scholarly journals Association of Adipocytokines with Lipid and Glycemic Profiles in Women with Normal Weight Obesity

2020 ◽  
Author(s):  
Ehsaneh Taheri ◽  
Saeed Hosseini ◽  
Mostafa Qorbani ◽  
Parvin Mirmiran
Keyword(s):  
Serum Levels ◽  
Normal Weight ◽  
Lipid Profiles ◽  
Anthropometric Measurement ◽  
Control Group ◽  
Model Assessment ◽  
Cardiometabolic Disorders ◽  
Homeostatic Model Assessment ◽  
Normal Weight Obesity ◽  
Group Serum

Abstract Background: Individuals with normal weight obesity (NWO) are prone to cardiometabolic disorders. The aim of this study is to investigate the circulating levels of vaspin and leptin and their association with glycemic and lipid profiles in women with NWO.Methods: Forty women with body mass index (BMI)=18.5-24.9 kg/m2 and fat mass (FM) ≥ 30% were assigned in the NWO group and thirty age-matched women with identical BMI range and FM<30% (normal weight non-obese; NWNO) as control group were invited. Anthropometric measurement, fasting blood sugar (FBS), insulin, glycated hemoglobin (HbA1c), lipid profiles and also, leptin and vaspin were measured.Results: The mean ± standard deviation (SD) age was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control condition. The NWO group had higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51, P = 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, P = 0.009) compared to the NWNO group. Serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, serum levels of leptin correlated positively with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was positively associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06). Conclusion: It is concluded that concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher levels of leptin and vaspin in the NWO group were associated with glycemic profiles.

scholarly journals Association of Adipocytokines with Lipid and Glycemic Profiles in Women with Normal Weight Obesity

2020 ◽  
Author(s):  
Ehsaneh Taheri ◽  
Saeed Hosseini ◽  
Mostafa Qorbani ◽  
Parvin Mirmiran
Keyword(s):  
Serum Level ◽  
Serum Levels ◽  
Normal Weight ◽  
Lipid Profiles ◽  
Anthropometric Measurement ◽  
Control Group ◽  
Model Assessment ◽  
Cardiometabolic Disorders ◽  
Normal Weight Obesity ◽  
Group Serum

Abstract Background: Subjects with normal weight obesity (NWO) are supposed to cardiometabolic disorders. The aim of this study was to investigate the circulating levels of vaspin and leptin and their association with glycemic and lipid profiles in women with NWO compared to controlsMethods: Forty women with body mass index (BMI)=18.5-24.9 kg/m2 and fat mass (FM) ≥ 30% as NWO group and 30 age matched women with same BMI range and FM<30% as control group were enrolled in this study. Anthropometric measurement, fasting serum levels of blood sugar (FBS), insulin, Glycated hemoglobin (HbA1c), lipid profiles and also, leptin and vaspin were measured.Results: The mean ± standard deviation (SD) of age was 28.76 ± 4.76 years in NWO group and 29.23 ± 4.50 years in controls. Subjects in NWO group had higher serum levels of insulin (9.02 ± 4.75 vs.6.24 ± 2.51, p= 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, p<0.001) and homeostatic model assessment for insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, p=0.009) as compared to normal weight non-obese (NWNO) as control group. Serum level of vaspin in NWO group (34.82 pg/ml) was higher than that in controls (27.72 pg/ml), (p=0.12). In NWO group, serum level of leptin was correlated positively with FBS (r=0.45, p=0.02), insulin (r=0.51, p=0.008), and HOMA-IR (r=0.46, p=0.02) and vaspin concentration was positively associated with insulin (r=0.36, p= 0.02) and HOMA-IR (r=0.30, p=0.06). Conclusion: We observed that concentration of insulin and HOMA-IR index were significantly increased in women with NWO compared to the controls. Higher levels of leptin and vaspin in NWO were associated with glycemic profiles in NWO group.

scholarly journals Association of Adipocytokines with Lipid and Glycemic Profiles in Women with Normal Weight Obesity

2020 ◽  
Author(s):  
Ehsaneh Taheri ◽  
Saeed Hosseini ◽  
Mostafa Qorbani ◽  
Parvin Mirmiran
Keyword(s):  
Serum Levels ◽  
Normal Weight ◽  
Lipid Profiles ◽  
Control Group ◽  
Model Assessment ◽  
Cardiometabolic Disorders ◽  
Homeostatic Model Assessment ◽  
Normal Weight Obesity ◽  
Circulating Levels ◽  
Group Serum

Abstract Background: Individuals with normal weight obesity (NWO) are prone to cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and lipid profiles in women with NWO.Methods: Forty women with body mass index (BMI) = 18.5-24.9 kg/m2 and fat mass (FM) ≥ 30% were assigned in the NWO group. Thirty age-matched women with identical BMI range and FM < 30% (normal weight non-obese; NWNO) were considered as a control group. In addition to anthropometric measurements, glycemic and lipid profiles and also, circulating levels of leptin and vaspin were measured.Results: The mean ± standard deviation (SD) age of participants was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control group. The NWO group had higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51, P = 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, P = 0.009) compared to the NWNO group. Serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, serum levels of leptin correlated positively with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was positively associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06).Conclusion: It is concluded that the concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher levels of leptin and vaspin in the NWO group were associated with glycemic profiles.

scholarly journals Association of Adipocytokines with Lipid and Glycemic Profiles in Women with Normal Weight Obesity

2020 ◽  
Author(s):  
Ehsaneh Taheri ◽  
Saeed Hosseini ◽  
Mostafa Qorbani
Keyword(s):  
Serum Level ◽  
Positive Association ◽  
Serum Levels ◽  
Normal Weight ◽  
Lipid Profiles ◽  
Anthropometric Measurement ◽  
Control Group ◽  
Cardiometabolic Disorders ◽  
Normal Weight Obesity ◽  
Group Serum

Abstract Background: Subjects with normal weight obesity (NOW) are supposed to cardiometabolic disorders. The aim of this study was to investigate the circulating levels of vaspin and leptin and their association with glycemic and lipid profiles in women with NWO compared to controlsMaterial & Methods: Forty women with BMI:18.5-24.9 kg/m2 and FM ≥ 30% as a NOW group and 30 age matched women with same BMI range and FM<30% as control group were enrolled. Anthropometric measurement, fasting serum levels of fasting blood sugar (FBS), insulin, HbA1c, lipid profiles and also, leptin and vaspin were measured. Results: The mean ± SD of age were 28.76±4.76 years in NWO group and 29.23 ± 4.50 years in controls. Subjects in NWO group had higher serum level of insulin (9.02 ± 4.75 vs.6.24 ± 2.51, p= 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, p<0.001) and HOMA-IR (33.77 ± 20.71 vs. 23.48 ± 10.03, p=0.009) compared to the NWNO group. Serum level of vaspin was higher in NWO (34.82 pg/ml) than control group (27.72 pg/ml),(p=0.12). In NWO subjects, serum level of leptin showed positive association with FBS (r=0.45, p=0.02), insulin (r=0.51, p=0.008), and HOMA-IR (r=0.46, p= 0.02) and vaspin concentration was positively associated with insulin (r=0.36, p= 0.02) and HOMA-IR (r=0.30, p=0.06). Conclusion: We observed that women with NWO had statistically significant increased concentration of insulin and HOMA-IR index compared to the controls. Higher levels of leptin and vaspin in NWO were associated with glycemic profiles in NWO.

scholarly journals Association of adipocytokines with lipid and glycemic profiles in women with normal weight obesity

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Ehsaneh Taheri ◽  
Saeed Hosseini ◽  
Mostafa Qorbani ◽  
Parvin Mirmiran
Keyword(s):  
Serum Levels ◽  
Normal Weight ◽  
Lipid Profiles ◽  
Control Group ◽  
Model Assessment ◽  
Cardiometabolic Disorders ◽  
Glycemic Profile ◽  
Homeostatic Model Assessment ◽  
Normal Weight Obesity ◽  
Circulating Levels

Abstract Background Individuals with normal weight obesity (NWO) are predisposed to having cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and lipid profiles in women with NWO. Methods Forty women with body mass index (BMI) = 18.5–24.9 kg/m2 and fat mass (FM) ≥ 30% were assigned in the NWO group. Thirty age-matched women with identical BMI range, and FM < 30% (normal weight non-obese; NWNO) were considered as a control group. In addition to anthropometric measurements, glycemic and lipid profiles and circulating levels of leptin and vaspin were measured. Results The mean ± standard deviation (SD) age of participants was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control group. The NWO group had the higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51, P = 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, P = 0.009) compared to the NWNO group. The serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, the serum levels of leptin had positive correlation with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06), positively. Conclusion It is concluded that the concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher concentrations of leptin and vaspin in the NWO group were associated with glycemic profile.

scholarly journals Association of Adipocytokines with Lipid and Glycemic Profiles in Women with Normal Weight Obesity

2020 ◽  
Author(s):  
Ehsaneh Taheri ◽  
Saeed Hosseini ◽  
Mostafa Qorbani ◽  
Parvin Mirmiran
Keyword(s):  
Serum Levels ◽  
Normal Weight ◽  
Lipid Profiles ◽  
Control Group ◽  
Model Assessment ◽  
Cardiometabolic Disorders ◽  
Glycemic Profile ◽  
Homeostatic Model Assessment ◽  
Normal Weight Obesity ◽  
Circulating Levels

Abstract Background: Individuals with normal weight obesity (NWO) are predisposed to having cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and lipid profiles in women with NWO.Methods: Forty women with body mass index (BMI) = 18.5-24.9 kg/m2 and fat mass (FM) ≥ 30% were assigned in the NWO group. Thirty age-matched women with identical BMI range, and FM < 30% (normal weight non-obese; NWNO) were considered as a control group. In addition to anthropometric measurements, glycemic and lipid profiles and circulating levels of leptin and vaspin were measured.Results: The mean ± standard deviation (SD) age of participants was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control group. The NWO group had the higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51, P = 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, P = 0.009) compared to the NWNO group. The serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, the serum levels of leptin had positive correlation with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06), positively.Conclusion: It is concluded that the concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher concentrations of leptin and vaspin in the NWO group were associated with glycemic profile.

Adiponectin and leptin levels in normal weight women with polycystic ovary syndrome

2020 ◽  
Vol 41 (4) ◽  
Author(s):  
Murat Gözüküçük ◽  
Aslı Yarcı Gürsoy ◽  
Emre Destegül ◽  
Salih Taşkın ◽  
Hakan Şatıroğlu
Keyword(s):  
Insulin Resistance ◽  
Polycystic Ovary ◽  
Statistical Significance ◽  
Free Testosterone ◽  
Normal Weight ◽  
Control Group ◽  
Study Group ◽  
Model Assessment ◽  
Homeostatic Model Assessment ◽  
The Difference

Abstract Objectives Since polycystic ovarian syndrome (PCOS) is prevalent in reproductive women with obesity and insulin resistance, adipocytokines are often accused and investigated for pathophysiology. The aim of this study was to evaluate the adiponectin and leptin levels in normal-weight women with PCOS. Methods Forty women with PCOS and 40 age and body mass index (BMI) matched controls were included in the study. Adiponectin and leptin levels in addition to other biochemical parameters were measured. Results Leptin levels were statistically significantly higher in the study group compared to the control group (6.53 ± 2.670 vs 3.37 ± 2.002 ng/mL, p < 0.001 respectively). Although Adiponectin levels were lower in the study group compared to the control group (28.89 ± 16.124 μg/mL vs 31.05 ± 20.507, p = 0.714 respectively) the difference did not reach statistical significance. Leptin levels were positively correlated with fasting glucose, fasting insulin, free testosterone levels and homeostatic model assessment of insulin resistance (HOMA-IR) values. Adiponectin levels were negatively correlated with BMI. Conclusions Adiponectin and leptin have been suggested to play a crucial role in the pathogenesis of PCOS. Different adipocytokine levels in the normal weight PCOS group compared to age and BMI matched controls support the idea that adipose tissue in this group of women has some distinctive features not only in high BMI subgroup but also in normal weight subgroup.

scholarly journals Expanded Normal Weight Obesity and Insulin Resistance in US Adults of the National Health and Nutrition Examination Survey

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Keilah E. Martinez ◽  
Larry A. Tucker ◽  
Bruce W. Bailey ◽  
James D. LeCheminant
Keyword(s):  
Insulin Resistance ◽  
Body Fat ◽  
Cross Sectional Study ◽  
Normal Weight ◽  
Body Fat Percentage ◽  
Model Assessment ◽  
Fat Percentage ◽  
Cross Sectional ◽  
Homeostatic Model Assessment ◽  
Normal Weight Obesity

This study aims to expand the evaluation of normal weight obesity (NWO) and its association with insulin resistance using an NHANES (1999–2006) sample of US adults. A cross-sectional study including 5983 men and women (50.8%) was conducted. Body fat percentage (BF%) was assessed using dual-energy X-ray absorptiometry. Expanded normal weight obesity (eNWO) categories, pairings of BMI and body fat percentage classifications, were created using standard cut-points for BMI and sex-specific median for BF%. Homeostatic model assessment-insulin resistance (HOMA-IR) levels were used to index insulin resistance. Mean ± SE values were BMI: 27.9 ± 0.2 (women) and 27.8 ± 0.1 (men); body fat percentage: 40.5 ± 0.2 (women) and 27.8 ± 0.2 (men); and HOMA-IR: 2.04 ± 0.05 (women) and 2.47 ± 0.09 (men). HOMA-IR differed systematically and in a dose-response fashion across all levels of the eNWO categories (F=291.3,P<0.0001). As BMI levels increased, HOMA-IR increased significantly, and within each BMI category, higher levels of body fat were associated with higher levels of HOMA-IR. Both high BMI and high BF% were strongly related to insulin resistance. Insulin resistance appears to increase incrementally according to BMI levels primarily and body fat levels secondarily. Including a precise measure of body fat with BMI adds little to the utility of BMI in the prediction of insulin resistance.

Withdrawn: Hepatoprotective effects of Tribulus terrestris L. (Zygophyllales: Zygophyllaceae) hydro-alcholic extract on non-alcoholic fatty liver-induced rats

2016 ◽  
Vol 3 (5) ◽  
pp. 143
Author(s):  
Fatemeh Almasi ◽  
Mozafar Khazaei ◽  
Shima Chehrei ◽  
Ali Ghanbari
Keyword(s):  
Fatty Liver ◽  
Liver Tissue ◽  
Serum Lipid ◽  
Histopathological Examination ◽  
Serum Levels ◽  
Lipid Profiles ◽  
Control Group ◽  
Tribulus Terrestris ◽  
Protective Effects ◽  
Alcoholic Fatty Liver

Non-alcoholic fatty liver induces many complications to the liver tissue and also serum related parameters. Medicinal plants are the safe therapeutic strategy for the treatment of diseases. In this regards, the present study was conducted to evaluate the effect of Tribulus terrestris L. (Zygophyllales: Zygophyllaceae) extract on non-alcoholic fatty liver in rats. In this experimental study, thirty male Wistar rats were divided into five groups (n = 6). Animals in experimental groups were received high fructose diet (70%) (HDF) daily alone or in combined with daily intraperitoneal injection of 500, 700 and 1,000 mg/kg extract of T. terrestris. Control group of rats was feed with standard chow. The serum levels of biomarkers of liver and serum lipid profiles were assessed, also histopathological examination of liver tissue done. Data were analyzed using One-way ANOVA method followed by Tukey’s post-hoc multiple comparison test and P < 0.05 was considered statistically significant. There were significant improvements for biomarkers of liver tissue (P < 0.05) and serum lipid profiles (P < 0.01) in the HFD-fed rats that were treated with T. terrestris extract compare to HFD-fed group. In addition, accumulation of lipids in hepatocytes was significantly reduced in the HFD-fed + extract administrated groups in comparison to HFD-fed rats (P < 0.01). T. terrestris extract has protective effects against non-alcoholic fatty liver by changing biomarkers of liver tissue, serum lipid profiles and histopathological anomalies of liver tissue, to normal range.

scholarly journals Association of Serum Levels of Zinc, Copper, and Iron with Risk of Metabolic Syndrome

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 548
Author(s):  
Chia-Wen Lu ◽  
Yi-Chen Lee ◽  
Chia-Sheng Kuo ◽  
Chien-Hsieh Chiang ◽  
Hao-Hsiang Chang ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Linear Models ◽  
Serum Zinc ◽  
Serum Levels ◽  
Least Square ◽  
Model Assessment ◽  
Serum Concentrations ◽  
Metabolic Factors ◽  
Homeostatic Model Assessment

The association between serum concentrations of zinc, copper, or iron and the risk of metabolic syndrome are inconclusive. Therefore, we conduct a case-control study to explore the relationship between serum levels of zinc, copper, or iron and metabolic syndrome as well as each metabolic factor and insulin resistance. We enrolled 1165 adults, aged ≥ 40 (65.8 ± 10) years in a hospital-based population to compare the serum levels of zinc, copper, and iron between subjects with and without metabolic syndrome by using multivariate logistic regression analyses. The least square means were computed by general linear models to compare serum concentrations of zinc, copper, and iron in relation to the number of metabolic factors. The mean serum concentrations of zinc, copper, and iron were 941.91 ± 333.63 μg/L, 1043.45 ± 306.36 μg/L, and 1246.83 ± 538.13 μg/L, respectively. The odds ratios (ORs) of metabolic syndrome for the highest versus the lowest quartile were 5.83 (95% CI: 3.35–10.12; p for trend < 0.001) for zinc, 2.02 (95% CI: 1.25–3.25; p for trend: 0.013) for copper, and 2.11 (95% CI: 1.24–3.62; p for trend: 0.021) for iron after adjusting for age, sex, personal habits, body mass index, and homeostatic model assessment insulin resistance. Additionally, the serum zinc, copper, and iron concentrations increased as the number of metabolic factors rose (p for trend < 0.001). This was the first study to clearly demonstrate that higher serum levels of zinc, copper, and iron were associated with the risk of metabolic syndrome and the number of metabolic factors independent of BMI and insulin resistance.

Serum β-glucuronidase activity as a biomarker for acute cholinesterase inhibitor pesticide poisoning

2018 ◽  
Vol 34 (12) ◽  
pp. 891-897 ◽  
Author(s):  
Doha M Beltagy ◽  
Kadry M Sadek ◽  
Amal S Hafez
Keyword(s):  
Serum Levels ◽  
Significant Negative Correlation ◽  
Repeated Measurements ◽  
Control Group ◽  
Pesticide Poisoning ◽  
Time Points ◽  
Diagnosis And Prognosis ◽  
Glucuronidase Activity ◽  
Reliable Marker ◽  
Group Serum

β-glucuronidase (BG) activity is a promising biomarker for diagnosis and prognosis after exposure to organophosphorous (OP) pesticides. The aim of this study was to evaluate the changes in serum BG activity in patients with acute OP poisoning and to determine whether these changes correlate with the severity of poisoning. Thirty patients with anticholinesterase pesticide poisoning were included, besides 10 healthy volunteers as a control group. Serum activities of butyrylcholinesterase (BuChE) and BG were measured for each subject on admission, then after 12 and 24 h. Serum levels of BuChE and BG in poisoned patients were significantly different from the control subjects; these differences persisted in repeated measurements. Moreover, the serum levels showed significant differences within each group of the three time points. A significant negative correlation was found between the serum activities of BuChE and BG in all groups at the three time points. In conclusion, serum BG activity seems a reliable marker for OP poisoning even when measured at 24 h after poisoning.

Sign in / Sign up

Export Citation Format

Share Document