scholarly journals Multisystem Inflammatory Syndrome In Neonates Associated With SARS-CoV2 infection- A case series.

2021 ◽  
Author(s):  
KIRAN MORE ◽  
Sheila Aiyer ◽  
Ashish Goti ◽  
Manan Parikh ◽  
Samir Sheikh ◽  
...  
Keyword(s):  
Respiratory Distress ◽  
Cardiac Dysfunction ◽  
Case Series ◽  
Clinical Findings ◽  
Igg Antibodies ◽  
Term Neonates ◽  
Proactive Management ◽  
High Index Of Suspicion ◽  
Inflammatory Syndrome ◽  
Mis 5

Abstract Multisystem inflammatory syndrome(MIS) in children (MIS-C) associated with severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) is well recognised in children, however, rarely reported in newborns. We describe a case series of 20 neonates who were diagnosed as MIS in neonates (MIS-N). We grouped cases into three categories as Most likely MIS(5), Possible MIS(9) and Unlikely MIS(6). All neonates had high titres of SARS CoV 2 IgG antibodies and were negative for SARS CoV 2 antigens. The most common clinical findings noted in Most Likely MIS neonates were respiratory distress (4/5), shock with hypotension (4/5) and encephalopathy (4/5). Inflammatory markers like CRP (1/5), Procalcitonin (1/5), Ferritin (3/5), D-dimer (4/5) and LDH (2/5) were found to be elevated, and four of them had significantly high levels of proBNP. The majority of them (4/5) responded to immunomodulators, three discharged home and two neonates died. The most common clinical findings in Possible MIS infants were fever (6/9), respiratory distress (3/9), refusal to feeds (6/9), lethargy (5/9) and tachycardia (3/9). ProBNP as a marker of cardiac dysfunction was noted to be elevated in five infants correlating with Echocardiography in two. All infants in this group responded to immunomodulators.MIS-N manifested as a milder disease in term neonates than preterms, where it was a more severe presentation with cardiac dysfunction. The diagnosis of MIS-N can be challenging and requires a high index of suspicion and early, proactive management. However, it is also important to be cautious of incorrect or overdiagnosis of this condition during the current pandemic.

scholarly journals A young adult with COVID-19 and multisystem inflammatory syndrome in children (MIS-C)-like illness: a case report

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Aaron D. Kofman ◽  
Emma K. Sizemore ◽  
Joshua F. Detelich ◽  
Benjamin Albrecht ◽  
Anne L. Piantadosi
Keyword(s):  
Cardiac Dysfunction ◽  
Clinical Characteristics ◽  
Kidney Injury ◽  
Clinical Findings ◽  
Low Grade ◽  
Rare Form ◽  
Case Presentation ◽  
Lymph Node Swelling ◽  
Inflammatory Syndrome

Abstract Background A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age. Case presentation The patient presented with 1 week of weakness, dyspnea, and low-grade fevers, followed by mild cough, sore throat, vomiting, diarrhea, and lymph node swelling. She was otherwise healthy, with no prior medical history. Her hospital course was notable for profound acute kidney injury, leukocytosis, hypotension, and cardiac dysfunction requiring ICU admission and vasopressor support. MIS-C-like illness secondary to COVID-19 was suspected due to physical exam findings of conjunctivitis, mucositis, and shock. She improved following IVIG, aspirin, and supportive care, and was discharged on hospital day 5. Conclusion MIS-C-like illness should be considered in adults presenting with atypical clinical findings and concern for COVID-19. Further research is needed to support the role of IVIG and aspirin in this patient population.

scholarly journals Vaping in today’s pandemic: E-cigarette, or vaping, product use–associated lung injury mimicking COVID-19 in teenagers presenting with respiratory distress

2020 ◽  
Vol 8 ◽  
pp. 2050313X2096959
Author(s):  
Daphne O Darmawan ◽  
Kriti Gwal ◽  
Brian D Goudy ◽  
Sanjay Jhawar ◽  
Kiran Nandalike
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Lung Injury ◽  
Respiratory Distress ◽  
Pediatric Patients ◽  
Clinical Presentation ◽  
Case Series ◽  
Product Use ◽  
Abdominal Symptoms ◽  
History Of ◽  
High Index Of Suspicion

The clinical presentation of children and adolescents infected with severe acute respiratory syndrome coronavirus 2 can range from asymptomatic to mild or moderate manifestations. We present a case series of three adolescents who presented during the coronavirus disease 2019 (COVID-19) pandemic with symptoms concerning for COVID-19, including fever, abdominal symptoms, cough, respiratory distress, and hypoxemia. Their laboratory results showed elevated inflammatory markers that are also commonly seen in COVID-19. The chest imaging studies mimicked COVID-19 with non-specific ground glass opacities and interstitial prominence patterns. However, severe acute respiratory syndrome coronavirus 2 testing was negative and further questioning of these adolescents and their parents revealed a history of vaping marijuana-related products leading to the eventual diagnosis of e-cigarette, or vaping, product use–associated lung injury. Our patients were successfully treated with corticosteroids. The providers caring for pediatric patients, especially adolescents, should continue to have a high index of suspicion for e-cigarette, or vaping, product use–associated lung injury in patients presenting with unexplained respiratory failure, while ruling out COVID-19.

scholarly journals Unusual Presentation of Kawasaki Disease with Multisystem Inflammation and Antibodies Against Severe Acute Respiratory Syndrome Coronavirus 2: A Case Report

2020 ◽  
Author(s):  
Haena Kim ◽  
Jung Yeon Shim ◽  
Jae-Hoon Ko ◽  
Aram Yang ◽  
Jae Won Shim ◽  
...  
Keyword(s):  
Kawasaki Disease ◽  
Severe Acute Respiratory Syndrome ◽  
Signs And Symptoms ◽  
Enzyme Linked Immunosorbent Assay ◽  
Igg Antibodies ◽  
Case Presentation ◽  
History Of ◽  
Polymerase Chain ◽  
High Index Of Suspicion ◽  
Inflammatory Syndrome

Abstract Background: Since mid-April 2020, cases of multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus disease (COVID-19) that mimic Kawasaki disease (KD) have been reported in Europe and North America. However, no cases have been in East Asia, where KD is more prevalent.Case presentation: A previously healthy 11-year-old boy was admitted with a 4-day history of fever and abdominal pain. He had no contact history to any patient with COVID-19. Blood acute inflammatory markers were highly elevated. He was treated with antibiotics for suspected bacterial enteritis, but he suddenly developed hypotension. Inotropics and intravenous immunoglobulin were administered to manage septic shock. On hospitalization day 6, he developed signs and symptoms of KD (conjunctival injection, strawberry tongue, cracked lip, and coronary artery dilatation) in addition to pleural/pericardial effusion and mesenteric lymphadenitis. The results of microbiologic tests, including reverse-transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), were negative. Fluorescent immunoassay and enzyme-linked immunosorbent assay revealed abundant IgG antibodies against SARS-CoV-2 in his serum, but no IgM antibodies. He was discharged successfully on day 13.Conclusion: MIS-C may occur in children with a previously asymptomatic COVID-19 infection. A high index of suspicion is required for this novel syndrome in unusual cases of KD or KD shock syndrome with multisystem inflammation, even when there is no clear history of contact or symptoms of COVID-19.

Gastrointestinal Mucormycosis Mimicking as Necrotizing Enterocolitis: Case Series of 5 Neonates

2018 ◽  
Vol 32 (2-3) ◽  
pp. 74-77
Author(s):  
Vivek Kumar Athwani ◽  
Pardeep Kumar Sharma ◽  
Tania Mahal ◽  
Bhupinder Kaur
Keyword(s):  
Risk Factor ◽  
Necrotizing Enterocolitis ◽  
Histopathological Examination ◽  
Perinatal Asphyxia ◽  
Case Series ◽  
Rapid Progression ◽  
Term Neonates ◽  
Improve Outcome ◽  
High Index Of Suspicion ◽  
Case Characteristics

Background: Gastrointestinal mucormycosis (GIM) is a rare potentially lethal fungal infection in neonates associated with rapid progression and high mortality. Case Characteristics: We herein report 2 preterm and 3 term cases of GIM; all term neonates had perinatal asphyxia. All cases were preoperatively diagnosed as necrotizing enterocolitis (NEC). Observation: All cases underwent laparotomy, and the diagnosis of GIM was made on postoperative histopathological examination. Results: Asphyxia might be an important risk factor for mucormycosis in term neonates, and to improve outcome, a high index of suspicion of GIM should be kept in cases of NEC in neonates, especially in term neonates.

scholarly journals A Young Adult with COVID-19 and Multisystem Inflammatory Syndrome in Children (MIS-C)-like Illness: A Case Report

2020 ◽  
Author(s):  
Aaron D. Kofman ◽  
Emma K. Sizemore ◽  
Joshua F. Detelich ◽  
Benjamin Albrecht ◽  
Anne L. Piantadosi
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Dysfunction ◽  
Clinical Characteristics ◽  
Kidney Injury ◽  
Clinical Findings ◽  
Low Grade ◽  
Rare Form ◽  
Lymph Node Swelling ◽  
Inflammatory Syndrome

Abstract Background: A healthy 25-year-old woman developed COVID-19 disease with clinical characteristics resembling Multisystem Inflammatory Syndrome in Children (MIS-C), a rare form of COVID-19 described primarily in children under 21 years of age.Case Presentation: The patient presented with one week of weakness, dyspnea, and low-grade fevers, followed by mild cough, sore throat, vomiting, diarrhea, and lymph node swelling. She was otherwise healthy, with no prior medical history. Her hospital course was notable for profound acute kidney injury, leukocytosis, hypotension, and cardiac dysfunction requiring ICU admission and vasopressor support. MIS-C-like illness secondary to COVID-19 was suspected due to physical exam findings of conjunctivitis, mucositis, and shock. She improved following IVIG, aspirin, and supportive care, and was discharged on hospital day 5.Conclusion: MIS-C-like illness should be considered in adults presenting with atypical clinical findings and concern for COVID-19. Further research is needed to support the role of IVIG and aspirin in this patient population.

Sign in / Sign up

Export Citation Format

Share Document