scholarly journals Anxiety Amplifies Plasma Oxytocin Levels in Older Individuals with type 2 Diabetes. Findings from the Cross-Sectional KORA-Age Study.

2021 ◽  
Author(s):  
Hamimatunnisa Johar ◽  
Seryan Atasoy ◽  
Linmiao Jiang ◽  
Martin Bidlingmaier ◽  
Johannes Kruse ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Energy Homeostasis ◽  
Statistical Significance ◽  
Population Based ◽  
Pathological Feature ◽  
Older Individuals ◽  
Cross Sectional ◽  
Obesity Status ◽  
Sectional Analysis

Abstract PurposeBeyond its role in parturition, lactation, and emotion regulation, oxytocin (OXT) plays an important role in metabolism and energy homeostasis, although evidence is still limited. We investigated the association between endogenous OXT levels and type 2 diabetes mellitus (T2DM) and whether anxiety may modify its association.MethodsA cross-sectional analysis was conducted in 1006 participants aged 65-93 years (mean=75.9, SD ± 6.6) from the population-based KORA-Age study. Multivariable generalized linear regression analyses were performed to examine the association between non-extracted plasma OXT levels and T2DM with adjustments for potential confounders. ResultsAcross the OXT tertile groups, no substantial differences between sociodemographic, lifestyle, cardiometabolic or psychosocial factors were found except for multimorbidity. The differences between the OXT tertile groups with respect to obesity status were on the borderline of statistical significance (P=0.05). However, a significant statistical interaction between T2DM and anxiety on OXT levels was found (p = 0.03). In T2DM individuals with anxiety, substantially higher plasma OXT levels (Least Squares (LS) mean = 340.82 pg/ml, 95% CI 231.12-502.59) were observed compared to those without anxiety (217.08 pg/ml, 95% CI 190.93 – 247.99) (p=0.02). No significant association between T2DM and OXT levels in individuals without anxiety was found. ConclusionOXT levels were significantly elevated in T2DM subjects, particularly among older individuals with anxiety. The modifying role of anxiety highlights that anxiogenic stimuli may be associated with enhanced OXT signalling, particularly in subjects who suffer from T2DM as a severe pathological feature of dysregulated metabolism.

scholarly journals Relationship of the Self-perception of Lifestyle with Level of Physical Activity in People with and without Type 2 Diabetes

2019 ◽  
pp. 1-7
Author(s):  
Briseida Mayel Perez-Avelino ◽  
Nicolás Padilla-Raygoza ◽  
Verónica Benitez-Guerrero ◽  
María Luisa Sánchez Padilla ◽  
Vicente Beltrán-Campos ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Statistical Significance ◽  
Self Perception ◽  
Chi Square ◽  
Cross Sectional ◽  
Lifestyle Questionnaire ◽  
Chi Square Test ◽  
Relationship Of

Objective: To determine the relationship of the perception of lifestyle with the level of physical activity in people with type 2 diabetes and without type 2 diabetes. Study Design: Analytical cross-sectional observational study in Celaya, Guanajuato, Mexico. Methodology: Sample composed of 100 people with type 2 diabetes and 100 people without type 2 diabetes, the lifestyle questionnaire and IPAQ questionnaire were used. Descriptive statistics were calculated for sociodemographic variables; it was calculated Chi-square test and Odds Ratio.  To demonstrate the statistical significance of results, the value of P was set at .05. Statistical analysis was performed in STATA 13.0 ®. Results: In patients with Type 2 Diabetes predominated females, married, who never went school and elementary and BMI ≥ 25 kg/m2; among patients without Type 2 Diabetes, predominant males, singles, went school or university, BMI ≥25 kg/m2; no relationship was found between lifestyle perception and level of physical activity in adults with type 2 diabetes (X² = 0.0022 gl 1 P = .96) neither it was found a significant relationship between lifestyle perception and level of physical activity in adults without type 2 diabetes (X² = 5.23 gl 1 P = .02 RM = 2.85 95% CI = 0.80 to 10.4). Conclusion: The results show that self-perception of lifestyle and physical activity is different in people with less age, more schooling, males.

scholarly journals Quantifying the risk of type 2 diabetes in East London using the QDScore: a cross-sectional analysis

2012 ◽  
Vol 62 (603) ◽  
pp. e663-e670 ◽  
Author(s):  
Rohini Mathur ◽  
Douglas Noble ◽  
Dianna Smith ◽  
Trisha Greenhalgh ◽  
John Robson
Keyword(s):  
Type 2 Diabetes ◽  
Cross Sectional ◽  
Cross Sectional Analysis ◽  
Sectional Analysis

scholarly journals Serum Potassium and Glucose Regulation in the ADDITION-Leicester Screening Study

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Patrice Carter ◽  
Danielle H. Bodicoat ◽  
Lauren M. Quinn ◽  
Francesco Zaccardi ◽  
David R. Webb ◽  
...  
Keyword(s):  
Population Based ◽  
Glucose Regulation ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Glucose Levels ◽  
Screening Study ◽  
Multiethnic Population ◽  
Baseline Characteristics ◽  
Sectional Analysis

Introduction. Previous observational studies have shown conflicting results between plasma K+concentrations and risk of type 2 diabetes. To help clarify the evidence we aimed to determine whether an association existed between serum K+and glucose regulation within a UK multiethnic population.Methods. Participants were recruited as part of the ADDITION Leicester study, a population based screening study. Individuals from primary care between the age of 40 and 75 years if White European or 25 and 75 years if South Asian or Afro Caribbean were recruited. Tests for associations between baseline characteristics and K+quartiles were conducted using linear regression models.Results. Data showed individuals in the lowest K+quartile had significantly greater 2-hour glucose levels (0.53 mmol/L, 95% CI: 0.36 to 0.70,P≤0.001) than those in the highest K+quartile. This estimation did not change with adjustment for potential confounders. Conversely, participants in the lowest K+quartile had a 0.14% lower HbA1c (95% CI −0.19 to −0.10:P≤0.001) compared to those in the highest K+quartile.Conclusion. This cross-sectional analysis demonstrated that lower K+was associated with greater 2 hr glucose. The data supports the possibility that K+may influence glucose regulation and further research is warranted.

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