scholarly journals Lower levels of serum albumin are associated with impairment of cognitive function in cirrhotic patients with early-stage hepatic encephalopathy: An exploratory data analysis of phase II/III clinical trials of rifaximin in Japan

2020 ◽  
Author(s):  
Kosuke Kaji ◽  
Kiwamu Okita ◽  
Kazuyuki Suzuki ◽  
Ikuya Sato ◽  
Masaki Fujisawa ◽  
...  
Keyword(s):  
Hepatic Encephalopathy ◽  
Cognitive Function ◽  
Serum Albumin ◽  
Neuropsychological Tests ◽  
Exploratory Data Analysis ◽  
Serum Albumin Level ◽  
Early Stage ◽  
Albumin Level ◽  
Exploratory Data ◽  
Cirrhotic Patients

Abstract Background Because covert hepatic encephalopathy (CHE) has been shown to affect the prognosis of cirrhotic patients, early diagnosis of HE is a prerequisite for preservation of patients’ quality of life and for prophylaxis of overt HE. Currently, neuropsychological tests are used for the diagnosis of early-stage HE including CHE. However, it would be inefficient to apply them to all cirrhotic patients. Thus, some biomarkers correlated with the above diagnostic modalities are available for screening examination. The aim of this study was to identify a clinical parameter to predict impairment of cognitive function in cirrhotic patients with early-stage HE.Methods This exploratory data analysis was based on the data from 172 patients with cirrhotic or idiopathic portosystemic shunt (PSS) in phase II/III trials of rifaximin in Japan. Their data at baseline before treatment with rifaximin were utilized to analyze the relationship between cognitive dysfunction and different clinical parameters We Classification and regression trees (CART) were constructed to identify clinical profiles related to cognitive dysfunction, as indicated by the prolongation of time required for the number connection test (NCT-B).Results CART analysis detected age 65 years as the variable for the initial split, and serum albumin level was selected as the variable for the second split among patients aged ≤ 65 years. In 27 cirrhotic patients aged ≤ 65 years without PSS, receiver-operating characteristic curve analysis revealed that the optimal albumin level cutoff point was 3.05 g/dL, and the area under the curve was 0.80 for the prolongation of NCT-B time, which was higher than that of other HE-related parameters including the branched-chain amino acids-to-tyrosine ratio (0.46), the prothrombin time–international normalized ratio (PT-INR) (0.68), serum ammonia (0.61), and total bilirubin (0.69).Conclusions Lower serum albumin level as a clinical biomarker associated with impaired cognitive function is available as a screening examination for early-stage HE in cirrhotic patients aged ≤ 65 years without PSS before undergoing neuropsychological tests.

scholarly journals Association between serum albumin and cognitive dysfunction in hepatic encephalopathy: An exploratory data analysis

JGH Open ◽  
2020 ◽  
Author(s):  
Kosuke Kaji ◽  
Kiwamu Okita ◽  
Kazuyuki Suzuki ◽  
Ikuya Sato ◽  
Masaki Fujisawa ◽  
...  
Keyword(s):  
Data Analysis ◽  
Hepatic Encephalopathy ◽  
Serum Albumin ◽  
Cognitive Dysfunction ◽  
Exploratory Data Analysis ◽  
Exploratory Data

scholarly journals Association of serum albumin level with incidence and mortality of overt hepatic encephalopathy in cirrhosis during hospitalization

2019 ◽  
Vol 12 ◽  
pp. 175628481988130
Author(s):  
Zhaohui Bai ◽  
Xiaozhong Guo ◽  
Frank Tacke ◽  
Yingying Li ◽  
Hongyu Li ◽  
...  
Keyword(s):  
Risk Factor ◽  
Hepatic Encephalopathy ◽  
Serum Albumin ◽  
Independent Risk Factor ◽  
Characteristic Curve ◽  
Human Albumin ◽  
Albumin Level ◽  
Receiver Operator Characteristic Curve ◽  
Incidence And Mortality ◽  
Cirrhotic Patients

Background: Hepatic encephalopathy (HE) is a serious complication of cirrhosis. Decreased serum albumin (ALB) level may facilitate the development of HE and accelerate the death of cirrhotic patients with HE. Recent evidence also suggests that human albumin infusion may reduce the incidence of HE and improve the outcomes of cirrhotic patients. This study aimed to explore the association of serum ALB level with the development of overt HE and HE-associated mortality during hospitalization. Methods: Cirrhotic patients admitted to our hospital between January 2010 and February 2019 were screened. Independent predictors for HE were identified by logistic regression analyses. Odds ratio (OR) with 95% confidence interval (95% CI) was calculated. Area under curve (AUC) was calculated by receiver operator characteristic curve analyses. Results: Of the 2376 included patients with cirrhosis but without HE at admission, 113 (4.8%) developed overt HE during hospitalizations. ALB level (OR = 0.878, 95% CI = 0.834–0.924) was an independent risk factor for development of overt HE. AUC of ALB level for predicting the development of overt HE was 0.770 (95% CI = 0.752–0.787, p < 0.0001), and the best cut-off value was ⩽31.6 g/l. Of the 183 included patients with cirrhosis and overt HE at admission, 20 (10.9%) died during hospitalizations. ALB level (OR = 0.864, 95% CI = 0.771–0.967) was an independent risk factor for death from overt HE. The AUC of ALB level for predicting death from overt HE was 0.737 (95% CI = 0.667–0.799, p = 0.0001), and the best cut-off value was ⩽22.8 g/l. Conclusions: Decreased serum ALB level may be associated with higher risk of overt HE and HE-associated mortality during hospitalizations in cirrhosis.

scholarly journals Association of Serum Albumin Level in Predicting of Preeclampsia among Pregnant Women in Dhaka City of Bangladesh

2019 ◽  
Vol 6 (2) ◽  
pp. 83-86 ◽  
Author(s):  
Taslima Begum ◽  
Md Anwar Habib ◽  
Shipra Chaudhury ◽  
Hasina Akter ◽  
Tahmida Firdousi ◽  
...  
Keyword(s):  
Serum Albumin ◽  
Pregnant Women ◽  
Serum Albumin Level ◽  
Early Stage ◽  
Albumin Level ◽  
Medical College Hospital ◽  
Singleton Pregnancy ◽  
College Hospital ◽  
Medical College ◽  
Obstetrics And Gynaecology

Background: Serum albumin level is very important during the pregnancy for the good outcome of delivery. Objective: The purpose of the present study was to see the association of serum albumin level in predicting of preeclampsia among the pregnant women. Methodology: This descriptive cohort study was conducted in the OPD of the Department of Obstetrics and Gynaecology at Rajshahi Medical College Hospital, Rajshahi, Bangladesh from January 2013 to December 2014 for a period of two (2) years. This study was carried on pregnant woman attending in outdoor department of Gynaecology, Rajshahi Medical College Hospital, Rajshahi, Bangladesh before 20 weeks of pregnancy who were healthy normotensive primigravidae with singleton pregnancy. Healthy normotensive primigravidae with singleton pregnancy were enrolled in this study before 20th weeks and were followed up after 28th weeks of pregnancy. The data of serum albumin in gm/dL before 20th weeks and after 28th weeks of pregnancy were collected. Result: A total number of 75 pregnant women were finally included in this study. PE was identified in 12(16%) women out of 75 patients on the basis of one or more following parameters. Mean serum albumin in 1st visit was 3.84±0.41 gm/dL. No association was found between development of preeclampsia and levels of serum albumin in early trimester of pregnancy (p=0.960). Conclusion: In conclusion serum albumin level is not a predictor of development of preeclampsia among the pregnant women in early stage. Journal of Current and Advance Medical Research 2019;6(2):83-86

scholarly journals Low Serum Albumin Level is Risk Factor for Patients with Percutaneous Endoscopic Gastrostomy

2010 ◽  
Vol 49 (21) ◽  
pp. 2283-2288 ◽  
Author(s):  
Naoyuki Tominaga ◽  
Ryo Shimoda ◽  
Ryuichi Iwakiri ◽  
Nanae Tsuruoka ◽  
Yasuhisa Sakata ◽  
...  
Keyword(s):  
Risk Factor ◽  
Serum Albumin ◽  
Percutaneous Endoscopic Gastrostomy ◽  
Serum Albumin Level ◽  
Albumin Level ◽  
Endoscopic Gastrostomy ◽  
Low Serum

Serum albumin level accurately reflects antioxidant potentials in idiopathic nephrotic syndrome

2011 ◽  
Vol 16 (3) ◽  
pp. 411-414 ◽  
Author(s):  
Kazunari Kaneko ◽  
Takahisa Kimata ◽  
Shoji Tsuji ◽  
Tomohiko Shimo ◽  
Masaya Takahashi ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Idiopathic Nephrotic Syndrome ◽  
Albumin Level

Association of preoperative hypoalbuminemia with postoperative acute kidney injury in patients undergoing brain tumor surgery: a retrospective study

2018 ◽  
Vol 128 (4) ◽  
pp. 1115-1122 ◽  
Author(s):  
Kyungmi Kim ◽  
Ji-Yeon Bang ◽  
Seon-Ok Kim ◽  
Saegyeol Kim ◽  
Joung Uk Kim ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Brain Tumor ◽  
Serum Albumin ◽  
Serum Albumin Level ◽  
Kidney Injury ◽  
Albumin Level ◽  
Tumor Surgery ◽  
Brain Tumor Surgery ◽  
Preoperative Serum ◽  
Postoperative Aki

OBJECTIVEHypoalbuminemia is known to be independently associated with postoperative acute kidney injury (AKI). However, little is known about the association between the preoperative serum albumin level and postoperative AKI in patients undergoing brain tumor surgery. The authors investigated the incidence of AKI, impact of preoperative serum albumin level on postoperative AKI, and death in patients undergoing brain tumor surgery.METHODSThe authors retrospectively reviewed the electronic medical records and laboratory results of 2363 patients who underwent brain tumor surgery between January 2008 and December 2014. Postoperative AKI was defined according to Kidney Disease: Improving Global Outcomes Definition and Staging (KDIGO). Multivariate logistic regression analysis was used to identify demographic, preoperative laboratory, and intraoperative factors associated with AKI development. Cox proportional hazards models were used to investigate the adjusted odds ratio and hazard ratio for the association between preoperative serum albumin level and outcome variables.RESULTSThe incidence of AKI was 1.8% (n = 43) using KDIGO criteria. The incidence of AKI was higher in patients with a preoperative serum albumin level < 3.8 g/dl (3.5%) than in those with a preoperative serum albumin level ≥ 3.8 g/dl (1.2%, p < 0.001). The overall mortality was also higher in the former than in the latter group (5.0% vs 1.8%, p < 0.001). After inverse probability of treatment-weighting adjustment, a preoperative serum albumin level < 3.8 g/dl was also found to be associated with postoperative AKI (OR 1.981, 95% CI 1.022–3.841; p = 0.043) and death (HR 2.726, 95% CI 1.522–4.880; p = 0.001).CONCLUSIONSThe authors’ results demonstrated that a preoperative serum albumin level of < 3.8 g/dl was independently associated with AKI and mortality in patients undergoing brain tumor surgery.

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