Risk Factors for Malignancies in Pediatric Population: Results of A Population-Based Case-Control Study

2021 ◽  
Author(s):  
Yolande Saab ◽  
Mirna Naccache ◽  
Rony Zeenny ◽  
Shereen Nabhani-Gebara ◽  
Lydia Sholy
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Pediatric Population ◽  
Population Data ◽  
Population Based ◽  
Case Control ◽  
Electrical Networks ◽  
Face To Face ◽  
History Of ◽  
Control Study

Abstract Cancer is the most common cause of disease-related deaths in childhood. Many sociodemographic, socioeconomic, environmental and genetic risk factors have been associated with a childhood cancer risk. However, few to no such studies have been conducted in the Middle East including Lebanon. This is a population-based case-control study that was conducted in the Lebanese pediatric population. Data was collected through face- to-face interviews, using a questionnaire, with parents of children with cancer in Lebanese pediatric cancer centers over a two-year period. In total, the sample consisted of 322 participants. Results showed that there are several sociodemographic, socioeconomic, environmental factors, in addition to consanguinity between parents, level of education and occupation of the parents , area of residence of the child (location and proximity to high-voltage electrical networks, garbage disposal areas, industrial factories and high-ways) as well as sibling history of cancer are risk factors for childhood cancers in Lebanon. Conclusion: This study informs policy makers on the risk factors in order to find solution as well as policies to decrease and mitigate these risks.

scholarly journals Risk factors for human cysticercosis morbidity: a population-based case-control study

1997 ◽  
Vol 119 (2) ◽  
pp. 231-235 ◽  
Author(s):  
W. CAO ◽  
C. P. B. VAN DER PLOEG ◽  
J. XU ◽  
C. GAO ◽  
L. GE ◽  
...  
Keyword(s):  
Risk Factors ◽  
Case Control Study ◽  
Taenia Solium ◽  
Population Based ◽  
Case Control ◽  
Personal Hygiene ◽  
Prevalence Survey ◽  
History Of ◽  
Behavioural Factors ◽  
Control Study

A population-based case-control study to determine social and behavioural risk factors for Taenia solium cysticercosis in humans was carried out in a rural area, Shandong province, China. Forty-eight cases with cysticercosis were ascertained through a prevalence survey conducted among 7281 persons in 1993. For each case, four controls residing in the same village and matched for age and sex were randomly selected. Information regarding demographic, social and behavioural factors was collected during house visits through interviews and direct observation. Risk factors strongly associated with human cysticercosis included poor personal hygiene, being unable to recognize cysticerci-containing meat, poor pig-raising practices and a history of passing tapeworm proglottides. The results indicate that health education in combination with chemotherapy for taeniasis is required for the control of cysticercosis in humans.

scholarly journals Risk factors for early-onset colorectal cancer: a population-based case–control study in Ontario, Canada

2021 ◽  
Author(s):  
Vicky C. Chang ◽  
Michelle Cotterchio ◽  
Prithwish De ◽  
Jill Tinmouth
Keyword(s):  
Colorectal Cancer ◽  
Risk Factors ◽  
Early Onset ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Dietary Factors ◽  
Supplement Use ◽  
History Of ◽  
Control Study

Abstract Purpose There has been an alarming increase in colorectal cancer (CRC) incidence among young adults aged < 50 years, and factors driving this upward trend are unknown. This study investigated associations between various medical, lifestyle, and dietary factors and risk of early-onset CRC (EO-CRC). Methods A population-based case–control study was conducted in Ontario, Canada during 2018–2019. EO-CRC cases aged 20–49 years (n = 175) were identified from the Ontario Cancer Registry; sex- and age group-matched controls (n = 253) were recruited through random digit dialing. Data on potential a priori risk factors were collected using a web-based self-reported questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using multivariable logistic regression. Results Family history of CRC in a first- or second-degree relative (OR 2.37; 95% CI 1.47–3.84), longer sedentary time (≥ 10 vs. < 5 h/day, OR 1.93; 95% CI 1.02–3.65), greater consumption of sugary drinks (≥ 7 vs. < 1 drinks/week, OR 2.99; 95% CI 1.57–5.68), and a more Westernized dietary pattern (quartile 4 vs. 1, OR 1.92; 95% CI 1.01–3.66) were each associated with an increased risk of EO-CRC. Conversely, calcium supplement use (OR 0.53; 95% CI 0.31–0.92), history of allergy or asthma (OR 0.62; 95% CI 0.39–0.98), and greater parity in females (≥ 3 vs. nulliparity, OR 0.29; 95% CI 0.11–0.76) were each associated with a reduced risk. Conclusion Modifiable factors, particularly sedentary behavior and unhealthy diet including sugary drink consumption, may be associated with EO-CRC risk. Our findings, if replicated, may help inform prevention strategies targeted at younger persons.

scholarly journals Association between infection with Campylobacter species, poor oral health and environmental risk factors on esophageal cancer: a hospital-based case–control study in Thailand

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Arisara Poosari ◽  
Thitima Nutravong ◽  
Prakasit Sa-ngiamwibool ◽  
Wises Namwat ◽  
Supaporn Chatrchaiwiwatana ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Cancer ◽  
Oral Hygiene ◽  
Case Control Study ◽  
Significant Risk ◽  
Case Control ◽  
Poor Oral Hygiene ◽  
History Of ◽  
Control Study ◽  
History Of Cancer

Abstract Background Previous studies have shown the association between Campylobacter species infection and that environmental factors, poor oral hygiene in particular, are linked to an increased risk of esophageal cancer (EC). However, no study has reported on these factors in Thailand. Thus, this study’s objective was to evaluate the impact of the relationship between Campylobacter infection and environmental factors on EC incidence in the population of Thailand. Methods Data from a case–control study were collected from 105 newly diagnosed EC cases and 105 controls recruited from 2007 to 2017. Infection with Campylobacter spp. was detected in the formalin-fixed paraffin-embedded (FFPE) tissue of EC taken from gastroesophageal biopsy specimens obtained from the participants, and evaluated using TaqMan® real-time PCR. Multivariable logistic regression was performed to calculate the odds ratios (ORs) and perform data analysis. Results Smoking, alcohol use, a family history of cancer, history of gastroesophageal reflux disease, poor oral hygiene and Campylobacter spp. infection were shown to be significant risk factors for EC (p  <  0.05). The combination of poor oral hygiene and infection with Campylobacter spp. constituted significant risk for EC (p  <  0.001). In addition, the risk of EC in subjects co-infected with C. rectus and C. concisus that practiced poor oral hygiene was even higher and was significant (ORadj  =  4.7; 95% CI 2.41–9.98; p  =  0.003). Conclusions In Thailand, the major risk factors for EC are smoking status, alcohol drinking, family history of cancer, GERD, poor oral hygiene and Campylobacter spp. infection. This study found Campylobacter spp. prevalence to be associated with EC and appears to be enhanced by poor oral hygiene, suggesting that a combination of poor oral hygiene and Campylobacter species infection may together act as an important etiological risk factor for EC.

scholarly journals Evaluation of Cardiovascular Risk of Selective and Nonselective Cyclooxygenase Inhibitors (COX-Is) in Arthritic Patients: A Comparative Matched Case Control Study

2014 ◽  
Vol 6 (2) ◽  
pp. 329-338
Author(s):  
N. Quraishi ◽  
U. Bhosale ◽  
R. Yegnanarayan ◽  
D. Devasthale
Keyword(s):  
Risk Factors ◽  
Lipid Profile ◽  
Case Control Study ◽  
Case Control ◽  
Cyclooxygenase Inhibitors ◽  
History Of ◽  
Matched Case ◽  
Cox 2 ◽  
Matched Case Control Study ◽  
Control Study

This study was conducted to assess and compare the cardiovascular risk and to explore the demography of CV risk of nonselective cyclooxygenase inhibitors (COX-Is) and selective COX-2-Is in arthritic patients. In this comparative matched case control study adult arthritic patients of either sex taking COX-Is for >1 yr; were included. Arthritic age and sex matched individuals with no history of COX-Is treatment were the controls. Patients those with history of any other disease (e.g. diabetes, hypertension, stroke, IHD etc.) were excluded. Patients were grouped into Control, nonselective COX-I and selective COX-2-I groups. The CV risk factors like blood pressure, blood sugar level(BSL), lipid profile, BMI(body mass index) etc. were assessed and compared; demography of CV risk factors i.e. age, sex, smoking, alcohol, heredity was also studied. Qualitative data was analyzed using Chi-square and quantitative data was analyzed by student’s‘t’-test. Study clearly revealed that all NSAIDs exhibit significant CV risk when taken over a period of time as in arthritis. However selective COX 2-Is found to exhibit more CV risk in this regard. Odds ratio (OR) for CV risk=10.3(95% CI: 1.45, 3.31) and OR for CV risk=5.2(95%CI: 1.05, 2.57) for nonselective COX-Is. BMI, BSL and lipid profile; the potential CV risk factors, showed significant impairment in selective COX 2-Is group; P<0.05, P<0.05 and P<0.01 (HDL), P<0.001 (cholesterol), respectively compared to controls and P<0.05 compared to nonselective COX-Is. This study portrays the potential CV risk of selective COX 2-Is and confirms and re-evaluate the results of earlier studies in this regard.  Keywords: Anti-arthritic agents; BMI; COX-Is; CV risk; Lipid profile.  © 2014 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.  doi: http://dx.doi.org/10.3329/jsr.v6i2.17039 J. Sci. Res. 6 (2), 328-338 (2014)  

scholarly journals Risk factors for Escherichia coli bacteraemia: a population-based case-control study

The Lancet ◽  
2017 ◽  
Vol 390 ◽  
pp. S85 ◽  
Author(s):  
Jiao Song ◽  
Angharad Walters ◽  
Damon Berridge ◽  
Ashley Akbari ◽  
Meirion Evans ◽  
...  
Keyword(s):  
Risk Factors ◽  
Escherichia Coli ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Control Study
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