scholarly journals Highly sensitive biomarker biosensor for early detection of cancer biomarkers

2021 ◽  
Author(s):  
Jaydev Upponi ◽  
Tiziana Musacchio ◽  
Salome Siavoshi ◽  
Asanterabi Malima ◽  
Cihan Yilmaz ◽  
...  
Keyword(s):  
Monoclonal Antibody ◽  
Early Detection ◽  
Carcinoembryonic Antigen ◽  
Early Detection Of Cancer ◽  
Cancer Biomarkers ◽  
Diagnostic Tools ◽  
Detection Systems ◽  
Highly Sensitive ◽  
Current Detection ◽  
Insufficient Sensitivity

Abstract Biomarkers are emerging as potentially important diagnostic tools for cancer and many other diseases. However, many current detection systems for suffer from insufficient sensitivity. To address this concern, we developed a highly sensitive biosensor, featuring monoclonal antibody-coated polystyrene nanobeads assembled in the trenches of a microchip, for the detection of cancer biomarkers. These biosensors detected nucleosomes and carcinoembryonic antigen in serum at concentrations of 62.5 and 15.6 pg/mL, respectively. Very low detection limits that suggest such devices might be beneficial for the early detection of tumors and for monitoring of patients in remission.

scholarly journals Diagnostic Proteomics: Serum Proteomic Patterns for the Detection of Early Stage Cancers

2004 ◽  
Vol 19 (4-5) ◽  
pp. 209-218 ◽  
Author(s):  
Li-Rong Yu ◽  
Ming Zhou ◽  
Thomas P. Conrads ◽  
Timothy D. Veenstra
Keyword(s):  
Early Detection ◽  
Early Diagnosis ◽  
Early Detection Of Cancer ◽  
Pattern Analysis ◽  
Early Stage ◽  
Clinical Samples ◽  
Diagnostic Biomarkers ◽  
Highly Sensitive ◽  
Disease Specific ◽  
Diagnosis Of Diseases

The ability to interrogate thousands of proteins found in complex biological samples using proteomic technologies has brought the hope of discovering novel disease-specific biomarkers. While most proteomic technologies used to discover diagnostic biomarkers are quite sophisticated, "proteomic pattern analysis" has emerged as a simple, yet potentially revolutionary, method for the early diagnosis of diseases. Utilizing this technology, hundreds of clinical samples can be analyzed per day and several preliminary studies suggest proteomic pattern analysis has the potential to be a novel, highly sensitive diagnostic tool for the early detection of cancer.

Enhanced biosensing strategies using electrogenerated chemiluminescence: recent progress and future prospects

2020 ◽  
Vol 8 (16) ◽  
pp. 3192-3212 ◽  
Author(s):  
Rashaad A. Husain ◽  
Snigdha Roy Barman ◽  
Subhodeep Chatterjee ◽  
Imran Khan ◽  
Zong-Hong Lin
Keyword(s):  
Early Detection ◽  
Early Detection Of Cancer ◽  
Recent Progress ◽  
Electrogenerated Chemiluminescence ◽  
Future Prospects ◽  
Highly Sensitive

An overview of enhancement strategies for highly sensitive ECL-based sensing of bioanalytes enabling early detection of cancer.

scholarly journals Precursor Lesions for Sporadic Pancreatic Cancer: PanIN, IPMN, and MCN

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
M. Distler ◽  
D. Aust ◽  
J. Weitz ◽  
C. Pilarsky ◽  
Robert Grützmann
Keyword(s):  
Pancreatic Cancer ◽  
Mortality Rate ◽  
Early Detection ◽  
Current Level ◽  
Diagnostic Tools ◽  
Precursor Lesions ◽  
Highly Sensitive ◽  
Level Of Knowledge ◽  
Clinical Measures ◽  
Sporadic Pancreatic Cancer

Pancreatic cancer is still a dismal disease. The high mortality rate is mainly caused by the lack of highly sensitive and specific diagnostic tools, and most of the patients are diagnosed in an advanced and incurable stage. Knowledge about precursor lesions for pancreatic cancer has grown significantly over the last decade, and nowadays we know that mainly three lesions (PanIN, and IPMN, MCN) are responsible for the development of pancreatic cancer. The early detection of these lesions is still challenging but provides the chance to cure patients before they might get an invasive pancreatic carcinoma. This paper focuses on PanIN, IPMN, and MCN lesions and reviews the current level of knowledge and clinical measures.

A family with pheochromocytoma-paraganglioma inherited tumour syndrome

2016 ◽  
Vol 55 (01) ◽  
pp. 34-40 ◽  
Author(s):  
P. Zschieschang ◽  
V. Prasad ◽  
D. Moskopp ◽  
B. Knie ◽  
M. Plotkin
Keyword(s):  
Early Detection ◽  
Neck Region ◽  
Hereditary Disease ◽  
Head And Neck Region ◽  
Pet Ct ◽  
Highly Sensitive ◽  
Hereditary Pheochromocytoma ◽  
Genetically Determined ◽  
Mass Lesions ◽  
Pet Ct Scan

SummaryAim: Hereditary pheochromocytoma-paraganglioma syndromes are characterized by multiple pheochromocytomas (PCC) and paragangliomas (PGLs), inherited in an autosomal dominant manner. Early detection and removal of tumours may prevent or minimize complications related to mass effects and malignant transformation. Having confirmed the diagnosis, it is important to localize the tumours and reveal their extent preoperatively. This study aimed to introduce 18F-DOPA PET/CT as a highly sensitive noninvasive diagnostic tool for early detection of mass lesions in patients with pheochromocytoma-paraganglioma inherited tumour syndrome and to report about its impact on patient management. Patients, methods: We are currently supervising one of the largest documented families in Germany with genetically determined SDHD gene mutation. We performed 18F-DOPA PET/CT in order to detect tumours in asymptomatic gene carriers and enable subsequent surgical therapy. Results: In seven patients undergoing 12 18F-DOPA PET/CT scans 17 lesions have been detected. Three of these lesions, located in the head and neck region, have had no morphologic correlate in CT and one had also no morphologic correlate in MRI. Of the six histologically analyzed lesions five have been tumors (PGL or PCC) and one has been a nodular hyperplasia. This means the 18F-DOPA PET/CT scan in our study group had a sensitivity of 83%. 18F-DOPA PET/CT investigations lead to change in the management in 5/7 studied patients (70%). Conclusion: The benefits of PET/ CT in detection of pheochromocytoma and paraganglioma are well documented, but we are the first to use this technique for screening of a rare hereditary disease (estimated prevalence 0.3/100 000).

Detection of spina bifida in the first trimester of gestation in association with triploidy

2017 ◽  
Author(s):  
K.K. Otaryan , C.G. Gagaev
Keyword(s):  
Spina Bifida ◽  
Early Detection ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
First Trimester ◽  
Termination Of Pregnancy ◽  
Diagnostic Tools ◽  
Prenatal Detection ◽  
Post Abortion

The case of prenatal detection of spina bifida at 12+3 weeks of gestation is described. Termination of pregnancy was performed at 13+3 weeks. Post-abortion karyotyping revealed triploidy (69XXX). Diagnostic tools for early detection of neural tube defects in the 1st trimester of gestation and subsequent appropriate management of pregnancy are discussed.

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