scholarly journals Association between Triglyceride Glucose Index and Insulin Resistance among Thai Obese Adolescents

2020 ◽  
Author(s):  
Thidarat Somdee ◽  
Udomsak Mahaweerawat ◽  
Chatchada Mahaweerawat ◽  
Suneerat Yangyuen
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Sugar ◽  
Multiple Logistic Regression Analysis ◽  
Surrogate Marker ◽  
Fasting Blood Sugar ◽  
Model Assessment ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Tyg Index

Introduction: Global adolescence obesity is considered as the risk factor associated with the development of Insulin Resistance (IR). And, Triglyceride Glucose (TyG) index has been used as an alternative tool to estimate IR. Thailand has also encountered the same trend especially the adolescence obesity risk is increasing because of malconsumption behaviour. Aim: The aim of this study was to assess the association between the TyG index and IR among Thai adolescents. Materials and Methods: This cross-sectional study was carried out on 300 obese adolescents selected from the Obesity Outpatient Clinic of Mahasarakham Provincial Public Health Office during 2009 to 2013. Anthropometric and IR risk factors were measured. The TyG index was calculated as in {fasting Triglycerides (TG) (mg/dL)×fasting blood sugar (mg/dL)}/2, while IR was estimated by Homeostasis Model Assessment for Insulin Resistance (HOMA-IR). Data were analysed by using a multiple logistics regression at 0.05 level of significance running with STATA version 13.0 software. Results: All subjects were divided into tertile groups based on the TyG index to analyse statistically significant differences (p<0.05). ANOVA revealed that there were significant differences in IR risk factors (Basal Metabolic Index, Fasting Blood Sugar level, and Triglyceride level) among the groups. Both TyG index and HOMA-IR level were statistically highly significant among the tertiles (p<0.001). Multiple logistic regression analysis revealed that TyG index can be used as an association factor for IR, in a fully adjusted model after adjusting BMI and Tricep thickness (3.06; 95% CI 1.780, 5.170; p<0.001). Conclusion: The results of the TyG index were significantly associated with IR in thai obese adolescents hence, supporting the use of TyG index as a surrogate marker for IR.

Triglyceride/glucose index is a reliable alternative marker for insulin resistance in South American overweight and obese children and adolescents

2019 ◽  
Vol 32 (10) ◽  
pp. 1163-1170 ◽  
Author(s):  
João Carlos Locateli ◽  
Wendell Arthur Lopes ◽  
Caroline Ferraz Simões ◽  
Gustavo Henrique de Oliveira ◽  
Karine Oltramari ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Children And Adolescents ◽  
Fasting Glucose ◽  
Surrogate Marker ◽  
South American ◽  
Model Assessment ◽  
Obese Children ◽  
Cross Sectional ◽  
Tyg Index ◽  
Triglyceride Glucose Index

Abstract Background The aim of the present study was to investigate the correlation between the triglyceride/glucose index (TyG index) and homeostasis model assessment of insulin resistance (HOMA-IR). Additionally, we compared the ability of the TyG index and triglycerides/high-density lipoprotein cholesterol (TG/HDL-c) index and the combination of these two indices (TyG index plus TG/HDL-c) to predict insulin resistance (IR) in South American overweight and obese children and adolescents. Methods A cross-sectional study was carried out in 345 overweight adolescents aged 10–18 years, from both the sexes. The TyG index was calculated as Ln (fasting triglycerides [mg/dL] × fasting glucose [mg/dL])/2, while the TG/HDL-c index was calculated by the division of TG (mg/dL) by HDL-c (mg/dL). HOMA-IR was calculated with the formula: fasting insulin (FI) (U/mL) × fasting glucose (mmol/L)/22.5. The cut-off point used to determine the presence of IR was HOMA-IR ≥ 3.16. Results The TyG index showed a positive correlation with HOMA-IR. The area under the receiver operating characteristic (ROC) curve of the TyG index was 0.74, indicating good sensitivity (75.7%) and specificity (67.4%). Furthermore, the TyG index cut-off point of >4.44 was established for IR prediction in this population. Conclusions The TyG index is a simple and cost-effective surrogate marker of IR in South American overweight children and adolescents. Moreover, due to its good accessibility, it can be used in large epidemiological studies.

scholarly journals Effect of Regular Khat Chewing on Serum Fasting Sugar Level in Diabetic patients versus Healthy Individuals; A comparative study

2021 ◽  
Vol 14 ◽  
pp. 117863882110352
Author(s):  
Yordanos Mengistu ◽  
Gobena Dedefo ◽  
Mesay Arkew ◽  
Gebeyehu Asefa ◽  
Gutema Jebessa ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Glucose ◽  
Glycemic Control ◽  
Glucose Oxidase ◽  
Blood Sugar ◽  
Poor Glycemic Control ◽  
Fasting Blood Sugar ◽  
Healthy Individuals ◽  
Cross Sectional ◽  
Khat Chewer

Background: Khat chewing is a long standing social-cultural habit in several countries. Even though many people chew khat simply for its pleasurable and stimulatory effect, evidence showed widely-held belief among khat chewers in Ethiopia and other part of the world that khat helps to lower blood glucose while some studies are contradicted on the effect of khat. There is limited data about khat’s effect on blood glucose especially in our setting, Harar estern Ethiopia. Objective: Primarily the present study aims to compare fasting blood sugar level among khat chewer diabetic and healthy individuals, and to asses risk factors associated with poor glycemic control in diabetic subjects. Method: A cross-sectional study included 200 confirmed diabetic and healthy subjects. Fasting blood sugar was determined by enzymatic method glucose oxidase and glucose hexokinase. Glycemic control was also determined for diabetic subjects based on the last 2-month diabetic clinic visits and current measurement. Result: (Median ± IQR [interquartile range]) fasting blood sugar difference among Khat chewer and non khat chewer were 159 ± 83 mg/dl and 202 ± 79 mg/dl respectively in diabetic subjects when tested by glucose oxidase. Similarly, in healthy non khat chewer and khat chewer, khat chewers has lower (Median ± IQR) fasting blood glucose level 82 ± 18 mg/dl than non khat chewers 94 ± 13 mg/dl when tested by glucose oxidase. Regarding risk factors associated with poor glycemic control in diabetic subjects, positive parental diabetes history, insulin medication, being overweight, obese were significantly associated with poor glycemic control. Conclusion: There was significant effect of khat on median FBS among khat chewers in diabetic and healthy individuals. And the proportion of glycemic control was high among diabetic subjects. Recommendation: Health care professional and patients should manage the risk factors to delay disease progression and restrain the damage. More studies should be conducted in randomized control trial manner to further elucidate khat effect on blood sugar level so that the actual effect of khat can be identified unlike in cross sectional where there may not be strong causal relationship.

scholarly journals Interleukin-6 and insulin resistance in obese adolescents

2016 ◽  
Vol 53 (5) ◽  
pp. 268
Author(s):  
Raynald Takumansang ◽  
Sarah M. Warouw ◽  
Hesti Lestari
Keyword(s):  
Insulin Resistance ◽  
Interleukin 6 ◽  
Cross Sectional Study ◽  
Normal Body Mass Index ◽  
Model Assessment ◽  
Tissue Mass ◽  
Cross Sectional ◽  
Obese Adolescents ◽  
Glucose Levels ◽  
The Mean

Background Obesity has become a rapidly growing epidemic worldwide, increasing the risk of morbidity and mortality in adolescents. Obesity is due to an expansion of adipose tissue mass, which is an important source of cytokines and contributes to an increase in pro-inflammatory cytokines, such as interleukin-6 (IL-6). Interleukin-6 is significantly increased in obesity and may lead to a state of insulin resistance.Objective To assess for a correlation between IL-6 levels and insulin resistance in obese adolescentsMethods We conducted a cross-sectional study from January to April 2012 in Manado, North Sulawesi. Subjects were either obese or normal body mass index (BMI) teens aged 13-18 years. Data collected were anthropometric status, BMI, and blood specimens for fasting plasma glucose levels, fasting insulin levels, and IL-6 levels. Insulin resistance was expressed as homeostatic model assessment of insulin resistance (HOMA-IR) level >2.77. Data was analyzed by Pearson’s correlation and linear regression tests to assess for a possible correlation between IL-6 levels and insulin resistance.Results The mean BMI in the obese group was 31.21 (SD 3.61) kg/m2 while the mean BMI in the normal group was 19.52 (SD 2.38) kg/m2. There was no significant association between IL-6 and the occurrence of insulin resistance (P=0.309). The log regression coefficient value of IL-6 was negative (b = -0.329).Conclusion There is no correlation between IL-6 levels and incidence of insulin resistance in obese adolescents.

scholarly journals Triglyceride-Glucose Index and HOMA-IR in Young Adulthood and Risk of Incident Congestive Heart Failure: The CARDIA Study

2021 ◽  
Author(s):  
Xianghui Zeng ◽  
Haobin Zhou ◽  
Yuting Xue ◽  
Xiao Wang ◽  
Qiong Zhan ◽  
...  
Keyword(s):  
Heart Failure ◽  
Insulin Resistance ◽  
Congestive Heart Failure ◽  
Young Adults ◽  
Young Adulthood ◽  
Surrogate Marker ◽  
Model Assessment ◽  
Tyg Index ◽  
Triglyceride Glucose Index ◽  
Increased Risk

Abstract Background: Triglyceride-glucose (TyG) index and homeostasis model assessment-insulin resistance (HOMA-IR) are related to insulin resistance (IR). The aim of this study was to assess the association between triglyceride-glucose index / HOMA-IR within young adults and congestive heart failure (CHF), and to explore whether triglyceride-glucose index can replace HOMA-IR as a surrogate marker for insulin resistance in predicting the risk of CHF.Methods：A total of 4992 participants between the ages of 18 and 30 were enrolled from the Coronary Artery Risk Development in Young Adults (CARDIA) investigation (from 1985 to 1986 [year 0]). Cox proportional hazard regression analysis was conducted for assessing correlations between baseline TyG index / HOMA-IR and congestive heart failure events, together with Receiver Operating Characteristic (ROC) Curve employed for scrutinizing TyG index / HOMA-IR and he risk of CHF.Results: During the 31-year follow-up period, 64 (1.3%) out of the 4992 participants developed congestive heart failure. In multivariable Cox proportional hazards models, adjusted for confounding factors for CHF, increased risk of CHF was associated with per-unit increase in TyG index (hazard ratio [HR] 2.8; 95% confidence interval [CI], 1.7-4.7) and HOMA-IR (HR 1.2; 95%CI, 1.1-1.3). Kaplan-Meier curve analysis showed that participants in the TyG index and HOMA-IR index Q4 group had a higher risk of congestive heart failure than those in the Q1 group. The area under curve (AUC) for TyG index and HOMA-IR consisted of 0.67 (95% CI, 0.6-0.742) and 0.675 (95%CI, 0.604-0.746), respectively. There were no significant differences between TyG index and HOMA-IR for AUC (P = 0.986).Conclusions: TyG index and HOMA-IR are independent risk factors for CHF. The TyG index can replace HOMA-IR in young adulthood as a surrogate marker for IR to predict the risk of CHF.

Sa1062 Effect of 12 Weeks of Oral Betaine on Homeostasic Model Assessment of Insulin Resistance (Homa-IR) in Non-Diabetic Subjects With Mildly Elevated Fasting Blood Sugar

2014 ◽  
Vol 146 (5) ◽  
pp. S-950 ◽  
Author(s):  
David Nolan ◽  
Timothy R. Morgan ◽  
Elango Kathirvel ◽  
Kengathevy Morgan ◽  
Rachel Gonzalez ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Blood Sugar ◽  
Fasting Blood Sugar ◽  
Model Assessment

scholarly journals Estimated GFR Is Biased by Non-Traditional Cardiovascular Risk Factors

2015 ◽  
Vol 41 (1) ◽  
pp. 7-15 ◽  
Author(s):  
Toralf Melsom ◽  
Ole Martin Fuskevåg ◽  
Ulla Dorte Mathisen ◽  
Harald Strand ◽  
Jørgen Schei ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Cystatin C ◽  
Cross Sectional Study ◽  
Model Assessment ◽  
Symmetric Dimethylarginine ◽  
Cross Sectional ◽  
Bias Risk ◽  
Liquid Chromatography Tandem Mass ◽  
Measured Gfr

Background: Estimated glomerular filtration rate (eGFR) based on either cystatin C or creatinine performs similarly in estimating measured GFR, but associate differently with cardiovascular disease (CVD) and mortality. This could be due to confounding by non-GFR-related traits associated with cystatin C and creatinine levels. We investigated non-GFR-related associations between eGFR and two types of nontraditional risk factors for CVD and death: L-arginine/dimethylarginine metabolism and insulin resistance. Methods: GFR was measured via iohexol clearance in a cross-sectional study of 1,624 middle-aged persons from the general population without CVD, diabetes or chronic kidney disease. The dimethylarginines were measured using liquid chromatography tandem mass spectrometry (LC-MSMS). Insulin resistance was determined by the homeostasis model assessment (HOMA-IR). Results: Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), the L-arginine/ADMA ratio and insulin resistance were associated with creatinine-based eGFR after accounting for measured GFR in multivariable adjusted analyses. The cystatin C-based eGFR showed a similar residual association with SDMA; an oppositely directed, borderline significant association with ADMA; and a stronger residual association with insulin resistance compared with eGFR based on creatinine. Conclusion: Both creatinine- and cystatin C-based eGFR are influenced by nontraditional risk factors, which may bias risk prediction by eGFR in longitudinal studies.

scholarly journals Triglyceride Glucose Index Is Associated With Arterial Stiffness and 10-Year Cardiovascular Disease Risk in a Chinese Population

2021 ◽  
Vol 8 ◽  
Author(s):  
Wen Guo ◽  
Wenfang Zhu ◽  
Juan Wu ◽  
Xiaona Li ◽  
Jing Lu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Arterial Stiffness ◽  
Disease Risk ◽  
Significant Risk ◽  
Surrogate Marker ◽  
Model Assessment ◽  
Operating Characteristics ◽  
Cvd Risk ◽  
Tyg Index

Background: Insulin resistance (IR) is a significant risk factor for cardiovascular disease (CVD). In this study, the association of the triglyceride glucose (TyG) index, a simple surrogate marker of IR, with arterial stiffness and 10-year CVD risk was evaluated.Methods: A total of 13,706 participants were enrolled. Anthropometric and cardiovascular risk factors were determined in all participants, while serum insulin levels were only measured in 955 participants. Arterial stiffness was measured through brachial-ankle pulse wave velocity (baPWV), and 10-year CVD risk was evaluated using the Framingham risk score.Results: All participants were classified into four groups according to the quartile of the TyG index. BaPWV and the percentage of participants in the 10-year CVD risk categories significantly increased with increasing quartiles of the TyG index. Logistic regression analysis showed that the TyG index was independently associated with a high baPWV and 10-year CVD risk after adjusting for traditional CVD risk factors. The area under the receiver operating characteristics curve (AUROC) of the TyG index for predicting a high baPWV was 0.708 (95%CI 0.693–0.722, P &lt; 0.001) in women, higher than that in men. However, the association of the homeostatic model assessment of IR (HOMA-IR) with a high baPWV and the 10-year CVD risk was absent when adjusting for multiple risk factors in 955 participants.Conclusions: The TyG index is independently associated with arterial stiffness and 10-year CVD risk.

Leptin, vitamin D, and cardiorespiratory fitness as risk factors for insulin resistance in European adolescents: gender differences in the HELENA Study

2014 ◽  
Vol 39 (5) ◽  
pp. 530-537 ◽  
Author(s):  
David Jiménez-Pavón ◽  
María A. Sesé ◽  
Jara Valtueña ◽  
Magdalena Cuenca-García ◽  
Marcela González-Gross ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Vitamin D ◽  
Cardiorespiratory Fitness ◽  
Body Fat ◽  
School Setting ◽  
Model Assessment ◽  
Cross Sectional ◽  
Gender Dimorphism ◽  
Modifiable Factors

The purpose of this study was to identify the relevance of a set of risk factors for insulin resistance in adolescents from Europe and to consider their possible gender-specific associations. The Healthy Lifestyle in Europe by Nutrition in Adolescence Cross-Sectional Study (HELENA-CSS) was conducted in 1053 European adolescents (mean age, 14.9 years) in a school setting in 9 countries. Three anthropometric markers of body fat and a dietary index were calculated. Total energy intake was estimated from a questionnaire. C-reactive protein, leptin, and vitamin D were assessed, and physical activity, cardiorespiratory fitness, and muscular strength were measured. Center, socioeconomic status, pubertal status, and season were used as potential confounders. The main outcome was the homeostasis model assessment used as a marker of insulin resistance. Correlations, analyses of covariance, and logistic regression models were used. In males, leptin was the only risk factor for insulin resistance after adjusting for confounders including markers of body fat (odds ratios (ORs) from 1.49 to 1.60). In females, leptin, vitamin D, and fitness were the remaining independent risk factors for insulin resistance after adjustments (OR 2.11; 95% confidential interval (CI) 1.29-3.45; OR 0.50, 95% CI 0.31-0.80; and OR 0.54, 95% CI 0.33-0.87, respectively). Our observations suggest a gender dimorphism in the identification of risk factors for high insulin resistance. Preventive strategies should focus on improving modifiable factors such as cardiorespiratory fitness and on ensuring vitamin D sufficiency. Randomized controlled trials focusing on these strategies are necessary to test their efficacy.

scholarly journals Acanthosis nigricans: a clinical marker of insulin resistance

2017 ◽  
Vol 3 (2) ◽  
pp. 161
Author(s):  
Sanjiv V. Choudhary ◽  
Vikrant Saoji ◽  
Adarshlata Singh ◽  
Shivani Mane
Keyword(s):  
Insulin Resistance ◽  
Blood Sugar ◽  
Acanthosis Nigricans ◽  
Serum Insulin ◽  
Univariate Analysis ◽  
Fasting Blood Sugar ◽  
P Value ◽  
Model Assessment ◽  
Fasting Insulin ◽  
Positive Correlation

<p><strong>Background:</strong> Very little information is available regarding the association of acanthosis nigricans with insulin resistance from rural areas of India. Therefore this study was carried out with the aim and objectives to study the association between acanthosis nigricans and insulin resistance and to evaluate correlation of acanthosis nigricans severity, neck severity and neck texture severity with fasting blood sugar &amp; serum insulin especially in this rural part of central India.</p><p><strong>Methods:</strong> In this cross sectional study with comparative group, total 162 age and sex matched subjects were divided into two groups of cases (81) with acanthosis nigricans and comparative subjects (81) without acanthosis nigricans. The severity acanthosis nigricans was assessed using the Burke’s quantitative scale. Fasting blood sugar and fasting insulin levels were estimated to know the Homeostasis model assessment of insulin resistance (HOMA-IR) values. Data was analyzed by using appropriate statistical tests.</p><p><strong>Results:</strong> The age range was 20 to 55 years with the mean of 32.82 ± 10.19 years for cases and 33.67 ± 8.09 for comparative subjects. Univariate analysis which showed significant association of acanthosis nigricans with fasting insulin and HOMA-IR with significant odds ratios and p value (p =0.0001) respectively. Fasting blood sugar showed greater risk of association in cases but it was statistically insignificant with p-value of (p =0.32). Spearman rank coefficient correlation showed weak correlation of HOMA-IR with acanthosis nigricans severity, neck severity and neck texture severity, but showed positive correlation of fasting insulin with acanthosis nigricans severity, neck severity and neck texture severity, with statistically significant P-value (p &lt;0.05).</p><p class="abstract"><strong>Conclusions:</strong> Acanthosis nigricans was strongly associated with insulin resistance with significant odds ratio and statistical significant p value (P &lt; 0.05). Acanthosis nigricans severity, neck severity and neck texture severity showed positive correlation with fasting serum insulin with statistically significant p value (P &lt;0.05). </p>

scholarly journals Association of Osteocalcin with Metabolic Syndrome and its Correlation with Insulin Resistance

2021 ◽  
Author(s):  
Nehali Pattanayak ◽  
Anuva Mishra ◽  
Sucharita Mohanty ◽  
Pramila Kumari Mishra ◽  
Putul Bara
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Blood Sugar ◽  
Serum Insulin ◽  
Fasting Blood Sugar ◽  
Enzyme Linked Immunosorbent Assay ◽  
Model Assessment ◽  
Serum Osteocalcin ◽  
Public Health Burden ◽  
Cardio Vascular

Introduction: Metabolic Syndrome (MetS) is an important public health burden associated with five-fold risk of developing Type 2 Diabetes Mellitus (T2DM) and two fold risk of Cardio Vascular Disease (CVD). Recent studies described that osteoblasts produce osteocalcin which increases insulin secretion and adiponectin production resulting in insulin sensitivity. Aim: To determine the association of serum osteocalcin with MetS and to assess the correlation of insulin resistance Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) with osteocalcin. Materials and Methods: This case-control study was carried out in the Department of Biochemistry at MKCG Medical College, Brahmapur, Odisha, India. By observing the mean and standard deviation from previous studies, with 95% Confidence Interval (CI) and 80% power of study, the sample size was calculated to be 45. Forty eight cases between 20-45 years of age meeting the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) criteria of MetS and 50 age and sex matched healthy individuals were taken as controls. Individuals with any systemic illness or on any kind of medications were excluded from the study. Fasting blood sugar, lipid profile were measured by standard procedures. Serum osteocalcin and serum insulin was estimated by Enzyme-linked Immunosorbent Assay (ELISA) LISA SCAN READER and ROCHE e COBAS 411 electrochemiluminiscence, respectively. Statistical analysis was done in Statistical Package for the Social Sciences (SPSS) 22.0 version software. Results: Serum osteocalcin was found to be lower in cases as compared to controls (7.74±4.62 ng/mL and 23.24±9.74 ng/mL) respectively. Osteocalcin was also found to be significantly negatively correlated with HOMA-IR, Waist Circumference (WC), triglyceride and fasting blood sugar in cases with (r=-0.322, p=0.025), (r=-0.519, p<0.001), (r=-0.401, p=0.005), (r=-0.539, p<0.001), respectively and also in controls with (r=-0.494, p<0.001), (r=-0.176, p=0.245), (r=-0.398, p<0.05), (r=-0.141, p<0.05), respectively. Conclusion: Serum osteocalcin being negatively correlated with insulin resistance may have therapeutic role in prevention of MetS which may be substantiated with further study.

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