Population Diversity of Three Variants of the SLC47A2 Gene (MATE2-K transporter) in Mexican Mestizos and Native Americans

Abstract Background. MATE2-K is an efflux transporter protein of organic cation expressed mainly in the kidney and encoded by the SLC47A2 gene. Different variants of this gene have shown an impact on the pharmacokinetics of various drugs, including metformin, which represents one of the most widely used drugs in treating type 2 diabetes. The SLC47A2 gene variants have been scarcely studied in Mexican populations, especially in Native American groups. For this reason, we analyzed the distribution of the variants rs12943590, rs35263947, and rs9900497 within the SLC47A2 gene in 173 Native Americans (Tarahumara, Huichol, Maya, Puerépecha) and 182 Mestizos (admixed) individuals from Mexico. Methods and Results . Genotypes were determined through TaqMan probes (qPCR). The Hardy-Weinberg agreement was confirmed for all three SLC47A2 gene variants in all the Mexican populations analyzed. When worldwide populations were included for comparison purposes, for alleles and genotypes, a relative interpopulation homogeneity was observed for rs35263947 (C allele; range: 48.9–76.7%) and rs9900497 (G allele; range: 59.1–81.4%). Conversely, heterogeneity was evident for rs12943590 (G allele, range 40.9–77.9%), where the most differentiated population was the Huichol, with high frequencies of the risk genotype associated with decreased response to metformin treatment (A/A= 40.9%).Conclusions. Although the SLC47A2 gene variants allow predicting favorable response to the metformin treatment in Mexican populations, the probable high frequency of ineffectiveness should be discarded in Huichols.

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Type 2 Diabetes Prevention Among Native Americans: The Eagle Adventure Program

American Journal of Health Studies ◽

10.47779/ajhs.2020.197 ◽

2020 ◽

Vol 35 (2) ◽

Author(s):

Jill Fox ◽

Teresa Jackson ◽

Sarah Miracle ◽

Ursula O’Hara ◽

Stephany Parker

Keyword(s):

Type 2 Diabetes ◽

Native American ◽

Native Americans ◽

Social Cognitive ◽

Cognitive Theory ◽

Control And Prevention ◽

Adventure Program ◽

Program Components ◽

Tribal Nation

Eagle Adventure (EA), developed in collaboration between a Tribal Nation and university partners, is based on the Eagle Books published by the Centers for Disease Control and Prevention. The books and EA are based in the tradition of Native American storytelling and cultures but speak to all children. EA reinforces making healthy choices to grow-up healthy and prevent the development of type 2 diabetes. EA uses the socioecological model as a framework for program components and social cognitive theory constructs to address behavior change. Since 2010, over 6,000 students have participated in EA in partnership with numerous tribes throughout Oklahoma.

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Population diversity of three variants of the SLC47A2 gene (MATE2-K transporter) in Mexican Mestizos and Native Americans

Molecular Biology Reports ◽

10.1007/s11033-021-06628-y ◽

2021 ◽

Author(s):

Alma Faviola Favela-Mendoza ◽

Ingrid Fricke-Galindo ◽

Wendy Fernanda Cuevas-Sánchez ◽

José Alonso Aguilar-Velázquez ◽

Gabriela Martínez-Cortés ◽

...

Keyword(s):

Native Americans ◽

Population Diversity ◽

Mexican Mestizos

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Attitudes and Beliefs concerning Organ Donation among Native Americans in the Upper Midwest

Journal of Transplant Coordination ◽

10.1177/090591999800800305 ◽

1998 ◽

Vol 8 (3) ◽

pp. 153-156 ◽

Cited By ~ 6

Author(s):

Barbara L Danielson ◽

Amy J LaPree ◽

Mark D Odland ◽

Eugenia K Steffens

Keyword(s):

Native American ◽

Native Americans ◽

Organ Donation ◽

Specific Information ◽

Attitudes And Beliefs ◽

Upper Midwest ◽

Health Fairs ◽

Willingness To Donate ◽

High Incidence

Because of increasing access to renal replacement therapy and the high incidence of renal disease among Native Americans largely due to type 2 diabetes mellitus, it is important to determine attitudes and beliefs in this population toward organ donation. In a study conducted on reservations in the upper Midwest during traditional powwows and health fairs, it was discovered that willingness to donate was more likely to occur if Native Americans were approached by a healthcare worker from their culture, if they had already signed a donor card, or if they knew someone with diabetes. Willingness to be a living donor (81%) was greater than willingness to donate after death (ie, as a cadaveric donor) (54%). These findings indicate that cultural-specific information about organ failure rates and organ donation, when presented by knowledgeable individuals within the culture, could increase donation in the Native American population.

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Prevalence of protective haplotypes of the SLCO1B1 gene for statin transport in Mexican populations

Personalized Medicine ◽

10.2217/pme-2020-0172 ◽

2021 ◽

Author(s):

Alma Faviola Favela-Mendoza ◽

Brenda Guadalupe Rodríguez-Rodríguez ◽

Eduardo Rojas-Prado ◽

Mariana Chávez-Arreguin ◽

José Alonso Aguilar-Velázquez ◽

...

Keyword(s):

Native American ◽

Normal Activity ◽

Gene Variants ◽

Cholesterol Reduction ◽

Mexican Mestizo ◽

Taqman Probes ◽

Genotype Frequencies ◽

Genetic Distribution ◽

Slco1b1 Gene ◽

Mexican Populations

Aim: To evaluate the genetic distribution of the rs4149056 and rs2306283 variants in the SLCO1B1 gene in Mexican Mestizo (admixed) and Native American groups. Materials & methods: We recruited 360 volunteers who were qPCR-genotyped with TaqMan probes. Results: Allele and genotype frequencies are reported. Among the expected rs4149056– rs2306283 haplotypes, T–A (42.35–58.47%) was the most prevalent which relates to the normal activity of the OATP1B1 transporter. This was followed by the T–G haplotype associated with further statin transport and cholesterol reduction (32.49–43.76%). Conclusion: Based on these SLCO1B1 gene variants, we confirmed that a minimum fraction of the Mexican study populations would be at risk from decreasing simvastatin transport and the development of statin-induced myopathy.

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Interethnic variability of pharmacogenetic biomarkers in Mexican healthy volunteers: a report from the RIBEF (Ibero-American Network of Pharmacogenetics and Pharmacogenomics)

Drug Metabolism and Personalized Therapy ◽

10.1515/dmpt-2015-0030 ◽

2016 ◽

Vol 31 (2) ◽

Cited By ~ 4

Author(s):

Ingrid Fricke-Galindo ◽

Helgi Jung-Cook ◽

Adrián LLerena ◽

Marisol López-López

Keyword(s):

Healthy Volunteers ◽

Literature Search ◽

Population Diversity ◽

Allele Frequencies ◽

Inclusion Criteria ◽

Metabolic Phenotypes ◽

Complex Population ◽

Mexican Mestizos ◽

Mexican Populations

AbstractMexico presents a complex population diversity integrated by Mexican indigenous (MI) (7% of Mexico’s population) and Mexican mestizos (MMs). This composition highlights the importance of pharmacogenetic studies in Mexican populations. The aims of this study were to analyze the reported frequencies of the most relevant pharmacogenetic biomarkers and metabolic phenotypes in healthy volunteers from Mexican populations and to assess its interethnic variability across MI and MM populations. After a literature search in PubMed, and according to previously defined inclusion criteria, 63 pharmacogenetic studies performed in Mexican healthy volunteers up to date were selected. These reports comprised 56,292 healthy volunteers (71.58% MM). Allele frequencies in 31 pharmacogenetic biomarkers, from 121 searched, are described. Nine of these biomarkers presented variation within MM and MI groups. The frequencies of

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Native American sports mascots activate negative stereotypes about contemporary Native Americans

PsycEXTRA Dataset ◽

10.1037/e527772014-414 ◽

2011 ◽

Author(s):

Elizabeth Focella ◽

Jessica Whitehead ◽

Jeff Stone ◽

Stephanie Fryberg ◽

Rebecca Covarrubias

Keyword(s):

Native American ◽

Native Americans ◽

Negative Stereotypes

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Native Americans and the Third World Strike at UC Berkeley

Explorations in Ethnic Studies ◽

10.1525/esr.2019.42.2.32 ◽

2019 ◽

Vol 42 (2) ◽

pp. 32-39

Author(s):

LaNada War Jack

Keyword(s):

Native American ◽

Native Americans ◽

Personal Experience ◽

Third World ◽

Leadership Roles ◽

The Third ◽

The Creation ◽

The 1960S ◽

The Third World ◽

The University

The author reflects on her personal experience as a Native American at UC Berkeley in the 1960s as well as on her activism and important leadership roles in the 1969 Third World Liberation Front student strike, which had as its goal the creation of an interdisciplinary Third World College at the university.

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Indian Genocide – A Study Through The Works of Elizabeth Cook-Lynn

SMART MOVES JOURNAL IJELLH ◽

10.24113/ijellh.v6i9.9855 ◽

2018 ◽

Vol 6 (9) ◽

pp. 5

Author(s):

Poonam Chourey

Keyword(s):

Native American ◽

Native Americans ◽

South Dakota ◽

Native People ◽

The South ◽

The People ◽

Freedom Fighters ◽

Purpose Of Business ◽

Wounded Knee ◽

Shed Light

The research expounded the turmoil, uproar, anguish, pain, and agony faced by native Indians and Native Americans in the South Dakota region. To explain the grief, pain and lamentation, this research studies the works of Elizabeth Cook-Lyn. She laments for the people who died and also survived in the Wounded Knee Massacre. The people at that time went through huge exploitation and tolerated the cruelty of American Federal government. This research brings out the unchangeable scenario of the Native Americans and Native Indians. Mr. Padmanaban shed light on the works of Elizabeth Cook-Lynn who was activist. Mr. Padmanaban is very influenced with Elizabeth Cook-Lynn’s thoughts and works. She hails from Sioux Community, a Native American. She was an outstanding and exceptional scholar. She experienced the agony and pain faced by the native people. The researcher, Mr. Padmanaban is concerned the sufferings, agony, pain faced by the South Dakota people at that time. The researcher also is acknowledging the Indian freedom fighters who got India independence after over 200 years of sufferings. The foreign nationals entered our country with the sole purpose of business. Slowly and steadily the took over the reign of the country and ruled us for years, made all of us suffer a lot.

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