scholarly journals Impact of Daikenchuto (TU-100) on The Early Postoperative Period in Duodenal-Jejunal Bypass

2021 ◽  
Author(s):  
Shohei Okikawa ◽  
Hideya Kashihara ◽  
Yuji Morine ◽  
Mitsuo Shimada ◽  
Kozo Yoshikawa ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Postoperative Period ◽  
Gut Microbiome ◽  
Intestinal Inflammation ◽  
Diabetic Rats ◽  
Cytokine Expression ◽  
Early Postoperative Period ◽  
Microbiome Composition ◽  
Lower Blood ◽  
Jejunal Bypass

Abstract Introduction: We investigated the effect of Daikenchuto (TU-100) on the early postoperative period in duodenal-jejunal bypass (DJB).Methods: Study 1: The effect of TU-100 on diabetic rats was investigated. Rats were sacrificed after receiving TU-100 for one week. Study 2: The effect of TU-100 on DJB was investigated. Rats in the DJB and TU-100 treated DJB groups were sacrificed 24 hours postoperation to evaluate blood glucose, cytokine expression, and gut microbiome.Results: Study 1: TU-100 did not affect glucose or body weight. TU-100 suppressed intestinal inflammation and modified the gut microbiome. Specifically, Bifidobacterium and Blautia were increased, and Turicibacter were decreased in this group. Study 2: Both DJB and TU-100 treated DJB rats showed lower blood glucose at 24 hours postoperation than at preoperation. Cytokine expression in the liver and small intestine of the TU-100 treated DJB group was significantly lower than that of the DJB group. The gut microbiome composition in TU-100 treated DJB rats was altered. In particular, Bifidobacterium and Blautia were increased in this group.Conclusion: DJB suppressed blood glucose during the early postoperative period. TU-100 may enhance the anti-diabetic effect of metabolic surgery by changing the gut microbiome and suppressing inflammation in the early postoperative period.

scholarly journals Gut Microbiota as Early Predictor of Infectious Complications before Cardiac Surgery: A Prospective Pilot Study

2021 ◽  
Vol 11 (11) ◽  
pp. 1113
Author(s):  
Ekaterina Chernevskaya ◽  
Evgenii Zuev ◽  
Vera Odintsova ◽  
Anastasiia Meglei ◽  
Natalia Beloborodova
Keyword(s):  
Cardiac Surgery ◽  
Pilot Study ◽  
Bacterial Infection ◽  
Postoperative Period ◽  
Gut Microbiome ◽  
Fecal Microbiota ◽  
Infectious Complications ◽  
Early Postoperative Period ◽  
Microbial Composition ◽  
Close Relationship

Cardiac surgery remains a field of medicine with a high percentage of postoperative complications, including infectious ones. Modern data indicate a close relationship of infectious disorders with pathological changes in the composition of the gut microbiome; however, the extent of such changes in cardiac surgery patients is not fully clarified. In this prospective, observational, single center, pilot study, 72 patients were included, 12 among them with the infectious complications. We analyzed the features of the fecal microbiota before and in the early postoperative period, as one of the markers for predicting the occurrence of bacterial infection. We also discovered the significant change in microbial composition in the group of patients with infectious complications compared to the non-infectious group before and after cardiac surgery, despite the intra-individual variation in composition of gut microbiome. Our study demonstrated that the group of patients that had a bacterial infection in the early postoperative period already had an altered microbial composition even before the surgery. Further studies will evaluate the clinical significance of the identified proportions of individual taxa of the intestinal microbiota and consider the microbiota as a novel target for reducing the risk of infectious complications.

scholarly journals Application of sorbitol-based infusion preparation for normalization of biochemical indicators in the blood in surgery patients with direct rectal cancer

2020 ◽  
pp. 17-17
Author(s):  
Ye.S. Varivoda ◽  
I.Ya. Orishchin ◽  
V.M. Lutsiv ◽  
V.Ye. Varivoda ◽  
B.R. Dzis ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Rectal Cancer ◽  
Blood Glucose ◽  
Anterior Resection ◽  
Postoperative Period ◽  
Total Protein ◽  
Biochemical Parameters ◽  
Early Postoperative Period ◽  
Intravenous Infusions ◽  
Complex Drug

Objective. To study the effect of intravenous infusions of the complex drug Rheosorbilaсt polyfunctional action on the biochemical parameters in the blood in operated patients with rectal cancer after anterior resection of the rectum in the early postoperative period. Materials and methods. The study of biochemical parameters in the blood of 30 patients with colorectal cancer was performed in the first days after surgery, and on the 2nd, 3rd, 5th day after administration of the drug Rheosorbilact. The drug was administered intravenously at a rate of 40 drops per minute. The daily dose of Rheosorbilact was 800.0 ml. Results. As a result of biochemical studies in patients with colorectal cancer, in the first days after anterior resection of the rectum revealed a decrease in total protein, increased concentrations of urea, creatinine and blood glucose. To correct the biochemical parameters in the blood of such patients immediately after surgery was administered intravenous infusion of Rheosorbilact. After repeated intravenous infusions of Rheosorbilact for 5 days, a significant increase in total protein content, a significant decrease in the concentration of urea, creatinine and blood glucose in the operated patients was found. Therefore, multiple intravenous infusions of the complex drug Rheosorbilact multifunctional action lead to the normalization of biochemical parameters in the blood. Conclusions. In patients with rectal cancer after anterior resection of the rectum in the first days after surgery revealed a decrease in total protein, increased concentrations of urea, creatinine and blood glucose. Repeated intravenous infusions of the complex drug Rheosorbilact multifunctional action normalize the biochemical parameters in the blood in operated patients with rectal cancer after anterior resection of the rectum in the early postoperative period. Rheosorbilact infusion is recommended for widespread medical use in such patients, especially in the early postoperative period.

scholarly journals PENANGANAN PERIOPERATIF ANESTESI PADA RESEKSI FEOKROMOSITOMA

2013 ◽  
Vol 3 (1) ◽  
Author(s):  
Mordekhai Leopold Laihad
Keyword(s):  
Blood Pressure ◽  
Blood Glucose ◽  
Postoperative Period ◽  
Perioperative Management ◽  
Postoperative Management ◽  
Early Postoperative Period ◽  
Intravascular Volume ◽  
Anesthesia Management ◽  
Definitive Therapy ◽  
Intraoperative Management

Abstract: Definitive therapy of pheochromocytoma is a surgical resection. Anesthetic perioperative management toward pheochromocytoma resection plays a very important role in decreasing morbidity and mortality. This management includes preoperative preparations, intraoperative management and postoperative management. The preoperative preparations involving multidiscipline approaches have several objectives: controlling blood pressure, creating an adequate intravascular volume, assessing effects of the disease to end-organs, recognizing conditions pertaining to pheochromocytoma, and controlling blood glucose and electrolyte levels. The intraoperative management is a continuation of the preoperative preparations. Its main objective is to preclude the event of hypertension crisis. The postoperative management is aimed to anticipate important complications which possibly occur in the early postoperative period, such as: hypertension, hypotension, and hypoglycemia. Keywords: pheochromocytoma, anesthesia, management, preoperative, intraoperative, postoperative.   Abstrak: Terapi definitif terhadap feokromositoma adalah reseksi. Penanganan perioperatif anestesi pada reseksi feokromositoma sangat berperan dalam menekan morbiditas dan mortalitas. Penanganan ini meliputi persiapan preoperatif, penangananan intraoperatif dan penanganan pasca bedah. Persiapan preoperatif dilakukan secara multidisiplin dan bertujuan untuk mengendalikan tekanan darah, mencukupi volum intravaskuler, menilai pengaruh penyakit terhadap end-organ, mengenali dampak dari kondisi-kondisi yang terkait dengan feokromositoma, serta normalisasi kadar glukosa dan elektrolit. Penanganan intraoperatif merupakan kesinambungan dari persiapan preoperatif dan bertujuan utama menghindari terjadinya krisis hipertensi. Penanganan pasca bedah bertujuan untuk mengantisipasi kemungkinan terjadinya komplikasi penting pada periode pasca bedah dini yakni hipertensi, hipotensi dan hipoglikemi. Kata kunci: feokromositoma, anestesi, penanganan, preoperatif, intraoperatif, pasca bedah.

Sign in / Sign up

Export Citation Format

Share Document