scholarly journals Clinical-pathological Characteristics and Prognostic Factors for Malignant Peritoneal Mesothelioma in the Elderly

2021 ◽  
Author(s):  
Dan Pan ◽  
Mengyao Wang ◽  
Wencheng Liu ◽  
Yan Li ◽  
Lixuan Sang ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
The Elderly ◽  
Elderly Group ◽  
Peritoneal Mesothelioma ◽  
Adult Patients ◽  
Malignant Peritoneal Mesothelioma ◽  
Adult Group ◽  
Cancer Specific Survival ◽  
Pathological Characteristics ◽  
Significant Difference

Abstract Background: Malignant peritoneal mesothelioma (MPM) is a rare disease characterized by atypical symptoms, difficult diagnosis, variable course and poor prognosis, and it develops mainly in the elderly. The authors aimed to identify the clinical-pathological characteristics, prognosis, and prognostic factors in the elderly MPM patients.Methods: From the National Cancer Institute Surveillance Epidemiology End Results (SEER) database, 1492 patients with MPM from 1975 to 2016 were selected and divided into the elderly group (≥65) and the adult group (<65). We compared the clinical-pathological characteristics and treatment methods of elderly group (N=665) and adult group (N=827). At the same time, we analyzed specific selected clinical-pathological parameters and prognostic factors for the elderly MPM patients.Results: Compared with the adult group, the elderly group had a higher percentage of male patients (P = 0.017), white patients (P = 0.043), a lower proportion of insured patients (P < 0.001), married patients (P < 0.001), patients with peritoneal tumors (P = 0.006), patients who underwent surgery (P < 0.001), and chemotherapy (P < 0.001). There was a significant difference in the differentiation grade between the two groups (P = 0.003). The elderly patients had a shorter median survival time compared with the adult patients (6 months vs 19 months). Uninsured (hazard ratio (HR): 5.187, P = 0.005), sarcomatoid type (HR: 3.913, P <0.001), poorly differentiated (HR: 3.900, P < 0.001), distant metastasis (HR: 1.735, P = 0.001), no cancer-directed surgery (HR: 1.733, P < 0.001), and no chemotherapy (HR: 1.532, P < 0.001) were independently associated with poorer prognosis of elderly MPM patients.Conclusion: Compared with the adult patients, elderly MPM patients had higher male ratio, poor differentiation and relatively conservative treatment. The cancer-specific survival (CSS) rate of elderly MPM patients was significantly lower than that of adult patients. Insurance status, histology type, differentiation grade, stage, surgery status, and chemotherapy status were all independent prognostic factors for elderly MPM patients.

scholarly journals Prognostic factors influencing survival in 35 patients with malignant peritoneal mesothelioma

Neoplasma ◽  
2014 ◽  
Vol 61 (04) ◽  
pp. 433-438 ◽  
Author(s):  
H. KAYA ◽  
C. SEZGİ ◽  
A. C. TANRİKULU ◽  
M. TAYLAN ◽  
O. ABAKAY ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Peritoneal Mesothelioma ◽  
Malignant Peritoneal Mesothelioma ◽  
Factors Influencing

scholarly journals Malignant Peritoneal Mesothelioma: Prognostic Factors and Oncologic Outcome Analysis

2013 ◽  
Vol 21 (4) ◽  
pp. 1159-1165 ◽  
Author(s):  
Deepa Magge ◽  
Mazen S. Zenati ◽  
Frances Austin ◽  
Arun Mavanur ◽  
Magesh Sathaiah ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Oncologic Outcome ◽  
Peritoneal Mesothelioma ◽  
Outcome Analysis ◽  
Malignant Peritoneal Mesothelioma

Changes in Lingual Sensitivity as a Function of Age and Stimulus Exposure Time

1982 ◽  
Vol 55 (3_suppl) ◽  
pp. 1083-1090 ◽  
Author(s):  
Linda Petrosino ◽  
Donald Fucci ◽  
Randall R. Robey
Keyword(s):  
Young Adult ◽  
Exposure Time ◽  
Stimulus Duration ◽  
Age Groups ◽  
The Elderly ◽  
Elderly Group ◽  
Vibrotactile Threshold ◽  
Stimulus Exposure ◽  
Adult Group ◽  
Vibrotactile Thresholds

Effects of duration of stimulus exposure on lingual vibrotactile thresholds were examined across three groups of 10 subjects each ( n = 30). Subjects were grouped according to age (child group, mean age = 10.1 yr.; young adult group, mean age = 21.9 yr.; elderly group, mean age = 76.0 yr.). Lingual vibrotactile threshold measurements were obtained for all subjects under 5 conditions of exposure (1, 2, 3, 4, and 5 sec.). Results showed statistically significant differences in threshold among all three age groups. As age increased, thresholds of lingual sensitivity increased (became poorer). Stimulus duration also created significant differences in threshold for all age groups. As stimulus duration increased, thresholds of lingual sensitivity decreased (became better). The children appeared to be the most stable across conditions whereas the elderly group appeared to be the most affected by stimulus duration.

Oestrogen receptors are prognostic factors in malignant peritoneal mesothelioma

2013 ◽  
Vol 139 (6) ◽  
pp. 987-994 ◽  
Author(s):  
Krishna Pillai ◽  
Mohammad Hossein Pourgholami ◽  
Terence C. Chua ◽  
David Lawson Morris
Keyword(s):  
Prognostic Factors ◽  
Peritoneal Mesothelioma ◽  
Oestrogen Receptors ◽  
Malignant Peritoneal Mesothelioma

scholarly journals Quantitative evaluation of tongue protrusion force

2010 ◽  
Vol 36 (1) ◽  
pp. 33-43
Author(s):  
Renata Furlan ◽  
◽  
Amanda Valenti ◽  
Tatiana Vargas de Castro ◽  
Cláudio Gomes de Costa ◽  
...  
Keyword(s):  
Quantitative Evaluation ◽  
Isometric Force ◽  
The Elderly ◽  
Elderly Group ◽  
Maximum Force ◽  
Tongue Strength ◽  
Tongue Protrusion ◽  
Average Force ◽  
New Device ◽  
Significant Difference

The tongue plays an important role in the functions of speech, mastication, swallowing, and breathing. The tongue helps in the maintenance of proper dental alignment and arch stability. Adequate strength is essential for the tongue to perform these tasks. Recently the Biomechanical Engineering Group from Universidade Federal de Minas Gerais, Brazil, developed a device to improve tongue strength evaluation. The purpose of this study is to describe and compare the main results obtained in tongue protrusion force measurements in different age groups using this new device. Fifteen healthy subjects were given a qualitative evaluation and determined to have normal tongue strength. They were separated by age in three groups: children, adults and elderly. They were then given a quantitative evaluation. Maximum and average forces were analyzed. The time taken to reach maximum force was also assessed. Higher values of maximum and average tongue force were obtained in the adult group, followed by the elderly group and the group of children. Older subjects had greater tongue force when compared to children. However, there were statistically significant differences in the average force and in the maximum force only between children and adults. Time taken to reach maximal isometric force was longer in the elderly group and shorter in the group of children than in the group of adults although no statistically significant difference was found between groups.

scholarly journals Clinical Outcomes of Radiotherapy in Elderly and Younger Patients with T4 Esophageal Cancer: A Retrospective Single-Center Analysis

2021 ◽  
Author(s):  
Yosuke Takakusagi ◽  
Kio Kano ◽  
Satoshi Shima ◽  
Keisuke Tsuchida ◽  
Nobutaka Mizoguchi ◽  
...  
Keyword(s):  
Esophageal Cancer ◽  
Clinical Outcomes ◽  
Complete Response ◽  
The Elderly ◽  
Elderly Group ◽  
Cancer Center ◽  
Esophageal Fistula ◽  
Younger Patients ◽  
Significant Difference ◽  
T4 Esophageal Cancer

Abstract Background/AimThe standard of treatment for esophageal cancer with adjacent organ invasion (T4) has not been established. Radiotherapy (RT) is a treatment option, but its efficacy and safety in elderly patients remains unclear. We retrospectively analyzed the clinical outcomes of RT in elderly and younger patients with T4 esophageal cancer.Materials and MethodsSixty-nine patients with T4 esophageal cancer who underwent RT at the Kanagawa Cancer Center between January 2014 and November 2020 were included in this study. Patients aged ≥70 years were defined as the elderly group and those aged <70 years were defined as the younger group.The total dose of RT was set at 60 Gy in 30 fractions. Chemotherapy combined with 5-fluorouracil and cisplatin was administered concurrently with RT. The overall survival (OS) rate was estimated using the Kaplan–Meier method. Adverse events were assessed using the CTCAE v4.0. Clinical outcomes were compared between the elderly and younger groups.ResultsThe median survival time (MST) of the elderly group was 21.5 months, and the OS rates at 1, 3, and 5 years were 63.7%, 31.3%, and 15.6%, respectively. The MST of the younger group was 12.5 months, and the OS rates at 1, 3, and 5 years were 52.2%, 29.4%, and 29.4%, respectively. A significant difference in OS was not observed between the two groups (p = 0.767). Themultivariate analysis revealed thatthe complete response (CR) of the primary tumor and adjuvant chemotherapy (ACTx) were significant predictors of OS (p< 0.001 and<0.001, respectively). Regarding toxicity, the frequency of thrombocytopenia was significantly higher in the elderly group, whereas the frequency of esophageal fistula was significantly higher in the younger group (p = 0.012 and 0.022, respectively). Other toxicities were not significantly different between the two groups.ConclusionsOS was not significantly different between the elderly and younger groups. ACTx and CR were predictors of OS. The frequency of thrombocytopenia was higher in the elderly group and that of esophageal fistula was higher in the younger group. However, other toxicities were not significantly differentbetween the two groups.

scholarly journals Efficacy, safety, and adherence of tocilizumab therapy in elderly patients with rheumatoid arthritis: A real-world observational study

2021 ◽  
Vol 19 ◽  
pp. 205873922110457
Author(s):  
Yoshinobu Nakao ◽  
Yu Funakubo Asanuma ◽  
Takuma Tsuzuki Wada ◽  
Mayumi Matsuda ◽  
Hiroaki Yazawa ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Survival Rate ◽  
Elderly Patients ◽  
Disease Activity ◽  
Activity Index ◽  
The Elderly ◽  
Young Group ◽  
Elderly Group ◽  
Drug Survival ◽  
Significant Difference

Objective: We evaluated the efficacy, safety, and drug survival rate of tocilizumab in the elderly patients with rheumatoid arthritis (RA). Methods: This study was conducted in 108 RA patients who started tocilizumab between 2008 and 2018. The patients were divided into a young group (<65 years) and an elderly group (≥65 years). The efficacy, safety, and drug survival rate of tocilizumab were compared between the two groups. Results: At baseline, there were no significant differences between the elderly ( n = 45) and the young group ( n = 63) in RA duration, percentage of biologic-naïve, and RA disease activity. Health Assessment Questionnaire-Disability Index (HAQ-DI) was higher, renal function was worse, and frequency of using methotrexate was lower in the elderly group. Tocilizumab demonstrated similar efficacy in the elderly and the young group with Clinical Disease Activity Index and HAQ-DI. Compared with baseline, the frequency of steroid use was lower at one year after initiation of tocilizumab in both groups. There was no significant difference between the groups in the drug survival rate of tocilizumab for three years. Discontinuation rates of TCZ due to toxic adverse events were similar between the two groups. Conclusions: The efficacy, steroid-sparing effect, and safety of tocilizumab therapy, as well as the drug survival rate for three years, were not inferior in elderly RA compared to young RA patients.

Hemifacial Spasm: Comparison of Results between Patients Older and Younger than 70 Years Operated on with Microvascular Decompression

2021 ◽  
Author(s):  
Hua Zhao ◽  
Jin Zhu ◽  
Yin-da Tang ◽  
Lin Shen ◽  
Shi-ting Li
Keyword(s):  
Elderly Patients ◽  
Hemifacial Spasm ◽  
Microvascular Decompression ◽  
Facial Palsy ◽  
The Elderly ◽  
Elderly Group ◽  
Effective Treatment Option ◽  
Younger Patients ◽  
Significant Difference ◽  
Csf Leakage

Abstract Objective The aim of the present study was to evaluate the efficacy and safety of microvascular decompression (MVD) for primary hemifacial spasm (HFS) in patients aged ≥70 years and to compare the outcome with a control cohort of younger patients(<70 years). Methods In this retrospective study, subjects were divided into two groups: an elderly group (patients who were ≥70 years) and a younger group. We compared demographic and clinical data, surgical outcome, MVD-related complications, and duration of operation and hospitalization after MVD between the two groups. Results At a mean follow-up of 32 ± 4.2 months, 188 elderly patients (90.4%) reported an effective outcome without need for any medication versus 379 (91.1%) of the younger cohort. There was no mortality in both cohorts. The prevalence of delayed facial palsy was 4.8% in the elderly group and 4.1% in the younger group. One (0.5%) patient in the elderly group and 3 (0.7%) patients in the younger group suffered cerebrospinal fluid (CSF) leakage. There was no significant difference between the two groups in terms of MVD-related complications, such as delayed facial palsy, hearing impairment, CSF leakage, and hematoma. Conclusions MVD is an effective treatment option in elderly patients with HFS as well as in younger patients. Age itself seems to be no relevant contraindication or, alternatively, risk factor regarding MVD.

scholarly journals Clinical-pathological Characteristics and Prognostic Factors for Papillary Thyroid Microcarcinoma in the Elderly

2018 ◽  
Vol 9 (2) ◽  
pp. 256-262 ◽  
Author(s):  
Jing Tang ◽  
Hans B. Liu ◽  
Lujiao Yu ◽  
Xin Meng ◽  
Sean X. Leng ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
The Elderly ◽  
Papillary Thyroid Microcarcinoma ◽  
Papillary Thyroid ◽  
Pathological Characteristics ◽  
Thyroid Microcarcinoma

Safety and feasibility of minimally invasive esophagectomy for elderly esophageal cancer patients

2020 ◽  
Author(s):  
Y Sugita ◽  
T Nakamura ◽  
R Sawada ◽  
G Takiguchi ◽  
N Urakawa ◽  
...  
Keyword(s):  
Minimally Invasive ◽  
Elderly Patients ◽  
Minimally Invasive Esophagectomy ◽  
The Elderly ◽  
Elderly Group ◽  
Hospital Death ◽  
Cancer Specific Survival ◽  
Invasive Esophagectomy ◽  
Short And Long Term

Summary The number of elderly patients with esophageal cancer has increased in recent years. The use of thoracoscopic esophagectomy has also increased, and its minimal invasiveness is believed to contribute to postoperative outcomes. However, the short- and long-term outcomes in elderly patients remain unclear. This study aimed to elucidate the safety and feasibility of minimally invasive esophagectomy in elderly patients. This retrospective study included 207 patients who underwent radical thoracoscopic esophagectomy for thoracic esophageal squamous cell carcinoma at Kobe University Hospital between 2005 and 2014. Patients were divided into non-elderly (&lt;75 years) and elderly (≥75 years) groups. A propensity score matching analysis was performed for sex and clinical T and N stage, with a total of 29 matched pairs. General preoperative data, surgical procedures, intraoperative data, postoperative complications, in-hospital death, cancer-specific survival, and overall survival were compared between groups. The elderly group was characterized by lower preoperative serum albumin levels and higher American Society of Anesthesiologists grade. Intraoperative data and postoperative complications did not differ between the groups. The in-hospital death rate was 4% in the elderly group, which did not significantly differ from the non-elderly group. Cancer-specific survival was similar between the two groups. Although overall survival tended to be poor in the elderly group, it was not significantly worse than that of the non-elderly group. In conclusion, the short- and long-term outcomes of minimally invasive esophagectomy in elderly versus non-elderly patients were acceptable. Minimally invasive esophagectomy is a safe and feasible modality for elderly patients with appropriate indications.

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