scholarly journals Local Steroid Treatment: An Effective Procedure for Idiopathic Granulomatous Mastitis, Including Complicated Cases

2021 ◽  
Author(s):  
Taha Furkan Ertürk ◽  
Özgür Çakır ◽  
Büşra Yaprak Bayrak ◽  
Abdullah Güneş ◽  
Selahattin Aydemir ◽  
...  
Keyword(s):  
High Efficiency ◽  
Topical Steroid ◽  
Steroid Treatment ◽  
Maximum Diameter ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Surgical Methods ◽  
Before And After ◽  
Intralesional Steroid Injection ◽  
Pre Treatment

Abstract Background: This study aimed to evaluate the effectiveness of local steroid treatment (LST) for idiopathic granulomatous mastitis (IGM) and to compare with surgical methods.Methods: Data was retrospectively collected from hospital electronic records. The patients were divided into two groups, the LST group and the surgery group. Intralesional steroid injection and topical steroid administration were applied in LST group. Surgery and LST were compared with regard to: pain before and after the treatment; complication rate; recurrence rate; and treatment cost.Results: Seventy of 72 lesions responded completely to LST. Pre-treatment median maximum diameter was 23.50 (15.25-35.25) mm, which regressed to 16 (12-25) mm after the first LST session. LST was found to be superior to surgery in pain management. No recurrence occurred in any patients in LST group.Conclusion: LST is a treatment for IGM that is cheap, with high efficiency, negligible recurrence, and has good esthetic outcome.

scholarly journals Local Steroid Treatment: An Effective Procedure for Idiopathic Granulomatous Mastitis, Including Complicated Cases

2021 ◽  
Author(s):  
Taha Furkan Ertürk ◽  
Özgür Çakır ◽  
Büşra Yaprak Bayrak ◽  
Abdullah Güneş ◽  
Selahattin Aydemir ◽  
...  
Keyword(s):  
Steroid Treatment ◽  
Maximum Diameter ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Pain Scores ◽  
Surgical Methods ◽  
Significant Difference ◽  
Pre Treatment ◽  
Group 2 ◽  
Group 1

Abstract Purpose To evaluate the effectiveness of treatment with topical and intralesional steroids for idiopathic granulomatous mastitis (IGM) and to compare with surgical methods.Methods Data was retrospectively collected from records. Intralesional steroid injection and topical steroid administration, hereafter referred to as local steroid treatment (LST) were applied in Group 1. Surgery (local excision, wide excision and mastectomy) was performed in Group 2. In Group 1 changes in lesion sizes were recorded and factors complicating treatment were identified. The Numeric Pain Rating Scale was used to determine subjective pain. LST and surgery were compared with regard to: pain before and after the treatment; complication rate; recurrence rate; and treatment cost.Results There were 38 and 48 patients in Group 1 and Group 2, respectively. In the LST group 72 lesions were present and 70 of 72 (97%) responded completely to treatment. Pre-treatment median maximum diameter was 23.50 (15.25-35.25) mm, which regressed to 16 (12-25) mm after the first session. While the pre-treatment pain scores of Group 1 and Group 2 were similar (p=0.756), there was a significant difference in the post-treatment pain scores (p<0.001). No recurrence occurred in any patients in Group 1, while recurrence developed in 15 (31.2%) patients in Group 2 (p<0.001).Conclusion LST is a treatment for IGM that is cheap, with high efficiency, negligible recurrence, and has good esthetic outcome. Our results suggest that LST should be the first-line treatment option for all IGM patients, including complicated cases.

scholarly journals Effect of Topical Steroid Treatment on Idiopathic Granulomatous Mastitis: Clinical and Radiologic Evaluation

2014 ◽  
Vol 20 (6) ◽  
pp. 586-591 ◽  
Author(s):  
Yasemin Gunduz ◽  
Fatih Altintoprak ◽  
Lacin Tatli Ayhan ◽  
Taner Kivilcim ◽  
Fehmi Celebi
Keyword(s):  
Topical Steroid ◽  
Steroid Treatment ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Radiologic Evaluation

scholarly journals Local Steroid Treatment: An Effective Procedure for Idiopathic Granulomatous Mastitis, Including Complicated Cases

2021 ◽  
pp. 1-7
Author(s):  
Taha Furkan Ertürk ◽  
Özgür Çakır ◽  
Büşra Yaprak Bayrak ◽  
Abdullah Güneş ◽  
Selahattin Aydemir ◽  
...  
Keyword(s):  
Steroid Treatment ◽  
Effective Procedure ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis

scholarly journals Treatment of Idiopathic Granulomatous Mastitis: Combined Intralesional Steroid Injection with Topical Steroid Administration vs. Systemic (Oral) Steroid

2021 ◽  
Author(s):  
Osman toktas ◽  
Nursen Toprak ◽  
Sadi Elasan ◽  
Iskan Calli ◽  
Serhat Binici
Keyword(s):  
Treatment Group ◽  
Side Effects ◽  
Steroid Injection ◽  
Corticosteroid Treatment ◽  
Oral Steroid ◽  
Granulomatous Mastitis ◽  
Idiopathic Granulomatous Mastitis ◽  
Caseating Granuloma ◽  
Intralesional Steroid ◽  
Intralesional Steroid Injection

Abstract BackgroundIdiopathic granulomatous mastitis (IGM)is characterized by non-caseating granuloma and microabscess formation limited to mammary gland lobules. It is a form of chronic mastitis of unknown pathogenesis. In this study, we aimed to compare the effectiveness of intralesional steroid injection with topical steroids versus systemic steroid therapy in the treatment of IGM. MethodsBetween June 2017 and December 2020, the patients were collected and assessed. IGM was diagnosed histopathologically by tru-cut biopsy in patients with breast mass, pain, and erythema with suspicion of IGM. Included in the study were one hundred and eleven patients who were diagnosed with IGMand who were treated with local or oral administration of corticosteroids, with at least 6 months of follow-up. The patients were divided into 2 groups: a local corticosteroid treatment group (LC, group 1, n=57); and a peroral corticosteroid treatment group (OC, group 2, n=54). Demographic characteristics, treatment responses, recurrence rates, side effects of the steroid, and the need for surgery were compared.ResultsWhile the rate of smoking was 12.3% in the LC group, was 20.4% in the OC group. There was no history of oral contraceptive use in either group of patients. Previous steroid use was significantly lower in the LC group (10.5%) compared to the OC group (55.6%) (p = 0.001). Previous antibiotic use was significantly lower in the LC group (75.4%) compared to the OC group (100%) (p = 0.001). When complete and partial responders were grouped as “responders,” 96.5% in the LC group and 75.9% in the OC group responded after the first course of treatment (p=0.001). 98.2% in the LC group and 87.0% in the OC group were complete responders after the third course of treatment (p=0.003). While 7% of the patients in the LC group had recurrence, 37% in the OC group had recurrence (p=0.001). Steroid-related side effects were lower in the LC group (no) compared to the OC group (11.1%) (p=0.010). Surgery was performed in 3.5% of the LC group, while surgery was performed in 57.3% of the OC group (p=0.001). ConclusionSteroid injection is an IGM treatment with proven efficacy, short response time, low recurrence rate, and lower need surgery. The treatment is easy to administer and minimizes the risk of systemic side effects. Even in clinically severe cases, we believe that steroid injection might be used as monotherapy, or in combination with other therapies, to improve treatment efficacy and create a transition to less aggressive treatments.

Cytoprotective Effect of Tocotrienol-Rich Fraction and α-Tocopherol Vitamin E Isoforms Against Glutamate-Induced Cell Death in Neuronal Cells

2014 ◽  
Vol 84 (3-4) ◽  
pp. 0140-0151 ◽  
Author(s):  
Thilaga Rati Selvaraju ◽  
Huzwah Khaza’ai ◽  
Sharmili Vidyadaran ◽  
Mohd Sokhini Abd Mutalib ◽  
Vasudevan Ramachandran ◽  
...  
Keyword(s):  
Vitamin E ◽  
Cell Viability ◽  
Neuronal Cells ◽  
Positive Control ◽  
Post Treatment ◽  
Mitochondrial Activity ◽  
Before And After ◽  
Pre Treatment ◽  
Tocotrienol Rich Fraction ◽  
Major Mediator

Glutamate is the major mediator of excitatory signals in the mammalian central nervous system. Extreme amounts of glutamate in the extracellular spaces can lead to numerous neurodegenerative diseases. We aimed to clarify the potential of the following vitamin E isomers, tocotrienol-rich fraction (TRF) and α-tocopherol (α-TCP), as potent neuroprotective agents against glutamate-induced injury in neuronal SK-N-SH cells. Cells were treated before and after glutamate injury (pre- and post-treatment, respectively) with 100 - 300 ng/ml TRF/α-TCP. Exposure to 120 mM glutamate significantly reduced cell viability to 76 % and 79 % in the pre- and post-treatment studies, respectively; however, pre- and post-treatment with TRF/α-TCP attenuated the cytotoxic effect of glutamate. Compared to the positive control (glutamate-injured cells not treated with TRF/α-TCP), pre-treatment with 100, 200, and 300 ng/ml TRF significantly improved cell viability following glutamate injury to 95.2 %, 95.0 %, and 95.6 %, respectively (p < 0.05).The isomers not only conferred neuroprotection by enhancing mitochondrial activity and depleting free radical production, but also increased cell viability and recovery upon glutamate insult. Our results suggest that vitamin E has potent antioxidant potential for protecting against glutamate injury and recovering glutamate-injured neuronal cells. Our findings also indicate that both TRF and α-TCP could play key roles as anti-apoptotic agents with neuroprotective properties.

EFFICIENCY OF NEW HEMOSORBENT IN ACUTE AMITRIPTYLINE AND CYCLODOL POISONING

2020 ◽  
pp. 14-18
Author(s):  
A. M. Fomin
Keyword(s):  
Clinical Effect ◽  
High Efficiency ◽  
Initial Level ◽  
Synthetic Polymer ◽  
Complex Treatment ◽  
Direct Hemoperfusion ◽  
Selective Sorption ◽  
Positive Clinical Effect ◽  
Before And After

A complex treatment of a patient with acute amitriptyline and cyclodol poisoning using enterosorption, intestinal lavage and hemosorption on a new column with a synthetic sorbent is presented. A two-layer synthetic polymer column developed for the selective sorption of cytokines by direct hemoperfusion was used for hemosorption. Quantitative determinations of amitriptyline and cyclodol levels before and after the column, as well as before and after hemosorption have showed high efficiency of the sorbent to remove the toxicant from the blood. The use of 6-hour hemosorption allowed to reduce the level of amitriptyline from the initial level by more than 4 times and the level of cyclodol - by more than 3 times to therapeutic levels and to obtain a pronounced positive clinical effect in the complex treatment of a patient with severe poisoning.

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