scholarly journals Triglyceride-Glucose Index and HOMA-IR in Young Adulthood and Risk of Incident Congestive Heart Failure: The CARDIA Study

2021 ◽  
Author(s):  
Xianghui Zeng ◽  
Haobin Zhou ◽  
Yuting Xue ◽  
Xiao Wang ◽  
Qiong Zhan ◽  
...  
Keyword(s):  
Heart Failure ◽  
Insulin Resistance ◽  
Congestive Heart Failure ◽  
Young Adults ◽  
Young Adulthood ◽  
Surrogate Marker ◽  
Model Assessment ◽  
Tyg Index ◽  
Triglyceride Glucose Index ◽  
Increased Risk

Abstract Background: Triglyceride-glucose (TyG) index and homeostasis model assessment-insulin resistance (HOMA-IR) are related to insulin resistance (IR). The aim of this study was to assess the association between triglyceride-glucose index / HOMA-IR within young adults and congestive heart failure (CHF), and to explore whether triglyceride-glucose index can replace HOMA-IR as a surrogate marker for insulin resistance in predicting the risk of CHF.Methods：A total of 4992 participants between the ages of 18 and 30 were enrolled from the Coronary Artery Risk Development in Young Adults (CARDIA) investigation (from 1985 to 1986 [year 0]). Cox proportional hazard regression analysis was conducted for assessing correlations between baseline TyG index / HOMA-IR and congestive heart failure events, together with Receiver Operating Characteristic (ROC) Curve employed for scrutinizing TyG index / HOMA-IR and he risk of CHF.Results: During the 31-year follow-up period, 64 (1.3%) out of the 4992 participants developed congestive heart failure. In multivariable Cox proportional hazards models, adjusted for confounding factors for CHF, increased risk of CHF was associated with per-unit increase in TyG index (hazard ratio [HR] 2.8; 95% confidence interval [CI], 1.7-4.7) and HOMA-IR (HR 1.2; 95%CI, 1.1-1.3). Kaplan-Meier curve analysis showed that participants in the TyG index and HOMA-IR index Q4 group had a higher risk of congestive heart failure than those in the Q1 group. The area under curve (AUC) for TyG index and HOMA-IR consisted of 0.67 (95% CI, 0.6-0.742) and 0.675 (95%CI, 0.604-0.746), respectively. There were no significant differences between TyG index and HOMA-IR for AUC (P = 0.986).Conclusions: TyG index and HOMA-IR are independent risk factors for CHF. The TyG index can replace HOMA-IR in young adulthood as a surrogate marker for IR to predict the risk of CHF.

Triglyceride/glucose index is a reliable alternative marker for insulin resistance in South American overweight and obese children and adolescents

2019 ◽  
Vol 32 (10) ◽  
pp. 1163-1170 ◽  
Author(s):  
João Carlos Locateli ◽  
Wendell Arthur Lopes ◽  
Caroline Ferraz Simões ◽  
Gustavo Henrique de Oliveira ◽  
Karine Oltramari ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Children And Adolescents ◽  
Fasting Glucose ◽  
Surrogate Marker ◽  
South American ◽  
Model Assessment ◽  
Obese Children ◽  
Cross Sectional ◽  
Tyg Index ◽  
Triglyceride Glucose Index

Abstract Background The aim of the present study was to investigate the correlation between the triglyceride/glucose index (TyG index) and homeostasis model assessment of insulin resistance (HOMA-IR). Additionally, we compared the ability of the TyG index and triglycerides/high-density lipoprotein cholesterol (TG/HDL-c) index and the combination of these two indices (TyG index plus TG/HDL-c) to predict insulin resistance (IR) in South American overweight and obese children and adolescents. Methods A cross-sectional study was carried out in 345 overweight adolescents aged 10–18 years, from both the sexes. The TyG index was calculated as Ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL])/2, while the TG/HDL-c index was calculated by the division of TG (mg/dL) by HDL-c (mg/dL). HOMA-IR was calculated with the formula: fasting insulin (FI) (U/mL) × fasting glucose (mmol/L)/22.5. The cut-off point used to determine the presence of IR was HOMA-IR ≥ 3.16. Results The TyG index showed a positive correlation with HOMA-IR. The area under the receiver operating characteristic (ROC) curve of the TyG index was 0.74, indicating good sensitivity (75.7%) and specificity (67.4%). Furthermore, the TyG index cut-off point of >4.44 was established for IR prediction in this population. Conclusions The TyG index is a simple and cost-effective surrogate marker of IR in South American overweight children and adolescents. Moreover, due to its good accessibility, it can be used in large epidemiological studies.

scholarly journals Inverse Association Between Triglyceride Glucose Index and Muscle Mass in Korean Adults: 2008–2011 KNHANES

2020 ◽  
Author(s):  
Sung Ho Ahn ◽  
Jun hyuk Lee ◽  
JI WON LEE
Keyword(s):  
Insulin Resistance ◽  
Muscle Mass ◽  
Surrogate Marker ◽  
Multivariate Logistic Regression Model ◽  
Inverse Association ◽  
Tyg Index ◽  
Korean Adults ◽  
Triglyceride Glucose Index ◽  
Using Data ◽  
The Relationship

Abstract Aim: The early detection and prevention of sarcopenia is increasingly emphasized considering that sarcopenia is an important risk factor for falls or cardiovascular disease. Recently, there have been emerging evidences that support the relationship between sarcopenia, insulin resistance, and inflammation. The TyG index, a novel surrogate marker of insulin resistance and systemic inflammation, has not yet been verified for an association with sarcopenia. This study aimed to examine the relationship between the TyG index and muscle mass in Korean adults.Methods: This study included 15,741 non-diabetic adults over 19 years old using data from the 2008–2011 Korea National Health and Nutrition Examination Survey. Participants were divided into three groups according to tertiles of the TyG index. Low skeletal muscle mass index (LMSI) was defined by the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project criteria. Weighted multivariate logistic regression model was used to analyze the relationship between TyG index tertiles and LSMI.Results: The ORs (95% CIs) for LSMI of the second and third tertiles, compared to first tertile, were 1.300 (1.001–1.689) and 1.448 (1.104–1.900), respectively, after adjusting for confounding factors. Higher TyG index was also associated with increased odds of LSMI in subgroups such as adults under 65-year old who did not exercise regularly, who consumed less than 30g alcohol per day, who did not currently smoke, and who ate less than 1.5g protein/kg/day.Conclusion: The TyG index was significantly and positively associated with LSMI in Korean adults.

scholarly journals The triglyceride-glucose index as a measure of insulin resistance and risk of obesity-related cancers

2019 ◽  
Vol 49 (1) ◽  
pp. 193-204 ◽  
Author(s):  
Josef Fritz ◽  
Tone Bjørge ◽  
Gabriele Nagel ◽  
Jonas Manjer ◽  
Anders Engeland ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Standard Deviation Increase ◽  
Cox Models ◽  
Tyg Index ◽  
Triglyceride Glucose Index ◽  
Increased Risk ◽  
Males And Females ◽  
Surrogate Measure

Abstract Background The role of insulin resistance as a mediator in the association of body mass index (BMI) with site-specific cancer risk has, to our knowledge, never been systematically quantified. Methods Altogether 510 471 individuals from six European cohorts, with a mean age of 43.1 years, were included. We used the triglyceride glucose product (TyG index) as a surrogate measure for insulin resistance. We fitted Cox models, adjusted for relevant confounders, to investigate associations of TyG index with 10 common obesity-related cancers, and quantified the proportion of the effect of BMI mediated through TyG index on the log-transformed hazard ratio (HR) scale. Results During a median follow-up of 17.2 years, 16 052 individuals developed obesity-related cancers. TyG index was associated with the risk of cancers of the kidney HR per one standard deviation increase 1.13, 95% confidence interval: 1.07 to 1.20], liver (1.13, 1.04 to 1.23), pancreas (1.12, 1.06 to 1.19), colon (1.07, 1.03 to 1.10) and rectum (1.09, 1.04 to 1.14). Substantial proportions of the effect of BMI were mediated by TyG index for cancers of the pancreas (42%), rectum (34%) and colon (20%); smaller proportions for kidney (15%) and liver (11%). Little or no mediation was observed for breast (postmenopausal), endometrial and ovarian cancer. Results were similar for males and females, except for pancreatic cancer where the proportions mediated were 20% and 91%, respectively. Conclusions The TyG index was associated with increased risk of cancers of the digestive system and substantially mediated the effect of BMI, suggesting that insulin resistance plays a promoting role in the pathogenesis of gastrointestinal cancers.

scholarly journals Triglyceride–glucose index is associated with the risk of myocardial infarction: an 11-year prospective study in the Kailuan cohort

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Xue Tian ◽  
Yingting Zuo ◽  
Shuohua Chen ◽  
Qian Liu ◽  
Boni Tao ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Surrogate Marker ◽  
Tyg Index ◽  
Triglyceride Glucose Index ◽  
Increased Risk ◽  
The Mean ◽  
Adjusted Model ◽  
Multivariable Adjusted Model

Abstract Background The triglyceride–glucose (TyG) index, which is a simple surrogate marker of insulin resistance, has been suggested as a contributor of cardiovascular disease. However, evidence on the effect of long-term elevation of the TyG index exposure on myocardial infarction (MI) is limited. The current study aimed to evaluate the association of baseline and long-term elevation of the TyG index exposure with the risk of MI. Methods A total of 98,849 participants without MI at baseline (2006) were enrolled from the Kailuan study. The baseline TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting glucose (mg/dL)/2]. The long-term TyG index was characterized in two ways as follows. The updated mean TyG index was calculated as the mean of TyG index at all previous visits before MI occurred or the end of follow-up; alternatively, the TyG index was calculated as the number of visits with a high TyG index in 2006, 2008, and 2010, ranging from 0 (no exposure) to 3 (had high TyG index at all three study visits). Hazard ratio (HR) and 95% confidence interval (CI) was estimated using multivariable Cox proportion hazard models. Results During a median follow-up of 11.03 years, 1555 incident MI occurred. In the multivariable-adjusted model, the risk of MI increased with quartiles of the baseline and updated mean TyG index, the HR in quartile 4 versus quartile 1 was 2.08 (95% CI,1.77–2.45) and 1.58 (1.18–2.12), respectively. Individuals with a high TyG index at all three visits had a 2.04-fold higher risk (95% CI, 1.63–2.56) of MI compared with no exposure. Subgroup analyses showed that the associations were more pronounced in women than in men (Pinteraction = 0.0411). Conclusions Elevated levels of the baseline and long-term TyG index are associated with an increased risk of MI. This finding indicates that the TyG index might be useful in identifying people at high risk of developing MI.

scholarly journals Inverse association between triglyceride glucose index and muscle mass in Korean adults: 2008–2011 KNHANES

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Sung-Ho Ahn ◽  
Jun-Hyuk Lee ◽  
Ji-Won Lee
Keyword(s):  
Insulin Resistance ◽  
Muscle Mass ◽  
Surrogate Marker ◽  
Multivariate Logistic Regression Model ◽  
Inverse Association ◽  
Tyg Index ◽  
Korean Adults ◽  
Health And Nutrition ◽  
Triglyceride Glucose Index ◽  
Using Data

Abstract Background Since sarcopenia is an important risk factor for falls or cardiovascular disease, early detection and prevention of sarcopenia are being increasingly emphasized. Emerging evidence has indicated relationships between sarcopenia, insulin resistance, and inflammation. The triglyceride glucose (TyG) index, a novel surrogate marker of insulin resistance and systemic inflammation, has not yet been shown to be associated with sarcopenia. This study aimed to examine the relationship between the TyG index and muscle mass in Korean adults. Methods This study included 15,741 non-diabetic adults over 19 years old using data from the 2008–2011 Korea National Health and Nutrition Examination Survey. Participants were divided into three groups according to tertiles of the TyG index. A low skeletal muscle mass index (LSMI) was defined by the Foundation for the National Institutes of Health Sarcopenia Project criteria. A weighted multivariate logistic regression model was used to analyze relationships between TyG index tertiles and LSMI. Results The ORs (95% CIs) for LSMI in the second and third TyG tertiles, compared to the first tertile, were 1.463 (1.131–1.892) and 1.816 (1.394–2.366), respectively, after adjusting for confounding factors. Higher TyG index values were also associated with increased odds of LSMI in adults under 65 years who did not exercise regularly, who consumed less than 30 g of alcohol per day, who did not currently smoke, and who ate less than 1.5 g of protein/kg/day. Conclusion The TyG index was significantly and positively associated with LSMI in Korean adults.

scholarly journals The insulin resistance by triglyceride glucose index and risk for dementia: population-based study

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Sangmo Hong ◽  
Kyungdo Han ◽  
Cheol-Young Park
Keyword(s):  
Insulin Resistance ◽  
Effect Size ◽  
Large Scale ◽  
Smoking Status ◽  
Large Population ◽  
Surrogate Marker ◽  
Population Based ◽  
Tyg Index ◽  
Increased Risk ◽  
Small Effect Size

Abstract Background Insulin resistance is suggested to have negative effects on cognition; however, results from large population studies are lacking. In this study, the potential relationships between the triglyceride glucose (TyG) index, a simple surrogate marker of insulin resistance, and dementia were evaluated using a large-scale population dataset. Methods This was a retrospective, observational, cohort study using data from the National Health Information Database from 2009 to 2015 and included 5,586,048 participants 40 years age or older. The TyG index was used as a measure of insulin resistance, and participants were divided into quartiles based on TyG index. The incidence of dementia was assessed using hazard ratios (HRs) estimated with Cox proportional hazard modeling. Results During a median follow-up of 7.21 years, dementia was diagnosed in 142,714 (2.55%) participants. Alzheimer’s disease (AD) and vascular dementia (VD) were diagnosed in 74.3% and 12.5% of the participants. Multivariate-adjusted HRs for patients in the TyG index 4th quartile were higher for dementia (HRs = 1.14; 95% confidence interval [CI] 1.12–1.16), AD (HRs = 1.12; 95% CI 1.09–1.14), and VD (HRs = 1.18; 95% CI 1.12–1.23) compared with the 1st quartile of TyG index; however, this had a small effect size (Cohen’s d = 0.10, 0.08, and 0.13, respectively). These effects were independent of age, sex, smoking status, physical activity, body mass index, systolic blood pressure, and total cholesterol. Conclusion In this large population study, TyG index was associated with an increased risk of dementia, including AD and VD, that was independent of traditional cardiovascular risk factors, although the effect size of the TyG index was small.

scholarly journals Association between Triglyceride Glucose Index and Insulin Resistance among Thai Obese Adolescents

2020 ◽  
Author(s):  
Thidarat Somdee ◽  
Udomsak Mahaweerawat ◽  
Chatchada Mahaweerawat ◽  
Suneerat Yangyuen
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Sugar ◽  
Multiple Logistic Regression Analysis ◽  
Surrogate Marker ◽  
Fasting Blood Sugar ◽  
Model Assessment ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Tyg Index

Introduction: Global adolescence obesity is considered as the risk factor associated with the development of Insulin Resistance (IR). And, Triglyceride Glucose (TyG) index has been used as an alternative tool to estimate IR. Thailand has also encountered the same trend especially the adolescence obesity risk is increasing because of malconsumption behaviour. Aim: The aim of this study was to assess the association between the TyG index and IR among Thai adolescents. Materials and Methods: This cross-sectional study was carried out on 300 obese adolescents selected from the Obesity Outpatient Clinic of Mahasarakham Provincial Public Health Office during 2009 to 2013. Anthropometric and IR risk factors were measured. The TyG index was calculated as in {fasting Triglycerides (TG) (mg/dL)×fasting blood sugar (mg/dL)}/2, while IR was estimated by Homeostasis Model Assessment for Insulin Resistance (HOMA-IR). Data were analysed by using a multiple logistics regression at 0.05 level of significance running with STATA version 13.0 software. Results: All subjects were divided into tertile groups based on the TyG index to analyse statistically significant differences (p<0.05). ANOVA revealed that there were significant differences in IR risk factors (Basal Metabolic Index, Fasting Blood Sugar level, and Triglyceride level) among the groups. Both TyG index and HOMA-IR level were statistically highly significant among the tertiles (p<0.001). Multiple logistic regression analysis revealed that TyG index can be used as an association factor for IR, in a fully adjusted model after adjusting BMI and Tricep thickness (3.06; 95% CI 1.780, 5.170; p<0.001). Conclusion: The results of the TyG index were significantly associated with IR in thai obese adolescents hence, supporting the use of TyG index as a surrogate marker for IR.

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