Automated detection of skeletal metastasis of lung cancer with bone scans using convolutional nuclear network

Bone scan is widely used for surveying bone metastases caused by various solid tumors. Scintigraphic images are characterized by inferior spatial resolution, bringing a significant challenge to manual analysis of images by nuclear medicine physicians. We present in this work a new framework for automatically classifying scintigraphic images collected from patients clinically diagnosed with lung cancer. The framework consists of data preparation and image classification. In the data preparation stage, data augmentation is used to enlarge the dataset, followed by image fusion and thoracic region extraction. In the image classification stage, we use a self-defined convolutional neural network consisting of feature extraction, feature aggregation, and feature classification sub-networks. The developed multi-class classification network can not only predict whether a bone scan image contains bone metastasis but also tell which subcategory of lung cancer that a bone metastasis metastasized from is present in the image. Experimental evaluations on a set of clinical bone scan images have shown that the proposed multi-class classification network is workable for automated classification of metastatic images, with achieving average scores of 0.7392, 0.7592, 0.7242, and 0.7292 for accuracy, precision, recall, and F-1 score, respectively.

Permissible Region Extraction Strategies for XLCT: A Comparative Study

Permissible region (PR) strategy has been used successfully to alleviate the ill-posedness of the X-ray luminescence computed tomography (XLCT) reconstruction problem. In the previous researches on the permissible region strategy, it is obvious that permissible region strategy can solve the reconstruction problem efficiently. This paper aims to research the performances of four types of permissible region extraction strategies, including a permissible region manually extraction strategy, a permissible region extraction strategy with a priori information of the surface nanophosphors distribution, a permissible region extraction strategy based on the first-time reconstruction result and a precise permissible region extraction strategy. In addition, some heuristic conclusions are provided for the future study in this paper. Fast iterative shrinkage-thresholding algorithm (FISTA) is used to reconstruct in this paper. The numerical simulation experiments and physical phantom experiments are setup to evaluate and illustrate the performances of the four different types of permissible region strategies.

DW-UNet: Loss Balance under Local-Patch for 3D Infection Segmentation from COVID-19 CT Images

(1) Background: COVID-19 has been global epidemic. This work aims to extract 3D infection from COVID-19 CT images; (2) Methods: Firstly, COVID-19 CT images are processed with lung region extraction and data enhancement. In this strategy, gradient changes of voxels in different directions respond to geometric characteristics. Due to the complexity of tubular tissues in lung region, they are clustered to the lung parenchyma center based on their filtered possibility. Thus, infection is improved after data enhancement. Then, deep weighted UNet is established to refining 3D infection texture, and weighted loss function is introduced. It changes cost calculation of different samples, causing target samples to dominate convergence direction. Finally, the trained network effectively extracts 3D infection from CT images by adjusting driving strategy of different samples. (3) Results: Using Accuracy, Precision, Recall and Coincidence rate, 20 subjects from a private dataset and eight subjects from Kaggle Competition COVID-19 CT dataset tested this method in hold-out validation framework. This work achieved good performance both in the private dataset (99.94–00.02%, 60.42–11.25%, 70.79–09.35% and 63.15–08.35%) and public dataset (99.73–00.12%, 77.02–06.06%, 41.23–08.61% and 52.50–08.18%). We also applied some extra indicators to test data augmentation and different models. The statistical tests have verified the significant difference of different models. (4) Conclusions: This study provides a COVID-19 infection segmentation technology, which provides an important prerequisite for the quantitative analysis of COVID-19 CT images.

Camouflaged Target Detection Based on Snapshot Multispectral Imaging

The spectral information contained in the hyperspectral images (HSI) distinguishes the intrinsic properties of a target from the background, which is widely used in remote sensing. However, the low imaging speed and high data redundancy caused by the high spectral resolution of imaging spectrometers limit their application in scenarios with the real-time requirement. In this work, we achieve the precise detection of camouflaged targets based on snapshot multispectral imaging technology and band selection methods in urban-related scenes. Specifically, the camouflaged target detection algorithm combines the constrained energy minimization (CEM) algorithm and the improved maximum between-class variance (OTSU) algorithm (t-OTSU), which is proposed to obtain the initial target detection results and adaptively segment the target region. Moreover, an object region extraction (ORE) algorithm is proposed to obtain a complete target contour that improves the target detection capability of multispectral images (MSI). The experimental results show that the proposed algorithm has the ability to detect different camouflaged targets by using only four bands. The detection accuracy is above 99%, and the false alarm rate is below 0.2%. The research achieves the effective detection of camouflaged targets and has the potential to provide a new means for real-time multispectral sensing in complex scenes.