scholarly journals Machine Learning Guided Postnatal Gestational Age Assessment Using Newborn Screening Metabolomic Data in South Asia and Sub-Saharan Africa

2021 ◽  
Author(s):  
Sunil Sazawal ◽  
Kelli Ryckman ◽  
Sayan Das ◽  
Rasheda Khanam ◽  
Imran Nisar ◽  
...  
Keyword(s):  
Machine Learning ◽  
Birth Weight ◽  
Gestational Age ◽  
Roc Analysis ◽  
Model Building ◽  
Learning Algorithms ◽  
Population Level ◽  
Machine Learning Algorithms ◽  
Sub Saharan Africa ◽  
Age Dating

Abstract Background: Babies born early and/or small for gestational age in Low- and Middle-income countries (LMIC) contribute substantially to global neonatal and infant mortality. Tracking this metric is critical at a population level for informed policy, advocacy, resources allocation and program evaluation and at an individual level for targeted care. Early prenatal ultrasound is not available in these settings, gestational age (GA) is estimated using newborn assessment, LMP recalls and birth weight, which are unreliable. Algorithms in developed settings, using metabolic screen data, provided GA estimates within 1-2 weeks of ultrasound-based GA. We sought to leverage machine learning algorithms to improve accuracy and applicability of this approach to LMIC settings.Methods: This study uses data from AMANHI-ACT prospective pregnancy cohorts in Asia and Africa where early pregnancy ultrasound estimated GA and birth weight are available and metabolite screening data in a subset of 1318 newborn are available. We utilized this opportunity to develop machine learning (ML) algorithms. Random Forest Regressor was used where data was randomly split into model-building and model-testing dataset. Mean absolute error (MAE) and root mean square error (RSME) were used to evaluate performance. Bootstrap procedures were used to estimate confidence intervals (CI) for RMSE and MAE. For pre-term birth identification ROC analysis with bootstrap and exact estimation of CI for area under curve (AUC) were performed.Results: Overall model estimated GA, had MAE of 5.8 days (95%CI 5.6-6.3), which was similar to performance in SGA, MAE 6.3 days (95%CI 5.6-7.0). GA was correctly estimated to within 1 week for 70.9% (95%CI 67.9-73.7). For preterm birth classification, AUC in ROC analysis was 92.6% (95%CI 87.5-96.1; p<0.001). This model performed better than Iowa regression, AUC Difference 2.8% (95%CI 0.9-11.8%; p=0.021).Conclusions: Machine learning algorithms and models applied to metabolomic gestational age dating offer a ladder of opportunity for providing accurate population-level gestational age estimates in LMIC settings. These findings also point to an opportunity for investigation of region-specific models, more focused feasible analyte models, and broad untargeted metabolome investigation.

scholarly journals Machine learning guided postnatal gestational age assessment using new-born screening metabolomic data in South Asia and sub-Saharan Africa

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Sunil Sazawal ◽  
Kelli K. Ryckman ◽  
Sayan Das ◽  
Rasheda Khanam ◽  
Imran Nisar ◽  
...  
Keyword(s):  
Machine Learning ◽  
Birth Weight ◽  
Gestational Age ◽  
Roc Analysis ◽  
Learning Algorithms ◽  
Population Level ◽  
Machine Learning Algorithms ◽  
Sub Saharan Africa ◽  
Age Dating ◽  
New Born

Abstract Background Babies born early and/or small for gestational age in Low and Middle-income countries (LMICs) contribute substantially to global neonatal and infant mortality. Tracking this metric is critical at a population level for informed policy, advocacy, resources allocation and program evaluation and at an individual level for targeted care. Early prenatal ultrasound examination is not available in these settings, gestational age (GA) is estimated using new-born assessment, last menstrual period (LMP) recalls and birth weight, which are unreliable. Algorithms in developed settings, using metabolic screen data, provided GA estimates within 1–2 weeks of ultrasonography-based GA. We sought to leverage machine learning algorithms to improve accuracy and applicability of this approach to LMICs settings. Methods This study uses data from AMANHI-ACT, a prospective pregnancy cohorts in Asia and Africa where early pregnancy ultrasonography estimated GA and birth weight are available and metabolite screening data in a subset of 1318 new-borns were also available. We utilized this opportunity to develop machine learning (ML) algorithms. Random Forest Regressor was used where data was randomly split into model-building and model-testing dataset. Mean absolute error (MAE) and root mean square error (RMSE) were used to evaluate performance. Bootstrap procedures were used to estimate confidence intervals (CI) for RMSE and MAE. For pre-term birth identification ROC analysis with bootstrap and exact estimation of CI for area under curve (AUC) were performed. Results Overall model estimated GA had MAE of 5.2 days (95% CI 4.6–6.8), which was similar to performance in SGA, MAE 5.3 days (95% CI 4.6–6.2). GA was correctly estimated to within 1 week for 85.21% (95% CI 72.31–94.65). For preterm birth classification, AUC in ROC analysis was 98.1% (95% CI 96.0–99.0; p < 0.001). This model performed better than Iowa regression, AUC Difference 14.4% (95% CI 5–23.7; p = 0.002). Conclusions Machine learning algorithms and models applied to metabolomic gestational age dating offer a ladder of opportunity for providing accurate population-level gestational age estimates in LMICs settings. These findings also point to an opportunity for investigation of region-specific models, more focused feasible analyte models, and broad untargeted metabolome investigation.

scholarly journals Predicting Alert Source Device using Machine Learning Algorithms

2020 ◽  
Vol 9 (9) ◽  
pp. 1-10
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Model Building ◽  
Learning Algorithm ◽  
Learning Algorithms ◽  
Research Work ◽  
Machine Learning Algorithms ◽  
Training Dataset ◽  
Imbalanced Dataset ◽  
Daunting Task

In a large distributed virtualized environment, predicting the alerting source from its text seems to be daunting task. This paper explores the option of using machine learning algorithm to solve this problem. Unfortunately, our training dataset is highly imbalanced. Where 96% of alerting data is reported by 24% of alerting sources. This is the expected dataset in any live distributed virtualized environment, where new version of device will have relatively less alert compared to older devices. Any classification effort with such imbalanced dataset present different set of challenges compared to binary classification. This type of skewed data distribution makes conventional machine learning less effective, especially while predicting the minority device type alerts. Our challenge is to build a robust model which can cope with this imbalanced dataset and achieves relative high level of prediction accuracy. This research work stared with traditional regression and classification algorithms using bag of words model. Then word2vec and doc2vec models are used to represent the words in vector formats, which preserve the sematic meaning of the sentence. With this alerting text with similar message will have same vector form representation. This vectorized alerting text is used with Logistic Regression for model building. This yields better accuracy, but the model is relatively complex and demand more computational resources. Finally, simple neural network is used for this multi-class text classification problem domain by using keras and tensorflow libraries. A simple two layered neural network yielded 99 % accuracy, even though our training dataset was not balanced. This paper goes through the qualitative evaluation of the different machine learning algorithms and their respective result. Finally, two layered deep learning algorithms is selected as final solution, since it takes relatively less resource and time with better accuracy values.

scholarly journals The Difference of Machine Learning and Deep Learning Algorithms

2021 ◽  
Author(s):  
Yew Kee Wong
Keyword(s):  
Machine Learning ◽  
Big Data ◽  
Data Analysis ◽  
Data Analytics ◽  
Model Building ◽  
Learning Algorithms ◽  
Big Data Analytics ◽  
Machine Learning Algorithms ◽  
Human Intervention ◽  
The Difference

In the information era, enormous amounts of data have become available on hand to decision makers. Big data refers to datasets that are not only big, but also high in variety and velocity, which makes them difficult to handle using traditional tools and techniques. Due to the rapid growth of such data, solutions need to be studiedand provided in order to handle and extract value and knowledge from these datasets. Machine learning is a method of data analysis that automates analytical model building. It is a branch of artificial intelligence based on the idea that systems can learn from data, identify patterns and make decisions with minimal human intervention. Such minimal human intervention can be provided using big data analytics, which is the application of advanced analytics techniques on big data. This paper aims to analyse some of the different machine learning algorithms and methods which can be applied to big data analysis, as well as the opportunities provided by the application of big data analytics in various decision making domains.

Forecasting US movies box office performances in Turkey using machine learning algorithms

2020 ◽  
Vol 39 (5) ◽  
pp. 6579-6590
Author(s):  
Sandy Çağlıyor ◽  
Başar Öztayşi ◽  
Selime Sezgin
Keyword(s):  
Machine Learning ◽  
Global Economy ◽  
Learning Algorithms ◽  
Forecast Model ◽  
Machine Learning Algorithms ◽  
Gradient Boosting ◽  
High Stakes ◽  
Box Office ◽  
Industry Forecast ◽  
The Impact

The motion picture industry is one of the largest industries worldwide and has significant importance in the global economy. Considering the high stakes and high risks in the industry, forecast models and decision support systems are gaining importance. Several attempts have been made to estimate the theatrical performance of a movie before or at the early stages of its release. Nevertheless, these models are mostly used for predicting domestic performances and the industry still struggles to predict box office performances in overseas markets. In this study, the aim is to design a forecast model using different machine learning algorithms to estimate the theatrical success of US movies in Turkey. From various sources, a dataset of 1559 movies is constructed. Firstly, independent variables are grouped as pre-release, distributor type, and international distribution based on their characteristic. The number of attendances is discretized into three classes. Four popular machine learning algorithms, artificial neural networks, decision tree regression and gradient boosting tree and random forest are employed, and the impact of each group is observed by compared by the performance models. Then the number of target classes is increased into five and eight and results are compared with the previously developed models in the literature.

Intelligent system of English composition scoring model based on improved machine learning algorithm

2020 ◽  
pp. 1-11
Author(s):  
Jie Liu ◽  
Lin Lin ◽  
Xiufang Liang
Keyword(s):  
Machine Learning ◽  
Evaluation System ◽  
Intelligent System ◽  
Learning Algorithm ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Assessment System ◽  
English Composition ◽  
Region Extraction ◽  
Constraint Model

The online English teaching system has certain requirements for the intelligent scoring system, and the most difficult stage of intelligent scoring in the English test is to score the English composition through the intelligent model. In order to improve the intelligence of English composition scoring, based on machine learning algorithms, this study combines intelligent image recognition technology to improve machine learning algorithms, and proposes an improved MSER-based character candidate region extraction algorithm and a convolutional neural network-based pseudo-character region filtering algorithm. In addition, in order to verify whether the algorithm model proposed in this paper meets the requirements of the group text, that is, to verify the feasibility of the algorithm, the performance of the model proposed in this study is analyzed through design experiments. Moreover, the basic conditions for composition scoring are input into the model as a constraint model. The research results show that the algorithm proposed in this paper has a certain practical effect, and it can be applied to the English assessment system and the online assessment system of the homework evaluation system algorithm system.

The Unlearnable Checkerboard Pattern

2019 ◽  
Vol 1 (2) ◽  
pp. 78-80
Author(s):  
Eric Holloway
Keyword(s):  
Machine Learning ◽  
Learning Algorithms ◽  
Machine Learning Algorithms ◽  
Checkerboard Pattern ◽  
Simple Task

Detecting some patterns is a simple task for humans, but nearly impossible for current machine learning algorithms.  Here, the "checkerboard" pattern is examined, where human prediction nears 100% and machine prediction drops significantly below 50%.

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