scholarly journals Association Between the Alterations in the Blood Routine Check Parameters and Cognitive Impairment in the Shenzhen Ageing-related Disorder Cohort in China

2021 ◽  
Author(s):  
Kaiyu Wu ◽  
Chunyan Xu ◽  
Xiaoping Tian ◽  
Guozhen Qiu ◽  
Wei Liu ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Nonparametric Test ◽  
Mean Corpuscular Hemoglobin ◽  
Monocyte Count ◽  
Retrospective Case ◽  
Related Disorder ◽  
Routine Blood ◽  
Normal Cognitive Function ◽  
Function Group

Abstract Background: Previous studies have suggested a correlation between alterations in the routine blood check markers and cognitive impairment. Objective: We aimed to explore the relationship between routine blood parameters and cognitive impairment. Methods: In this retrospective case-control study, 8,025 people over 60 years of age were enrolled from 51 community health centers in Luohu District of Shenzhen City from 2017 to 2018. According to the mini-mental state examination (MMSE) score and educational level, participants were divided into a cognitive impairment group (n=385) and normal cognitive function group (n=7,640). Nonparametric test, chi-square test, and binary logistic regression were applied to analyze the data. Results: Compared to the normal cognitive function group, the lymphocyte-to-monocyte ratio (LMR), packed-cell volume (PCV), and platelet count (PLT) in the cognitive impairment group were significantly lower (7.26 [5.50,8.81] vs. 7.45 [5.80,9.35]; 40.1 [36.65,42.95] vs. 40.5 [37.7,43.1]; 216 [190,258] vs. 228 [196,261], p<0.05, respectively), while the monocyte count and mean corpuscular hemoglobin concentration (MCHC) were higher (0.31 [0.25, 0.38] vs. 0.3 [0.24, 0.37]; 336 [330, 343] vs. 335 [328, 342], p<0.05, respectively). Additionally, MCHC [odds ratio (OR):1.011, 95% confidence interval (CI) :1.001–1.021, p = 0.033] and PCV [OR: 0.993, 95% CI: 0.987–0.999, p = 0.033) were independently associated with cognitive impairment. Conclusion: The alterations in some routine blood check parameters, including reduced LMR, PCV, and PLT, and elevated monocyte count and MCHC, may be associated with cognitive impairment.

Association of Neutrophil-Lymphocyte Ratio with Mild Cognitive Impairment in Elderly Chinese Adults: A Case-control Study

2020 ◽  
Vol 16 (14) ◽  
pp. 1309-1315
Author(s):  
Peilin An ◽  
Xuan Zhou ◽  
Yue Du ◽  
Jiangang Zhao ◽  
Aili Song ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Predictive Values ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Elderly Chinese ◽  
Normal Cognitive Function ◽  
The Absolute

Background: Inflammation plays a significant role in the pathophysiology of cognitive impairment in previous studies. Neutrophil-lymphocyte ratio (NLR) is a reliable measure of systemic inflammation. Objective: The aim of this study was to investigate the association between NLR and mild cognitive impairment (MCI), and further to explore the diagnostic potential of the inflammatory markers NLR for the diagnosis of MCI in elderly Chinese individuals. Methods: 186 MCI subjects and 153 subjects with normal cognitive function were evaluated consecutively in this study. Neutrophil (NEUT) count and Lymphocyte (LYM) count were measured in fasting blood samples. The NLR was calculated by dividing the absolute NEUT count by the absolute LYM count. Multivariable logistic regression was used to evaluate the potential association between NLR and MCI. NLR for predicting MCI was analyzed using Receiver Operating Characteristic (ROC) curve analysis. Results: The NLR of MCI group was significantly higher than that of subjects with normal cognitive function (2.39 ± 0.55 vs. 1.94 ± 0.51, P < 0.001). Logistic regression analysis showed that higher NLR was an independent risk factor for MCI (OR: 4.549, 95% CI: 2.623-7.889, P < 0.001). ROC analysis suggested that the optimum NLR cut-off point for MCI was 2.07 with 73.66% sensitivity, 69.28% specificity, 74.48% Positive Predictive Values (PPV) and 68.36% negative predictive values (NPV). Subjects with NLR ≥ 2.07 showed higher risk relative to NLR < 2.07 (OR: 5.933, 95% CI: 3.467-10.155, P < 0.001). Conclusion: The elevated NLR is significantly associated with increased risk of MCI. In particular, NLR level higher than the threshold of 2.07 was significantly associated with the probability of MCI.

scholarly journals The Role of Daily Social Interactions in Detecting Mild Cognitive Impairment

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 598-598
Author(s):  
Ruixue Zhaoyang ◽  
Stacey Scott ◽  
Eric Cerino ◽  
Martin Sliwinski
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Social Interactions ◽  
Social Relationships ◽  
Daily Basis ◽  
Community Dwelling ◽  
Normal Cognitive Function ◽  
Social Markers

Abstract Social relationships play an important role in cognitive health and aging. However, it is unclear how older adult’s cognitive function affects their everyday social interactions, especially for those with mild cognitive impairment (MCI). This study examined whether older adults with intact cognition vs. MCI differed in their daily social interactions. Community-dwelling older adults from the Einstein Aging Study (N=244, 70-91 yrs) reported their social interactions five times daily for 14 consecutive days using smartphones. Compared to those with normal cognitive function, older adults with MCI reported less frequent positive social interactions (p=0.012) and in-person social activities (p=0.006) on a daily basis. These two groups, however, did not show significant differences in their social relationships assessed by a conventional global questionnaire. The results support that, relative to global social relationships, daily social interactions are more sensitive, ecologically valid social markers that can facilitate the early detection of MCI.

scholarly journals Can Performance on Daily Activities Discriminate Between Older Adults with Normal Cognitive Function and Those with Mild Cognitive Impairment?

2014 ◽  
Vol 62 (7) ◽  
pp. 1347-1352 ◽  
Author(s):  
Juleen Rodakowski ◽  
Elizabeth R. Skidmore ◽  
Charles F. Reynolds ◽  
Mary Amanda Dew ◽  
Meryl A. Butters ◽  
...  
Keyword(s):  
Older Adults ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
Daily Activities ◽  
Normal Cognitive Function

scholarly journals Right Frontoinsular Cortex: A Potential Imaging Biomarker to Evaluate T2DM-Induced Cognitive Impairment

2021 ◽  
Vol 13 ◽  
Author(s):  
Dongsheng Zhang ◽  
Yumeng Lei ◽  
Jie Gao ◽  
Fei Qi ◽  
Xuejiao Yan ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Cognitive Function ◽  
Cognitive Dysfunction ◽  
Inferior Frontal Gyrus ◽  
Brain Network ◽  
Imaging Biomarker ◽  
Linear Processes ◽  
Significant Difference ◽  
Normal Cognitive Function ◽  
The Right

Cognitive impairment in type 2 diabetes mellitus (T2DM) is associated with functional and structural abnormalities in the intrinsic brain network. The salience network (SN) is a neurocognitive network that maintains normal cognitive function, but it has received little attention in T2DM. We explored SN changes in patients with T2DM with normal cognitive function (DMCN) and in patients with T2DM with mild cognitive impairment (DMCI). Sixty-five T2DM patients and 31 healthy controls (HCs) underwent a neuropsychological assessment, independent component analysis (ICA), and voxel-based morphometry (VBM) analysis. The ICA extracted the SN for VBM to compare SN functional connectivity (FC) and gray matter (GM) volume (GMV) between groups. A correlation analysis examined the relationship between abnormal FC and GMV and clinical/cognitive variables. Compared with HCs, DMCN patients demonstrated increased FC in the left frontoinsular cortex (FIC), right anterior insula, and putamen, while DMCI patients demonstrated decreased right middle/inferior frontal gyrus FC. Compared with DMCN patients, DMCI patients showed decreased right FIC FC. There was no significant difference in SN GMV in DMCN and DMCI patients compared with HCs. FIC GMV was decreased in the DMCI patients compared with DMCN patients. In addition, right FIC FC and SN GMV positively correlated with Montreal Cognitive Assessment and Mini-Mental State Examination (MMSE) scores. These findings indicate that changes in SN FC, and GMV are complex non-linear processes accompanied by increased cognitive dysfunction in patients with T2DM. The right FIC may be a useful imaging biomarker for supplementary assessment of early cognitive dysfunction in patients with T2DM.

scholarly journals Gambaran skor MMSE dan MoCA-INA pada pasien cedera kepala ringan dan sedang yang dirawat di RSUP Prof. Dr. R. D. Kandou Manado

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Nurindah Athika ◽  
Junita Maja PS ◽  
Arthur H.P. Mawuntu
Keyword(s):  
Traumatic Brain Injury ◽  
Cognitive Impairment ◽  
Brain Injury ◽  
Cognitive Function ◽  
Head Injury ◽  
Descriptive Study ◽  
Direct Examination ◽  
Function Impairment ◽  
Normal Cognitive Function ◽  
Better Than

Abstract: Traumatic Brain Injury (TBI) is the most common case in hospital. TBI can caused cognitive impairment. This study aimed to obtain the description of cognitive function in patients with mild and moderate TBI that were admitted to Prof. Dr. R. D. Kandou Hospital Manado. This was a prospective descriptive study by conducting direct examination to the patients diagnosed with mild or moderate TBI by using MMSE and Ina MoCA instruments. Thee results showed that there of 50 subjects there were 74% with mild TBI and 26% with moderate TBI. MMSE showed 96% normal while Ina MoCA showed 76% normal. Cognitive function impairment was more visible on Ina MoCA examination. Conclusion: Ina MoCA was better than MMSE examination in description of cognitive function impairment.Keywords: head injury, cognitive function Abstrak: Cedera kepala merupakan suatu kegawatan yang paling sering dijumpai di Rumah Sakit. Cedera kepala dapat menyebabkan gangguan fungsi kognitif. Penelitian ini bertujuan untuk mengetahui gambaran skor MMSE dan MoCA-Ina pada pasien cedera kepala ringan dan sedang yang dirawat di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini ialah deskriptif prospektif dengan melakukan pemeriksaan langsung pada pasien yang didiagnosis cedera kepala ringan atau sedang menggunakan instrumen MMSE dan MoCA-Ina. Hasil penelitian mendapatkan subjek sebanyak 50 orang dengan persentase cedera kepala ringan sebanyak 74% dan cedera kepala sedang 26%. Pada MMSE didapatkan 96% normal sedangkan pada MoCA-Ina didapatkan 76% normal. Penurunan fungsi kognitif lebih terlihat pada pemeriksaan MoCA-Ina. Simpulan: MoCA-Ina lebih dapat menggambarkan gangguan fungsi kognitif daripada pemeriksaan MMSE. Kata kunci: cedera kepala, fungsi kognitif

scholarly journals Overview Independence and Cognitive Function of Elderly

2019 ◽  
Vol 1 (1) ◽  
pp. 81-86
Author(s):  
Yulia Susanti ◽  
Livana PH
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Cognitive Function ◽  
The Elderly ◽  
The Body ◽  
Advanced Stage ◽  
Normal Cognitive Function ◽  
The City ◽  
Physiological And Biochemical ◽  
Descriptive Method

Elderly is not a disease, but is an advanced stage of a life process characterized by a decrease in the body's ability to adapt to environmental stress. Elderly causes anatomical, physiological, and biochemical changes in the body, so that it will affect the overall function and ability of the body. The study aims to determine the picture of independence and cognitive function in the elderly. The study used a descriptive method with a sample of 108 elderly in the City of Kendal Indonesia. Data were analyzed using frequency distribution. The results showed the majority of respondents (81.5%) elderly were categorized as having the ability to independently level and 78.6% had normal cognitive function, 18.5% had mild cognitive impairment, and 1.9% had severe cognitive impairment.  Keywords: independence, cognitive function, elderly

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