Association of Adipocytokines with Lipid and Glycemic Profiles in Women with Normal Weight Obesity

Abstract Background: Individuals with normal weight obesity (NWO) are predisposed to having cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and lipid profiles in women with NWO.Methods: Forty women with body mass index (BMI) = 18.5-24.9 kg/m2 and fat mass (FM) ≥ 30% were assigned in the NWO group. Thirty age-matched women with identical BMI range, and FM < 30% (normal weight non-obese; NWNO) were considered as a control group. In addition to anthropometric measurements, glycemic and lipid profiles and circulating levels of leptin and vaspin were measured.Results: The mean ± standard deviation (SD) age of participants was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control group. The NWO group had the higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51, P = 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, P = 0.009) compared to the NWNO group. The serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, the serum levels of leptin had positive correlation with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06), positively.Conclusion: It is concluded that the concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher concentrations of leptin and vaspin in the NWO group were associated with glycemic profile.

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Association of adipocytokines with lipid and glycemic profiles in women with normal weight obesity

BMC Endocrine Disorders ◽

10.1186/s12902-020-00648-8 ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Ehsaneh Taheri ◽

Saeed Hosseini ◽

Mostafa Qorbani ◽

Parvin Mirmiran

Keyword(s):

Serum Levels ◽

Normal Weight ◽

Lipid Profiles ◽

Control Group ◽

Model Assessment ◽

Cardiometabolic Disorders ◽

Glycemic Profile ◽

Homeostatic Model Assessment ◽

Normal Weight Obesity ◽

Circulating Levels

Abstract Background Individuals with normal weight obesity (NWO) are predisposed to having cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and lipid profiles in women with NWO. Methods Forty women with body mass index (BMI) = 18.5–24.9 kg/m2 and fat mass (FM) ≥ 30% were assigned in the NWO group. Thirty age-matched women with identical BMI range, and FM < 30% (normal weight non-obese; NWNO) were considered as a control group. In addition to anthropometric measurements, glycemic and lipid profiles and circulating levels of leptin and vaspin were measured. Results The mean ± standard deviation (SD) age of participants was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control group. The NWO group had the higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51, P = 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, P = 0.009) compared to the NWNO group. The serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, the serum levels of leptin had positive correlation with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06), positively. Conclusion It is concluded that the concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher concentrations of leptin and vaspin in the NWO group were associated with glycemic profile.

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Association of Adipocytokines with Lipid and Glycemic Profiles in Women with Normal Weight Obesity

10.21203/rs.3.rs-22359/v4 ◽

2020 ◽

Author(s):

Ehsaneh Taheri ◽

Saeed Hosseini ◽

Mostafa Qorbani ◽

Parvin Mirmiran

Keyword(s):

Serum Levels ◽

Normal Weight ◽

Lipid Profiles ◽

Control Group ◽

Model Assessment ◽

Cardiometabolic Disorders ◽

Homeostatic Model Assessment ◽

Normal Weight Obesity ◽

Circulating Levels ◽

Group Serum

Abstract Background: Individuals with normal weight obesity (NWO) are prone to cardiometabolic disorders. This study aims to investigate the circulating levels of vaspin, leptin and their association with glycemic and lipid profiles in women with NWO.Methods: Forty women with body mass index (BMI) = 18.5-24.9 kg/m2 and fat mass (FM) ≥ 30% were assigned in the NWO group. Thirty age-matched women with identical BMI range and FM < 30% (normal weight non-obese; NWNO) were considered as a control group. In addition to anthropometric measurements, glycemic and lipid profiles and also, circulating levels of leptin and vaspin were measured.Results: The mean ± standard deviation (SD) age of participants was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control group. The NWO group had higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51, P = 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, P = 0.009) compared to the NWNO group. Serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, serum levels of leptin correlated positively with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was positively associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06).Conclusion: It is concluded that the concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher levels of leptin and vaspin in the NWO group were associated with glycemic profiles.

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Association of Adipocytokines with Lipid and Glycemic Profiles in Women with Normal Weight Obesity

10.21203/rs.3.rs-22359/v3 ◽

2020 ◽

Author(s):

Ehsaneh Taheri ◽

Saeed Hosseini ◽

Mostafa Qorbani ◽

Parvin Mirmiran

Keyword(s):

Serum Levels ◽

Normal Weight ◽

Lipid Profiles ◽

Anthropometric Measurement ◽

Control Group ◽

Model Assessment ◽

Cardiometabolic Disorders ◽

Homeostatic Model Assessment ◽

Normal Weight Obesity ◽

Group Serum

Abstract Background: Individuals with normal weight obesity (NWO) are prone to cardiometabolic disorders. The aim of this study is to investigate the circulating levels of vaspin and leptin and their association with glycemic and lipid profiles in women with NWO.Methods: Forty women with body mass index (BMI)=18.5-24.9 kg/m2 and fat mass (FM) ≥ 30% were assigned in the NWO group and thirty age-matched women with identical BMI range and FM<30% (normal weight non-obese; NWNO) as control group were invited. Anthropometric measurement, fasting blood sugar (FBS), insulin, glycated hemoglobin (HbA1c), lipid profiles and also, leptin and vaspin were measured.Results: The mean ± standard deviation (SD) age was 28.76 ± 4.76 years in the NWO group and 29.23 ± 4.50 years in the control condition. The NWO group had higher mean serum levels of insulin (9.02 ± 4.75 vs. 6.24 ± 2.51, P = 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, P < 0.001) and homeostatic model assessment of insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, P = 0.009) compared to the NWNO group. Serum level of vaspin was higher in the NWO group compared to the control group (34.82 pg/ml vs. 27.72 pg/ml, respectively, P = 0.12). In NWO group, serum levels of leptin correlated positively with FBS (r = 0.45, P = 0.02), insulin (r = 0.51, P = 0.008), and HOMA-IR (r = 0.46, P = 0.02) and vaspin concentration was positively associated with insulin (r = 0.36, P = 0.02) and HOMA-IR (r = 0.30, P = 0.06). Conclusion: It is concluded that concentration of insulin and HOMA-IR index were significantly higher in women with NWO compared to NWNO. Higher levels of leptin and vaspin in the NWO group were associated with glycemic profiles.

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Association of Adipocytokines with Lipid and Glycemic Profiles in Women with Normal Weight Obesity

10.21203/rs.3.rs-22359/v2 ◽

2020 ◽

Author(s):

Ehsaneh Taheri ◽

Saeed Hosseini ◽

Mostafa Qorbani ◽

Parvin Mirmiran

Keyword(s):

Serum Level ◽

Serum Levels ◽

Normal Weight ◽

Lipid Profiles ◽

Anthropometric Measurement ◽

Control Group ◽

Model Assessment ◽

Cardiometabolic Disorders ◽

Normal Weight Obesity ◽

Group Serum

Abstract Background: Subjects with normal weight obesity (NWO) are supposed to cardiometabolic disorders. The aim of this study was to investigate the circulating levels of vaspin and leptin and their association with glycemic and lipid profiles in women with NWO compared to controlsMethods: Forty women with body mass index (BMI)=18.5-24.9 kg/m2 and fat mass (FM) ≥ 30% as NWO group and 30 age matched women with same BMI range and FM<30% as control group were enrolled in this study. Anthropometric measurement, fasting serum levels of blood sugar (FBS), insulin, Glycated hemoglobin (HbA1c), lipid profiles and also, leptin and vaspin were measured.Results: The mean ± standard deviation (SD) of age was 28.76 ± 4.76 years in NWO group and 29.23 ± 4.50 years in controls. Subjects in NWO group had higher serum levels of insulin (9.02 ± 4.75 vs.6.24 ± 2.51, p= 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, p<0.001) and homeostatic model assessment for insulin resistance (HOMA-IR) (33.77 ± 20.71 vs. 23.48 ± 10.03, p=0.009) as compared to normal weight non-obese (NWNO) as control group. Serum level of vaspin in NWO group (34.82 pg/ml) was higher than that in controls (27.72 pg/ml), (p=0.12). In NWO group, serum level of leptin was correlated positively with FBS (r=0.45, p=0.02), insulin (r=0.51, p=0.008), and HOMA-IR (r=0.46, p=0.02) and vaspin concentration was positively associated with insulin (r=0.36, p= 0.02) and HOMA-IR (r=0.30, p=0.06). Conclusion: We observed that concentration of insulin and HOMA-IR index were significantly increased in women with NWO compared to the controls. Higher levels of leptin and vaspin in NWO were associated with glycemic profiles in NWO group.

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Association of Adipocytokines with Lipid and Glycemic Profiles in Women with Normal Weight Obesity

10.21203/rs.3.rs-22359/v1 ◽

2020 ◽

Author(s):

Ehsaneh Taheri ◽

Saeed Hosseini ◽

Mostafa Qorbani

Keyword(s):

Serum Level ◽

Positive Association ◽

Serum Levels ◽

Normal Weight ◽

Lipid Profiles ◽

Anthropometric Measurement ◽

Control Group ◽

Cardiometabolic Disorders ◽

Normal Weight Obesity ◽

Group Serum

Abstract Background: Subjects with normal weight obesity (NOW) are supposed to cardiometabolic disorders. The aim of this study was to investigate the circulating levels of vaspin and leptin and their association with glycemic and lipid profiles in women with NWO compared to controlsMaterial & Methods: Forty women with BMI:18.5-24.9 kg/m2 and FM ≥ 30% as a NOW group and 30 age matched women with same BMI range and FM<30% as control group were enrolled. Anthropometric measurement, fasting serum levels of fasting blood sugar (FBS), insulin, HbA1c, lipid profiles and also, leptin and vaspin were measured. Results: The mean ± SD of age were 28.76±4.76 years in NWO group and 29.23 ± 4.50 years in controls. Subjects in NWO group had higher serum level of insulin (9.02 ± 4.75 vs.6.24 ± 2.51, p= 0.009), leptin (17.31 ± 8.10 vs. 9.94 ± 4.30, p<0.001) and HOMA-IR (33.77 ± 20.71 vs. 23.48 ± 10.03, p=0.009) compared to the NWNO group. Serum level of vaspin was higher in NWO (34.82 pg/ml) than control group (27.72 pg/ml),(p=0.12). In NWO subjects, serum level of leptin showed positive association with FBS (r=0.45, p=0.02), insulin (r=0.51, p=0.008), and HOMA-IR (r=0.46, p= 0.02) and vaspin concentration was positively associated with insulin (r=0.36, p= 0.02) and HOMA-IR (r=0.30, p=0.06). Conclusion: We observed that women with NWO had statistically significant increased concentration of insulin and HOMA-IR index compared to the controls. Higher levels of leptin and vaspin in NWO were associated with glycemic profiles in NWO.

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Adiponectin and leptin levels in normal weight women with polycystic ovary syndrome

Hormone Molecular Biology and Clinical Investigation ◽

10.1515/hmbci-2020-0016 ◽

2020 ◽

Vol 41 (4) ◽

Cited By ~ 1

Author(s):

Murat Gözüküçük ◽

Aslı Yarcı Gürsoy ◽

Emre Destegül ◽

Salih Taşkın ◽

Hakan Şatıroğlu

Keyword(s):

Insulin Resistance ◽

Polycystic Ovary ◽

Statistical Significance ◽

Free Testosterone ◽

Normal Weight ◽

Control Group ◽

Study Group ◽

Model Assessment ◽

Homeostatic Model Assessment ◽

The Difference

Abstract Objectives Since polycystic ovarian syndrome (PCOS) is prevalent in reproductive women with obesity and insulin resistance, adipocytokines are often accused and investigated for pathophysiology. The aim of this study was to evaluate the adiponectin and leptin levels in normal-weight women with PCOS. Methods Forty women with PCOS and 40 age and body mass index (BMI) matched controls were included in the study. Adiponectin and leptin levels in addition to other biochemical parameters were measured. Results Leptin levels were statistically significantly higher in the study group compared to the control group (6.53 ± 2.670 vs 3.37 ± 2.002 ng/mL, p < 0.001 respectively). Although Adiponectin levels were lower in the study group compared to the control group (28.89 ± 16.124 μg/mL vs 31.05 ± 20.507, p = 0.714 respectively) the difference did not reach statistical significance. Leptin levels were positively correlated with fasting glucose, fasting insulin, free testosterone levels and homeostatic model assessment of insulin resistance (HOMA-IR) values. Adiponectin levels were negatively correlated with BMI. Conclusions Adiponectin and leptin have been suggested to play a crucial role in the pathogenesis of PCOS. Different adipocytokine levels in the normal weight PCOS group compared to age and BMI matched controls support the idea that adipose tissue in this group of women has some distinctive features not only in high BMI subgroup but also in normal weight subgroup.

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Expanded Normal Weight Obesity and Insulin Resistance in US Adults of the National Health and Nutrition Examination Survey

Journal of Diabetes Research ◽

10.1155/2017/9502643 ◽

2017 ◽

Vol 2017 ◽

pp. 1-8 ◽

Cited By ~ 11

Author(s):

Keilah E. Martinez ◽

Larry A. Tucker ◽

Bruce W. Bailey ◽

James D. LeCheminant

Keyword(s):

Insulin Resistance ◽

Body Fat ◽

Cross Sectional Study ◽

Normal Weight ◽

Body Fat Percentage ◽

Model Assessment ◽

Fat Percentage ◽

Cross Sectional ◽

Homeostatic Model Assessment ◽

Normal Weight Obesity

This study aims to expand the evaluation of normal weight obesity (NWO) and its association with insulin resistance using an NHANES (1999–2006) sample of US adults. A cross-sectional study including 5983 men and women (50.8%) was conducted. Body fat percentage (BF%) was assessed using dual-energy X-ray absorptiometry. Expanded normal weight obesity (eNWO) categories, pairings of BMI and body fat percentage classifications, were created using standard cut-points for BMI and sex-specific median for BF%. Homeostatic model assessment-insulin resistance (HOMA-IR) levels were used to index insulin resistance. Mean ± SE values were BMI: 27.9 ± 0.2 (women) and 27.8 ± 0.1 (men); body fat percentage: 40.5 ± 0.2 (women) and 27.8 ± 0.2 (men); and HOMA-IR: 2.04 ± 0.05 (women) and 2.47 ± 0.09 (men). HOMA-IR differed systematically and in a dose-response fashion across all levels of the eNWO categories (F=291.3,P<0.0001). As BMI levels increased, HOMA-IR increased significantly, and within each BMI category, higher levels of body fat were associated with higher levels of HOMA-IR. Both high BMI and high BF% were strongly related to insulin resistance. Insulin resistance appears to increase incrementally according to BMI levels primarily and body fat levels secondarily. Including a precise measure of body fat with BMI adds little to the utility of BMI in the prediction of insulin resistance.

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The Effects of Obesity on Local and Circulating Levels of Tumor Necrosis Factor-α and Interleukin-6 in Patients with Chronic Periodontitis

Journal of Periodontology & Implant Dentistry ◽

10.15171/jpid.2015.002 ◽

2015 ◽

Vol 7 (1) ◽

pp. 7-14 ◽

Cited By ~ 2

Author(s):

Oğuz Kose ◽

Varol Canakcı ◽

Cenk Fatih Canakcı ◽

Abdulkadir Yıldırım ◽

Eda Kermen ◽

...

Keyword(s):

Chronic Periodontitis ◽

Tumor Necrosis ◽

Serum Levels ◽

Normal Weight ◽

Control Group ◽

Tnf Α ◽

Factor Α ◽

Circulating Levels ◽

Necrosis Factor ◽

Control Group Group

Background and aims. The aim of this study was to evaluate the possible effects of obesity on the local (salivary) and systemic TNF-α and IL-6 levels in patients with chronic periodontitis (CP). Materials and methods. This study included 88 subjects assigned to four groups of 22 subjects each, as follows: group O+P+ (patients with obesity and CP), group O-P+ (patients with normal weight and CP), group O+P- (periodontally healthy patients with obesity), and the control group, group O-P- (periodontally healthy patients with normal weight). Serum and salivary samples were obtained a week before the recording of clinical periodontal parameters. Local and systemic TNF-α and IL-6 levels were determined biochemically. Results. In serum and saliva, both TNF-α and IL-6 levels were the lowest in O-P- group (P < 0.05). The highest TNF-α and IL-6 levels were observed in O+P+ group, while only IL-6 levels were statistically significant (P < 0.05). Conclusion. Obesity upregulated the salivary and serum levels of TNF-α and IL-6. In patients with periodontitis, who were also obese, the serum and saliva levels of IL-6 were significantly high. Obesity might play a destructive and provocative role in the pathogenesis of periodontitis by negatively affecting IL-6 levels.

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Withdrawn: Hepatoprotective effects of Tribulus terrestris L. (Zygophyllales: Zygophyllaceae) hydro-alcholic extract on non-alcoholic fatty liver-induced rats

Brazilian Journal of Biological Sciences ◽

10.21472/bjbs.030513 ◽

2016 ◽

Vol 3 (5) ◽

pp. 143

Author(s):

Fatemeh Almasi ◽

Mozafar Khazaei ◽

Shima Chehrei ◽

Ali Ghanbari

Keyword(s):

Fatty Liver ◽

Liver Tissue ◽

Serum Lipid ◽

Histopathological Examination ◽

Serum Levels ◽

Lipid Profiles ◽

Control Group ◽

Tribulus Terrestris ◽

Protective Effects ◽

Alcoholic Fatty Liver

Non-alcoholic fatty liver induces many complications to the liver tissue and also serum related parameters. Medicinal plants are the safe therapeutic strategy for the treatment of diseases. In this regards, the present study was conducted to evaluate the effect of Tribulus terrestris L. (Zygophyllales: Zygophyllaceae) extract on non-alcoholic fatty liver in rats. In this experimental study, thirty male Wistar rats were divided into five groups (n = 6). Animals in experimental groups were received high fructose diet (70%) (HDF) daily alone or in combined with daily intraperitoneal injection of 500, 700 and 1,000 mg/kg extract of T. terrestris. Control group of rats was feed with standard chow. The serum levels of biomarkers of liver and serum lipid profiles were assessed, also histopathological examination of liver tissue done. Data were analyzed using One-way ANOVA method followed by Tukey’s post-hoc multiple comparison test and P < 0.05 was considered statistically significant. There were significant improvements for biomarkers of liver tissue (P < 0.05) and serum lipid profiles (P < 0.01) in the HFD-fed rats that were treated with T. terrestris extract compare to HFD-fed group. In addition, accumulation of lipids in hepatocytes was significantly reduced in the HFD-fed + extract administrated groups in comparison to HFD-fed rats (P < 0.01). T. terrestris extract has protective effects against non-alcoholic fatty liver by changing biomarkers of liver tissue, serum lipid profiles and histopathological anomalies of liver tissue, to normal range.

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The possible role of Interleukin-6 as a regulator of insulin sensitivity in patients with neuromyelitis optica spectrum disorder

BMC Neurology ◽

10.1186/s12883-021-02198-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Zhila Maghbooli ◽

Abdorreza Naser Moghadasi ◽

Nasim Rezaeimanesh ◽

Abolfazl Omidifar ◽

Tarlan Varzandi ◽

...

Keyword(s):

Insulin Sensitivity ◽

Neuromyelitis Optica ◽

Serum Levels ◽

Spectrum Disorder ◽

Control Group ◽

Neuromyelitis Optica Spectrum Disorder ◽

Downstream Signaling ◽

Reduce Insulin Sensitivity ◽

Circulating Levels

Abstract Background Neuromyelitis optica spectrum disorder (NMOSD) is associated with inflammatory mediators that may also trigger downstream signaling pathways leading to reduce insulin sensitivity. Methods We aimed to determine the risk association of hyperinsulinemia in NMOSD patients with seropositive AQP4-IgG and the serum levels of interleukin (IL)-6 and IL-17A compared with the control group. Serum levels of metabolic (Insulin, Fasting Blood Sugar (FBS), lipid profile) and inflammatory (IL-6 and IL-17) markers were assessed in 56 NMOSD patients and 100 controls. Results Hyperinsulinemia was more prevalent in NMOSD patients independent of age, sex and body mass index (BMI) (48.2% vs. 26%, p = 0.005) compared to control group. After adjusting age, sex and BMI, there was significant association between lower insulin sensitivity (IS) and NMOSD risk (95% CI: Beta = 0.73, 0.62 to 0.86, p = 0.0001). Circulating levels of IL-6 and IL-17 were higher in NMOSD patients, and only IL-6 had an effect modifier for the association between lower insulin sensitivity and NMOSD risk. Conclusions Our data suggests that inflammatory pathogenesis of NMOSD leads to hyperinsulinemia and increases the risk of insulin resistance.

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