scholarly journals Garenoxacin is effective against bacteria invading cells such as Streptococcus pyogenes and Haemophilus influenzae

2021 ◽  
Author(s):  
Hiroyuki Iuchi ◽  
Junichiro Ohori ◽  
Satoshi Kiyama
Keyword(s):  
Haemophilus Influenzae ◽  
Streptococcus Pyogenes ◽  
Recurrent Tonsillitis ◽  
Effective Agent ◽  
Antibacterial Drugs ◽  
Intracellular Invasion

Abstract Background: Recurrent tonsillitis is one of the most common otolaryngological disorders caused by bacteria invading cells such as Streptococcus pyogenes (S. pyogenes) and Haemophilus influenzae. The aim of this study was to investigate the effect of antibacterial drugs against bacteria that have invaded cells.Results: The intracellular invasion of Detroit 562 cells by five strains of nontypeable Haemophilus influenzae (NTHi) and four strains of Streptococcus pyogenes was investigated. The antibacterial drugs used were garenoxacin (GRNX), clarithromycin (CAM), amoxicillin (AMPC), cefditoren pivoxil (CDTR-PI), and levofloxacin (LVFX). Both NTHi and S. pyogenes fully invaded Detroit 562 cells in 6 h. Both NTHi and S. pyogenes had reduced susceptibility to CAM. GRNX, CAM, and LVFX were effective against bacteria invading the cells, but AMPC and CDTR-PI were not effective. GRNX was the most effective.Conclusion: GRNX was the most effective agent against bacteria invading cells.

scholarly journals Effectiveness of antibacterial agents against cell-invading bacteria such as Streptococcus pyogenes and Haemophilus influenzae

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Hiroyuki Iuchi ◽  
Junichiro Ohori ◽  
Satoshi Kiyama ◽  
Naoko Imuta ◽  
Junichiro Nishi ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Streptococcus Pyogenes ◽  
Antibacterial Agents ◽  
Recurrent Tonsillitis ◽  
Effective Agent ◽  
Intracellular Invasion

Abstract Background Recurrent tonsillitis is one of the most common otolaryngological disorders caused by cell-invading bacteria, such as Streptococcus pyogenes (S. pyogenes) and Haemophilus influenzae. The aim of this study was to investigate the effect of antibacterial agents against cell-invading bacteria. Methods The intracellular invasion of Detroit 562 cells by five strains of nontypeable Haemophilus influenzae (NTHi) and four strains of S. pyogenes was investigated. The antibacterial agents used were garenoxacin (GRNX), clarithromycin (CAM), amoxicillin (AMPC), cefditoren pivoxil (CDTR-PI), and levofloxacin (LVFX). Results Both NTHi and S. pyogenes fully invaded Detroit 562 cells in 6 h and were less sensitive to CAM. GRNX, CAM, and LVFX were effective against bacteria invading the cells, but AMPC and CDTR-PI were not effective. GRNX was the most effective. Conclusion GRNX was the most effective agent against bacteria invading cells.

scholarly journals Susceptibilidad a antimicrobianos de patógenos respiratorios en niños provenientes de la comunidad

2013 ◽  
Vol 65 (1) ◽  
pp. 14
Author(s):  
José M Guevara ◽  
Rosaluz Aróstegui ◽  
Wini Agurto ◽  
Iliana Sobrevilla ◽  
Esther Valencia ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Streptococcus Pneumoniae ◽  
Haemophilus Influenzae ◽  
Streptococcus Pyogenes ◽  
Moraxella Catarrhalis

OBJETIVO: Determinar la resistencia de los patógenos respiratorios a diferentes antimicrobianos. MATERIAL Y MÉTODOS: Entre abril y noviembre de 2002 se estudió 177 pacientes que asistieron al consultorio externo de otorrinolaringología del Hospital Nacional Docente Madre-Niño San Bartolomé. RESULTADOS: Streptococcus pneumoniae fue la bacteria patógena más aislada (57,2%), luego Moraxella catarrhalis (42,7%), Staphylococcus aureus (18,6%) y en pequeña cantidad Haemophilus influenzae (3,4%) y Streptococcus pyogenes (0,7%). Streptococcus pneumoniae presentó 31,3% de resistencia a la penicilina. El 96,7% de Moraxella catarrhalis fueron productoras de betalactamasa y 7,4% de los Staphylococcus aureus fueron resistentes a la oxacilina. CONCLUSIÓN: Streptococcus pneumoniae es el principal agente causal de los procesos infecciosos altos en niños y su resistencia a la penicilina aumentó a 31,3%

scholarly journals Antimicrobial Resistance among Respiratory Pathogens in Spain: Latest Data and Changes over 11 Years (1996-1997 to 2006-2007)

2010 ◽  
Vol 54 (7) ◽  
pp. 2953-2959 ◽  
Author(s):  
Emilio Pérez-Trallero ◽  
Jose E. Martín-Herrero ◽  
Ana Mazón ◽  
Celia García-Delafuente ◽  
Purificación Robles ◽  
...  
Keyword(s):  
Streptococcus Pneumoniae ◽  
Antimicrobial Resistance ◽  
Haemophilus Influenzae ◽  
Streptococcus Pyogenes ◽  
Temporal Trends ◽  
Surveillance Study ◽  
Respiratory Pathogens ◽  
Ampicillin Resistance ◽  
Increasing Trend

ABSTRACT A nationwide multicenter susceptibility surveillance study (Susceptibility to the Antimicrobials Used in the Community in España [SAUCE] project), SAUCE-4, including 2,559 Streptococcus pneumoniae, 2,287 Streptococcus pyogenes, and 2,736 Haemophilus influenzae isolates was carried out from May 2006 to June 2007 in 34 Spanish hospitals. Then, the results from SAUCE-4 were compared to those from all three previous SAUCE studies carried out in 1996-1997, 1998-1999, and 2001-2002 to assess the temporal trends in resistance and the phenotypes of resistance over the 11-year period. In SAUCE-4, on the basis of the CLSI breakpoints, penicillin (parenteral, nonmeningitis breakpoint) and cefotaxime were the antimicrobials that were the most active against S. pneumoniae (99.8% and 99.6%, respectively). Only 0.9% of isolates had a penicillin MIC of ≥2 μg/ml. In S. pyogenes, nonsusceptibility to erythromycin was observed in 19.4% of isolates. Among the H. influenzae isolates, a β-lactamase-positive prevalence of 15.7% was found. A statistically significant temporal decreasing trend over the 11-year period was observed for nonsusceptibility (from 60.0% to 22.9%) and resistance (from 36.5% to 0.9%) to penicillin and for the proportion of erythromycin-resistant isolates of S. pneumoniae of the macrolide-lincosamide-streptogramin B (MLSB) phenotype (from 98.4% to 81.3%). A similar trend was observed for the prevalence of ampicillin resistance (from 37.6% to 16.1%), β-lactamase production (from 25.7% to 15.7%), and β-lactamase-negative ampicillin resistance (BLNAR) in H. influenzae (from 13.5% to 0.7%). Among erythromycin-resistant isolates of S. pyogenes, a significant increasing trend in the prevalence of MLSB was observed (from 7.0% to 35.5%). SAUCE-4 confirms a generalized decline in the resistance of the main respiratory pathogens to the antimicrobials as well as a shift in their resistance phenotypes.

scholarly journals Transformed Recombinant Enrichment Profiling Rapidly Identifies HMW1 as an Intracellular Invasion Locus in Haemophilus influenzae

2016 ◽  
Vol 12 (4) ◽  
pp. e1005576 ◽  
Author(s):  
Joshua Chang Mell ◽  
Cristina Viadas ◽  
Javier Moleres ◽  
Sunita Sinha ◽  
Ariadna Fernández-Calvet ◽  
...  
Keyword(s):  
Haemophilus Influenzae ◽  
Intracellular Invasion

scholarly journals Susceptibility of common bacterial respiratory pathogens to antimicrobial agents in outpatients from south Backa District

2014 ◽  
Vol 67 (3-4) ◽  
pp. 71-77 ◽  
Author(s):  
Olga Horvat ◽  
Mira Mihajlovic-Ukropina ◽  
Vesna Mijatovic ◽  
Ana Sabo
Keyword(s):  
Respiratory Tract ◽  
Haemophilus Influenzae ◽  
Streptococcus Pyogenes ◽  
Antimicrobial Agents ◽  
National Guideline ◽  
Diffusion Method ◽  
Respiratory Pathogens ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Susceptibility Tests

Introduction. Acute infections of the upper respiratory tract are the most common reasons why patients visit general practitioners. Overuse of antibiotics in treatment of these conditions is extremely common practice although these infections are most frequently caused by viruses. The aim of this study was to determine the distribution and susceptibility of common pathogens to antimicrobial agents that cause infections of the upper respiratory tract in outpatients and to determine whether the results obtained from the examined sample were in accordance with the recommendations of the current National Guideline. Material and Methods. .The study included 945 strains isolated from the throat and nasal swabs from January 1st to March 31st, 2008, as well as from 330 strains isolated from January 1st to March 31st, 2013 in South Backa District, Serbia. Susceptibility tests were performed by the standard disc diffusion method and according to the criteria recommended by the Clinical and Laboratory Standards Institute. Results. The most commonly isolated strains were Streptococcus pyogenes, Staphylococcus aureus, Streptococcus pneumoniae, Branchamella catarrhalis, and Haemophilus influenzae. Susceptibility of Streptococcus pyogenes, Branchamella catarrhalis and Haemophilus influenzae to examined antibiotics did not substantially change over the two study periods. None of the isolates of Staphylococcus aures demonstrated resistance to methicillin in 2008, while the percentage of resistant strains was 5.93% in 2013. Susceptibility rates of Staphylococcus pneumoniae isolates to erythromycin and clindamycin were lower in 2013 than in 2008. Conclusion. The investigation results follow the recommendations of the National Guideline for the usage of natural penicillin in the treatment of tonsillopharyngitis. Amoxicillin/clavulanic acid is recommended for the treatment of rhinosinusitis, and second generation cephalosporins are the second choice.

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