Biomechanical Comparison of Lag Screw and Non-spiral Blade Fixation of a Novel Femoral Trochanteric Nail in an Osteoporotic Bone Model

Abstract PurposeThere is no consensus regarding the advantages of the lag screw type over the blade type for treating femoral trochanteric fractures. We aimed to investigate whether non-spiral blade (Conventional-Blade, Fid-Blade) nails provide better biomechanical fixation than lag screws in a severe osteoporotic bone model.MethodsDifferent severities of osteoporotic cancellous bone were modelled using polyurethane foam blocks of three densities (0.24, 0.16, and 0.08 g/cm3). Three torsional tests were performed using each component for each bone density and the maximum torque was recorded, and the energy required to achieve 30° rotation was calculated. Using a push-in test, the maximum force was recorded, and the energy required to achieve 4-mm displacement was calculated. ResultsFor 0.08-g/cm3 density, the peak torques to achieve 30° rotation, energy required to achieve 30° rotation, peak force to achieve 4-mm displacement, and energy required to achieve 4-mm displacement were significantly greater for Conventional-Blade and Fid-Blade than for Lag Screw. ConclusionsConventional-Blade and Fid-Blade nails exhibited significantly higher values than Lag Screw under any test condition. The blade-type nail component may have a better fixation capability than the lag screw type in a severe osteoporotic bone model.

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A Locking Contoured Plate for Distal Fibular Fractures: Mechanical Evaluation in an Osteoporotic Bone Model Using Screws of Different Length

Journal of Applied Biomechanics ◽

10.1123/jab.2013-0018 ◽

2014 ◽

Vol 30 (1) ◽

pp. 50-57 ◽

Cited By ~ 5

Author(s):

Robert K. Zahn ◽

Michael Jakubietz ◽

Sönke Frey ◽

Stefanie Doht ◽

Alexander Sauer ◽

...

Keyword(s):

Testing Machine ◽

Functional Treatment ◽

Ankle Fractures ◽

Fixation Strength ◽

Osteoporotic Bone ◽

Failure Rates ◽

Cyclic Testing ◽

Maximum Torque ◽

Bone Model ◽

Conventional Plate

Osteoporotic bone with poor mechanical capacity provides limited stability after fixation of ankle fractures. Stabilization with an implant providing increased fixation strength in osteoporotic bone could reduce failure rates of fixation and allow a more functional treatment. The purpose of this study was to evaluate a locking contoured plate for fixation of distal fibular fractures in comparison with a conventional contoured plate in an osteoporotic bone model. Eighty cylinders of osteoporotic bone surrogates were fixed with the two plates. We performed torque-to-failure and cyclic testing experiments using screws of different length with a Zwick/Roell testing machine. The locking system showed higher torque-to-failure and maximum torque levels as compared with the conventional plate in torque-to-failure experiments and torsional cyclic testing. The locking contoured plate provides improved fixation strength in the osteoporotic bone model. The locking system may be appropriate for fixation of distal fibular fractures, especially in osteoporotic bone with poor mechanical capacity.

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Strength Insertion Implant Fixed on Trabecular Bone Density Based on Insertion Torque and Pull Out

Advanced Materials Research ◽

10.4028/www.scientific.net/amr.976.222 ◽

2014 ◽

Vol 976 ◽

pp. 222-226 ◽

Cited By ~ 1

Author(s):

Clara Isabel G. López ◽

Juan Carlos M. Moreno ◽

Julio C. Pinillos

Keyword(s):

Bone Density ◽

Trabecular Bone ◽

Cancellous Bone ◽

Insertion Torque ◽

Trabecular Bone Density ◽

Maximum Torque ◽

Bone Interface ◽

Pull Out ◽

Torque Wrench ◽

Molar Region

The main purpose of this research was to measure the resistance of insertion of a dental implant screw designed based on norm, made of the alloy Ti6Al4V [1], which was designed for the cancellous bone density (BD) molar region of the human jaw. The implants were embedded in the in a simulated bone polymer (Sawbone®) [2] and were compared with specimens of the region molar of human jaw cadaver [3]. Using a digital torque wrench, the values of the insertion torque (IT) were calculated in the specimens with the implants inserted [4]. The minimum measured value was 25 Ncm or 0.25 Nm and the density of the maximum torque value measured was 110 Ncm or 1.1 in Nm recorded in the cadaver jawbone. The Pull Out Test (POT) was then carried out in order to determine the resistance of the insertion implant at the bone interface. The experimental results obtained for density, IT and resistance to insertion were then compared in order to determine the strength of fixation of the implant to the bone interface.

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Faculty Opinions recommendation of Risk of subsequent fractures and mortality in elderly women and men with fragility fractures with and without osteoporotic bone density: the Dubbo Osteoporosis Epidemiology Study.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725077796.793506597 ◽

2015 ◽

Author(s):

Gordon Klein

Keyword(s):

Bone Density ◽

Elderly Women ◽

Fragility Fractures ◽

Osteoporotic Bone ◽

Epidemiology Study ◽

Osteoporosis Epidemiology

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Quantitative Estimation of Bone Density and Bone Quality Using Acoustic Parameters of Cancellous Bone for Fast and Slow Waves

Japanese Journal of Applied Physics ◽

10.1143/jjap.44.4578 ◽

2005 ◽

Vol 44 (6B) ◽

pp. 4578-4582 ◽

Cited By ~ 61

Author(s):

Takahiko Otani

Keyword(s):

Bone Density ◽

Bone Quality ◽

Cancellous Bone ◽

Quantitative Estimation ◽

Slow Waves ◽

Acoustic Parameters ◽

Fast And Slow Waves

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Small peptide (P-15) bone substitute efficacy in a rabbit cancellous bone model

Journal of Biomedical Materials Research Part B Applied Biomaterials ◽

10.1002/jbm.b.31676 ◽

2010 ◽

pp. n/a-n/a ◽

Cited By ~ 3

Author(s):

Emily M. Lindley ◽

Fernando A. Guerra ◽

Jack. T. Krauser ◽

Sergio M. Matos ◽

Evalina L. Burger ◽

...

Keyword(s):

Cancellous Bone ◽

Bone Substitute ◽

Small Peptide ◽

Bone Model

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General Influence of Biphasic Calcium Phosphate on Osteoporotic Bone Density

Proceedings of the Latvian Academy of Sciences Section B Natural Exact and Applied Sciences ◽

10.2478/prolas-2019-0029 ◽

2019 ◽

Vol 73 (2) ◽

pp. 185-188

Author(s):

Vladislavs Ananjevs ◽

Aleksandra Ananjeva ◽

Jānis Vētra ◽

Andrejs Skaģers ◽

Ilze Salma ◽

...

Keyword(s):

Bone Density ◽

Mass Density ◽

Cone Beam ◽

Bone Mass Density ◽

Osteoporotic Bone ◽

Left Femur ◽

Experimental Osteoporosis ◽

The Right ◽

General Influence

Abstract Bone density of the femur body of rabbit was determined in vivo. Experimental osteoporosis was induced by ovariectomy and subsequent injections of methylprednisolone. In the greater trochanter region of right femur, defects were created and filled with granules of hydroxyapatite and tricalcium phosphate (HAP/TCP 70/30) or HAP/TCP 70/30 together with 5% strontium. After three months, the animals were euthanized. The bone mass density of the right and left body of femur was measured by cone beam computed tomography (CT) scan. The results of the study showed that the right femur of the rabbit, where biomaterials had been implanted, and the left femur, where no biomaterial implantation occurred, became denser after filling the defect with HAP/TCP 70/30 ceramic granules or 5% Sr modified HAP/TCP ceramic granules. There was no difference between operated and non-operated legs and HAP/TCP and HAP/TCP with 5% strontium groups.

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Sacral and iliac articular cartilage thickness and cellularity: relationship to subchondral bone end-plate thickness and cancellous bone density

Rheumatology ◽

10.1093/rheumatology/41.4.375 ◽

2002 ◽

Vol 41 (4) ◽

pp. 375-380 ◽

Cited By ~ 32

Author(s):

G. J. McLauchlan

Keyword(s):

Articular Cartilage ◽

Bone Density ◽

Subchondral Bone ◽

Cancellous Bone ◽

Plate Thickness ◽

Cartilage Thickness ◽

End Plate

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Mesenchymal Stem Cells Coated with Synthetic Bone-Targeting Polymers Enhance Osteoporotic Bone Fracture Regeneration

Bioengineering ◽

10.3390/bioengineering7040125 ◽

2020 ◽

Vol 7 (4) ◽

pp. 125

Author(s):

Yuliya Safarova (Yantsen) ◽

Farkhad Olzhayev ◽

Bauyrzhan Umbayev ◽

Andrey Tsoy ◽

Gonzalo Hortelano ◽

...

Keyword(s):

Stem Cells ◽

Mesenchymal Stem Cells ◽

Bone Density ◽

Active Sites ◽

Bone Fractures ◽

Bone Fragility ◽

Female Rats ◽

Osteoporotic Bone ◽

Osteoblast Progenitor ◽

Osteoclastic Activity

Osteoporosis is a progressive skeletal disease characterized by reduced bone density leading to bone fragility and an elevated risk of bone fractures. In osteoporotic conditions, decrease in bone density happens due to the augmented osteoclastic activity and the reduced number of osteoblast progenitor cells (mesenchymal stem cells, MSCs). We investigated a new method of cell therapy with membrane-engineered MSCs to restore the osteoblast progenitor pool and to inhibit osteoclastic activity in the fractured osteoporotic bones. The primary active sites of the polymer are the N-hydroxysuccinimide and bisphosphonate groups that allow the polymer to covalently bind to the MSCs’ plasma membrane, target hydroxyapatite molecules on the bone surface and inhibit osteolysis. The therapeutic utility of the membrane-engineered MSCs was investigated in female rats with induced estrogen-dependent osteoporosis and ulnar fractures. The analysis of the bone density dynamics showed a 27.4% and 21.5% increase in bone density at 4 and 24 weeks after the osteotomy of the ulna in animals that received four transplantations of polymer-modified MSCs. The results of the intravital observations were confirmed by the post-mortem analysis of histological slices of the fracture zones. Therefore, this combined approach that involves polymer and cell transplantation shows promise and warrants further bio-safety and clinical exploration.

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Association of Collagen Type 1 α1 Gene Polymorphism with Bone Density in Early Childhood1

The Journal of Clinical Endocrinology & Metabolism ◽

10.1210/jcem.84.3.5575 ◽

1999 ◽

Vol 84 (3) ◽

pp. 853-855

Author(s):

Jesus Sainz ◽

Jan M. Van Tornout ◽

James Sayre ◽

Francine Kaufman ◽

Vicente Gilsanz

Keyword(s):

Bone Density ◽

Gene Polymorphism ◽

Bone Mass ◽

Cancellous Bone ◽

Vertebral Fractures ◽

Collagen Type ◽

Elderly Women ◽

Structural Basis ◽

Type I ◽

Vertebral Bone

Osteoporosis is a disease characterized by the development of nontraumatic fractures, most commonly in the vertebrae of elderly women. Approximately 500,000 elderly women in the United States are newly diagnosed with vertebral fractures every year, as the compressive strength of the vertebra, mainly determined by the density of cancellous bone and its cross-sectional area, declines with age. A recent study in women suggested that a polymorphism in the Sp1 binding site of the collagen type I gene (COLIA1) was related to decreased vertebral bone mass and vertebral fractures. Determining the phenotypic trait(s) responsible for this relationship and whether this association is manifested in childhood would further define the structural basis for decreased bone mass and help identify children “at risk” for fractures later in life. We therefore studied the COLIA1 gene polymorphism and measurements of the size and the density of vertebral bone in 109 healthy, prepubertal girls. On average, 22 girls with the Ss genotype and one girl with the ss genotype had 6.7% and 49.4% lower cancellous bone density in the vertebrae than girls with the SS genotype. In contrast, there was no association between the size of the vertebrae and the COLIA1 genotypes.

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