Survival Analysis of 335 Patients With Colorectal Cancer Undergoing Combined Treatment 

2021 ◽  
Author(s):  
Daem Roshani ◽  
Ghobad Moradi ◽  
Mohammad Rasouli
Keyword(s):  
Colorectal Cancer ◽  
Survival Rate ◽  
Cox Regression ◽  
Survival Curve ◽  
Combined Treatment ◽  
Survival Rates ◽  
Rank Test ◽  
Cancer Registration ◽  
Cancer Specific Survival ◽  
Registration System

Abstract Introduction: If colorectal cancer (CRC) is diagnosed in the early stages, the patients will have higher survival rates. Although there might be some other factors which affect the survival rate, the kind of treatment available based on existing health and therapeutic facilities, is very important as well. The aim of this study was to explore the best type of treatment in colorectal cancer patients.Methods: The data of 335 patients with CRC in Kurdistan province were collected using population-based cancer registration system from first of March 2009 to 2014. Demographic and clinical- pathologic data of the patients were gathered through their medical and pathology records and going to the door of their houses. The cancer-specific survival rate were calculated using Kaplan-Meier survival curve, log-rank test, univariate and multivariate Cox regression. The data was analyzed using Stata 12 software. Results: One-year, three-year and five-year survival rates were %87, %57 and %33 respectively. The median of survival was 42.6 months. The five-year survival rate for those patients who had received both surgical and chemotherapy treatments was %55.8. There was less mortality rate among the patients who had received both surgical and chemotherapy treatments compared to those who had not received any treatment (HR=0.57, 95% CI 0.24-0.93).Conclusion: When CRC patients are treated using both surgical and chemotherapy treatments, they will have higher survival rate. Therefore, it is suggested to use both treatments for CRC patients.

Survival Analysis Of 335 Patients With Colorectal Cancer Undergoing Combined Treatment

2021 ◽  
Author(s):  
Ghobad Moradi ◽  
Mohammad Aziz Rasouli ◽  
Daem Roshani
Keyword(s):  
Colorectal Cancer ◽  
Survival Rate ◽  
Cox Regression ◽  
Survival Curve ◽  
Combined Treatment ◽  
Survival Rates ◽  
Rank Test ◽  
Cancer Registration ◽  
Cancer Specific Survival ◽  
Registration System

Abstract Purpose: If colorectal cancer (CRC) is diagnosed in the early stages, the patients will have higher survival rates. Although there might be some other factors which affect the survival rate, the kind of treatment available based on existing health and therapeutic facilities, is very important as well. The aim of this study was to explore the best type of treatment in colorectal cancer patients.Methods: The data of 335 patients with CRC in Kurdistan province were collected using population-based cancer registration system from first of March 2009 to 2014. Demographic and clinical- pathologic data of the patients were gathered through their medical and pathology records and going to the door of their houses. The cancer-specific survival rate were calculated using Kaplan-Meier survival curve, log-rank test, univariate and multivariate Cox regression. The data was analyzed using Stata 12 software. Results: One-year, three-year and five-year survival rates were %87, %57 and %33 respectively. The median of survival was 42.6 months. The five-year survival rate for those patients who had received both surgical and chemotherapy treatments was %55.8. There was less mortality rate among the patients who had received both surgical and chemotherapy treatments compared to those who had not received any treatment (HR=0.57, 95% CI 0.24-0.93).Conclusion: When CRC patients are treated using both surgical and chemotherapy treatments, they will have higher survival rate. Therefore, it is suggested to use both treatments for CRC patients.

scholarly journals Oral and oropharyngeal cancer: epidemiology and survival analysis

2018 ◽  
Vol 16 (2) ◽  
Author(s):  
Juliana da Silva Moro ◽  
Marília Cunha Maroneze ◽  
Thiago Machado Ardenghi ◽  
Luisa Machado Barin ◽  
Cristiane Cademartori Danesi
Keyword(s):  
Survival Rate ◽  
Oropharyngeal Cancer ◽  
Survival Curve ◽  
Survival Rates ◽  
University Hospital ◽  
Rank Test ◽  
Anatomical Location ◽  
Anatomical Site ◽  
Patient Death ◽  
Oral And Oropharyngeal Cancer

ABSTRACT Objective To evaluate the epidemiological profile and survival rate of oral and oropharyngeal cancer patients seen at a university hospital. Methods A cross-sectional study was carried out by means of the pathological reports of patients with oral and oropharyngeal cancer, seen at a university hospital of the Southern Region, between January 2004 and December 2014. Information was collected on patients and tumors. The mortality rate was gathered from the patient death registry in the Mortality Information System. Data were analyzed using the Kaplan-Meier survival curve and the log-rank test to compare variables. Results The 5- and 10-year survival rates were 42% and 38%, respectively. The anatomical location had a significant association with survival rate (p=0.001), with the rates were better in the lips (p=0.04), and worse in the oropharynx (p=0.03). There were no statistically significant differences between survival rates according to age, sex, ethnicity, schooling level and histologic grade. Conclusion The survival rates of oral and oropharyngeal cancer were and associated with the anatomical site of the tumor.

scholarly journals EYA4 could be an indicator signifying colorectal cancer sufferers' prognoses

2020 ◽  
Author(s):  
Yang Yan ◽  
Xiaohui Du ◽  
Shaoyou Xia ◽  
Songyan Li ◽  
Da Teng ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Cox Regression ◽  
Survival Curve ◽  
Mrna Level ◽  
Clinicopathological Characteristics ◽  
Rank Test ◽  
Normal Tissues ◽  
Log Rank Test ◽  
Low Expression

Abstract Background Eyes absent 4 (EYA4) is involved in various biological processes. The aim of this study was to investigate the expression of EYA4 and its prognostic value in colorectal cancer (CRC). Methods The mRNA level of EYA4 in diseased tissues and adjacent normal tissues of CRC patients were detected by quantitative real-time polymerase chain reaction (qRT-PCR). The association between EYA4 expression and clinicopathological characteristics was analyzed by χ2 test. Kaplan-Meier analysis with log rank test was performed to evaluate the effects of EYA4 expression on overall survival of CRC patients. Cox regression model was applied for prognosis analysis in CRC. Results The mRNA level of EYA4 was significantly decreased in CRC tissues compared with that in the adjacent normal tissue (P < 0.01). And its expression was affected by DUKE stage (P = 0.034), differentiation (P = 0.027) and vascular invasion (P = 0.037). Survival curve showed that patients with low expression of EYA4 had a significantly shorter overall survival than those with high expression (log rank test, P = 0.008). Low expression of EYA4 (HR = 1.989, 95%CI = 1.090-3.62902, P = 0.025) was an independent biomarker for poor prognosis in CRC patients. Conclusion EYA4 expression is decreased in CRC patients and negatively correlated with aggressive tumor progression. EYA4 may be a potential prognostic biomarker for CRC.

scholarly journals Treatment and Outcomes of Colorectal Cancer in Armenia: A Real-World Experience From a Developing Country

2020 ◽  
pp. 1286-1297
Author(s):  
Samvel Bardakhchyan ◽  
Sergo Mkhitaryan ◽  
Davit Zohrabyan ◽  
Liana Safaryan ◽  
Armen Avagyan ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Prognostic Factors ◽  
Cox Regression ◽  
Survival Rates ◽  
Stage Iv ◽  
Final Analysis ◽  
Stage Ii ◽  
Stage Iii ◽  
Rank Test

PURPOSE In Armenia, colorectal cancer (CRC) is one of the most frequently diagnosed cancers. It is in the third place by incidence. The aim of this study was to evaluate treatment and outcomes of CRC in Armenia during the last 9 years. MATERIALS AND METHODS For this retrospective hospital-based study, we have collected data from two main oncology centers in Armenia: National Oncology Center and “Muratsan” Hospital of Yerevan State Medical University. The information about patients with CRC who were treated at these two centers between January 1, 2010 and July 1, 2018 was collected from the medical records. Log-rank test and Kaplan-Meier curves were used for survival analysis. Prognostic factors were identified by Cox regression. RESULTS A total of 602 patients with CRC were involved in the final analysis. Median follow-up time was 37 months (range, 3-207 months). A total of 8.6% of patients had stage I, 32.9% stage II, 38.0% stage III, and 17.6% stage IV cancer; for 2.7% patients, the stage was unknown. The main independent prognostic factors for overall survival (OS) were tumor stage, grade, and histology. Adjuvant chemotherapy has been shown to improve survival in stage II colon cancer and stage III rectal but not in stage II rectal cancer. Radiotherapy did not yield survival improvement in stage II or III rectal cancer. Three- and 5-year OS rates were 62.9% and 51.8% for all stages combined and 79.7% and 68.5% for stages I-II, 62.5% and 48.4% for stage III, and 24.4% and 17% for stage IV respectively. CONCLUSION As seen from our results, our survival rates are lower than those of the developed world. Additional research is needed to identify the underlying reasons and to improve patients’ treatment and outcomes in Armenia.

scholarly journals Copy Number Analysis Reveal Genetic Risks of Penile Cancer

2020 ◽  
Vol 10 ◽  
Author(s):  
Yongbo Yu ◽  
Chengwen Gao ◽  
Yuanbin Chen ◽  
Meilan Wang ◽  
Jianfeng Zhang ◽  
...  
Keyword(s):  
Survival Rate ◽  
Copy Number ◽  
Penile Cancer ◽  
Survival Rates ◽  
Rank Test ◽  
Cancer Specific Survival ◽  
Functional Roles ◽  
Kaplan Meier ◽  
Genome Analysis Toolkit ◽  
Penile Squamous Cell Carcinoma

ObjectivesTo evaluate copy number alterations (CNAs) in genes associated with penile cancer (PeC) and determine their correlation and prognostic ability with PeC.MethodsWhole-exome sequencing was performed for tumor tissue and matched normal DNA of 35 patients diagnosed with penile squamous cell carcinoma from 2011 to 2016. Somatic CNAs were detected using the Genome Analysis Toolkit (GATK). Retrospective clinical data were collected and analyzed. All the data were statistically analyzed using SPSS 16.0 software. The cancer-specific survival rates were estimated by Kaplan-Meier curves and compared with the log-rank test.ResultsCNAs in the MYCN gene was detected in 19 (amplification: 54.29%) patients. Other CNAs gene targets were FAK (amplification: 45.72%, deletion: 8.57%), TP53 (amplification: 2.86%, deletion: 51.43%), TRKA (amplification: 34.29%, deletion: 2.86%), p75NTR (amplification: 5.71%, deletion: 42.86%), Miz-1 (amplification: 14.29%, deletion: 20.00%), Max (amplification: 17.14%, deletion: 2.86%), Bmi1 (amplification:14.29%, deletion: 48.57%), and MDM2 (amplification: 5.71%, deletion: 45.72%). The CNAs in MYCN and FAK correlated significantly with patient prognosis (P&lt;0.05). The 3-year Recurrence-free survival rate was 87.10% among patients followed up. The 5-year survival rate of patients with MYCN amplification was 69.2%, compared to 94.4% in the non-amplification group. The 5-year survival rate of patients with FAK amplification was 65.6%, compared to 94.7% in the non-amplification group. The PPI network showed that TP53 and MYCN might play meaningful functional roles in PeC.ConclusionMYCN and FAK amplification and TP53 deletion were apparent in PeC. MYCN and TP53 were hub genes in PeC. MYCN and FAK amplification was also detected and analyzed, and the findings indicated that these two genes are predictors of poor prognosis in PeC.

EPIDEMIOLOGY AND SURVIVAL ANALYSIS OF MOUTH AND OROPHARYNGEAL CANCER PATIENTS TREATED AT A PUBLIC HOSPITAL IN RIO DE JANEIRO, BRAZIL

2020 ◽  
Author(s):  
Jackeline Nogueira de Paula Barros
Keyword(s):  
Survival Rate ◽  
Rio De Janeiro ◽  
Survival Curve ◽  
Survival Rates ◽  
Rank Test ◽  
Anatomical Location ◽  
Anatomical Site ◽  
Global Public Health ◽  
Oral Neoplasms ◽  
Epidemiological Profile

AbstractMouth and oropharyngeal cancers (CAs) are considered to be global public health problems, with high psychosocial impacts and high costs. Developing an epidemiological profile and examining the survival rate among patients with CAs of the mouth and oropharynx are important for the development of public policy. Therefore, this retrospective study aimed to evaluate mouth and oropharyngeal CA patients treated at the Municipal Hospital Salgado Filho in Rio de Janeiro, Brazil between 2007 and 2017. Patient data regarding gender, age, ethnicity, diagnosis, anatomical site affected by the tumor, and habits were obtained from patient records and reports, and data regarding the deaths of patients were obtained from records and the Mortality Information System. After tabulation, data were descriptively analyzed using the Kaplan-Meier survival curve, and the log-rank test was used for the comparison of variables. Survival rates at 5 and 8 years were 71.1% and 48.8%, respectively. There were no significant differences among survival rates according to age, sex, ethnicity, or the anatomical location of tumors. The survival rates among mouth and oropharyngeal CA patients in this study were comparable with the results reported in developed countries.Keywords: Oral neoplasms, epidemiology, survival rate;

scholarly journals Is repeated pulmonary metastasectomy justified?

2020 ◽  
Vol 37 (6) ◽  
pp. 675-682 ◽  
Author(s):  
Céline Forster ◽  
Amaya Ojanguren ◽  
Jean Yannis Perentes ◽  
Matthieu Zellweger ◽  
Sara Federici ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Survival Rate ◽  
Pulmonary Resection ◽  
Cox Regression ◽  
Survival Rates ◽  
Pulmonary Metastasectomy ◽  
Primary Tumors ◽  
Operative Morbidity ◽  
Operative Outcomes

AbstractRecurrence after pulmonary metastasectomy (PM) is frequent, but it is unclear to whom repeated pulmonary metastasectomy (RPM) offers highest benefits. Retrospective analysis of oncological and post-operative outcomes of consecutive patients who underwent PM from 2003 to 2018. Overall survival (OS) and disease-free interval (DFI) were calculated. Cox regression was used to identify variables influencing OS and DFI. In total, 264 patients (female/male: 114/150; median age: 62 years) underwent PM for colorectal cancer (32%), sarcoma (19%), melanoma (16%) and other primary tumors (33%). Pulmonary metastasectomy was approached by video-assisted thoracic surgery (VATS) in 73% and pulmonary resection was realized by non-anatomical resection in 76% of cases. The overall median follow-up time was 33 months (IQR 16–56 months) and overall 5-year survival rate was 62%. Local or distant recurrences were observed in 172 patients (65%) and RPM could be performed in 66 patients (25%) for a total of 116 procedures. RPM was realized by VATS in 49% and pulmonary resection by wedge in 77% of cases. In RPM patients, the 5-year survival rate after first PM was 79%. Post-operative cardio-pulmonary complication rate (13% vs. 12%; p = 0.8) and median length of stay (4 vs. 5 days; p = 0.2) were not statistically different between first PM and RPM. Colorectal cancer (HR 0.56), metachronous metastasis (HR 0.48) and RPM (HR 0.5) were associated with better survival. In conclusion, our results suggest that RPM offers favorable survival rates without increasing post-operative morbidity.

scholarly journals Survival of Cervical Cancer Patients in Brunei Darussalam: 2002-2017

2021 ◽  
Author(s):  
Shirley Lee ◽  
Nurlaylasahira Abdul Rahim ◽  
Sok King Ong ◽  
Hanif Abdul Rahman ◽  
Lin Naing
Keyword(s):  
Cervical Cancer ◽  
Survival Rate ◽  
Cancer Patients ◽  
Cox Regression ◽  
Survival Rates ◽  
Rank Test ◽  
Cox Regression Analysis ◽  
Brunei Darussalam ◽  
Kaplan Meier ◽  
Risk Of Mortality

Abstract BACKGROUND: Cervical cancer is the fourth leading cause of cancer deaths among Bruneian women. This study aims to investigate the survival rate of cervical cancer patients in Brunei Darussalam between 2002 and 2017, to compare survival of cervical cancer patients between two periods: 2002-2009 and 2010-2017 and to identify prognostic factors of cervical cancer.METHODS: A retrospective cohort study on cervical cancer patients registered in Brunei Darussalam Cancer Registry between 2002 and 2017. De-identified data from the registry was extracted and survival analysis was performed using Kaplan-Meier estimator, log-rank test and multiple Cox regression analysis.RESULTS: The 1-, 3- and 5-year survival rates of cervical cancer patients in Brunei Darussalam were 88.2%, 78.9% and 74.1% respectively from 2002-2017. The 5-year survival rate for 2002-2009 and 2010-2017 were 77.5% and 72.1% respectively. The risk of mortality was significantly higher in 2010-2017 compared to 2002-2009 after adjusting for other variables (Adjusted HR=1.57; 95% CI: 1.06, 2.31; p=0.025). Cervical cancer patients ≥ 60 years (Adjusted HR=1.85; 95% CI: 1.11, 3.09; p=0.019), and patients with distant cancer (Adjusted HR=49.47; 95% CI: 6.64, 368.52; p<0.001) had the highest risk of mortality.CONCLUSION: The 5-year survival rate of cervical cancer patients in Brunei Darussalam was 74.1%, which ranks relatively high globally. However, increased mortality among elderly patients, and patients diagnosed with cervical cancers at the later stages, calls for raising awareness, early detection, and management.

scholarly journals Survival Rate of Colorectal Cancer and Its Effective Factors in Iran

2021 ◽  
Author(s):  
Mohammad Abbasi ◽  
Saeedeh Asgari ◽  
Azar Pirdehghan ◽  
Abdol Azim Sedighi Pashaki ◽  
Farzaneh Esna-Ashari
Keyword(s):  
Colorectal Cancer ◽  
Survival Rate ◽  
Cox Regression ◽  
Survival Rates ◽  
Early Screening ◽  
Cox Regression Analysis ◽  
Effective Factors ◽  
Risk Of Death ◽  
Phone Calls ◽  
Increased Risk

Colorectal cancer is one of the most common cancers in Iran. Regarding the prevalence of this cancer and its mortality and morbidity, in this study, 5 Year Survival Rate and its Effective Factors of patients with colorectal cancer were investigated. This study was conducted using the retrospective cohort method. All patients diagnosed with colorectal cancer in Hamadan Imam Khomeini Clinic of Hematology and Oncology and Mahdieh Oncology Center between 2006 and 2011 were studied. Data were extracted from the patients’ medical records, and to obtain extra information about them, telephone calls were made. The data were analyzed by SPPS version 16, and the assessment of survival rates was conducted using Kaplan-Meier methods and Cox regression method. A total number of 108 patients with colorectal cancer were studied. The status of 74 patients was determined at the end of the study by making follow-up phone calls. The one, two, three, four, and five survival rates were 77, 66, 50, 45, and 42%, respectively. The median overall survival was 46.8 months (1.3-135.6 months). Cox regression analysis showed that Metastatic tumor (P=0.001), lymphatic involvement (P=0.043), and is associated with underlying disease (P=0.025) was accompanied by increased risk. Multivariate cox regression test showed that metastasis was associated with an increase in the risk of death significantly (HR=2.83, P=0.013). According to the findings of the study, early screening is recommended for people with greater risk to increase the survival rate.

scholarly journals EPIDEMIOLOGY AND SURVIVAL ANALYSIS OF MOUTH AND OROPHARYNGEAL CANCER PATIENTS TREATED AT A PUBLIC HOSPITAL IN RIO DE JANEIRO, BRAZIL.

2020 ◽  
Author(s):  
Jackeline Nogueira de Paula Barros
Keyword(s):  
Survival Rate ◽  
Rio De Janeiro ◽  
Survival Curve ◽  
Survival Rates ◽  
Rank Test ◽  
Anatomical Location ◽  
Anatomical Site ◽  
Global Public Health ◽  
Oral Neoplasms ◽  
Epidemiological Profile

AbstractMouth and oropharyngeal cancers (CAs) are considered to be global public health problems, with high psychosocial impacts and high costs. Developing an epidemiological profile and examining the survival rate among patients with CAs of the mouth and oropharynx are important for the development of public policy. Therefore, this retrospective study aimed to evaluate mouth and oropharyngeal CA patients treated at the Municipal Hospital Salgado Filho in Rio de Janeiro, Brazil between 2007 and 2017. Patient data regarding gender, age, ethnicity, diagnosis, anatomical site affected by the tumor, and habits were obtained from patient records and reports, and data regarding the deaths of patients were obtained from records and the Mortality Information System. After tabulation, data were descriptively analyzed using the Kaplan-Meier survival curve, and the log-rank test was used for the comparison of variables. Survival rates at 5 and 8 years were 71.1% and 48.8%, respectively. There were no significant differences among survival rates according to age, sex, ethnicity, or the anatomical location of tumors. The survival rates among mouth and oropharyngeal CA patients in this study were comparable with the results reported in developed countries.Keywords: Oral neoplasms, epidemiology, survival rate;

Sign in / Sign up

Export Citation Format

Share Document