scholarly journals Synergistic effect of Vitamin D Supplement and mindfulness on insulin resistance and different aspects of cognitive function in Vitamin D Deficient Type 2 Diabetic mellitus (T2DM) women: A pilot randomized clinical trial with placebo-controlled

2020 ◽  
Author(s):  
mohammadreza davoudi ◽  
Parnian Rezaei ◽  
Seyyed Mojtaba Ahmadi ◽  
Amir Abbas Taheri
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Cognitive Function ◽  
Synergistic Effect ◽  
Synergistic Effects ◽  
Controlled Trial ◽  
Oral Dosage ◽  
Significant Difference ◽  
Type 2 Diabetic

Abstract Purpose This study aimed to examining Synergistic effect of Vitamin D (VD) Supplement and mindfulness on insulin resistance and different aspects of cognitive function in VD Deficient Type 2 Diabetic women. Methods In this randomized-controlled trial, totally 225 women with T2DM and VD deficiency were randomly allocated to five groups: (1) mindfulness, (2) mindfulness and VD, (3) mindfulness and placebo, (4) VD, and (5) placebo. Mindfulness includes 12 sessions and VD patients received a daily 4000 IU oral dosage (two capsules) with 28,000 IU vitamin D weekly for 12 weeks. Sun exposure, anthropometric indices, dietary intake, physical activity, energy levels, laboratory analyses, were measured at the pre-test and after 12-week supplementation. dependent variables include cognitive function (Risky decision making, IQ and Trail Making Test) and insulin resistance. Results In baseline, measures were not different among the groups. At the end of treatment, cognitive function results showed improvement for all groups except the “placebo” group. About other groups, there was not any difference between VD and mindfulness groups (or combinations with placebo). but in “VITAMIN + MINDFULNESS” has a greater improvement rather than other groups (P < 0.05). This result exactly repeated for insulin resistance. However, there were not any significant difference among groups for IQ(P > 0.05). There was any difference among groups for sunlight exposure and BMI (P > 0.05). For FBS only in combined group (VD + Mindfulness) the FBS significantly reduced that is synergistic effects (P < 0.05). Conclusion Combining VD Supplement and mindfulness can reduce insulin resistance and improve different aspects of cognitive function in VD Deficient patients.

The synergistic effect of vitamin D supplement and mindfulness on insulin resistance and different aspects of cognitive function in vitamin D deficient type 2 diabetic mellitus women: A pilot randomized clinical trial with placebo-controlled

2021 ◽  
Author(s):  
mohammadreza davoudi ◽  
Parnian Rezaie ◽  
Seyed Mojtaba Ahmadi ◽  
Farhang Djafari ◽  
zeinab khosrojerdi
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Cognitive Function ◽  
Synergistic Effect ◽  
Controlled Trial ◽  
Oral Dosage ◽  
Risky Decision ◽  
Significant Difference ◽  
Type 2 Diabetic

Abstract Purpose This study aimed to examine the synergistic effect of Vitamin D (VD) supplement and mindfulness on insulin resistance and different aspects of cognitive function in VD deficient type 2 diabetic women. Methods In this randomized-controlled trial, totally 225 women with type 2 diabetes mellitus (T2DM) and VD deficiency were randomly allocated to five groups: (1) mindfulness, (2) mindfulness and VD, (3) mindfulness and placebo, (4) VD, and (5) placebo. Mindfulness includes 12 sessions and VD patients received a daily 4000 IU oral dosage (two capsules) with 28,000 IU vitamin D weekly for 12 weeks. Sun exposure, anthropometric indices, dietary intake, physical activity, energy levels, and laboratory analyses were measured at the pre-test and after 12-week supplementation. Dependent variables include cognitive function (Risky decision making, IQ and Trail Making Test) and insulin resistance. Results In baseline, measures were not different among the groups. At the end of the treatment, cognitive function results showed improvement for all groups except the “placebo” group. About other groups, there was not any differences between VD and mindfulness groups (or combinations with placebo). However, in “VITAMIN + MINDFULNESS” group, a greater improvement compared to other groups was observed (P < 0.05). This result exactly repeated for insulin resistance. Furthermore, there were not any significant difference among groups for IQ (as one aspect of cognitive function) (P > 0.05). Moreover, there was not any differences among groups for sunlight exposure and BMI (P > 0.05). Only in combined group (VD + Mindfulness) the fasting blood sugar (FBS) significantly reduced that shows the synergistic effect of VD supplementation and Mindfulness (P < 0.05). Conclusion Combining VD Supplementation and mindfulness can reduce insulin resistance and improve different aspects of cognitive function in VD Deficient patients.

scholarly journals The effects of vitamin D supplementation on adiponectin level and insulin resistance in first-degree relatives of subjects with type 2 diabetes: a randomized double-blinded controlled trial

10.19082/2849 ◽  
2016 ◽  
Vol 8 (9) ◽  
pp. 2849-2854 ◽  
Author(s):  
Seyed Mohammad Mohammadi ◽  
Seyed Ahmad Eghbali ◽  
Sedighah Soheilikhah ◽  
Saeedeh Jam Ashkezari ◽  
Maryam Salami ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Adiponectin Level ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
First Degree Relatives ◽  
Double Blinded

scholarly journals Analysis of the Associations between Vitamin D and Albuminuria orβ-Cell Function in Chinese Type 2 Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Xiaoling Cai ◽  
Zhaoheng Hu ◽  
Ling Chen ◽  
Xueyao Han ◽  
Linong Ji
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Cell Function ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Albumin Creatinine Ratio ◽  
Urine Albumin ◽  
Vitamin D Supplement ◽  
Type 2 Diabetic

Objective. To investigate the associations of 25-(OH)D andβ-cell function or insulin resistance or albuminuria in Chinese type 2 diabetic patients.Methods. In total, 1408 type 2 diabetic patients without vitamin D supplement were included in this retrospective study.Results. Comparison between patients with and without 25-(OH)D deficiency indicated that, compared with patients with 25-(OH)D ≥ 50 nmol/L, patients with 25-(OH)D < 50 nmol/L showed a higher level of urine albumin-creatinine ratio (ACR) (90.15±10.30 mg/g versus52.79±14.97 mg/g). Multiple regression analysis indicated that 25-(OH)D was independently and negatively correlated with urine ACR (OR=0.985, 95%CI 0.972–0.999,P=0.03), adjusted by age, diabetic duration, HBP duration, SBP, HbA1c, creatinine, LDL-C, triglyceride, total cholesterol, and HDL-C. Compared with patients with normal level of urine ACR, patients with higher level of urine ACR showed a significant lower level of 25-(OH)D (34.49±13.52 nmol/L versus37.46±13.6 nmol/L,P=0.00). Analysis of the associations of 25-(OH)D andβ-cell function or insulin resistance showed that 25-(OH)D may not correlate withβ-cell function or insulin resistance.Conclusion. 25-(OH)D was independently associated with albuminuria in Chinese type 2 diabetic patients but was not associated withβ-cell function or insulin resistance.

scholarly journals Assessment of vitamin D status and its association with insulin resistance among type 2 diabetic subjects

2018 ◽  
Vol 6 (12) ◽  
pp. 3825
Author(s):  
Jaitra Bhattacharya
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Vitamin D Levels ◽  
Type 2 Diabetic

Background: The 21st century has seen the rise of diabetes mellitus as one of the major metabolic issues as is vitamin D deficiency which has been found to be pandemic worldwide. The present study is an endeavor to study the status of serum vitamin D levels in relation to the glycemic and insulin resistance status in type 2 diabetes mellitus patients.Methods: The present is a cross-sectional study with a sample size of 100 type 2 diabetic subjects in the age group of 30-60 years. Serum vitamin D and Insulin levels were estimated using the ELISA technique. HbA1c levels were measured using immunoturbidimetric assays and plasma glucose levels were determined using glucose oxidase- peroxidase method.Results: The fasting plasma glucose, HbA1c and serum insulin levels were found to be significantly higher in those with vitamin D levels below the normal cut-off value of less than 30ng/ml (p value <0.01). Also, the insulin resistance calculated using HOMA-IR was found to be higher in those subjects having vitamin D deficiency or insufficiency.Conclusions: Hence, the study suggests that vitamin D deficiency contributes to further insulin resistance and poorer long-term diabetic control in type 2 diabetes mellitus subjects.

Synergistic actions of vitamin D and metformin on skeletal muscles and insulin resistance of type 2 diabetic rats

2018 ◽  
Vol 233 (8) ◽  
pp. 5768-5779 ◽  
Author(s):  
Shaimaa N. Amin ◽  
Usama K. Hussein ◽  
Hanan D. Yassa ◽  
Sherif S. Hassan ◽  
Laila A. Rashed
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Skeletal Muscles ◽  
Diabetic Rats ◽  
Type 2 Diabetic

scholarly journals Serum Vitamin D Level in Type 2 Diabetic Subjects: Relation to Glycemic Control, Insulin Resistance and Proinflammatory Markers

2017 ◽  
Vol 47 (2) ◽  
pp. 62-68
Author(s):  
Talaat Abdel Aaty ◽  
Magdy Magallaa ◽  
Hend Abdel Moneim ◽  
Hanaa Ismail ◽  
Doaa Genena ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Vitamin D ◽  
Glycemic Control ◽  
Serum Vitamin ◽  
Serum Vitamin D ◽  
Type 2 Diabetic

scholarly journals Investigation of the Cumulative Effect of Diabetes and Hypothyroidism on Serum Resistin Levels in Type 2 Diabetic Patients

2020 ◽  
Vol 18 (2) ◽  
Author(s):  
Shahnaz Tofangchiha ◽  
Atoosa Moetaghedi Larijani ◽  
Iraj Mirzaii-Dizgah ◽  
Mahdi Isazadeh ◽  
Shima Rahimi ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Pearson Correlation ◽  
Cumulative Effect ◽  
P Value ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Significant Difference ◽  
Hypothyroid Patients ◽  
Type 2 Diabetic

Background: Type 2 diabetes and thyroid disorders cause extensive changes in insulin resistance. An increase in serum resistin level is associated with insulin resistance. Objectives: The current study aimed to investigate the cumulative effect of diabetes and hypothyroidism on the serum resistin levels of type 2 diabetic patients. Methods: Participants were divided into four groups using the convenience sampling method. Each group contained 30 diabetic patients, 32 hypothyroid patients, 30 diabetics + hypothyroid patients, and 29 healthy individuals. Serum samples were taken from participants and their serum resistin levels were measured. Data were collected and analyzed using SPSS version 23. Pearson correlation test, ANOVA statistical analysis, and Tukey post hoc test were used to analyze the data. A P-value of < 0.05 was used as statistically significant. Results: Among patients with hypothyroidism, resistin, and thyroid-stimulating hormone were moderately correlated (P = 0.001, r = 0.580). ANOVA revealed a statistically significant difference between the resistin levels in the studied groups (P = 0.000, F = 6.813). Conclusions: Serum resistin levels are significantly lower in people with diabetes + hypothyroidism than in people with only one of these two conditions. Therefore, the cumulative effect of diabetes and hypothyroidism on resistin levels cannot be deduced from the findings of the present study.

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