scholarly journals Generalized Muscle Quality Loss as a Risk Factor for Pelvic Organ Prolapse: A Single-Center, Observational Study

2021 ◽  
Author(s):  
Yoko Chino ◽  
Daisuke Inoue ◽  
Makoto Yamamoto ◽  
Toshimichi Onuma ◽  
Yoshio Yoshida
Keyword(s):  
Risk Factor ◽  
Pelvic Organ Prolapse ◽  
Muscle Mass ◽  
Pelvic Organ ◽  
Muscle Quality ◽  
Fatty Tissue ◽  
Visceral Fat Accumulation ◽  
Independent Risk Factors ◽  
Benign Gynecological Diseases ◽  
The Relationship

Abstract Among the physiological changes associated with aging, myopenia due to increased amounts of fatty tissue in muscles and loss of muscle mass have recently gained attention. This study retrospectively examined the relationship between generalized muscle quality and pelvic organ prolapse (POP). Participants comprised 25 patients between 40 and 79 years old showing a Pelvic Organ Prolapse Quantification system stage of 3 or higher who underwent surgery between 2017 and 2019. Control cases comprised 23 patients with benign gynecological diseases who underwent surgery without POP. CT performed within 3 months before surgery was used to measure muscle mass. Smooth muscle index (SMI) was significantly higher in the POP group than in the non-POP group (p = 0.017), and muscle mass was rather large in the POP group. Comparing the POP and non-POP groups, both subcutaneous and visceral fat accumulation were significantly higher in the POP group (p = 0.03, p = 0.002 respectively). Conversely, intramuscular adipose tissue content (IMAC), indicating lower muscle quality, was significantly higher in the POP group (p = 0.024). Multivariate analysis revealed BMI and number of deliveries, but not IMAC, as significant independent risk factors of POP. Although not an independent risk factor, decreased muscle quality was involved in the pathophysiology of POP.

scholarly journals Rectal–vaginal pressure gradient in patients with pelvic organ prolapse and symptomatic rectocele

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Cheng Tan ◽  
Man Tan ◽  
Jing Geng ◽  
Jun Tang ◽  
Xin Yang
Keyword(s):  
Pelvic Organ Prolapse ◽  
Pressure Gradient ◽  
Obstructed Defecation ◽  
Elevated Pressure ◽  
Pelvic Organ ◽  
Lower Grade ◽  
Translabial Ultrasound ◽  
Rectal Ampulla ◽  
The Relationship ◽  
Posterior Vaginal Prolapse

Abstract Objective The aim of this study is to examine the relationship between rectal–vaginal pressure and symptomatic rectocele in patients with pelvic organ prolapse (POP). Method Patients with posterior vaginal prolapse staged III or IV in accordance with the POP Quantitation classification method who were scheduled for pelvic floor reconstructive surgery in the years 2016–2019 were included in the study. Rectocele was diagnosed using translabial ultrasound, and obstructed defecation (OD) was diagnosed in accordance with the Roma IV diagnostic criteria. Both rectal and vaginal pressure were measured using peritron manometers at maximum Vasalva. To ensure stability, the test was performed three times with each patient. Results A total of 217 patients were enrolled in this study. True rectocele was diagnosed in 68 patients at a main rectal ampulla depth of 19 mm. Furthermore, 36 patients were diagnosed with OD. Symptomatic rectocele was significantly associated with older age (p < 0.01), a higher OD symptom score (p < 0.001), and a lower grade of apical prolapse (p < 0.001). The rectal–vaginal pressure gradient was higher in patients with symptomatic rectocele (37.4 ± 11.7 cm H2O) compared with patients with asymptomatic rectocele (16.9 ± 8.4 cm H2O, p < 0.001), and patients without rectocele (17.1 ± 9.2 cm H2O, p < 0.001). Conclusion The rectal–vaginal pressure gradient was found to be a risk factor for symptomatic rectocele in patients with POP. A rectal–vaginal pressure gradient of > 27.5 cm H2O was suggested as the cut-off point of the elevated pressure gradient.

CNTF genotype is associated with muscular strength and quality in humans across the adult age span

2001 ◽  
Vol 90 (4) ◽  
pp. 1205-1210 ◽  
Author(s):  
Stephen M. Roth ◽  
Matthew A. Schrager ◽  
Robert E. Ferrell ◽  
Steven E. Riechman ◽  
E. Jeffrey Metter ◽  
...  
Keyword(s):  
Muscle Mass ◽  
Body Mass ◽  
Muscular Strength ◽  
Peak Torque ◽  
Fat Free Mass ◽  
Muscle Quality ◽  
Knee Extensors ◽  
Muscular Power ◽  
Adult Age ◽  
The Relationship

The relationship between ciliary neurotrophic factor (CNTF) genotype and muscle strength was examined in 494 healthy men and women across the entire adult age span (20–90 yr). Concentric (Con) and eccentric (Ecc) peak torque were assessed using a Kin-Com isokinetic dynamometer for the knee extensors (KE) and knee flexors (KF) at slow (0.52 rad/s) and faster (3.14 rad/s) velocities. The results were covaried for age, gender, and body mass or fat-free mass (FFM). Individuals heterozygous for the CNTF null (A allele) mutation (G/A) exhibited significantly higher Con peak torque of the KE and KF at 3.14 rad/s than G/G homozygotes when age, gender, and body mass were covaried ( P < 0.05). When the dominant leg FFM (estimated muscle mass) was used in place of body mass as a covariate, Con peak torque of the KE at 3.14 rad/s was also significantly greater in the G/A individuals ( P < 0.05). In addition, muscle quality of the KE (peak torque at 3.14 rad · s−1 · leg muscle mass−1) was significantly greater in the G/A heterozygotes ( P < 0.05). Similar results were seen in a subanalysis of subjects 60 yr and older, as well as in Caucasian subjects. In contrast, A/A homozygotes demonstrated significantly lower Ecc peak torque at 0.52 rad/s for both KE and KF compared with G/G and G/A groups ( P < 0.05). No significant relationships were observed at 0.52 rad/s between genotype and Con peak torque. These data indicate that individuals exhibiting the G/A genotype possess significantly greater muscular strength and muscle quality at relatively fast contraction speeds than do G/G individuals. Because of high positive correlations between fast-velocity peak torque and muscular power, these findings suggest that further investigations should address the relationship between CNTF genotype and muscular power.

Exploring the Role of Muscle Mass, Obesity, and Age in the Relationship Between Muscle Quality and Physical Function

2014 ◽  
Vol 15 (4) ◽  
pp. 303.e13-303.e20 ◽  
Author(s):  
Sébastien Barbat-Artigas ◽  
Charlotte H. Pion ◽  
Jean-Philippe Leduc-Gaudet ◽  
Yves Rolland ◽  
Mylène Aubertin-Leheudre
Keyword(s):  
Physical Function ◽  
Muscle Mass ◽  
Muscle Quality ◽  
The Relationship

scholarly journals Hydroureteronephrosis in women with pelvic organ prolapse: a prospective cohort study

2018 ◽  
Vol 7 (9) ◽  
pp. 3664
Author(s):  
Pushplata Kumari ◽  
Emily Divya Ebenezer ◽  
Caroline Salomi ◽  
Vaibhav Londhe ◽  
Aruna Nitin Kekre
Keyword(s):  
Chronic Kidney Disease ◽  
Risk Factor ◽  
Pelvic Organ Prolapse ◽  
Kidney Disease ◽  
Prospective Observational Study ◽  
Surgical Repair ◽  
Significant Risk ◽  
Significant Risk Factor ◽  
Pelvic Organ ◽  
The Mean

Background: Pelvic organ prolapses (POP) is a common problem in women. The prevalence of POP increase with age. The true prevalence and risk factor for developing hydroureteronephrosis (HUN) in women with pelvic organ prolapse is still unclear due to lack of prospective studies on sufficiently large cohorts. This prospective study was done to study the prevalence of HUN in women with POP and to identify the risk factors for developing HUN.Methods: In this prospective observational study 219 patients were recruited for surgical repair for pelvic organ prolapse for 2 years.  Preoperatively, all patients had transabdominal scan to assess the uterus, adnexa and to look for Hydroureteronephrosis (HUN). Women with presence of HUN were followed postoperatively look for the resolution of HUN.Results: The prevalence of bilateral HUN was 6.85%. The mean age of women with HUN ranged from 51-69 years. Diabetes and hypertension were significant risk factor for development of HUN (OR 4.70, 95% CI -1.59-13.88 and OR 3.72, 95% CI- 1.23-11.1 respectively). There was a statistically significant correlation between chronic kidney disease and HUN. (OR 1 with 95%: CI 9.49-30.42). The correlation between stage of pelvic organ prolapse and HUN was not statistically significant (p = 0.062). There was a statistically significant correlation between the duration (2years -15 years) of POP to HUN. (OR 0.233, 95%0.13-0.419). Patients were followed up post operatively for resolution of HUN. HUN resolved in 9 women (60%) and persisted in 6 (40%).Conclusions: The prevalence of bilateral HUN in women with pelvic organ prolapse was 6.8%. Presence of hypertension, diabetes and chronic kidney disease was a risk factor for HUN. HUN resolved in 60% of women after pelvic reconstructive surgery.

scholarly journals The relationship between pelvic organ prolapse, genital body image, and sexual health

2012 ◽  
Vol 31 (7) ◽  
pp. 1145-1148 ◽  
Author(s):  
Ruth Zielinski ◽  
Janis Miller ◽  
Lisa Kane Low ◽  
Carolyn Sampselle ◽  
John O.L. DeLancey
Keyword(s):  
Body Image ◽  
Pelvic Organ Prolapse ◽  
Sexual Health ◽  
Pelvic Organ ◽  
The Relationship

scholarly journals Metabolic Syndrome and Sarcopenia

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3519
Author(s):  
Hiroki Nishikawa ◽  
Akira Asai ◽  
Shinya Fukunishi ◽  
Shuhei Nishiguchi ◽  
Kazuhide Higuchi
Keyword(s):  
Skeletal Muscle ◽  
Metabolic Syndrome ◽  
Muscle Mass ◽  
The Elderly ◽  
Muscle Quality ◽  
Health Events ◽  
Persistent Inflammation ◽  
Major Organ ◽  
Skeletal Muscle Loss ◽  
The Relationship

Skeletal muscle is a major organ of insulin-induced glucose metabolism. In addition, loss of muscle mass is closely linked to insulin resistance (IR) and metabolic syndrome (Met-S). Skeletal muscle loss and accumulation of intramuscular fat are associated with a variety of pathologies through a combination of factors, including oxidative stress, inflammatory cytokines, mitochondrial dysfunction, IR, and inactivity. Sarcopenia, defined by a loss of muscle mass and a decline in muscle quality and muscle function, is common in the elderly and is also often seen in patients with acute or chronic muscle-wasting diseases. The relationship between Met-S and sarcopenia has been attracting a great deal of attention these days. Persistent inflammation, fat deposition, and IR are thought to play a complex role in the association between Met-S and sarcopenia. Met-S and sarcopenia adversely affect QOL and contribute to increased frailty, weakness, dependence, and morbidity and mortality. Patients with Met-S and sarcopenia at the same time have a higher risk of several adverse health events than those with either Met-S or sarcopenia. Met-S can also be associated with sarcopenic obesity. In this review, the relationship between Met-S and sarcopenia will be outlined from the viewpoints of molecular mechanism and clinical impact.

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