Red Cell Distribution Width: a Novel Predictive Biomarker for Stroke Risk After Transient Ischemic Attack

Abstract Objective: Predicting the prognosis of transient ischemic attack (TIA) is difficult for many frontline clinicians. The purpose of this study was to determine whether subsequent stroke in TIA patients can be predicted via the red blood cell distribution width(RDW).Material and methods: A total of 309 consecutive age- and sex-matched patients with new onset TIA, in our stroke center, were enrolled over the period studied. The patients were divided into two groups :103 TIA patients and 206 patients who had a stroke within 7 days after TIA. Complete blood count, biochemical parameters and brain imaging were performed in all patients. Results: The mean RDW values of patients with stroke after TIA were significantly higher than patients with TIA (12.84 ±1.19, 13.35 ±1.59, p= 0.001). In a multivariate model, RDW was independently associated with stroke after TIA (OR=2.52, 95% CI 1.46 to 3.35, P= 0.002). We also found that the higher levels of RDW, the earlier the stroke onset (p=0.024). Compared to ABCD2 score, the diagnostic power of RDW in the differentiation of patients with stroke after TIA is better (AUCs:0.613vs0.731, p= 0.015). When an RDW cut-off value of 13.95% is accepted for differentiating patients with stroke after TIA from TIA, the sensitivity and specificity were 73.7% and 74.3%, respectively.Conclusions: The early determination of RDW is a promising, rapid, easy and inexpensive biomarker to predict the subsequent stroke in TIA patients.

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Correlation between Red Blood Cell Distribution width, Neutrophil to Lymphocyte Ratio and Neutrophil to Platelet Ratio with 3-month Prognosis of Patients with Intracerebral Hemorrhage: A Retrospective Study

10.21203/rs.3.rs-1200296/v1 ◽

2022 ◽

Author(s):

Sheida Shaafi ◽

Ehsan Bonakdari ◽

Yalda Sadeghpour ◽

Seyed Aria Nejadghaderi

Keyword(s):

Prognostic Factor ◽

Blood Cell ◽

Intracerebral Hemorrhage ◽

Red Blood Cell ◽

Large Scale ◽

Complete Blood Count ◽

Cell Distribution ◽

Distribution Width ◽

Significant Difference ◽

The Mean

Abstract Background: Red cell distribution width (RDW) is a parameter that indicates the heterogeneity of red blood cell size and could be as a prognostic factor in some diseases. Also, intracerebral hemorrhage (ICH) is considered a vascular event with a high mortality rate. Here, we aimed to examine the role of RDW, neutrophil to lymphocyte (NLR) and neutrophil to platelet ratios (NPR) in predicting the prognosis of patients with ICH.Methods: This is a retrospective cohort study which conducted on 140 patients with ICH admitted to the neurology ward and intensive care unit (ICU) in Imam Reza Hospital, Tabriz, Iran. Demographic data, National Institutes of Health Stroke Scale (NIHSS), and complete blood count (CBC) test parameters evaluated within 24 hours after hospitalization. These variables collected and re-evaluated three months later. Results: The mean age of the study population was 61.14 (±16) years and 51% were male. RDW had a significant positive correlation with hemoglobin concentration (r=0.3; p<0.001) and significant negative correlation with MCHC (r=-0.57; p<0.001) and neutrophil count (r=-0.235; p=0.006). Also, the mean NLR (p=0.05), neutrophil and platelet count (p=0.05), NIHSS (p=0.05), and RDW (p=0.01) had a significant difference between the deceased patients and those who partially recovered after 3 months. Moreover, the results of logistic regression showed variables including RDW (p=0.006) and NIHSS (p<0.001) levels were correlated significantly with mortality. Conclusion: RDW could be an appropriate prognostic factor and predictor in determining 3-months survival in ICH. Nevertheless, further large-scale prospective cohorts might be needed to evaluate the associations.

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Faculty Opinions recommendation of Association of New-Onset Atrial Fibrillation After Noncardiac Surgery With Subsequent Stroke and Transient Ischemic Attack.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.738590355.793579499 ◽

2020 ◽

Author(s):

Thomas Slaughter

Keyword(s):

Atrial Fibrillation ◽

Transient Ischemic Attack ◽

Noncardiac Surgery ◽

Ischemic Attack ◽

Onset Atrial Fibrillation ◽

New Onset

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Faculty Opinions recommendation of Association of New-Onset Atrial Fibrillation After Noncardiac Surgery With Subsequent Stroke and Transient Ischemic Attack.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.738590355.793580008 ◽

2020 ◽

Author(s):

Wilbert Aronow

Keyword(s):

Atrial Fibrillation ◽

Transient Ischemic Attack ◽

Noncardiac Surgery ◽

Ischemic Attack ◽

Onset Atrial Fibrillation ◽

New Onset

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62 Feeding Chicory-plantain Silage and Se-yeast to Lactating Ewes Subjected to Intramammary Infection: Effect on the Immune System

Journal of Animal Science ◽

10.1093/jas/skab235.056 ◽

2021 ◽

Vol 99 (Supplement_3) ◽

pp. 32-33

Author(s):

Hunter Ford ◽

Massimo Bionaz ◽

Serkan Ates ◽

Joe Klopfenstein ◽

Jorge Vanegas ◽

...

Keyword(s):

Fixed Effects ◽

Complete Blood Count ◽

Random Effect ◽

Mean Cell Volume ◽

Distribution Width ◽

Intramammary Infection ◽

Alfalfa Meal ◽

The Mean ◽

To Receive ◽

Positive Effect

Abstract The objective was to test the effect on the immune status by feeding a combination of chicory-plantain and Se-yeast in lactating ewes subjected to intramammary infection (IMI) with 2×107CFU of Strep uberis in both glands. For the purpose we enrolled 28 Polypay lactating sheep from a prior study where they were randomly allocated to receive chicory (CS) or grass (GC) silage and either 3.6 mg of Se/day as Se-yeast (DiaMune, Diamond V) (Y) or isoenergetic-isonitrogenous alfalfa meal (C) for 2 months. For the present study, ewes were kept on the original dietary regiment except the CT group received a chicory-plantain silage(50% each). Blood was collected prior to and for 10 days after IMI for a complete blood count(VetScan HM5), leukocytes migration, and rectal temperature (RT). Data were analyzed using GLIMMIX (SAS)with time, silage type, and Se and their interactions as the fixed effects and ewe as random effect with significance declared at P ≤ 0.05. RT was lower in chicory vs. grass before IMI and Se limited the RT increase after IMI. Total WBC levels tended (P = 0.06) to increase in animals fed with Se after IMI, which was driven by a larger number of lymphocytes. Hematocrit, red blood cells, and hemoglobin were strongly decreased by IMI. The mean cell volume was overall larger in ewes fed with chicory-plantain silage while mean cell hemoglobin was larger in animal fed with grass silage. The platelet distribution width was affected by silage*Se interaction due to a positive effect by Se in grass-fed but negative in chicory-plantain-fed ewes. Migration of neutrophils was larger in animals fed with chicory-plantain before IMI but similar between groups after IMI. Overall, these findings indicate that Se supplementation can increase lymphocytes with no effect on neutrophils while activity of neutrophils is positively affected by feeding chicory-plantain silage.

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Red cell distribution width and mortality in pediatric sepsis

Paediatrica Indonesiana ◽

10.14238/pi56.6.2016.320-4 ◽

2017 ◽

Vol 56 (6) ◽

pp. 320 ◽

Cited By ~ 1

Author(s):

Trina Devina ◽

Munar Lubis ◽

Erna Mutiara ◽

Gema Nazri Yanni ◽

Rina Amalia C. Saragih ◽

...

Keyword(s):

Complete Blood Count ◽

Cross Sectional Study ◽

Red Cell Distribution Width ◽

Hematological Parameter ◽

Red Cell ◽

Cell Distribution ◽

Chi Square ◽

Cross Sectional ◽

Distribution Width ◽

Pediatric Sepsis

Background Red cell distribution width (RDW) is a hematological parameter routinely obtained as part of the complete blood count. Recently, RDW has emerged as a potential independent predictor of clinical outcomes in adults with sepsis. However, RDW as a mortality predictor in pediatric populations has not been well established.Objective To determine the relationship between RDW value and mortality outcomes in pediatric sepsis patients.Methods We performed a cross-sectional study of 40 consecutive pediatric patients with sepsis admitted to the PICU from December 2013 to March 2014. All patients’ RDW were collected within 24 hours of sepsis diagnosis. We determined the association between RDW and hemoglobin (Hb) using Spearman’s correlation. The RDW values of 11.5-14.5% were considered to be normal while those > 14.5% were considered to be elevated. We compared mortality and PICU length of stay (LoS) between the normal and elevated RDW groups using Chi-square and Mann-Whitney tests.Results The median age of patients was 34 months (range 2 months to 17 years). There were 28 (70%) male subjects. Subjects’ median RDW was 14.8% (range 11.2-27.8%) and was not correlated with Hb (r=0.056; P=0.73). Mortality rates in the normal and elevated RDW groups were 40% and 45%, respectively. There were no significant associations between RDW group and mortality (P=0.749) or PICU LoS (P=0.350).Conclusion Unlike in adults, RDW values are not correlated with mortality in pediatric sepsis patients.

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A Novel Parameter for Predicting Therapeutic Response in Iron Deficiency Anemia: Red Blood Cell Distribution Width

Eurasian Journal of Family Medicine ◽

10.33880/ejfm.2019080303 ◽

2019 ◽

Vol 8 (3) ◽

pp. 107-112

Author(s):

Aslı Korur ◽

Didar Yanardag Acik ◽

Soner Solmaz ◽

Cigdem Gereklioglu ◽

Suheyl Asma ◽

...

Keyword(s):

Blood Cell ◽

Red Blood Cell ◽

Blood Count ◽

Complete Blood Count ◽

Reticulocyte Count ◽

Iron Therapy ◽

Deficiency Anemia ◽

Cell Distribution ◽

Distribution Width ◽

Red Blood Cell Distribution

Aim: Anemia is a public health problem worldwide. Cost effectiveness and efficient use of resources are vitally important. Red blood cell distribution width, which can be obtained from a standard complete blood count, is a measure of the variability in size of circulating erythrocytes. The present study was performed to investigate whether red blood cell distribution width can be used to predict response to iron therapy. Methods: This study was conducted in 50 patients admitted to hematology and family medicine clinics. Complete blood count and reticulocyte count were determined on day 5; complete blood count was examined 1 month after commencement of therapy. Results: Statistically significant differences were detected between hemoglobin levels and red blood cell distribution width values at the time of diagnosis and on day 5 and after 1 month of therapy. A significant positive correlation was found between the increase in red blood cell distribution width and the increase in hemoglobin. Conclusion: Red blood cell distribution width may be used in place of reticulocyte count to predict response to iron therapy. Red blood cell distribution width is the best biomarker for this purpose as a component of complete blood count, and therefore it may be accepted as superior to reticulocyte count.

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