scholarly journals Age-dependent Oral Manifestations of Neurofibromatosis Type 1: A Case-control Study

2021 ◽  
Author(s):  
Eshwar Thota ◽  
John Jim’s Veeravalli ◽  
Sai Krishna Manchala ◽  
Bhargavi Priya Lakkepuram ◽  
Jayasurya Kodapanen ◽  
...  
Keyword(s):  
Oral Cavity ◽  
Neurofibromatosis Type ◽  
Salivary Flow ◽  
Ph Values ◽  
Oral Complications ◽  
Age Dependent ◽  
Salivary Ph ◽  
Periodontal Destruction ◽  
Control Study

Abstract Introduction: Craniofacial manifestations of neurofibromatosis type 1 (NF1) are considered as a result of tumor compression. We sought to determine age-dependent salivary changes, carious, and periodontal complications in NF1 patients without tumors in the oral cavity.Objective and methods: Eleven NF1 patients without tumors in the oral cavity and 29 matched controls without NF1 were enrolled in this case-control study. Demographic information, medical history, and data of intraoral examinations, including the Decayed, Missing, and Filled Teeth (DMFT) scores and Russel’s periodontal index (PI), were recorded. The functional salivary analysis was performed for sialometry, salivary pH values, and amylase activity. Ingenuity Systems Pathway Analysis (IPA) was conducted to identify mutually activated pathways for NF1-associated oral complications.Results: NF1 patients were associated with periodontitis (OR=1.40, 95% CI=1.06-1.73, P = 0.04), gingivitis (OR=1.55, 95% CI=1.09-2.01, P = 0.0002), and decreased salivary flow rate (OR=1.40, 95% CI=1.05-1.76, P = 0.005). Periodontal destruction, salivary changes, and dental caries in NF1 patients were age dependent. Subgroup analyses based on age stratification suggested that salivary flow rates and salivary amylase activity were significantly lower among NF1 patients aged over 20 years and that salivary pH values, PI and DMFT scores were higher among NF1- controls aged over 20. All oral complications were not significantly presented among NF1 patients aged below 20. IPA analyses suggested that cellular mechanisms underlying NF1-associated oral complications involved chronic inflammatory pathways as well as fibrosis signalling pathway.Conclusion: NF1 patients without tumors in the oral cavity presented with a higher prevalence of age-dependent oral complications, including periodontal destruction and salivary gland dysfunction, which were associated with chronic inflammatory pathogenesis.

scholarly journals Characteristics of Saliva in FK Ukrida Students After Chewing Paraffin, Xylitol and Sucrose Gum

2021 ◽  
Vol 5 (1) ◽  
pp. 24-30
Author(s):  
Wan Aishah Fariha Binti Wan Nazri ◽  
William Daud ◽  
Flora Rumiati
Keyword(s):  
Flow Rate ◽  
Ph Value ◽  
Salivary Flow ◽  
Reducing Sugar ◽  
Salivary Flow Rate ◽  
Resistant Bacteria ◽  
Chewing Gum ◽  
Ph Values ◽  
Salivary Ph ◽  
Sugar Levels

Data from the Ministry of Health of the Republic of Indonesia in 2009 shows that national sugar consumption per capita reaches 12kg / year. Snacks consumed mostly were based on sucrose sugar and it turns out that sucrose is increasing the insidens of caries because sugar-based foods and drinks cause acid-resistant bacteria to obtain a suitable environment for growth. To overcome this problem sucrose was replaced with alcohol sugar such as xylitol, especially in chewing gum. However, it is still unknown the effect of xylitol on saliva. The purpose of this study was to see whether there were differences in salivary characteristics after consuming paraffin, xylitol chewing gum and sucrose chewing gum by looking at salivary pH values, reducing sugar levels in saliva and salivary flow rates. Saliva collection is done by spitting method then the total volume is divided by the time of collection to get the flow rate of saliva. Salivary pH is measured using a pH meter while reducing sugar levels are measured using the Benedict's test. The sample for this study consisted of 50 Ukrida FK students. The results of this study indicate that the highest salivary flow rate is after chewing xylitol chewing gum. While the reducing sugar levels in saliva are only found after chewing sucrose chewing gum. For salivary pH values, after chewing sucrose chewing gum the most acidic pH was obtained when compared to after chewing paraffin and xylitol chewing gum. From the research that has been done, after consuming paraffin, xylitol chewing gum and sucrose chewing gum, the highest salivary flow rate was obtained after consuming xylitol chewing gum, while the lowest was after consuming paraffin. Meanwhile, the highest pH value of saliva was after consuming paraffin and the lowest was after consuming sucrose chewing gum. Meanwhile, reducing sugar levels in saliva was only found after consuming sucrose chewing gum and was not found after consuming paraffin and xylitol chewing gum. From this study it can be concluded that there are differences in the characteristics of saliva among FK Ukrida students after consuming paraffin, xylitol chewing gum and sucrose chewing gum.

scholarly journals Scalp hair whorl patterns in patients affected by Neurofibromatosis Type 1: A case-control study

2020 ◽  
Vol 12 (2) ◽  
pp. 56
Author(s):  
Annalisa Patrizi ◽  
Andrea Sechi ◽  
Iria Neri ◽  
Michela Starace ◽  
Francesco Savoia ◽  
...  
Keyword(s):  
Neurofibromatosis Type 1 ◽  
Case Control Study ◽  
Scalp Hair ◽  
Neurofibromatosis Type ◽  
Case Control ◽  
Control Study

scholarly journals Hypopigmented macules in Neurofibromatosis type 1: a case control study

2020 ◽  
Author(s):  
Francisco Javier García-Martínez ◽  
Anna Duat-Rodriguez ◽  
Antonio Torrelo ◽  
Lucero Noguera Morel ◽  
Angela Hernández-Martín
Keyword(s):  
Neurofibromatosis Type 1 ◽  
Case Control Study ◽  
Neurofibromatosis Type ◽  
Case Control ◽  
Control Study

scholarly journals An obstructive tongue neurofibroma

2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Gama R ◽  
◽  
Sousa M ◽  
Castro F ◽  
Condé A ◽  
...  
Keyword(s):  
Adjuvant Therapy ◽  
Oral Cavity ◽  
Autosomal Dominant ◽  
Neck Region ◽  
Neurofibromatosis Type ◽  
The Body ◽  
Benign Lesions ◽  
Autosomal Dominant Disorder ◽  
Head And Neck Region

Neurofibromatosis type 1 (NF1) is an autosomal dominant disorder characterized by multiple manifestations, including the presence of neurofibromas. These benign lesions can potentially affect every site of the body; its location in the head and neck region is not uncommon, but the oral cavity, and specially the tongue, are rarely affected. We aim to present a case of a giant recurrent neurofibroma of the tongue in a NF1 patient, conditiong obstructive symptoms, as well as to ouline its successful treatment with topical mitomycin-C as an adjuvant therapy to surgical ressection. Keywords: neurofibromatosis; neurofibroma; recurrence; airway obstruction.

scholarly journals Solitary central neurofibroma of the maxilla: A Case Report

2020 ◽  
Vol 23 (4) ◽  
pp. 6p
Author(s):  
Hossein Danesteh ◽  
Azita Sadeghzade ◽  
Dana Jafarpour
Keyword(s):  
Oral Cavity ◽  
Benign Tumor ◽  
Neurofibromatosis Type ◽  
Von Recklinghausen’S Disease ◽  
Von Recklinghausen's Disease ◽  
Solitary Lesion ◽  
Maxillary Bone ◽  
Recklinghausen's Disease ◽  
Recklinghausen’S Disease

Neurofibroma is a benign tumor which rarely occurs in the oral cavity. Generally, oral neurofibroma is part of a neurofibromatosis type-1 like syndrome (Von Recklinghausen’s disease) and rarely occurs as a solitary lesion of oral cavity. Up to now, few cases have been reported with the solitary neurofibromas of tongue and submandibular gland. The tumor can also be rarely located centrally in the bone. This research presents a central neurofibroma case in the maxillary bone which has no relationship with the neurofibromatosis. Keywords Central neurofibroma; Neurofibromatosis; Solitary neurofibroma; Von Recklinghausen’s disease.

Age-Dependent Changes in Sirolimus Metabolite Formation in Patients With Neurofibromatosis Type 1

2015 ◽  
Vol 37 (3) ◽  
pp. 395-399 ◽  
Author(s):  
Chie Emoto ◽  
Tsuyoshi Fukuda ◽  
Tomoyuki Mizuno ◽  
Shareen Cox ◽  
Björn Schniedewind ◽  
...  
Keyword(s):  
Neurofibromatosis Type 1 ◽  
Neurofibromatosis Type ◽  
Metabolite Formation ◽  
Age Dependent
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