scholarly journals General Influence of Biphasic Calcium Phosphate on Osteoporotic Bone Density

2019 ◽  
Vol 73 (2) ◽  
pp. 185-188
Author(s):  
Vladislavs Ananjevs ◽  
Aleksandra Ananjeva ◽  
Jānis Vētra ◽  
Andrejs Skaģers ◽  
Ilze Salma ◽  
...  
Keyword(s):  
Bone Density ◽  
Mass Density ◽  
Cone Beam ◽  
Bone Mass Density ◽  
Osteoporotic Bone ◽  
Left Femur ◽  
Experimental Osteoporosis ◽  
The Right ◽  
General Influence

Abstract Bone density of the femur body of rabbit was determined in vivo. Experimental osteoporosis was induced by ovariectomy and subsequent injections of methylprednisolone. In the greater trochanter region of right femur, defects were created and filled with granules of hydroxyapatite and tricalcium phosphate (HAP/TCP 70/30) or HAP/TCP 70/30 together with 5% strontium. After three months, the animals were euthanized. The bone mass density of the right and left body of femur was measured by cone beam computed tomography (CT) scan. The results of the study showed that the right femur of the rabbit, where biomaterials had been implanted, and the left femur, where no biomaterial implantation occurred, became denser after filling the defect with HAP/TCP 70/30 ceramic granules or 5% Sr modified HAP/TCP ceramic granules. There was no difference between operated and non-operated legs and HAP/TCP and HAP/TCP with 5% strontium groups.

scholarly journals In vivo uptake of [14C]leucine by skeletal muscle ribosomes after injury in rats fed two levels of protein

1969 ◽  
Vol 23 (2) ◽  
pp. 271-280 ◽  
Author(s):  
V. R. Young ◽  
P. C. Huang
Keyword(s):  
Skeletal Muscle ◽  
Specific Activity ◽  
Male Rats ◽  
Thigh Muscle ◽  
Left Femur ◽  
The Right ◽  
And Control ◽  
The Relationship ◽  
In Vivo Uptake

1. After 14 days on a diet containing 5 or 25% casein male rats received a fracture of the left femur. Four hours before they were killed the injured and control rats were injected with [1-14C]leucine; the incorporation of radioactivity into an isolated fraction of skeletal muscle ribosomes was studied 6, 12, 24, 48, 72, 96 and 228 h after injury.2. The incorporation of [14C]leucine into the ribosome fraction in right thigh muscles dropped to 40% of control values 72 h after fracture in well-nourished rats and after 96 h with diets containing 5 or 25%, casein.3. The specific activity of the trichloroacetic acid-soluble fraction of muscle from injured rats was equal to or higher than that of the controls during the first 72 h but lower at 96 h.4. These results suggest that a reduced incorporation of amino acids by ribosomes from the right thigh muscle occurred on day 3 after fracture in the group receiving 25% casein but not in the group receiving 5% casein.5. Muscle RNA and DNA concentrations were not affected by the injury.6. The relationship between these findings and the loss of muscle N after injury is discussed.

A Pull-Out Resistant Pedicle Screw for the Osteoporotic Spine

2007 ◽  
Author(s):  
Karthik Ponnusamy ◽  
Sravisht Iyer ◽  
Alex Hui ◽  
Gaurav Gupta ◽  
Kartik Trehan ◽  
...  
Keyword(s):  
Bone Mass ◽  
Mass Density ◽  
Pedicle Screws ◽  
Bone Mass Density ◽  
Vertebral Compression Fractures ◽  
Osteoporotic Bone ◽  
Low Bone Mass ◽  
Compression Fractures ◽  
Pull Out ◽  
Increased Risk

Pedicle screws are commonly used in spine surgery to implant and affix metal devices to the spine. These screws are most commonly associated with cases that require rod or plate implantation. Use of pedicle screws in osteoporotic patients, however, is limited because they suffer from low bone mass density (BMD). The low BMD is harmful to patients in two ways — it leads to increased incidence of spinal trauma and also prevents surgeons from instrumenting osteoporotic patients because screws do not achieve the required fixation in osteoporotic patients [1]. The risk of trauma is increased due to the brittle bone and vertebral compression fractures, resulting in spinal misalignment and increased risk of future trauma. Instrumenting these cases with rods or plates, however, is impossible because osteoporotic bone is not strong enough to “hold” pedicle screws in, i.e., prevent screws from pulling out [2, 3].

scholarly journals The Effects of Vitamin D Supplementation on Serum Levels of 25 (OH) D, Serum Calcium, and Bone Density in Adolescent: A Literature Review

2021 ◽  
Vol 5 (2) ◽  
pp. 180
Author(s):  
Nurnashriana Jufri ◽  
Nurmaladewi Nurmaladewi ◽  
Fifi Nirmala
Keyword(s):  
Vitamin D ◽  
Bone Density ◽  
Literature Review ◽  
Bone Mass ◽  
Serum Calcium ◽  
Biochemical Parameters ◽  
Linear Growth ◽  
Mass Density ◽  
Vitamin D Supplementation ◽  
Bone Mass Density

Latar Belakang: Stunting dan penurunan densitas tulang merupakan salah satu masalah gizi yang umum diderita oleh remaja. Hal ini terjadi akibat kurangnya asupan zat gizi yang adekuat terutama vitamin D yang berfungsi untuk pertumbuhan tulang dan mineralisasi jaringan. Jumlah yang terbatas dari makanan dan faktor pigmentasi kulit menjadi penyebab terjadinya defisiensi vitamin D sehingga dibutuhkan upaya suplementasi untuk memenuhi kebutuhan tersebut.Tujuan: Untuk menganalisis efek suplementasi vitamin D terhadap pertumbuhan linier remaja.Metode: Penelusuran artikel pada tinjauan pustaka ini dilakukan menggunakan mesin pencarian melalui Medline, PubMed, EBSCO, ELSEVIER, Cambridge Core, dan WILEY. Artikel memuat teks penuh, berbahasa inggris dan tahun terbit mulai dari 2010 hingga 2020. Kata kunci pencarian yang dimasukkan adalah vitamin D supplementation, adolescent or teenagers, linear growth, dan Bone Mass Density (BMD).Hasil: Hasil skrining menemukan 12 artikel yang memenuhi kriteria inklusi dan diklasifikasikan berdasarkan luaran penelitian yaitu kadar serum 25(OH)D merupakan parameter biokimia yang merupakan luaran yang terdapat pada 10 artikel penelitian. Parameter biokimia serum kalsium sebanyak 6 artikel, densitas tulang sebanyak 8 artikel, dan tinggi badan 2 artikel.Kesimpulan: Suplementasi vitamin D yang diberikan pada remaja yang sehat maupun tidak sehat terbukti meningkatkan kadar serum 25(OH)D.Kata kunci: Suplementasi vitamin D, serum 25(OH)D, densitas massa tulang, pertumbuhan linier remaja. ABSTRACT Background: Stunting and decreased bone density are some of the common nutritional problems that remain by adolescents. This occurs due to lack of adequate nutrition, especially vitamin D which functions for bone growth and tissue mineralization. A limited amount of food and skin pigmentation factors cause vitamin D deficiency so supplementation efforts are needed to meet those needs.Objective: To analyze the effect of vitamin D supplementation on the linear growth of adolescents.Method: Searching for articles in this literature review was done using a search engine through Medline, PubMed, EBSCO, ELSEVIER, Cambridge Core, and WILEY. The article contains the full text, English language, and year of publication from 2010 to 2020. The search keywords entered are vitamin D supplementation, adolescent or teenagers, linear growth, and Bone Mass Density (BMD).Results: The screening results found 12 articles that met the inclusion criteria and were classified based on research outcomes, namely serum 25 (OH) D levels were biochemical parameters which were the results contained in 10 research articles. Biochemical parameters of serum calcium were 6 articles, bone density were 8 articles, and height were 2 articles.Conclusion: Vitamin D supplementation given to healthy and unhealthy adolescents has been shown to increase serum 25 (OH) D levels.Keywords: Vitamin D supplementation, serum 25 (OH) D, bone mass density, adolescent linear growth. 

scholarly journals Low Bone Mineral Density and Calcium Levels as Risks for Mortality in Patients with Self-Discontinuation of Anti-Osteoporosis Medication

2021 ◽  
Vol 19 (1) ◽  
pp. 197
Author(s):  
Chun-Sheng Hsu ◽  
Shin-Tsu Chang ◽  
Yuan-Yang Cheng ◽  
Hsu-Tung Lee ◽  
Chih-Hui Chen ◽  
...  
Keyword(s):  
Lumbar Spine ◽  
Femoral Neck ◽  
Mortality Risk ◽  
Calcium Level ◽  
Cox Regression ◽  
Mass Density ◽  
Bone Mass Density ◽  
Mineral Density ◽  
Osteoporosis Medication ◽  
The Right

Bone mass density (BMD) has been used universally in osteoporosis diagnosis and management. Adherence to anti-osteoporosis medication is related to mortality risk. This study aimed to investigate the relationship between mortality and low BMD of the femoral neck and vertebra among patients self-discontinuing anti-osteoporosis medication. Between June 2016 and June 2018, this single-center retrospective study recruited 596 participants who self-discontinued anti-osteoporosis medication. Patients were categorized into four groups by BMD of the right femoral neck and lumbar spine. Occurrence and causes of mortality were obtained from medical records. Independent risk factors and the five-year survival of various levels of BMD were analyzed by Cox regression and the Kaplan–Meier survival analysis. BMD value and serum calcium level were significantly lower in the mortality group (p < 0.001). Compared to the reference, the adjusted hazard ratio (HR) for all-cause mortality in patients with lower BMD of both the lumbar spine and femoral neck was 3.03. The five-year cumulative survival rate was also significantly lower (25.2%, p < 0.001). A low calcium level was also associated with mortality (HR: 0.87, 95% CI: 0.76–0.99, p = 0.033). In conclusion, lower BMD and calcium levels were associated with higher mortality risk in patients with poor adherence. Hence, patients self-discontinuing anti-osteoporosis medication should be managed accordingly.

scholarly journals Pengaruh Latihan Resisten terhadap Kepadatan Tulang

2021 ◽  
Vol 9 (2) ◽  
Author(s):  
Audy K. Bella ◽  
Hedison Polii ◽  
Herlina I. S. Wungow
Keyword(s):  
Resistance Training ◽  
Bone Density ◽  
Literature Review ◽  
Bone Mass ◽  
Resistance Exercise ◽  
Mass Density ◽  
Anaerobic Exercise ◽  
Google Scholar ◽  
Bone Mass Density ◽  
Mineral Density

Abstract : Resistance or resistance training has been recommended as a widely used treatment strategy for dealing with bone loss. Types of exercise that can be done include walking, running, weights bearing, and swimming. According to WHO in 2018, more than 80% of the adult population worldwide has less physical activity. Studies show that resistant exercise can increase bone density. This literature review aims to determine the effect of resistance training on bone density. This study was in the form of a literature review with data searches using four databases, which are ClinicalKey, Pubmed, MedLine, and Google Scholar. Resistance exercise can increase bone density. There are two types of exercise, named aerobic and anaerobic exercises. Research has shown that anaerobic exercise is more effective in increasing bone mass density compared to aerobic exercise because anaerobic exercise provides a bigger mechanical load to the bones, which triggers the bones to regenerate. The conclusion is that resistance exercise can increase bone density.Keywords : Resistance exercise, bone density.  Abstrak : Latihan tahanan atau resisten telah direkomendasikan sebagai strategi pengobatan yang banyak digunakan untuk menghadapi hilangnya massa tulang. Jenis latihan yang bisa dilakukan antara lain jalan kaki, berlari, angkat beban, dan berenang. Menurut WHO pada tahun 2018, lebih dari 80% populasi orang dewasa di seluruh dunia memiliki aktivitas fisik yang kurang. Penelitian-penelitian membuktikan bahwa latihan resisten dapat meningkatkan kepadatan tulang. Tinjauan pustaka ini bertujuan untuk mengetahui pengaruh latihan resisten terhadap kepadatan tulang. Penelitian ini berbentuk literature review dengan pencarian data menggunakan empat database yaitu ClinicalKey, Pubmed, MedLine, dan Google Scholar. Kata kunci yang digunakan yaitu physical exercise ATAU resistance exercise ATAU resistance training ATAU effect of resistance exercise ATAU latihan tahanan ATAU latihan beban DAN bone mass ATAU bone mineral density. Latihan secara resisten dapat meningkatkan kepadatan tulang. Latihan dapat dilakukan dengan dua jenis, yaitu latihan aerobik dan anaerobik. Penelitian membuktikan bahwa latihan anaerobik lebih efektif dalam menungkatkan kepadatan massa tulang dibandingkan dengan latihan aerobik karena latihan anaerobik memberikan beban mekanik yang lebih besar untuk tulang sehingga memicu tulang untuk melakukan regenerasi.  Kesimpulannya adalah latihan resisten dapat meningkatkan kepadatan tulang.Kata Kunci : Latihan resisten, kepadatan tulang

scholarly journals ASSESSMENT OF BONE QUALITY IN THE FRONTAL PART OF MANDIBLES IN FEMALE PATIENTS OF VARIOUS AGES USING CONE-BEAM COMPUTED TOMOGRAPHY

2020 ◽  
Vol 16 (3) ◽  
pp. 83-89
Author(s):  
Natal'ya Nurieva ◽  
Irina Shelegova ◽  
Dar'ya Vazhenina
Keyword(s):  
Bone Density ◽  
Optical Density ◽  
Cone Beam ◽  
Microsoft Excel ◽  
Female Patients ◽  
Lower Jaw ◽  
Frontal Part ◽  
Age Related ◽  
The Right ◽  
Symmetrical Points

Thing. The optical density of the lower jaw in the frontal part of female patients was studied, age-related differences in the optical density of the lower jaw were revealed. The aim is to reveal the variability of the values of optical density of the lower jaw in the anterior region in female patients. Methodology. Computed tomograms of the lower jaws of 26 patients were analyzed. The optical density of the bone was assessed using the method of computer densitometry in Hounsfield arbitrary units, measurements were carried out in the area of the root apexes of the lower canines. Statistical analysis was carried out using Microsoft Excel, Windows 9. Results. In 84.6 % of cases, the optical density of bone tissue in the area of 3.3 and 4.3 teeth is within the same class according to the Misch classification. In this group, 72.7 % of patients had class D2, 18.18 ― D1, 9 ― D3; in 15.4 %, the bone density on the right and left sides of the mandible belongs to D2 and D3. The optical density between two relatively symmetrical points is in the range from 2 to 238 units, between the right and left sides it is 129.66 HU. In the group of 30―39 (n = 6) years, in 50 % of cases, bone density belongs to class D2, in 33.33 ― D1, in 16.66 ― D3; 40―49 (n = 8) years in 87.5 % of cases ― D2, in 12.5 ― D1; 50―59 (n = 6) years at 50 % ― D2 and at 50 ― D3; 60―68 (n = 6) years at 50 % ― D2 and at 50 ― D3. Conclusions. With increasing age of patients, there is a decrease in bone density in the lower jaw in the canine area.

Calcaneal Bone Mass Modification in Recreational Runners

2016 ◽  
Vol 106 (6) ◽  
pp. 381-386 ◽  
Author(s):  
Elena Escamilla-Martínez ◽  
Alfonso Martínez-Nova ◽  
Beatriz Gómez-Martín ◽  
Raquel Sánchez-Rodríguez ◽  
Lourdes María Fernández-Seguín ◽  
...  
Keyword(s):  
Bone Density ◽  
Bone Mass ◽  
Mass Density ◽  
Control Sample ◽  
Bone Mass Density ◽  
Running Shoes ◽  
Negative Effect ◽  
Trabecular Bone Mass ◽  
Recreational Runners ◽  
The Impact

Background: The calcaneus is the bone of the foot that first receives the impact of running, generating vibrations that might have a positive effect in modifying the trabecular bone mass. The objective of this study was to determine the variation in calcaneal bone density in runners during a 6-month training season, comparing it with a control sample. Methods: Bone density of the heel was measured in 33 male recreational runners by means of a contact ultrasonic bone analyzer. Measurements were made on three occasions during a training season: at the beginning, at 350 km, and at 700 km. All of the runners wore the same model of running shoes during this period. Measurements of bone density were also made in a control sample of 62 men who did not engage in physical exercise. Results: There was a significant decrease in mean calcaneal bone density over the course of the training season (from 86.1 dB/MHz to 83.2 dB/MHz; P = .006), but no significant differences with the control sample value (from 80.7 dB/MHz to 81.1 dB/MHz; P = .314). The runners' body composition changed during the study period, with lean mass increasing and fat mass decreasing. Conclusions: Distance running seems to have a negative effect on calcaneal bone mass density during the course of a 700-km training season.

Modeling of Ultrasonic Wave Propagation Path through Cancellous Bone and Quantitative Estimation of Bone Density and Bone Quality

2006 ◽  
Vol 321-323 ◽  
pp. 857-861
Author(s):  
Takahiko Otani
Keyword(s):  
Bone Density ◽  
Bone Mass ◽  
Ultrasonic Wave ◽  
Cancellous Bone ◽  
Mass Density ◽  
Propagation Path ◽  
Bone Mass Density ◽  
Ultrasonic Wave Propagation ◽  
Fast And Slow Waves ◽  
Ultrasonic Parameters

Osteoporosis is a disease characterized by decreasing bone density, and is assessed by the bone mass density of cancellous bone. An X-ray method is widely used for noninvasive measurement of bone mass density [mg/cm3]. An ultrasonic method has the potential to evaluate the elastic properties, however measured ultrasonic parameters are the slope of frequency dependent attenuation (BUA [dB/MHz]) and the speed of sound (SOS [m/s]), not the bone mass density [mg/cm3]. In previous study, two longitudinal waves, the fast and slow waves, were observed in cancellous bone. In this study, the propagation path through cancellous bone is modeled to specify the causality between ultrasonic wave parameters and bone density. Then bone density and bone elasticity are quantitatively formulated. A novel ultrasonic bone densitometry, prototype LD-100, have been developed. The bone density [mg/cm3] and the bone elasticity [GPa] are evaluated by ultrasonic parameters based on the fast and slow waves in cancellous bone using a modeling of ultrasonic wave propagation path.

The influence of thyroid disorders on bone density and biochemical markers of bone metabolism

2018 ◽  
Vol 35 (1) ◽  
Author(s):  
Konstantinos Tsevis ◽  
Eftihios Trakakis ◽  
Vasilios Pergialiotis ◽  
Eleni Alhazidou ◽  
Melpomeni Peppa ◽  
...  
Keyword(s):  
Bone Density ◽  
Bone Mass ◽  
Thyroid Function ◽  
Mass Density ◽  
Bone Mass Density ◽  
Thyroid Disorders ◽  
Increased Risk ◽  
Menopausal Women ◽  
Post Menopausal ◽  
The Impact

Abstract Background Thyroid dysfunction, predominantly hyperthyroidism, has been previously linked to impaired bone mass density (BMD) and increased risk of fractures. On the other hand, data in the field of hypothyroidism (HT) are missing. The purpose of the present study was to investigate the impact of thyroid disorders on bone density serum and urine calcium (Ca) and phosphate (P) as well as serum osteocalcin and alkaline phosphatase and urine hydroxyproline in a series of post-menopausal women. Materials and methods The study was conducted in the Reproductive Endocrinology Outpatient Clinic of our hospital. A consecutive series of post-menopausal women was included, after excluding patients under hormone treatment (including levothyroxine supplementation) and those who received raloxifene, tamoxifen or tibolone during the study period as well as those who received treatment during the previous 12 months were excluded from the present study. Results Overall, 188 women were included in the present study. Among them, 143 women had normal thyroid function, 32 women had hyperthyroidism and 13 women had HT. Correlation of thyroid function indices with osteoporosis indices revealed statistically significant correlations between thyroxine (T4) and free triiodothyronine (T3) with T-, Z-scores and BMD. Logistic regression analysis concerning the impact of HT and hyperthyroidism on T-score, Z-score and bone mass density revealed that both pathological entities negatively affect bone health (p < 0.05). Conclusion The findings of our study suggest that not only hyperthyroidism, but also HT negatively affects BMD. Future studies should investigate this association and corroborate our findings.

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