Extremophilic Fungi from Marine Environments: Underexplored Sources of Antitumor, Anti-Infective and Other Biologically Active Agents

Marine environments are underexplored terrains containing fungi that produce a diversity of natural products given unique environmental pressures and nutrients. While bacteria are commonly the most studied microorganism for natural products in the marine world, marine fungi are also abundant but remain an untapped source of bioactive metabolites. Given that their terrestrial counterparts have been a source of many blockbuster antitumor agents and anti-infectives, including camptothecin, the penicillins, and cyclosporin A, marine fungi also have the potential to produce new chemical scaffolds as leads to potential drugs. Fungi are more phylogenetically diverse than bacteria and have larger genomes that contain many silent biosynthetic gene clusters involved in making bioactive compounds. However, less than 5% of all known fungi have been cultivated under standard laboratory conditions. While the number of reported natural products from marine fungi is steadily increasing, their number is still significantly lower compared to those reported from their bacterial counterparts. Herein, we discuss many varied cytotoxic and anti-infective fungal metabolites isolated from extreme marine environments, including symbiotic associations as well as extreme pressures, temperatures, salinity, and light. We also discuss cultivation strategies that can be used to produce new bioactive metabolites or increase their production. This review presents a large number of reported structures though, at times, only a few of a large number of related structures are shown.

Trade-Offs Between Hepatic Host Defense and Metabolic Programs Underlie Sex-Biased Diseases

Current concepts in evolutionary medicine propose that trade-offs and mismatches with a shifting environment increase disease risk. While biological sex also impacts disease prevalence, contributions of environmental pressures to sex-biased diseases remain unexplored. Here, we show that sex-dependent hepatic programs confer a robust (~300%) survival advantage for male mice during lethal bacterial infection. The transcription factor BCL6, which masculinizes hepatic gene expression at puberty, is essential for this advantage. However, protection by BCL6 comes at a cost following dietary excess, resulting in overt fatty liver and glucose intolerance in males. Deleting hepatic BCL6 reverses these phenotypes but markedly lowers male fitness during infection, thus establishing a sex-dependent tradeoff between host defense and metabolic systems. We suggest that these tradeoffs, coupled with current environmental pressures, drive metabolic disease in males.

The role of fine management techniques in association between agricultural pollution and farmer income: The case of fruit industry

Abstract text is required. Whilst the agriculture enjoys booming development, it is facing increasingly serious environmental pressures. With the growth of fruit planting scale, the inorganic minerals elements are one of the main sources of non-point pollution. How to achieve the sustainable production of agriculture is an issue that needs urgent attention in the current rural development. In this paper, based on the micro-production data of peach farmers in eighteen prefecture-level provinces, we introduce fine management techniques into the production function to analyze the effects of different techniques and further explore the influence of fine management techniques on the fertilizer efficiency. Findings show that with no changes in the degree of fine management techniques investment, the increase of chemical fertilizers and pesticides not only made little contribution to increase in profit, but also resulted in excessive investment of fertilizers that worsens the environment. Notably, the fine management techniques exerting positive effects on the application efficiency of minerals elements could be an efficient and sustainable way to ease the conflict between environment and profit. However, those techniques are rarely used in practices due to the lack of economic incentives. A brief review of main measures, such as market information timely-updating，agricultural product branding, and socialized services, is offered.

Nhà trọ, rental rooms for fragments of life. Temporary footprint of rural migrants in Ho Chi Minh city

In Ho Chi Minh City, private complexes of rental rooms designated in Vietnamese asnhtrọform one of the cheapest housing stocks, targeting the working-class, including internal rural migrants. This article combines the insights of both migration and urban studies to analyze the occupation of thenhtrọthrough the concept of temporariness. It addresses the tensions between present constraints and long-term plans of rural migrants as well as their translation into the occupation of the urban space. The method draws upon observations of rental housing and interviews conducted in two suburban neighborhoods of HoChiMinhCity in 2020 and 2021, with migrants coming from deltaic and coastal rural areas of Vietnam. It is found that thenh trọprovide housing for rural migrants who are in a long-term temporary situation, within a tight urban fabric with scarce opportunities for access to urban land ownership. Informants have moved to the city up to thirty years ago. Both the move and the duration are explained by multiple factors, from economic and social mutations to environmental pressures on the deltas and the coast. Relative job stability and trust-based interpersonal relationships in the city may strengthen over time, encouraging migrants to stay. Nevertheless, no matter how long they remain in Ho Chi Minh City, many migrants perceive their stay as temporary before a projected return to the hometown, where their permanent residence registration remains. The occupation of thenhtrọobserved, their adaptations, and the narratives of migrants reveal the relative nature of temporariness in migration and draw the contours of the spatial footprint of low-skilled rural migrants in Ho Chi Minh City.

Team Learning and the Human Resource Development/Human Resource Management Interface

This editorial reviews my work on team learning published in HRDR, celebrating the 20th anniversary of the journal. The articles conceptualized the value and need for member expansiveness; team’s and individual members’ readiness to change; and the effects of environmental pressures for adaptive, generative, and transformative team learning. I conclude this review with directions for future research and practice in HRD and HRM to support changing conditions, collective self-awareness, and variations in team interactions using advancing technologies.

Pengaruh Tekanan Lingkungan, Tekanan Pemegang Saham, dan Ukuran Perusahaan terhadap Kualitas Sustainability Reporting

Company to have good environmental and social performance, besides its financial performance. Stakeholders demand this information in a report called sustainability reporting. The size of a company is directly proportional to the public attention received, so that large companies are more receptive to get negative views. To answer this view, the company will increase the transparency of its information, including sustainability reporting. This study aims to determine the effect of environmental pressure, shareholder pressure, and company size on the quality of sustainability reporting. This research was conducted on 22 companies that participated in ASRRAT in the period 2018-2020 which were selected using purposive sampling. This study uses a panel data logistic regression model. The results show that environmental pressures and company size have a positive influence on the quality of sustainability reporting. Meanwhile, shareholder pressure shows a negative effect on the quality of sustainability reporting. Keywords : Quality of Sustainability Reporting, Environmental Pressure, Shareholder Pressure, Company Size, Asian Sustainability Reporting Rating.

The Eclectic Nature of Glioma-Infiltrating Macrophages and Microglia

Glioblastomas (GBMs) are complex ecosystems composed of highly multifaceted tumor and myeloid cells capable of responding to different environmental pressures, including therapies. Recent studies have uncovered the diverse phenotypical identities of brain-populating myeloid cells. Differences in the immune proportions and phenotypes within tumors seem to be dictated by molecular features of glioma cells. Furthermore, increasing evidence underscores the significance of interactions between myeloid cells and glioma cells that allow them to evolve in a synergistic fashion to sustain tumor growth. In this review, we revisit the current understanding of glioma-infiltrating myeloid cells and their dialogue with tumor cells in consideration of their increasing recognition in response and resistance to immunotherapies as well as the immune impact of the current chemoradiotherapy used to treat gliomas.

Growth Parameters of Sentani Gudgeon Fish (Oxyeleotris heterodon) in Sentani Lake, Papua

ABSTRACTThe Sentani Gudgeon Fish (Oxyeleotris heterodon, Weber 1907) from the family Butidae with the general name Sentani Gudgeon is known locally as Gabus Malas and Himen. Sentani Snakehead Fish is one source of animal protein that is very important for the community around Lake Sentani. The population of the Sentani Gudgeon Fish species is at a crucial level. The issue could be affected by environmental pressures, continuous catches, competition with introduced species from outside Papua, intensive predation systems, and imbalances in ecological systems. The condition made a decline in population size until it became extinct. Gudgeon Sentani fish is the main target of catching in the lake. This condition significantly affects stock, size when first captured, population decline, reproductive cycle, and average catch. Until now, data and information on the growth of snakehead fish as the basis for fisheries management in the waters of Lake Sentani are not widely known. Considering the importance of preserving the native species of Lake Sentani, especially the Snakehead Fish, efforts to manage the fisheries in Lake Sentani's waters are urgent. This research was conducted in March - October 2020, located at Lake Sentani. The specimens were obtained from the catch of fishers with various gill nets and chopsticks. Enumerators or field assistants assisted the recording of the number and measurement of the total length of fish caught by fishermen daily. The results of the analysis showed: asymptotic size (L?) 46.20 cm, growth coefficient (K) 0.29, the total mortality rate (Z) 0.80 per year, natural mortality (M) 0.74 per year, the mortality rate due to fishing (F) 0.06 per year and exploitation rate (E) 0.075 per year.

Unraveling Admixture, Inbreeding, and Recent Selection Signatures in West African Indigenous Cattle Populations in Benin

The Dwarf Lagune and the Savannah Somba cattle in Benin are typical representatives of the endangered West African indigenous Shorthorn taurine. The Lagune was previously exported to African and European countries and bred as Dahomey cattle, whereas the Somba contributed to the formation of two indigenous hybrids known as Borgou and Pabli cattle. These breeds are affected by demographic, economic, and environmental pressures in local production systems. Considering current and historical genomic data, we applied a formal test of admixture, estimated admixture proportions, and computed genomic inbreeding coefficients to characterize the five breeds. Subsequently, we unraveled the most recent selection signatures using the cross-population extended haplotype homozygosity approach, based on the current and historical genotypes. Results from principal component analyses and high proportion of Lagune ancestry confirm the Lagune origin of the European Dahomey cattle. Moreover, the Dahomey cattle displayed neither indicine nor European taurine (EUT) background, but they shared on average 40% of autozygosity from common ancestors, dated approximately eight generations ago. The Lagune cattle presented inbreeding coefficients larger than 0.13; however, the Somba and the hybrids (Borgou and Pabli) were less inbred (≤0.08). We detected evidence of admixture in the Somba and Lagune cattle, but they exhibited a similar African taurine (AFT) ancestral proportion (≥96%) to historical populations, respectively. A moderate and stable AFT ancestral proportion (62%) was also inferred for less admixed hybrid cattle including the Pabli. In contrast, the current Borgou samples displayed a lower AFT ancestral proportion (47%) than historical samples (63%). Irrespective of the admixture proportions, the hybrid populations displayed more selection signatures related to economic traits (reproduction, growth, and milk) than the taurine. In contrast, the taurine, especially the Somba, presented several regions known to be associated with adaptive traits (immunity and feed efficiency). The identified subregion of bovine leukocyte antigen (BoLA) class IIb (including DSB and BOLA-DYA) in Somba cattle is interestingly uncommon in other African breeds, suggesting further investigations to understand its association with specific adaptation to endemic diseases in Benin. Overall, our study provides deeper insights into recent evolutionary processes in the Beninese indigenous cattle and their aptitude for conservation and genetic improvement.