age, female gender, lack of formal education and asymptomatic malaria parasitaemia were associated with poor glycemic control.Conclusion: The study revealed that Type 2 diabetes mellitus patients in Ido-Ekiti, Nigeria, harbor asymptomatic malaria parasitaemia and that Asymptomatic malaria parasitaemia, old age, female gender and illiteracy were negative predictors of glycemic control. Therefore, type 2 diabetes mellitus patient with poor glycemic control should be screened for asymptomatic malaria parasitaemia. Also, respondents with these identified predictors should be targeted with focus care and qualitative health education to improve their glycemic control level.

scholarly journals Laboratory Parameters of Hemostasis, Adhesion Molecules, and Inflammation in Type 2 Diabetes Mellitus: Correlation with Glycemic Control

2020 ◽  
Vol 17 (1) ◽  
pp. 300 ◽  
Author(s):  
Eleonora Palella ◽  
Rossella Cimino ◽  
Salvatore A. Pullano ◽  
Antonino S. Fiorillo ◽  
Elio Gulletta ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
Adhesion Molecules ◽  
Adhesion Molecule ◽  
Vascular Complications ◽  
Poor Glycemic Control ◽  
Pai 1

Background: Type 2 diabetes mellitus (T2DM) is characterized by a prothrombotic state, predisposing to vascular complications. Some related markers, linking thrombophilia to hemostasis and inflammation, however, have been poorly explored in relation to patients’ glycemia. We therefore investigated the association of laboratory hemostatic parameters, circulating adhesion molecules (ADMs), white blood cell (WBC) count, and neutrophil/lymphocyte ratio (NLR) with T2DM and glycemic control. Research design: In this study, 82 subjects, grouped into T2DM patients (n = 41) and healthy individuals (n = 41) were enrolled. To evaluate glycemic control, the T2DM cohort was expanded to 133 patients and sub-classified according to glycated hemoglobin (HbA1c) <7% and ≥ 7% (n = 58 and n = 75, respectively). We assessed glycemia, HbA1c, prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, plasminogen activator inhibitor-1 (PAI-1), platelet and leukocyte parameters, vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and selectins (E-, P-, L-). Results: PT % activity, PAI-1, VCAM-1, WBC, and neutrophil counts were significantly higher in T2DM patients than in healthy subjects. Poor glycemic control (HbA1c ≥ 7%) was correlated with increased PT activity (p = 0.015), and higher levels of E-selectin (p = 0.009), P-selectin (p = 0.012), and NLR (p = 0.019). Conclusions: Both T2DM and poor glycemic control affect some parameters of hemostasis, inflammation, and adhesion molecules. Further studies are needed to establish their clinical utility as adjuvant markers for cardio-vascular risk in T2DM patients.

scholarly journals Rate of glycemic control and associated factors among type two diabetes mellitus patients in Ethiopia: A cross sectional study

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251506
Author(s):  
Shambel Nigussie ◽  
Nigussie Birhan ◽  
Firehiwot Amare ◽  
Getnet Mengistu ◽  
Fuad Adem ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Glycemic Control ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Poor Glycemic Control ◽  
Diabetic Patients ◽  
Sectional Study ◽  
Cross Sectional

Objective To assess the rate of glycemic control and associated factors among type 2 diabetes mellitus patients at Dilchora Referral Hospital, Dire Dawa, Eastern Ethiopia. Methods A cross-sectional study was conducted from 13 May to 16 August 2019. Type 2 diabetic patients on follow up at Dilchora Referral Hospital who fulfilled the inclusion criteria of the study were included. Systematic random sampling was used to select study participants. Data was collected by a face-to-face interview and review of medical records. The primary outcome was the level of blood glucose during three consecutive visits. Poor glycemic control was defined as a blood sugar level of more than 154 mg/dL based on the average of measurements from three consecutive visits. Multivariate logistic regression analysis was used to identify determinants of glycemic control. Result A total of 394 participants responded to the interview and were included in the final analysis. The overall prevalence of poor glycemic control was 45.2% (95%CI: 40.6%-50.0%). Patients who were on oral anti-diabetic drug plus insulin had more than two times greater chance of poor glycemic control than patients on oral anti-diabetic drug alone: 2.177(95%CI:1.10–4.29). The odds of poor glycemic control in patients who did not understand the pharmacist’s instructions was two times higher than patients with good understanding of instructions 1.86(95%CI: 1.10–3.13). Patients who had poor level of practice were found to have poor glycemic control: 1.69(95% CI: 1.13–2.55). Conclusion The overall prevalence of poor glycemic control was high among type 2 diabetes patients. Oral anti-diabetic drugs in combination with insulin, lack of understanding of pharmacist’s advice, and poor practice of diabetic patients were significant factors of poor glycemic control. Pharmacists should reassure the understanding of patients before discharge during counseling. Optimization of the dose of antidiabetic medications and combination of oral hypoglycemic agents should be considered.

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