scholarly journals Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

2020 ◽  
Author(s):  
Qiangqiang Zhao ◽  
Xiaoying Sun ◽  
Bin Wu ◽  
Yinghui Shang ◽  
Xueyuan Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cell Membrane ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Ph Value ◽  
Mesoporous Silica Nanoparticles ◽  
Low Ph

Abstract Background: Non-Hodgkin's lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibod y targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine has long been used in the treatment of malignant tumors. Therefore, we constructed a low pH value sensitivity drug delivery system based on the cancer cell membrane modified mesoporous silica nanoparticles loaded with traditional Chinese medicine, which can reduce systemic toxicity and improve the therapeutic effect for the targeted drug delivery of tumor cells. Results: Accordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. The proposed nano-platform has characteristics of immune escape, anti-phagocytosis, high drug loading rate, low pH value sensitivity, good biocompatibility and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis.Conclusions: Furthermore, this study provides a theoretical basis in finding novel clinical treatments for lymphoma.

scholarly journals Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Qiangqiang Zhao ◽  
Xiaoying Sun ◽  
Bin Wu ◽  
Yinghui Shang ◽  
Xueyuan Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cell Membrane ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Ph Value ◽  
Mesoporous Silica Nanoparticles ◽  
Low Ph

Abstract Background Non-Hodgkin’s lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibody targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine has long been used in the treatment of malignant tumors. Therefore, we constructed a low pH value sensitivity drug delivery system based on the cancer cell membrane modified mesoporous silica nanoparticles loaded with traditional Chinese medicine, which can reduce systemic toxicity and improve the therapeutic effect for the targeted drug delivery of tumor cells. Results Accordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. The proposed nano-platform has characteristics of immune escape, anti-phagocytosis, high drug loading rate, low pH value sensitivity, good biocompatibility and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis. Conclusions Furthermore, this study provides a theoretical basis in finding novel clinical treatments for lymphoma.

scholarly journals Construction of homologous cancer cell membrane camouflage in a nano-drug delivery system for the treatment of lymphoma

2020 ◽  
Author(s):  
Qiangqiang Zhao ◽  
Xiaoying Sun ◽  
Bin Wu ◽  
Yinghui Shang ◽  
Xueyuan Huang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cell Membrane ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Ph Value ◽  
Mesoporous Silica Nanoparticles ◽  
Low Ph

Abstract BackgroundNon-Hodgkin's lymphoma (NHL) possesses great heterogeneity in cytogenetics, immunophenotype and clinical features, and chemotherapy currently serves as the main treatment modality. Although employing monoclonal antibody targeted drugs has significantly improved its overall efficacy, various patients continue to suffer from drug resistance or recurrence. Chinese medicine has long been used in the treatment of malignant tumors. Therefore, we constructed a low pH value sensitivity drug delivery system based on the cancer cell membrane modified mesoporous silica nanoparticles loaded with traditional Chinese medicine, which can reduce systemic toxicity and improve the therapeutic effect for the targeted drug delivery of tumor cells.ResultsAccordingly, this study put forward the construction of a nano-platform based on mesoporous silica nanoparticles (MSNs) loaded with the traditional Chinese medicine isoimperatorin (ISOIM), which was camouflaged by the cancer cell membrane (CCM) called CCM@MSNs-ISOIM. The proposed nano-platform has characteristics of immune escape, anti-phagocytosis, high drug loading rate, low pH value sensitivity, good biocompatibility and active targeting of the tumor site, blocking the lymphoma cell cycle and promoting mitochondrial-mediated apoptosis.ConclusionsFurthermore, this study provides a theoretical basis in finding novel clinical treatments for lymphoma.

Cancer cell membrane-cloaked mesoporous silica nanoparticles with a pH-sensitive gatekeeper for cancer treatment

2019 ◽  
Vol 175 ◽  
pp. 477-486 ◽  
Author(s):  
Chang-Ming Liu ◽  
Guang-Bing Chen ◽  
Hui-Hong Chen ◽  
Jia-Bin Zhang ◽  
Hui-Zhang Li ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Mesoporous Silica ◽  
Cancer Treatment ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Mesoporous Silica Nanoparticles ◽  
Ph Sensitive

scholarly journals Cancer cell membrane-modified biodegradable mesoporous silica nanocarriers for berberine therapy of liver cancer

RSC Advances ◽  
2018 ◽  
Vol 8 (70) ◽  
pp. 40288-40297 ◽  
Author(s):  
Juan Yue ◽  
Zheng Wang ◽  
Dan Shao ◽  
Zhimin Chang ◽  
Rui Hu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Cell Membrane ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Mesoporous Silica Nanoparticles

We described biodegrade mesoporous silica nanoparticles coating cancer cell membrane for berberine therapy of liver cancer.

Cancer-Cell-Specific Induction of Apoptosis Using Mesoporous Silica Nanoparticles as Drug-Delivery Vectors

Small ◽  
2010 ◽  
Vol 6 (11) ◽  
pp. 1234-1241 ◽  
Author(s):  
Jessica M. Rosenholm ◽  
Emilia Peuhu ◽  
Laurel Tabe Bate-Eya ◽  
John E. Eriksson ◽  
Cecilia Sahlgren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cell ◽  
Mesoporous Silica Nanoparticles ◽  
Specific Induction ◽  
Induction Of Apoptosis

Fabrication of Chitosan-coated Mesoporous Silica Nanoparticles Bearing Rosuvastatin as Drug Delivery System

2021 ◽  
Vol 18 ◽  
Author(s):  
Mojdeh Rahnama Ghahfarokhi ◽  
Ghasem Dini ◽  
Behrooz Movahedi
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Specific Surface ◽  
Silica Nanoparticles ◽  
Surface Area ◽  
Specific Surface Area ◽  
Ph Value ◽  
Mesoporous Silica Nanoparticles ◽  
Molar Ratio

Aim: In this work, to improve the solubility and bioavailability of the rosuvastatin (RSV) drug, chitosan-coated mesoporous silica nanoparticles (CS-MSNs) as drug delivery systems were fabricated. Methods: To do this, first MSNs with a maximum specific surface area were synthesized from sodium silicate as silica source and different molar ratios of cethyl trimethylammonium bromide (CTAB) and pluronics (P123, PEO20PPO17PEO20) as surfactants via the sol-gel process. Then, the synthesized MSNs were coated by CS polymer with the help of (3-glycidoxypropyl)methyldiethoxysilane (GPTMS) as a linker between MSNs and CS. Subsequently, the RSV drug was loaded into the synthesized CS-coated MSNs. The products were characterized by different techniques, including X-ray diffraction (XRD), the Brunauer-Emmett-Teller (BET), scanning electron microscopy (SEM), dynamic light scattering (DLS), and Fourier-transform infrared spectroscopy (FTIR). The in vitro drug release profile of the fabricated DDS was evaluated in a typical phosphate-buffered saline (PBS) solution at different pH values (i.e., 4, 6, and 7.4) for 48 h. To assess the cytotoxicity, the viability of the human fibroblast cells exposed to the fabricated DDS was also examined. Results: The results showed that at an optimal molar ratio of P123/CTAB, the amorphous MSNs with a specific surface area of about 1080 m2/g, a pore diameter of 4 nm, a pore volume of 1.1 cm3/g, and an average size of about 30 nm were synthesized. Also, the presence of all the components, including the CS coating and the RSV drug, was confirmed in the structure of the fabricated DDS by FTIR analysis. Due to the pH-responsive feature of the CS coating, the RSV drug release from the fabricated DDS showed a reasonable environmental response; as the pH value of the PBS solution decreased, the degree of drug release increased. Conclusion: The CS coating enhanced the cytotoxicity of the fabricated DDS and led to sustainable drug release behavior, which would provide a beneficial approach for drug delivery technology.

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