The effect of electroacupuncture on hemodialysis patients with restless legs syndrome (RLS): study protocol for a randomized crossover trial

Abstract Background The aim of the present study was to evaluate the effects of electroacupuncture (EA) in hemodialysis patients with restless leg syndrome (RLS) by heart rate variability (HRV) monitor. Methods112 subjects who were hemodialysis patients with RLS will be divided into 2 groups: experimental and control. Each subject will receive the treatment relevant to their group 2 times a week for 4 weeks. After 4 weeks of treatment the subject will enter a 2-week washout period, after which the subjects will switch groups. Measurements will include HRV recordings, International Restless Legs Syndrome Rating Scale (IRLSRS) and Insomnia Severity Index (ISI). DiscussionThis study is the first investigation to analyze the relationship between EA and the change of HRV by an objective monitor. If the findings of the current trial are positive, this study will also help support an effective, safe and cheap approach to clinical treatment of this challenging disorder, help foster improved understanding the relationship between RLS and HRV, and ultimately contribute to elucidate the mechanisms of EA. Trial registrationClinicalTrials.gov Identifier: NCT04356794; registration date: April 22, 2020.

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The Relationship between Serum Ferritin Levels and 5-Year All-Cause Mortality in Hemodialysis Patients

Blood Purification ◽

10.1159/000515639 ◽

2021 ◽

pp. 1-7

Author(s):

Emre Erdem ◽

Ahmet Karatas ◽

Tevfik Ecder

Keyword(s):

Serum Ferritin ◽

Hemodialysis Patients ◽

Rank Test ◽

Significant Difference ◽

All Cause Mortality ◽

Group 3 ◽

Group 2 ◽

The Relationship ◽

Group 1

Introduction: The effect of high serum ferritin levels on long-term mortality in hemodialysis patients is unknown. The relationship between serum ferritin levels and 5-year all-cause mortality in hemodialysis patients was investigated in this study. Methods: A total of 173 prevalent hemodialysis patients were included in this study. The patients were followed for up to 5 years and divided into 3 groups according to time-averaged serum ferritin levels (group 1: serum ferritin <800 ng/mL, group 2: serum ferritin 800–1,500 ng/mL, and group 3: serum ferritin >1,500 ng/mL). Along with the serum ferritin levels, other clinical and laboratory variables that may affect mortality were also included in the Cox proportional-hazards regression analysis. Results: Eighty-one (47%) patients died during the 5-year follow-up period. The median follow-up time was 38 (17.5–60) months. The 5-year survival rates of groups 1, 2, and 3 were 44, 64, and 27%, respectively. In group 3, the survival was lower than in groups 1 and 2 (log-rank test, p = 0.002). In group 1, the mortality was significantly lower than in group 3 (HR [95% CI]: 0.16 [0.05–0.49]; p = 0.001). In group 2, the mortality was also lower than in group 3 (HR [95% CI]: 0.32 [0.12–0.88]; p = 0.026). No significant difference in mortality between groups 1 and 2 was found (HR [95% CI]: 0.49 [0.23–1.04]; p = 0.063). Conclusion: Time-averaged serum ferritin levels >1,500 ng/mL in hemodialysis patients are associated with an increased 5-year all-cause mortality risk.

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Acupressure reduce the severity of restless legs syndrome in hemodialysis patients: A cluster-randomized crossover pilot study

Biomedical Journal ◽

10.1016/j.bj.2021.05.005 ◽

2021 ◽

Author(s):

Li-Hung Tsai ◽

Chuan-Mei Chen ◽

Li-Mei Lin ◽

Ching-Ching Tsai ◽

Yi Han ◽

...

Keyword(s):

Pilot Study ◽

Restless Legs Syndrome ◽

Hemodialysis Patients ◽

Restless Legs ◽

Cluster Randomized

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The Relationship between Restless Legs Syndrome and Quality of Life in Patients with Myasthenia Gravis

European Neurology ◽

10.1159/000502002 ◽

2019 ◽

Vol 81 (3-4) ◽

pp. 205-208

Author(s):

Monica F. Ataide ◽

Carolina da Cunha-Correia ◽

Katia C.L. Petribú

Keyword(s):

Quality Of Life ◽

Myasthenia Gravis ◽

Restless Legs Syndrome ◽

Rating Scale ◽

Cross Sectional Study ◽

Cross Sectional ◽

Restless Legs ◽

Study Population ◽

Clinical Conditions

Background: Restless legs syndrome (RLS) is characterized for an uncomfortable sensation in legs and an irresistible desire to move them. This disorder has been more recently recognized in patients with myasthenia gravis (MG) and can interfere with the quality of life (QOL). Objectives: The aims of this study are to describe the prevalence of RLS and its severity and influence on the QOL in patients with MG. Method: This was a cross-sectional study conducted from May to June 2016 in Recife, Brazil. A sample of 42 patients was interviewed using a sociodemographic questionnaire, MG QOL questionnaire-15 and The RLS Rating Scale. Results: RLS was present in 47.6% of patients and of these 40.5% met moderate to severe RLS criteria. Patients were 45 years on average (SD ± 14.4) and women represented 57.1% of the study population. Among patients with RSL, the quality-of-life scores were worse (p = 0.010) on average. There was no association of RLS with the duration of MG, use of immunosuppressant or clinical conditions that could mimic the occurrence of RLS. Conclusion: RLS is a prevalent condition in patients with MG, and may be severe enough to negatively impact QOL.

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The Safety and Efficacy of Pregabalin Add-on Therapy in Restless Legs Syndrome Patients

Frontiers in Neurology ◽

10.3389/fneur.2021.786408 ◽

2021 ◽

Vol 12 ◽

Author(s):

Hyoeun Bae ◽

Yong Won Cho ◽

Keun Tae Kim ◽

Richard P. Allen ◽

Christopher J. Earley

Keyword(s):

Side Effects ◽

Restless Legs Syndrome ◽

Severity Index ◽

Efficacy And Safety ◽

Restless Legs ◽

Persistent Symptoms ◽

Before And After ◽

Severity Index Score ◽

Irls Score ◽

Symptomatic Control

Pregabalin is increasingly being used as a first-line treatment for symptomatic control of restless legs syndrome (RLS). This study aimed to evaluate the efficacy and safety of pregabalin as add-on therapy in RLS patients already taking dopamine agonists (DA) but still in need of further management. Patients with idiopathic RLS were enrolled, and all had already been prescribed DA for at least 3 months but still had either persistent symptoms, side effects, or comorbid insomnia. An initial dose of 75 mg pregabalin was begun, adjusted as needed, and maintained at a stable dose for 4 weeks, followed by observation for a total of 8 weeks. RLS symptoms and insomnia scores were evaluated before and after add-on pregabalin treatment. Patients were monitored for side effects that could be attributed to pregabalin. A total of 32 RLS patients were enrolled, and 20 subjects remained until the endpoint. After the pregabalin add-on, the mean IRLS score showed significant improvement compared to the baseline (p < 0.001). The insomnia severity index score also improved (p = 0.036), and no serious adverse effects were observed. Our preliminary data suggests the potential for pregabalin as an add-on therapy to DA with regards to both efficacy and safety in patients who have inadequate RLS improvement.

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Objective psychology. Academician V. Bekhterev. Issue I. St. Petersburg. 1907 year

Neurology Bulletin ◽

10.17816/nb95873 ◽

1907 ◽

Vol XIV (3-4) ◽

pp. 194-196

Author(s):

V. Osipova

Keyword(s):

Mental Life ◽

Subjective Experiences ◽

The Subject ◽

And Control ◽

Relationship Of ◽

The Relationship ◽

Living Creature

The author begins his work with the words that the psychology that he will expound bears little resemblance to the psychology that has been the subject of study until now. In objective psychology, there should be no place for questions about subjective processes or processes of consciousness, therefore there should be no place for introspection. Self-observation is not enough even to study one's own mental life. Objective psychology has in mind to study and explain only the relationship of a living creature to the surrounding conditions that affect it in one way or another, without aiming to find out those internal or subjective experiences, which are known as conscious phenomena and which are accessible only to self-observation. All mental items should only be subject to objective registration and control.

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