scholarly journals Inflammatory Myofibroblastoma Tumor of Intraocular Ciliary Body: A Case Report and Literature Review

2020 ◽  
Author(s):  
he yu ◽  
Nianting Tong ◽  
Weiqing Huang ◽  
Zhan Yu Zhou
Keyword(s):  
Ciliary Body ◽  
Rare Case ◽  
Positive Staining ◽  
Slit Lamp ◽  
Ki 67 ◽  
Case Presentation ◽  
S 100 ◽  
Hematoxylin And Eosin ◽  
Ciliary Body Tumor ◽  
Slit Lamp Biomicroscopy

Abstract Background: IMTs are extremely rare in eyes. This is the first report of a IMT of the ciliary body.Case presentation: A ciliary body tumor was found under slit lamp biomicroscopy in a 55-year-old male first diagnosed with cataract. Then this patient underwent trans-sclera resection via partial lamellar sclerouvectomy and par plans vitrectomy to remove the mass. Hematoxylin and eosin (HE) staining and immunohistochemistry findings showed that the characteristics of the tumor were consistent with inflammatory myofibroblastoma tumor (IMT).Conclusions: we reported a rare case of intraocular IMT, which is confirmed by H&E staining, and IHC positive staining for Vimentin, Desmin and ALK, while negative staining for SMA, S-100, ki-67, CK, CD68, and calponin.

scholarly journals Achondroplasia Associated with Bilateral Keratoconus

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Ammar M. Al Mahmood ◽  
Hind M. Al Katan ◽  
Ghada Y. Al Bin Ali ◽  
Samar A. Al-Swailem
Keyword(s):  
Visual Acuity ◽  
Rare Case ◽  
Penetrating Keratoplasty ◽  
Slit Lamp ◽  
Poor Vision ◽  
The Past ◽  
Uncorrected Visual Acuity ◽  
Hard Contact ◽  
Slit Lamp Biomicroscopy ◽  
Contact Lens Fitting

We report a rare case of bilateral keratoconus in association with achondroplasia. A 26-year-old male, with a known case of achondroplasia, complained of bilateral gradual deterioration in vision for the past few years. Slit lamp biomicroscopy showed bilateral central corneal protrusion and stromal thinning at the apex consistent with keratoconus. a trial of hard contact lens fitting failed to improve VA in the left eye (LE). Right eye (RE) improved to 20/25. The patient underwent penetrating keratoplasty (PKP) in his LE. Twenty-seven months postoperatively, uncorrected visual acuity (UCVA) was 20/30. Ophthalmologists should be aware that patients with achondroplasia who complain of poor vision should be suspected of having keratoconus once other more common conditions are ruled out.

scholarly journals Corneal erforation casused by eyelid margin trichilemmal carcinoma: A case report

2019 ◽  
Author(s):  
Liying Zhang ◽  
Zhirong Lin ◽  
Huping Wu
Keyword(s):  
Rare Case ◽  
The Elderly ◽  
Corneal Perforation ◽  
Slit Lamp ◽  
Blurred Vision ◽  
Eyelid Margin ◽  
Case Presentation ◽  
Adnexal Tumor ◽  
History Of

Abstract Background: Trichilemmal carcinoma (TLC) is a rare malignant adnexal tumor predominantly affecting the scalp, eyelids, neck and face of the elderly. Here, we firstly report a rare case of corneal perforation caused by TLC grown in eyelid margin. Case presentation: A 68-year-old female presented with two months history of unprovoked redness, pain and blurred vision in the left eye. On slit-lamp examination, a 1×2mm aseptic corneal perforation embedded by iris prolapsed was noted. After excluding other causes through examinations and case history inquiry, we speculated that the severe MGD and subsequent BKC might be the cause. In order to prevent the ulcer enlargement and intraocular infection, the patient was treated with penetrating keratoplasty immediately. However, a terrible phenomenon has aroused our concern that several small nodules gradually developed on the eyelid margin, accompanied with bleeding, burst and madarosis postoperatiely. The biopsy revealed the eyelid was involved by TLC and then the lesionectomy was performed immediately. There was no evidence of local recurrence and metastasis during 1 year follow-up. Conclusions: The involvement of eyelid margin by TLC, and subsequent BKC and corneal perforation were very rare and it has not been reported yet. The concomitant BKC can be gradually healed after rectifying eyelid margin by total excision of TLC. It is very important to offer careful follow-up to all patients.

scholarly journals Primary pleomorphic liposarcoma of the liver: a case report and literature review

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Yuri Terunuma ◽  
Kazuhiro Takahashi ◽  
Manami Doi ◽  
Osamu Shimomura ◽  
Yoshihiro Miyazaki ◽  
...  
Keyword(s):  
Literature Review ◽  
Tumor Cells ◽  
Adrenocortical Carcinoma ◽  
Treatment Method ◽  
Ki 67 ◽  
Surgical Specimen ◽  
Case Presentation ◽  
S 100 ◽  
Laboratory Examinations ◽  
The Right

Abstract Background Primary liposarcoma arising from the liver is exceedingly rare. There have been very few reports documenting primary hepatic liposarcoma, especially of the pleomorphic subtype. Surgery is currently the only established treatment method, and the prognosis remains poor. In this report, we present an unusual case of hepatic liposarcoma of the pleomorphic subtype with literature review. In addition, we discuss theories regarding pathogenesis and the pathological and clinical features of primary hepatic liposarcoma to better outline this rare entity. Case presentation An asymptomatic 65-year-old female was found to have a right hepatic mass on a computed tomography scan 2 years after surgical resection of the left adrenal gland and kidney for adrenocortical carcinoma. Laboratory examinations were unremarkable. Magnetic resonance imaging demonstrated a 16-mm mass in the right hepatic lobe. Adrenocortical carcinoma metastasis was suspected. Laparoscopic partial hepatectomy completely removed the tumor with clear margins. Macroscopically, the surgical specimen contained a nodular, yellow–white mass lesion 20 mm in diameter. On pathologic examination, pleomorphic, spindle-shaped tumor cells containing hypochromatic, irregularly shaped nuclei of various sizes formed fascicular structures. Scattered lipoblasts intervened in varying stages. Mitotic cells were frequent. Ki-67 labeling index was 15%. Immunohistochemically, the tumor cells were diffusely positive for vimentin and focally positive for CD34 and alpha-SMA; lipoblasts were focally positive for S-100. Tumor cells were nonreactive for SF-1, inhibin alpha, desmin, HHF35, HMB45, Melan A, MITF, c-kit, DOG1, cytokeratin AE1/AE3, h-caldesmon, STAT6, CD68, MDM2, CDK4, c17, DHEAST, 3BHSD, CD31, Factor 8, and ERG. From these findings, primary hepatic liposarcoma of pleomorphic subtype was diagnosed. The tumor recurred intrahepatically 3 years later, and the patient died 5 months after recurrence. Conclusions In our report, we discussed the rarity, theories regarding pathogenesis, and a review of the literature of this atypical condition. To the best of our search, this is the 14th case of primary hepatic liposarcoma and the 2nd case of the pleomorphic subtype reported throughout the world. Further research regarding the etiology of this unusual clinical entity is warranted to establish effective diagnostic and management protocols.

scholarly journals A Misdiagnosis of a Huge Lung Fibroleiomyomatous Hamartoma in Pleural Cavity

2021 ◽  
Author(s):  
Minghui Liu ◽  
Xin Li ◽  
Hongbing Zhang ◽  
Fan Ren ◽  
Ming Dong ◽  
...  
Keyword(s):  
Benign Tumor ◽  
Pleural Cavity ◽  
Good Prognosis ◽  
Positive Staining ◽  
Case Presentation ◽  
Napsin A ◽  
Mediastinal Germ Cell Tumor ◽  
S 100 ◽  
Rare Benign Tumor ◽  
Percutaneous Lung Biopsy

Abstract Backgroud: Lung fibroleiomyomatous hamartoma is an extremely rare benign tumor in lung, it belongs to hamartoma. There were only five patients with solitary pulmonary fibroleiomyomatous hamartoma reported in literatures and our case has the largest size of the tumor from lung.Case presentation: Our case is a 36-year woman with a huge mass in pleural cavity. She was once misdiagnosed mediastinal germ cell tumor with pleural effusion through percutaneous lung biopsy in other hospital. After traditional thoracotomy, a huge size of 22 x 18 x 5.5 cm mass was completely dissected and a diagnosis of pulmonary fibroleiomyomatous hamartoma was given by pathology combined with immunohistochemical staining, which showed the positive staining of SMA, Desmin, CD34, BCL2, TTF1, Napsin A, and CK7, and the negative staining of S-100 and Calretinin. The patient recovered well with 40 months following up without recurrence.Conclusions:In our case, we had reported the largest size of lung fibroleiomyomatous hamartoma. The treatment of fibroleiomyomatous hamartoma is completely resected it and have a good prognosis.

Histologic evaluation of Ki-67 and cleaved caspase-3 expression in feline mammary carcinoma

2016 ◽  
Vol 19 (4) ◽  
pp. 440-445 ◽  
Author(s):  
Millena N Silva ◽  
Juliana S Leite ◽  
Marcela FV Mello ◽  
Kassia VGC Silva ◽  
Katia B Corgozinho ◽  
...  
Keyword(s):  
Mammary Carcinoma ◽  
Caspase 3 ◽  
Mammary Tumors ◽  
Proliferation Index ◽  
Positive Staining ◽  
Ki 67 ◽  
Feline Mammary Carcinoma ◽  
Histologic Evaluation ◽  
Positive Immunostaining ◽  
Hematoxylin And Eosin

Objectives The purpose of this study was to evaluate histopathologic aspects of, and the expression of Ki-67 and cleaved caspase-3 in, feline mammary carcinoma (FMC). Methods Feline mammary tumors were surgically obtained by mastectomy from 30 female cats and were fixed with formalin and embedded in paraffin wax. Four-micron sections were stained with hematoxylin and eosin for histopathologic diagnosis. Ki-67 and cleaved caspase-3 were analyzed by immunohistochemistry. Results Samples were histologically confirmed as FMC. Positive immunostaining was observed in all cancer samples for both nuclear Ki-67 and cleaved caspase-3, with a mean positive staining percentage of 27.5% and 21.2%, respectively. No statistically significant correlations between Ki-67 and cleaved caspase-3 were observed within FMC. Conclusions and relevance A high proliferation index was found in feline mammary tumors. This is the first study evaluating cleaved caspase-3 expression in FMC.

scholarly journals Isolated intracranial Rosai-Dorfman disease in an adult man: Report of a rare case

2020 ◽  
Vol 8 (1) ◽  
pp. 18-18
Author(s):  
Somaye Rezaei ◽  
Fariba Zarzanalivan ◽  
Pouya Pirouti ◽  
Mohammad Reza Amiri Nikpour ◽  
Abdolreza Javadi ◽  
...  
Keyword(s):  
Rare Case ◽  
Clinical Symptoms ◽  
Histopathological Examination ◽  
Braf V600e Mutation ◽  
Braf V600e ◽  
Total Resection ◽  
Case Presentation ◽  
Rosai Dorfman Disease ◽  
S 100

Background: Isolated intracranial Rosai-Dorfman disease (RDD) is an extremely rare, idiopathic histo-proliferative disorder. RDD is associated with the proliferation of histiocytes and emperipolesis. Case Presentation: we report a case with isolated intracranial RDD. A 47-year- old man presented with a dizziness, falling, and then secondary generalized seizure, hemiparesis and right hemisensory deficit. This case preoperatively was misdiagnosed with meningioma. Histopathological examination revealed pale histiocytes displaying emperipolesis which were positive for S-100 and CD68 proteins and negative for CD1a marker. BRAF V600E mutation was negative. Conclusion: In this case, total resection was performed and clinical symptoms were regressed completely.

scholarly journals Primary Bartholin Adenocarcinoma: a Rare Case and Radiotherapy as Definitive Treatment

Folia Medica ◽  
2021 ◽  
Vol 63 (6) ◽  
pp. 985-989
Author(s):  
Lokot Donna Lubis ◽  
Sarah Dina ◽  
Derissa Khairina Khaidirman
Keyword(s):  
Estrogen Receptor ◽  
Rare Case ◽  
Hpv Infection ◽  
Definitive Treatment ◽  
Gynecologic Malignancies ◽  
Ki 67 ◽  
Hpv Dna ◽  
Molecular Features ◽  
S 100

Primary vulvar adenocarcinoma is a very rare neoplasm, accounting for only 1% of all gynecologic malignancies. Most of the glandular carcinomas originated from the Bartholin’s gland. Because of the rare incidence, the pathogenesis and radiotherapy response are not fully understood. A 47-year-old female from our hospital was diagnosed with primary Bartholin adenocarcinoma and received radiotherapy as definitive treatment. We evaluated the presence of high-risk and low-risk human papillomavirus (HPV) DNA to associate the role of HPV infection, and evaluated its molecular features by the expression of vimentin, p16, estrogen receptor, progesterone receptor, S-100, and Ki 67.

scholarly journals Primary Melanotic Paraganglioma of Thyroid Gland: Report of a Rare Case With Clinicopathologic and Immunohistochemical Analysis and a Literature Review

2017 ◽  
Vol 10 ◽  
pp. 117955571668467
Author(s):  
Yan-jun Dong ◽  
Zhi-wen Zhang ◽  
Zhen Wang ◽  
Xin-ying Wang ◽  
Zhi-zhen Tian ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Tumor Cells ◽  
Stromal Cells ◽  
Immunohistochemical Analysis ◽  
Ki 67 ◽  
Intercellular Substance ◽  
Case Presentation ◽  
First Case ◽  
Low Malignant Potential ◽  
S 100

Background: Pigmented paraganglioma is a special type of paraganglioma, and it is rare in the thyroid. Case Presentation: We report a case of a 41-year-old woman who had complained of a mass in the thyroid gland. Histology revealed tumor cells arranged in a nest-like or organoid pattern, separated by delicate fibrovascular septa. Two distinct components were observed. In the first, which constituted the majority of the tumor cells, no pigments were observed. In the second, a few cells with pigment showed intercellular substance, but the structure was unclear. Using immunohistochemistry, cells in the first component were confirmed to be diffuse strong positive for synaptophysin, but negative for chromogranin A, pan-cytokeratin, calcitonin, and thyroglobulin. About 1% of tumor cells were stained by Ki-67. In the margins of the tumor, a few cells were observed to be positive for HMB-45 and Melan A after bleaching by oxalic acid. The stromal cells were positive for S-100. Using electron microscopy, a few cells containing many round melanin bodies with greater electron density granules of nonuniform size were observed. The diagnosis of primary melanotic paraganglioma of the thyroid gland was made. Conclusion: Primary melanotic paraganglioma of the thyroid gland is a rare, low malignant potential tumor. To the best of our knowledge, this is the first case described.

scholarly journals A case of laparoscopic partial hepatic S7 resection for postoperative liver metastasis of rectal malignant melanoma

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Makoto Takahashi ◽  
Yasuhiro Morita ◽  
Tatsuya Hayashi ◽  
Susumu Yanagibasi ◽  
Shunsuke Sato ◽  
...  
Keyword(s):  
Liver Metastasis ◽  
Malignant Melanoma ◽  
Poor Prognosis ◽  
Rare Case ◽  
Laparoscopic Resection ◽  
Case Presentation ◽  
Liver Segment ◽  
Hepatic Recurrence ◽  
Pathological Analysis ◽  
S 100

Abstract Background Anorectal malignant melanoma (ARMM) has an extremely poor prognosis, and there is no report of resection of liver metastases so far. We report herein a rare case of postoperative laparoscopic partial hepatic S7 resection for rectal malignant melanoma. Case presentation A 51-year-old female patient with a diagnosis of an ARMM underwent a laparoscopic rectal amputation. Eleven months later, computed tomography (CT) revealed a 14-mm nodule in liver segment 7 (S7), which was diagnosed as a hepatic recurrence of the ARMM. Because no other recurrences were found, a laparoscopic partial resection of S7 was performed. Pathological analysis found intracellular melanin deposition, and immunostaining was S-100 (+), HMB-45 (+), and SOX-10 (+). Based on these findings, a liver metastasis of malignant melanoma was diagnosed. The patient is alive 7 months after the second surgery and has so far experienced no recurrences. Conclusion We reported an extremely rare case of a laparoscopic resection of a liver metastasis following surgery for ARMM.

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