scholarly journals Identification of early response to hypertonic dextrose prolotherapy markers in knee osteoarthritis patients by an inflammation-related cytokine array

2020 ◽  
Author(s):  
Hsing-Chun Kuo ◽  
Po-Jung Pan ◽  
Jia-Chi Wang ◽  
Chih-Chun Tsai
Keyword(s):  
Synovial Fluid ◽  
Knee Joint ◽  
Protein Expression ◽  
Joint Space Width ◽  
Joint Space ◽  
Knee Oa ◽  
Womac Index ◽  
Minimum Joint Space Width ◽  
Space Width ◽  
Hypertonic Dextrose

Abstract BACKGROUND/AIMOsteoarthritis (OA) is one of the most common forms of arthritis, and hypertonic dextrose prolotherapy has long been used clinically to treat knee OA. The aim of this study was to investigate the inflammation-related protein-expression profile characterizing the efficacy of the hypertonic dextrose prolotherapy in knee OA as prognostic markers.METHODSOA patients over the age of 65 were recruited for Western Ontario McMaster University Osteoarthritis (WOMAC) index, knee X ray evaluation and knee joint synovial fluid analysis before and after hypertonic dextrose prolotherapy. The expressions of inflammation-related factors were measured using a novel cytokine antibody array methodology. The cytokine levels were quantified by quantitative protein expression and analyzed by ELISA using the patients’ knee-joint synovial fluid. The WOMAC Index and minimum joint space width prior to receiving the intra-articular injection and at 2-week intervals were compared.RESULTS12 patients who received OA intervention were enrolled and finally a clinical evaluation of 12 knee joints and knee synovial fluid samples were analyzed. In this study, after receiving hypertonic dextrose prolotherapy, the OA patients clearly demonstrated a significant improvement in WOMAC index and increasing tendency in the medial minimum joint space width after intervention. Meanwhile, we observed a significantly associated tendency between the high-glucose treatment of knee OA and the upregulation of MMP2, TIMP-1, EGF, CXCL9 and IL-22. These findings provide knee OA patients receiving hypertonic dextrose prolotherapy, which accompanying with the improvement of knee pain, stiffness, and function and increasing tendency in the medial minimum joint space width.

scholarly journals A novel method for the assessment of knee joint space width and subchondral bone micro architecture

2016 ◽  
Vol 24 ◽  
pp. S379
Author(s):  
R. Ljuhar ◽  
B. Norman ◽  
D. Ljuhar ◽  
T. Haftner ◽  
J. Hladuvka ◽  
...  
Keyword(s):  
Knee Joint ◽  
Subchondral Bone ◽  
Joint Space Width ◽  
Joint Space ◽  
Novel Method ◽  
Space Width

scholarly journals A measurement method of knee joint space width by ultrasound: a large multicenter study

2020 ◽  
Vol 10 (5) ◽  
pp. 979-987 ◽  
Author(s):  
Jiaan Zhu ◽  
Bing Li ◽  
Li Qiu ◽  
Hongmei Liu ◽  
Mi Zhang ◽  
...  
Keyword(s):  
Knee Joint ◽  
Multicenter Study ◽  
Measurement Method ◽  
Joint Space Width ◽  
Joint Space ◽  
Large Multicenter Study ◽  
Space Width

scholarly journals Association between disease progression and depression onset in persons with radiographic knee osteoarthritis

Rheumatology ◽  
2020 ◽  
Vol 59 (11) ◽  
pp. 3390-3399
Author(s):  
Alan M Rathbun ◽  
Michelle D Shardell ◽  
Alice S Ryan ◽  
Michelle S Yau ◽  
Joseph J Gallo ◽  
...  
Keyword(s):  
Disease Progression ◽  
Disease Severity ◽  
Gait Speed ◽  
Joint Space Width ◽  
Joint Space ◽  
Knee Oa ◽  
Increased Risk ◽  
Pain Subscale ◽  
Space Width

Abstract Objectives Osteoarthritis (OA) disease progression may lead to deteriorating psychosocial function, but it is unclear what aspects of disease severity are related to the onset of depression. This study assessed which components of OA disease progression cumulatively contribute to depression onset in persons with radiographic knee OA. Methods Osteoarthritis Initiative participants (n = 1651) with radiographic disease (Kellgren-Lawrence grade ≥2) in one or both knees and below the screening threshold for probable depression [Center for Epidemiological Studies Depression (CES-D) scale <16] at baseline were included. Disease severity was measured from baseline to the third annual follow-up visit using joint space width, 20-meter gait speed, and the Western Ontario and McMaster Universities Osteoarthritis Index pain subscale, each categorized into quintiles. Depression onset (CES-D ≥ 16) was assessed annually at four follow-up visits. Marginal structural models that account for time-dependent confounding and attrition evaluated the association between each time-varying disease severity measure and depression onset. Results Each disease severity measure exhibited a non-linear relationship concerning the probability of depression onset, with the higher quintiles generally being associated with a larger risk. The highest quintile (relative to the lowest) of joint space width and gait speed were both significantly associated with depression onset. By contrast, none of the higher pain quintiles compared with the lowest were significantly associated with the onset of depression. Conclusion Faster disease progression as measured by either worsening structural severity or decreasing physical performance corresponds to an increased risk of depression among individuals with radiographic knee OA.

Semiautomated digital analysis of knee joint space width using MR images

2007 ◽  
Vol 36 (5) ◽  
pp. 437-444 ◽  
Author(s):  
Filippo Agnesi ◽  
Kimberly K. Amrami ◽  
Carlo A. Frigo ◽  
Kenton R. Kaufman
Keyword(s):  
Knee Joint ◽  
Joint Space Width ◽  
Joint Space ◽  
Digital Analysis ◽  
Mr Images ◽  
Space Width

A novel method for the assessment of knee joint space width and subchondral bone micro architecture

2016 ◽  
Vol 32 (2) ◽  
pp. 210-211
Author(s):  
R. Ljuhar ◽  
B. Norman ◽  
T. Haftner ◽  
J. Hladuvka ◽  
A. Rodrigues ◽  
...  
Keyword(s):  
Knee Joint ◽  
Subchondral Bone ◽  
Joint Space Width ◽  
Joint Space ◽  
Novel Method ◽  
Space Width

scholarly journals Changes in Knee Joint Space Width in Treatment with a New Hyaluronic-Based Hydrogel

2017 ◽  
Vol 63 (3) ◽  
pp. 125-128
Author(s):  
Octav Marius Russu ◽  
Andrei Marian Feier ◽  
Tudor Sorin Pop ◽  
Marcela Todoran ◽  
István Gergely
Keyword(s):  
Hyaluronic Acid ◽  
Knee Joint ◽  
Knee Osteoarthritis ◽  
Joint Space Narrowing ◽  
Joint Space Width ◽  
Joint Space ◽  
One Year ◽  
A Minor ◽  
Space Width

AbstractObjective: Our purpose was to assess the effect of a new hyaluronic acid-based (Hymovis®) injections on joint space width narrowing in patients diagnosed with knee osteoarthritis.Methods: A prospective clinical trial was conducted in the Department of Orthopedics and Traumatology II from the Clinical County Hospital, Tîrgu Mureș, Romania. Thirty-five patients diagnosed with idiopathic knee osteoarthritis received two intraarticular injections with hyaluronic acid-based hydrogel (24 mg of hyaluronic acid/3 ml) at one-week interval. Anteroposterior radiographs were obtained before the injections, at six and twelve months after. Minimum joint space width was measured by two senior orthopaedics surgeons at each follow up. Each radiograph was measured again by the same evaluators two weeks apart.Results: Thirty-one patients were present at the final follow-up. A minor reduction in mean weight was noticed (from 82.2 kg ± 16.2 kg to 80.9 kg ± 16.0, p > 0.398) without any correlation with joint space width narrowing. There were no major changes at the first follow up (6 months) regarding joint space narrowing. A reduction in joint space width was observed however at 12 months varying from 4.4 mm (SD ± 1.64, range 1.8-7.1) at the first assessment to 4.3 mm (SD ± 1.26, range 0.0-6.8) at the final follow-up but with no statistical difference (p=0.237).Conclusion: No significant modification in joint space width at the final follow-up secondarily proved that two injections of Hymovis® may slow down narrowing in the knee joint space over a one-year period.

scholarly journals KNEE JOINT SPACE WIDTH MEASUREMENT: AN EXPERIMENTAL STUDY OF THE INFLUENCE OF RADIOGRAPHIC PROCEDURE AND JOINT POSITIONING

Rheumatology ◽  
1996 ◽  
Vol 35 (8) ◽  
pp. 761-766 ◽  
Author(s):  
P. RAVAUD ◽  
G.-R. AULELEY ◽  
C. CHASTANG ◽  
B. ROUSSELIN ◽  
L. PAOLOZZI ◽  
...  
Keyword(s):  
Experimental Study ◽  
Knee Joint ◽  
Joint Space Width ◽  
Joint Space ◽  
Width Measurement ◽  
Space Width
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