Decreasing the leakage of continuous femoral nerve catheter fixation using 2-octyl cyanoacrylate glue (Demabond®): A randomized controlled trial

2021 ◽  
Author(s):  
Theerawat Chalacheewa ◽  
Vanlapa Arnuntasupakul ◽  
Lisa Sangkum ◽  
Rungrawan Buachai ◽  
Jiravud Chanvitayapongs
Keyword(s):  
Peripheral Nerve ◽  
Rating Scale ◽  
Controlled Trial ◽  
Insertion Site ◽  
Femoral Nerve ◽  
Numeric Rating Scale ◽  
Catheter Removal ◽  
Cyanoacrylate Glue ◽  
Catheter Dislodgement ◽  
Peripheral Nerve Catheter

Abstract Background: Continuous peripheral nerve catheters (CPNCs) have been used for postoperative pain relief. A common problem encountered with CPNCs is pericatheter leakage, which can lead to dressing adhesive failure. Frequent dressing changes increase the risk of catheter dislodgement and infections. Adhesive glue is effective in securing the peripheral nerve catheter and decreasing leakage around the catheter insertion site. This study aimed to evaluate the incidence of pericatheter leakage with fixation using 2-octyl cyanoacrylate glue (Dermabond®) as compared to sterile strips.Methods: Thirty patients undergoing unilateral total knee arthroplasty (TKA) with continuous femoral nerve catheter for postoperative analgesia were randomized into the catheter fixation with 2-octyl cyanoacrylate glue (Dermabond®) group or the sterile strip group. The primary outcome was the incidence of pericatheter leakage. Secondary outcomes included the frequent of catheter displacement, the difficulty of catheter removal, pain score and patient satisfaction.Results: The incidence of pericatheter leakage at 24 and 48 hours was 0% versus 93% and 0% versus 100% in the Dermabond® and sterile strip groups, respectively (P < 0.001). The incidence of displacement at 24 and 48 hours was 6.7% versus 93.3% and 6.7% versus 100% in the Dermabond® and sterile strip, respectively (P < 0.001). There was no difference in numeric rating scale, difficulty of catheter removal, or satisfaction scores between groups.Conclusion: Catheter fixation with 2-octyl cyanoacrylate glue (Dermabond®) decreased the incidence of pericatheter leakage, as well as catheter displacement, over 48 hours as compared to sterile strip fixation.

scholarly journals Decreasing the leakage of continuous femoral nerve catheter fixation using 2 - octyl cyanoacrylate glue (Demabond®): A Randomized Controlled Trial study

2020 ◽  
Author(s):  
Theerawat Chalacheewa ◽  
Vanlapa Arnuntasupakul ◽  
Lisa Sangkum ◽  
Rungrawan Buachai ◽  
jiravud Chanvitayapongs
Keyword(s):  
Peripheral Nerve ◽  
Rating Scale ◽  
Controlled Trial ◽  
Insertion Site ◽  
Femoral Nerve ◽  
Numeric Rating Scale ◽  
Catheter Removal ◽  
Cyanoacrylate Glue ◽  
Catheter Dislodgement ◽  
Peripheral Nerve Catheter

Abstract Background: Continuous peripheral nerve catheters (CPNCs) have been used for postoperative pain relief. A common problem encountered with CPNCs is pericatheter leakage which can lead to dressing adhesive failure. Frequent dressing changes increase the risk of catheter dislodgement and infections. Adhesive glue is effective in securing peripheral nerve catheter and decreasing leakage around the catheter insertion site. This study is aimed to evaluate the incidence of pericatheter leakage by using fixation with 2-octyl cyanoacrylate glue (Demabond®) compared to sterile strip.Methods: Thirty patients undergoing unilateral total knee arthroplasty (TKA) with continuous femoral nerve catheter for postoperative analgesia were randomized to catheter fixation with 2-octyl cyanoacrylate glue (Demabond®) group or sterile strip group. The primary outcome was the incidence of pericatheter leakage. Secondary outcomes included: frequent of catheter displacement, difficulty of catheter removal, pain score and patient satisfaction.Results: The incidence of pericatheter leakage at 24 and 48 hours was 0% versus 93% and 0% versus 100% in the Demabond and sterile strip group, respectively (P < 0.001). The incidence of displacement at 24 and 48 hours was 6.7% versus 93.3% and 6.7% versus 100%, respectively (P < 0.001). There was no difference in numeric rating scale, difficulty of catheter removal as well as satisfaction scores between groups.Conclusion: Catheter fixation with 2-octyl cyanoacrylate glue (Demabond®) decreased the incidence of pericatheter leakage as well as catheter displacement over 48 hours when compared to sterile strip fixation.

scholarly journals Decreasing leakage during continuous femoral nerve catheter fixation using 2-octyl cyanoacrylate glue (Dermabond®): a randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Theerawat Chalacheewa ◽  
Vanlapa Arnuntasupakul ◽  
Lisa Sangkum ◽  
Rungrawan Buachai ◽  
Jiravud Chanvitayapongs
Keyword(s):  
Peripheral Nerve ◽  
Rating Scale ◽  
Controlled Trial ◽  
Insertion Site ◽  
Femoral Nerve ◽  
Catheter Removal ◽  
Cyanoacrylate Glue ◽  
Clinical Trial Registry ◽  
Catheter Dislodgement ◽  
Peripheral Nerve Catheter

Abstract Background Continuous peripheral nerve catheters (CPNCs) have been used for postoperative pain relief. A common problem encountered with CPNCs is pericatheter leakage, which can lead to dressing adhesive failure. Frequent dressing changes increase the risk of catheter dislodgement and infections. Adhesive glue is effective in securing the peripheral nerve catheter and decreasing leakage around the catheter insertion site. This study aimed to evaluate the incidence of pericatheter leakage with fixation using 2-octyl cyanoacrylate glue (Dermabond®) as compared to sterile strips. Methods Thirty patients undergoing unilateral total knee arthroplasty (TKA) with continuous femoral nerve catheter for postoperative analgesia were randomized into the catheter fixation with 2-octyl cyanoacrylate glue (Dermabond®) group or the sterile strip group. The primary outcome was the incidence of pericatheter leakage. Secondary outcomes included the frequent of catheter displacement, the difficulty of catheter removal, pain score and patient satisfaction. Results The incidence of pericatheter leakage at 24 and 48 h was 0% versus 93 and 0% versus 100% in the Dermabond® and sterile strip groups, respectively (P < 0.001). The incidence of displacement at 24 and 48 h was 6.7% versus 93.3 and 6.7% versus 100% in the Dermabond® and sterile strip, respectively (P < 0.001). There was no difference in numeric rating scale, difficulty of catheter removal, or satisfaction scores between groups. Conclusions Catheter fixation with 2-octyl cyanoacrylate glue (Dermabond®) decreased the incidence of pericatheter leakage, as well as catheter displacement, over 48 h as compared to sterile strip fixation. Trial registration This trial was registered on Thai clinical trial registry: TCTR20200228002, registered 24 February 2020- Retrospectively registered.

scholarly journals Decreasing the leakage of continuous femoral nerve catheter fixation using 2 - octyl cyanoacrylate glue ( Demabond® ): A Randomized Controlled Trial study

2020 ◽  
Author(s):  
Theerawat Chalacheewa ◽  
Vanlapa Arnuntasupakul ◽  
Lisa Sangkum ◽  
Rungrawan Buachai
Keyword(s):  
Peripheral Nerve ◽  
Rating Scale ◽  
Femoral Nerve Block ◽  
Controlled Trial ◽  
Femoral Nerve ◽  
Catheter Removal ◽  
Control Group ◽  
Cyanoacrylate Glue ◽  
Peripheral Nerve Catheter ◽  
Perineural Catheter

Abstract Background : Continuous peripheral nerve catheters (CPNCs) have been used for postoperative pain relief. The common problem with CPNCs is pericatheter leakage that can compromise the sterile dressing, un-necessitating frequent dressing that may increase the risk of dislodgement and perineural catheter colonization or infections. Adhesive glue is useful for fixing peripheral nerve catheter as well as prevent leakage around the puncture site. This study aimed to evaluate the incidence of pericatheter leakage by using fixation with 2 -octyl cyanoacrylate glue (Demabond) compared to sterile strip. Methods : Thirty patients undergoing unilateral total knee arthroplasty and received continuous femoral nerve block were randomized to perineural catheter fixation with 2-octyl cyanoacrylate glue or sterile strip. The primary outcome was the incidence of pericatheter leakage. Secondary outcomes included frequent of catheter migration, difficulty of catheter removal, pain score and patient satisfaction. Results : The incidence of pericatheter leakage at 48 hours was 0% versus 100% in the intervention and control group. The incidence of displacement at 24 and 48 hours was 6.7% versus 93.3% and 6.7% versus 100%, respectively (P < 0.001). There was no difference in numeric rating scale, difficulty of catheter removal as well as satisfaction scores between groups. Conclusion : Catheter fixation with 2-octylcyanoacrylate reduced the incidence of pericatheter leakage as well as catheter displacement over 48 hours compare to sterile strip.

scholarly journals Decreasing the Leakage of Continuous Femoral Nerve Catheter Fixation Using 2-octyl Cyanoacrylate Glue ( Demabond® ): A Randomized Controlled Trial Study

2020 ◽  
Author(s):  
Vanlapa Arnuntasupakul ◽  
Lisa Sangkum ◽  
Rungrawan Buachai ◽  
Theerawat Chalacheewa
Keyword(s):  
Peripheral Nerve ◽  
Rating Scale ◽  
Femoral Nerve Block ◽  
Controlled Trial ◽  
Femoral Nerve ◽  
Catheter Removal ◽  
Control Group ◽  
Cyanoacrylate Glue ◽  
Peripheral Nerve Catheter ◽  
Perineural Catheter

Abstract Background: Continuous peripheral nerve catheters (CPNCs) have been used for postoperative pain relief. The common problem with CPNCs is pericatheter leakage that can compromise the sterile dressing, un-necessitating frequent dressing that may increase the risk of dislodgement and perineural catheter colonization or infections. Adhesive glue is useful for fixing peripheral nerve catheter as well as prevent leakage around the puncture site. This study aimed to evaluate the incidence of pericatheter leakage by using fixation with 2-octyl cyanoacrylate glue (Demabond®) compared to sterile strip.Methods: Thirty patients undergoing unilateral total knee arthroplasty and received continuous femoral nerve block were randomized to perineural catheter fixation with 2-octyl cyanoacrylate glue or sterile strip. The primary outcome was the incidence of pericatheter leakage. Secondary outcomes included frequent of catheter migration, difficulty of catheter removal, pain score and patient satisfaction.Results: The incidence of pericatheter leakage at 48 hours was 0% versus 100% in the intervention and control group. The incidence of displacement at 24 and 48 hours was 6.7% versus 93.3% and 6.7% versus 100%, respectively (P < 0.001). There was no difference in numeric rating scale, difficulty of catheter removal as well as satisfaction scores between groups.Conclusion: Catheter fixation with 2-octylcyanoacrylate reduced the incidence of pericatheter leakage as well as catheter displacement over 48 hours compare to sterile strip.

Electroanalgesia during a carboxytherapy procedure for cellulite: a study protocol for a randomized controlled trial

2020 ◽  
Vol 10 (5) ◽  
pp. 283-290
Author(s):  
Adria Yared Sadala ◽  
Érika Patrícia Rampazo da Silva ◽  
Richard Eloin Liebano
Keyword(s):  
Pain Intensity ◽  
Study Protocol ◽  
Rating Scale ◽  
Controlled Trial ◽  
Numeric Rating Scale ◽  
Secondary Outcome ◽  
Electrical Currents ◽  
Electrical Nerve Stimulation ◽  
Interferential Current ◽  
Clinical Trials Registry

The aim of the present study is to describe a study protocol to compare different types of analgesic electrical currents on pain intensity and sensory comfort during the application of carboxytherapy for the treatment of cellulite. Seventy five women with the presence of moderate and/or severe gluteal cellulite will be randomly allocated into three groups: carboxytherapy plus transcutaneous electrical nerve stimulation, carboxytherapy plus interferential current or carboxytherapy plus Aussie current. Pain intensity, which is the primary outcome, will be measured by a numeric rating scale (0–10). The secondary outcome is sensory comfort, which will be measured using the visual analogue scale (0–10). Trial registration: Brazilian Clinical Trials Registry: ReBEC (RBR-6z82zb) www.ensaiosclinicos.gov.br/rg/RBR-6z82zb/

Effect of Pregabalin on Radiotherapy-Related Neuropathic Pain in Patients With Head and Neck Cancer: A Randomized Controlled Trial

2019 ◽  
Vol 37 (2) ◽  
pp. 135-143 ◽  
Author(s):  
Jingru Jiang ◽  
Yi Li ◽  
Qingyu Shen ◽  
Xiaoming Rong ◽  
Xiaolong Huang ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Adverse Event ◽  
Neuropathic Pain ◽  
Rating Scale ◽  
Short Form ◽  
Controlled Trial ◽  
Numeric Rating Scale ◽  
Mood States ◽  
Numeric Rating

Purpose Neuropathic pain is an unavoidable treatment-related adverse event among patients with head and neck cancer who are undergoing radiotherapy. We aimed to test the efficacy and safety of pregabalin versus placebo in the treatment of radiotherapy-related neuropathic pain. Patients and Methods This randomized, double-blind, placebo-controlled trial was conducted in four centers in China. Eligible patients with a mean pain intensity score of 4 or more on an 11-point numeric rating scale were randomly assigned to receive either active treatment with a flexible dose of pregabalin or placebo for 16 weeks. The primary efficacy outcome was pain reduction measured on the numeric rating scale. Result There were 128 patients who received treatment as randomly assigned. Pain intensity reduction was 2.44 in the pregabalin arm and 1.58 in the placebo arm at week 16, yielding an adjusted mean difference of 0.87 (95% CI, 0.30 to 1.44; P = .003). In the pregabalin arm, 38 patients (59.4%) achieved at least 30% pain relief versus 21 (32.8%) in the placebo arm ( P = .006). Nineteen patients (29.7%) in the pregabalin group and five (7.8%) in the placebo group achieved 50% or greater pain relief ( P = .003). Total scores on the Profile of Mood States-Short Form, pain severity and functional interference of Brief Pain Inventory-Short Form, as well as the physiology and psychology domain of the WHO Quality of Life-BREF all were reduced significantly at week 16 in patients who received pregabalin compared with those who received placebo. There was no significant difference ( P = .29) in the incidence of experiencing at least one adverse event in the pregabalin arm (n = 35; 54.7%) versus the placebo arm (n = 29; 45.3%). Conclusion Patients treated with pregabalin with radiotherapy-related neuropathic pain had greater pain alleviation, better mood states, and higher quality of life compared with patients in the placebo group, with a good tolerability.

Effectiveness of Simulated Horseback Riding for Patients With Chronic Low Back Pain: A Randomized Controlled Trial

2020 ◽  
Vol 29 (2) ◽  
pp. 179-185 ◽  
Author(s):  
TaeYeong Kim ◽  
JaeHyuk Lee ◽  
SeJun Oh ◽  
Seungmin Kim ◽  
BumChul Yoon
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Oswestry Disability Index ◽  
Rating Scale ◽  
Controlled Trial ◽  
Numeric Rating Scale ◽  
Low Back ◽  
Baseline Values ◽  
Numeric Rating

Context: A simulated horseback riding (SHR) exercise is effective for improvement of pain and functional disability, but its comparative effectiveness with the other is unknown. Objective: The authors aimed to demonstrate the effect of a SHR exercise in people with chronic low back pain. Design: A randomized controlled trial. Settings: Community and university campus. Participants: A total of 48 participants with chronic low back pain were divided into 2 groups, and SHR exercises (n = 24) or stabilization (STB) exercises (n = 24) were performed. Interventions: The exercises were performed for 30 minutes, 2 days per week for 8 weeks. Main Outcome Measures: Numeric rating scale, functional disabilities (Oswestry disability index and Roland–Morris disability), and fear-avoidance beliefs questionnaire (FABQ) scores were measured at baseline and at 4 weeks, 8 weeks, and 6 months. Results: A 2-way repeated analysis of variance identified that between-group comparisons showed significant differences in the FABQ related to work scale (F = 21.422; P = .01). There were no significant differences in the numeric rating scale (F = 1.696; P = .21), Oswestry disability index (F = 1.848; P = .20), Roland–Morris disability (F = 0.069; P = .80), and FABQ related to physical scale (F = 1.579; P = .24). In within-group comparisons, both groups presented significant differences in numeric rating scale (both SHR and STB after 4 wk), Oswestry disability index (both SHR and STB after 6 mo), and Roland–Morris disability (SHR after 6 mo and STB after 8 wk) compared with baseline values. In FABQ-related physical (SHR after 4 wk) and work scales (SHR after 6 mo), there were only significant differences in the SHR compared with baseline values. Conclusions: SHR exercise for 8 weeks had a greater effect than STB exercise for reducing work-related FABQ. The SHR exercise performed in a seated position could substantially decrease pain-related fear disability in young adults with chronic low back pain.

scholarly journals Examining the effects of enhanced provider–patient communication on postoperative tonsillectomy pain: protocol of a randomised controlled trial performed by nurses in daily clinical care

BMJ Open ◽  
2017 ◽  
Vol 7 (11) ◽  
pp. e015505 ◽  
Author(s):  
Liesbeth M van Vliet ◽  
Sandra van Dulmen ◽  
Bram Thiel ◽  
Gerard W van Deelen ◽  
Stephanie Immerzeel ◽  
...  
Keyword(s):  
Randomised Controlled Trial ◽  
Rating Scale ◽  
Controlled Trial ◽  
Clinical Care ◽  
Numeric Rating Scale ◽  
Study Results ◽  
Audio Recordings ◽  
Registration Number ◽  
Randomised Controlled ◽  
Care Ward

IntroductionPlacebo effects (true biopsychological effects not attributable to the active ingredients of medical technical interventions) can be attributed to several mechanisms, such as expectancy manipulation and empathy manipulation elicited by a provider’s communication. So far, effects have primarily been shown in laboratory settings. The aim of this study is to determine the separate and combined effects of expectancy manipulation and empathy manipulation during preoperative and postoperative tonsillectomy analgesia care on clinical adult patients’ outcomes.Methods and analysisUsing a two-by-two randomised controlled trial, 128 adult tonsillectomy patients will be randomly assigned to one out of four conditions differing in the level of expectancy manipulation (standard vs enhanced) and empathy manipulation (standard vs enhanced). Day care ward nurses are trained to deliver the intervention, while patients are treated via the standard analgesia protocol and hospital routines. The primary outcome, perceived pain, is measured via hospital routine by a Numeric Rating Scale, and additional prehospitalisation, perihospitalisation and posthospitalisation questionnaires are completed (until day 3, ie, 2 days after the operation). The manipulation is checked using audio recordings of nurse–patient interactions.Ethics and disseminationAlthough communication is manipulated, the manipulations do not cross norms or values of acceptable behaviour. Standard medical care is provided. The ethical committee of the UMC Utrecht and the local OLVG hospital committee approved the study. Results will be published via (inter)national peer-reviewed journals and a lay publication.Trial registration numberNTR5994; Pre-results.

Pre-emptive ice cube cryotherapy for reducing pain from local anaesthetic injections for simple lacerations: a randomised controlled trial

2017 ◽  
Vol 35 (2) ◽  
pp. 103-107 ◽  
Author(s):  
JaeWoo Song ◽  
HyukHoon Kim ◽  
EunJung Park ◽  
Jung Hwan Ahn ◽  
Eunhui Yoon ◽  
...  
Keyword(s):  
Injection Site ◽  
Local Anaesthetic ◽  
Rating Scale ◽  
Controlled Trial ◽  
Numeric Rating Scale ◽  
Control Group ◽  
Ice Cube ◽  
Perceived Pain ◽  
Randomised Controlled ◽  
Numeric Rating

ObjectiveSubcutaneous local anaesthetic injection can be painful to patients in the ED. We evaluated the effect of cryotherapy by application of an ice cube to the injection site prior to injection in patients with simple lacerations.MethodsWe conducted a prospective, randomised, controlled trial in consented patients with simple lacerations needing primary repair at a single emergency centre from April to July 2016. We randomly assigned patients undergoing repair for simple lacerations to either the cryotherapy group or the control group (standard care; no cryotherapy or other pretreatment of the injection site). In cryotherapy group subjects, we applied an ice cube (size: 1.5×1.5×1.5 cm) placed inside a sterile glove on the wound at the anticipated subcutaneous lidocaine injection site for 2 min prior to injection. The primary outcome was a subjective numeric rating (0–10 scale) of the perceived pain from the subcutaneous local anaesthetic injections. Secondary outcomes were (a) perceived pain on a numeric scale for cryotherapy itself, that is, pain from contact of the ice cube/glove with the skin and (b) the rate of complications after primary laceration repair.ResultsFifty patients were enrolled, consented and randomised, with 25 in the cryotherapy group and 25 in the control group. The numeric rating scale for subcutaneous anaesthetic injections was median, IQR, 95% CI 2.0 (1 to 3.5), 1.81 to 3.47, respectively, in the cryotherapy group and 5.0 (3 to 7), 3.91 to 6.05 in the control group (Mann-Whitney U=147.50, p=0.001). No wound complications occurred in either group. The numeric rating scale for cryotherapy itself was median, IQR, 95% CI: 2.0 (1 to 3.5), 1.90 to 3.70.ConclusionPre-emptive topical injection site cryotherapy lasting 2 min before subcutaneous local anaesthetic injections can significantly reduce perceived pain from subcutaneous local anaesthetic injections in patients presenting for simple laceration repair.Trial registration numberKCT0001990.

ACCELERATING AXON GROWTH TO OVERCOME LIMITATIONS IN FUNCTIONAL RECOVERY AFTER PERIPHERAL NERVE INJURY

Neurosurgery ◽  
2009 ◽  
Vol 65 (suppl_4) ◽  
pp. A132-A144 ◽  
Author(s):  
Tessa Gordon ◽  
K. Ming Chan ◽  
Olawale A.R. Sulaiman ◽  
Esther Udina ◽  
Nasim Amirjani ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Controlled Trial ◽  
Peripheral Nerve Regeneration ◽  
Femoral Nerve ◽  
Axon Growth ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Clinical Tool

Abstract OBJECTIVE Injured peripheral nerves regenerate at very slow rates. Therefore, proximal injury sites such as the brachial plexus still present major challenges, and the outcomes of conventional treatments remain poor. This is in part attributable to a progressive decline in the Schwann cells' ability to provide a supportive milieu for the growth cone to extend and to find the appropriate target. These challenges are compounded by the often considerable delay of regeneration across the site of nerve laceration. Recently, low-frequency electrical stimulation (as brief as an hour) has shown promise, as it significantly accelerated regeneration in animal models through speeding of axon growth across the injury site. METHODS To test whether this might be a useful clinical tool, we carried out a randomized controlled trial in patients who had experienced substantial axonal loss in the median nerve owing to severe compression in the carpal tunnel. To further elucidate the potential mechanisms, we applied rolipram, a cyclic adenosine monophosphate agonist, to rats after axotomy of the femoral nerve. RESULTS We demonstrated that effects similar to those observed in animal studies could also be attained in humans. The mechanisms of action of electrical stimulation likely operate through up-regulation of neurotrophic factors and cyclic adenosine monophosphate. Indeed, the application of rolipram significantly accelerated nerve regeneration. CONCLUSION With new mechanistic insights into the influencing factors of peripheral nerve regeneration, the novel treatments described above could form part of an armament of synergistic therapies that could make a meaningful difference to patients with peripheral nerve injuries.

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