scholarly journals Influenza causes alterations to oligodendrocyte-specific transcripts and the myelin lipidome in the adult mouse central nervous system.

Author(s):  
Allison Louie ◽  
Justin Kim ◽  
Katiria Soto-Diaz ◽  
Payam Dibaeinia ◽  
Hisami Koito ◽  
...  

Abstract The notion that myelin remains static during adulthood has been challenged in recent years. Myelin is not only crucial for proper cognitive function and behavior, but it is vulnerable to alterations from external factors outside the window of development. Here, in the adult mouse CNS, RNA analysis revealed global downregulation and subsequent recovery of oligodendrocyte-specific transcripts in response to peripheral influenza viral infection. Furthermore, shot-gun lipidomic analysis revealed that infection alters the lipid profile in the prefrontal cortex as well as in purified brain myelin. Finally, treatment with the colony stimulating factor receptor (CSFR)1 antagonist GW2580 during infection suppressed glial activation and partially restored oligodendrocyte-specific myelin transcripts to baseline levels. Together, these findings reveal a yet unforeseen consequence of peripheral infection on oligodendrocyte homeostasis in the adult mouse.

MBIA ◽  
2019 ◽  
Vol 17 (2) ◽  
pp. 23-32
Author(s):  
Deddy Hendarwan

Attitudes and behaviors are the unity of a person's character which is formed by habit everyday. Entrepreneurial behavior is influenced by internal and external factors. These factors are ownership rights (property right, PR), abilities / competencies (competency / ability,), and incentives while external factors include the environment thus Attitudes and behavior can be changed by oneself and / or there are environmental pressures / influences. there is an influence from within themselves and from outside the environment to associate then grow indi attitudes and specific behaviors. It is necessary to anticipate small businesses’ difficulties by conducting an empirical study  on  the  entrepreneurial  spirit,  entrepreneurial  values,  and  assessment  of entrepreneurial behavior that may affect the realization of independence efforts. This study  aims to  analyze the  influence of  entrepreneurial spirit  and entrepreneurial values on entrepreneurial behavior to create business independence. The findings show that the entrepreneurial spirit has a direct positive influence on entrepreneurial behavior and positive indirect effect on the business independence.


2017 ◽  
Vol 61 (3-4-5) ◽  
pp. 257-265 ◽  
Author(s):  
Sophie Khazanov ◽  
Yael Paz ◽  
Amit Hefetz ◽  
Ben J. Gonzales ◽  
Yaara Netser ◽  
...  

Author(s):  
Олег Лемешев

Целью данной статьи является анализ изучения понятия «совесть» в оккультной концепции «Четвёртого пути». В качестве исследовательской задачи автор совершил попытку оценить ложные взгляды данной доктрины, а также охарактеризовать их с нейтральной стороны и дать им критическую оценку с точки зрения православного богословия. Кроме того, выделяются и описываются особенности оккультного учения, в которых лжеучителя пытаются перекинуть личную ответственность за свои грехи на абсолютно внешние факторы, не имеющие никакого отношения к жизни и поведению человека. Разоблачены действия оккультистов, которые благодаря подменам понятий пытаются абстрагировать христианскую мысль и, оперируя своим ложным учением, пытаются внести в православную терминологию ложные понятия. В работе наглядно показано, что учение данной доктрины приводит не к совести, а к экстазу. Автор приходит к выводу, что учение «Четвёртого пути» о «совести» не имеет никакого отношения к христианской совести, и вместо того, чтобы созидать личность, наоборот, личность у них разрушается и полностью пропадает. Данная проблема мало изучена и требует дальнейших исследований. The goal of this article is to explore into the idea of “conscience” in the occult concept of the Fourth Way movement. As a research task, the author attempted to check the misleading creed of movement as well as to characterize them from the neutral side and give them a critical assessment from the point of view of the Orthodox theology. In addition, the author are highlights the means, by which the movement leaders seek to transfer personal responsibility for one’s sins to external factors that are not related to human life and behavior. The author explains the movement’s activities, which involve substitution of concepts as they seek to abstract Christian thought and to introduce false ideas into the Orthodox Christian terminology. The author argues that teaching of this doctrine leads not to conscience but to an ecstasy. The author concludes that the teachings of the Fourth Way on “conscience” have nothing to do with the Christian conscience as it they harm and deconstruct personhood instead of affirming it. According to the author, the issue has not been studied enough so far and requires further research.


2013 ◽  
Vol 61 (10) ◽  
pp. 731-748 ◽  
Author(s):  
Natanael Zarco ◽  
Elizabeth Bautista ◽  
Manola Cuéllar ◽  
Paula Vergara ◽  
Paola Flores-Rodriguez ◽  
...  

2010 ◽  
Author(s):  
Nunes T. Ana ◽  
Ruolan Han ◽  
Kelcie Sprentall ◽  
Ornella Santoni ◽  
Mark Noble

RNA ◽  
2008 ◽  
Vol 14 (3) ◽  
pp. 432-444 ◽  
Author(s):  
M. Bak ◽  
A. Silahtaroglu ◽  
M. Moller ◽  
M. Christensen ◽  
M. F. Rath ◽  
...  

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e75720 ◽  
Author(s):  
Katarina Vajn ◽  
Barbara Viljetić ◽  
Ivan Večeslav Degmečić ◽  
Ronald L. Schnaar ◽  
Marija Heffer

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