Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: A case control study

Abstract Background: Sarcopenia is a syndrome characterized by progressive and systemic decreases in skeletal muscle mass and muscle strength. The influence or prognosis of various liver diseases in this condition have been widely investigated, but little is known about whether sarcopenia and/or muscle mass loss are related to minimal hepatic encephalopathy (MHE).Methods: To clarify the relationship between MHE and sarcopenia and/or muscle mass loss in patients with liver cirrhosis.Methods: Ninety-nine patients with liver cirrhosis were enrolled. MHE was diagnosed by a neuropsychiatric test. Skeletal mass index (SMI) and Psoas muscle index (PMI) were calculated by dividing skeletal muscle area and psoas muscle area at the third lumbar vertebra by the square of height in meters, respectively, to evaluate muscle volume.Results: This study enrolled 99 patients (61 males, 38 females). MHE was detected in 48 cases (48.5%) and sarcopenia in 6 cases (6.1%). Patients were divided into two groups, with or without MHE. Comparing groups, no significant differences were seen in serum ammonia concentration or rate of sarcopenia. SMI was smaller in patients with MHE (46.4 cm2/m2) than in those without (51.2 cm2/m2, P = 0.027). Similarly, PMI was smaller in patients with MHE (4.24 cm2/m2) than in those without (5.53 cm2/m2, P = 0.003). Skeletal muscle volume, which is represented by SMI or PMI was a predictive factor related to MHE (SMI ≥ 50 cm2/m2; odds ratio 0.300, P = 0.002, PMI ≥ 4.3 cm2/m2; odds ratio 0.192, P = 0.001).Conclusions: Muscle mass loss was related to minimal hepatic encephalopathy, although sarcopenia was not. Measurement of muscle mass loss might be useful to predict MHE.

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Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: A case control study

10.21203/rs.3.rs-42056/v2 ◽

2020 ◽

Author(s):

Masakuni Tateyama ◽

Hideaki Naoe ◽

Motohiko Tanaka ◽

Kentaro Tanaka ◽

Satoshi Narahara ◽

...

Keyword(s):

Skeletal Muscle ◽

Hepatic Encephalopathy ◽

Mass Loss ◽

Muscle Mass ◽

Odds Ratio ◽

Skeletal Muscle Mass ◽

Psoas Muscle ◽

Minimal Hepatic Encephalopathy ◽

Muscle Area ◽

Muscle Mass Loss

Abstract Background: Sarcopenia is a syndrome characterized by progressive and systemic decreases in skeletal muscle mass and muscle strength. The influence or prognosis of various liver diseases in this condition have been widely investigated, but little is known about whether sarcopenia and/or muscle mass loss are related to minimal hepatic encephalopathy (MHE). Methods: To clarify the relationship between MHE and sarcopenia and/or muscle mass loss in patients with liver cirrhosis. Methods: Ninety-nine patients with liver cirrhosis were enrolled. MHE was diagnosed by a neuropsychiatric test. Skeletal mass index (SMI) and Psoas muscle index (PMI) were calculated by dividing skeletal muscle area and psoas muscle area at the third lumbar vertebra by the square of height in meters, respectively, to evaluate muscle volume. Results: This study enrolled 99 patients (61 males, 38 females). MHE was detected in 48 cases (48.5%) and sarcopenia in 6 cases (6.1%). Patients were divided into two groups, with or without MHE. Comparing groups, no significant differences were seen in serum ammonia concentration or rate of sarcopenia. SMI was smaller in patients with MHE (46.4 cm 2 /m 2 ) than in those without (51.2 cm 2 /m 2 , P = 0.027). Similarly, PMI was smaller in patients with MHE (4.24 cm 2 /m 2 ) than in those without (5.53 cm 2 /m 2 , P = 0.003). Skeletal muscle volume, which is represented by SMI or PMI was a predictive factor related to MHE (SMI ≥ 50 cm 2 /m 2 ; odds ratio 0.300, P = 0.002, PMI ≥ 4.3 cm 2 /m 2 ; odds ratio 0.192, P = 0.001).Conclusions: Muscle mass loss was related to minimal hepatic encephalopathy, although sarcopenia was not. Measurement of muscle mass loss might be useful to predict MHE.

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Loss of skeletal muscle mass affects the incidence of minimal hepatic encephalopathy: a case control study

BMC Gastroenterology ◽

10.1186/s12876-020-01501-x ◽

2020 ◽

Vol 20 (1) ◽

Author(s):

Masakuni Tateyama ◽

Hideaki Naoe ◽

Motohiko Tanaka ◽

Kentaro Tanaka ◽

Satoshi Narahara ◽

...

Keyword(s):

Skeletal Muscle ◽

Hepatic Encephalopathy ◽

Mass Loss ◽

Muscle Mass ◽

Odds Ratio ◽

Skeletal Muscle Mass ◽

Psoas Muscle ◽

Minimal Hepatic Encephalopathy ◽

Muscle Area ◽

Muscle Mass Loss

Abstract Background Sarcopenia is a syndrome characterized by progressive and systemic decreases in skeletal muscle mass and muscle strength. The influence or prognosis of various liver diseases in this condition have been widely investigated, but little is known about whether sarcopenia and/or muscle mass loss are related to minimal hepatic encephalopathy (MHE). Methods To clarify the relationship between MHE and sarcopenia and/or muscle mass loss in patients with liver cirrhosis. Methods Ninety-nine patients with liver cirrhosis were enrolled. MHE was diagnosed by a neuropsychiatric test. Skeletal mass index (SMI) and Psoas muscle index (PMI) were calculated by dividing skeletal muscle area and psoas muscle area at the third lumbar vertebra by the square of height in meters, respectively, to evaluate muscle volume. Results This study enrolled 99 patients (61 males, 38 females). MHE was detected in 48 cases (48.5%) and sarcopenia in 6 cases (6.1%). Patients were divided into two groups, with or without MHE. Comparing groups, no significant differences were seen in serum ammonia concentration or rate of sarcopenia. SMI was smaller in patients with MHE (46.4 cm2/m2) than in those without (51.2 cm2/m2, P = 0.027). Similarly, PMI was smaller in patients with MHE (4.24 cm2/m2) than in those without (5.53 cm2/m2, P = 0.003). Skeletal muscle volume, which is represented by SMI or PMI was a predictive factor related to MHE (SMI ≥ 50 cm2/m2; odds ratio 0.300, P = 0.002, PMI ≥ 4.3 cm2/m2; odds ratio 0.192, P = 0.001). Conclusions Muscle mass loss was related to minimal hepatic encephalopathy, although sarcopenia was not. Measurement of muscle mass loss might be useful to predict MHE.

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Loss of Skeletal Muscle Mass Affects the Incidence of Minimal Hepatic Encephalopathy: A Case Control Study

10.21203/rs.3.rs-42056/v1 ◽

2020 ◽

Author(s):

Masakuni Tateyama ◽

Hideaki Naoe ◽

Motohiko Tanaka ◽

Kentaro Tanaka ◽

Satoshi Narahara ◽

...

Keyword(s):

Skeletal Muscle ◽

Liver Cirrhosis ◽

Hepatic Encephalopathy ◽

Mass Loss ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Lumbar Vertebra ◽

Minimal Hepatic Encephalopathy ◽

Skeletal Muscle Index ◽

Muscle Mass Loss

Abstract Background: Sarcopenia is a syndrome characterized by progressive and systemic decreases in skeletal muscle mass and muscle strength. The influence or prognosis of various liver diseases in this condition have been widely investigated, but little is known about whether sarcopenia and/or muscle mass loss are related to minimal hepatic encephalopathy.Methods: To clarify the relationship between minimal hepatic encephalopathy and sarcopenia and/or muscle mass loss in patients with liver cirrhosis. Ninety-nine patients with liver cirrhosis were enrolled. Minimal hepatic encephalopathy was diagnosed by a neuropsychiatric test. Skeletal mass index was calculated by dividing muscle area at the third lumbar vertebra by the square of height in meters.Results: MHE was detected in 48 cases (48.5%) and sarcopenia in 6 cases (6.1%). Patients were divided into two groups, with or without MHE. Comparing groups, no significant differences were seen in serum ammonia concentration or rate of sarcopenia. Skeletal muscle index was smaller in patients with minimal hepatic encephalopathy (46.4 cm2/m2) than in those without (51.2 cm2/m2, P = 0.027). Skeletal muscle index represented a predictive factor related to minimal hepatic encephalopathy (<50 cm2/m2; odds ratio 0.300, P = 0.002).Conclusions: Muscle mass loss was related to minimal hepatic encephalopathy, although sarcopenia was not. Measurement of muscle mass loss might be useful to predict MHE.

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Racial Differences in Relative Skeletal Muscle Mass Loss During Diet-Induced Weight Loss in Women

Obesity ◽

10.1002/oby.22201 ◽

2018 ◽

Vol 26 (8) ◽

pp. 1255-1260 ◽

Cited By ~ 5

Author(s):

Gary R. Hunter ◽

David R. Bryan ◽

Juliano H. Borges ◽

M. David Diggs ◽

Stephen J. Carter

Keyword(s):

Skeletal Muscle ◽

Weight Loss ◽

Mass Loss ◽

Racial Differences ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Muscle Mass Loss

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Factors predicting skeletal muscle mass loss after gastric cancer surgery: a retrospective observational study

Clinical Nutrition ESPEN ◽

10.1016/j.clnesp.2021.09.474 ◽

2021 ◽

Vol 46 ◽

pp. S711

Author(s):

Y. Shiozawa ◽

A. Naganuma ◽

Y. Ogawa ◽

F. Yamamoto ◽

M. Kimura ◽

...

Keyword(s):

Gastric Cancer ◽

Skeletal Muscle ◽

Observational Study ◽

Mass Loss ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Cancer Surgery ◽

Retrospective Observational Study ◽

Gastric Cancer Surgery ◽

Muscle Mass Loss

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Supplementation of protein-free diet with whey protein hydrolysates prevents skeletal muscle mass loss in rats

Journal of Nutrition & Intermediary Metabolism ◽

10.1016/j.jnim.2016.03.001 ◽

2016 ◽

Vol 4 ◽

pp. 1-5 ◽

Cited By ~ 8

Author(s):

Yodai Kobayashi ◽

Yuuki Somoto ◽

Eri Mitsuyama ◽

Azusa Tanaka ◽

Naoki Yuda ◽

...

Keyword(s):

Skeletal Muscle ◽

Mass Loss ◽

Whey Protein ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Protein Hydrolysates ◽

Whey Protein Hydrolysates ◽

Muscle Mass Loss ◽

Protein Free Diet

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Low muscle mass assessed by psoas muscle area is associated with clinical adverse events in elderly patients with heart failure

PLoS ONE ◽

10.1371/journal.pone.0247140 ◽

2021 ◽

Vol 16 (2) ◽

pp. e0247140

Author(s):

Takehiro Funamizu ◽

Yuji Nagatomo ◽

Mike Saji ◽

Nobuo Iguchi ◽

Hiroyuki Daida ◽

...

Keyword(s):

Heart Failure ◽

Skeletal Muscle ◽

Adverse Events ◽

Elderly Patients ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Psoas Muscle ◽

Composite Endpoint ◽

Left Ventricular Ejection ◽

Muscle Area

Background Acute decompensated heart failure (ADHF) is a growing healthcare burden with increasing prevalence and comorbidities due to progressive aging society. Accumulating evidence suggest that low skeletal muscle mass has a negative impact on clinical outcome in elderly adult population. We sought to determine the significance of psoas muscle area as a novel index of low skeletal muscle mass in elderly patients with ADHF. Methods In this single-center retrospective observational study, we reviewed consecutive 865 elderly participants (65 years or older) who were hospitalized for ADHF and 392 were available for analysis (79 years [74–85], 56% male). Cross-sectional areas of psoas muscle at the level of fourth lumbar vertebra were measured by computed tomography and normalized by the square of height to calculate psoas muscle index (PMI, cm2/m2). Results Dividing the patients by the gender-specific quartile value (2.47 cm2/m2 for male and 1.68 cm2/m2 for female), we defined low PMI as the lowest gender-based quartile of PMI. Multiple linear regression analysis revealed female sex, body mass index (BMI), and E/e’, but not left ventricular ejection fraction, were independently associated with PMI. Kaplan-Meier analysis showed low PMI was associated with higher rate of composite endpoint of all-cause death and ADHF re-hospitalization (P = 0.033). Cox proportional hazard model analysis identified low PMI, but not BMI, was an independent predictor of the composite endpoint (Hazard ratio: 1.52 [1.06–2.16], P = 0.024). Conclusions PMI predicted future clinical adverse events in elderly patients with ADHF. Further studies are needed to assess whether low skeletal muscle mass can be a potential therapeutic target to improve the outcome of ADHF.

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