What Should We Focus on Sepsis Fluid Resuscitation? – a Research Based on Scientometrics and Visual Analysis

Background: Sepsis is a life-threatening condition and a global disease burden. Intravenous fluid therapy has been one of the cornerstones of sepsis treatment for decades. Many of the current views and programs are still controversial. With the rapid development of data science and bibliometrics, it is possible to comprehensively review and discover future research trends by analyzing the temporal evolution of topics. Methods: In this paper, bibliometric method was used to get a comprehensive review and quantitatively analyze the global development trend, regional distribution and discipline layout of fluid resuscitation in sepsis. VOSviewer and SciMAT were used to analyze the research hotspots, strategic layout and theme changes of fluid resuscitation in sepsis, and to explore the future research direction. Results: With the development of multi-disciplinary research on fluid resuscitation of sepsis, more attention has been paid to the early prediction and treatment in the emergency medicine department, and the number of basic research (effects of different components of resuscitation fluid) has a downward trend, but the role of albumin is still worthy of further study. The key points of fluid resuscitation in sepsis are the timing of fluid resuscitation, early intervention in the emergency medicine department, looking for accurate and timely indexes of microcirculation perfusion, fluid resuscitation volume in different resuscitation stages and its effect on respiration, kidney and abdominal cavity. Conclusion: The method can identify hotspots and detect future directions conveniently, quickly and effectively. The clinical research of fluid resuscitation in sepsis, especially “the early intervention” and “the precise resuscitation”, is paid more attention, and even the recommendations of the consensus and guidelines need to be further confirmed by “multi center research”, which may become the development direction in the future. Trial registration: it was not registered, because it is an bibliometric analysis based on the published articles.