Androgenic TRPM8 activity drives sexual dimorphism in a murine model of chronic migraine

Abstract The mechanisms contributing to the high prevalence of chronic migraine in females are yet elusive. Here, we used a mouse model of nitroglycerin-induced chronic migraine that displays a sexual dimorphic phenotype and unveiled a role of TRPM8 as a testosterone receptor that provides antinociceptive resilience exclusively in males. Nitroglycerin induced similar mechanosensitivity to both sexes trough activation of TRPA1 channels, but triggered persistent hypersensitivity solely in females, as males readily recovered from the migraine crisis. Notably, we found that testosterone exerted an antinociceptive activity through its interaction with the TRPM8 channel. Downregulation of this protective mechanism in males led to persistent mechanical hypersensitivity, whereas administration of testosterone to females favoured their recovery. Thus, our findings reveal a novel protective function of TRPM8 through pre-clinical models of acute and chronic pain and highlights the interest of molecular solutions mimicking the pain-relieving activity of testosterone on TRPM8.

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How Indonesians Cope with Chronic Pain: Does Seeking Help and Comfort from God Work?

Psychological Research on Urban Society ◽

10.7454/proust.v4i2.110 ◽

2021 ◽

Vol 4 (2) ◽

pp. 38

Author(s):

Mutmainah Mufidah Gozan ◽

Sali Rahadi Asih

Keyword(s):

Chronic Pain ◽

Religious Coping ◽

Pain Catastrophizing ◽

Coping Styles ◽

Pain Interference ◽

High Prevalence ◽

Seeking Help ◽

The Impact ◽

Positive Religious Coping

Chronic pain is a significant health problem in many countries including Indonesia, with high prevalence and the possibility to increase in the future. Individuals experiencing chronic pain elicit cognitive and behavioral responses, including pain catastrophizing which can cause high pain interference. Effective coping ability can help reduce the impact of pain catastrophizing on pain interference. Previous research focused on emotion-focused and problem-focused coping in dealing with chronic pain. However, Indonesia as a country with a strong influence from religious values and practices encourages the exploration of positive religious coping. A part of a longitudinal study on psychological factors in chronic pain development, this study aimed to examine the moderating role of three coping styles on pain catastrophizing and pain interference associations. Results from 368 participants male and female with chronic pain showed that positive religious coping and problem-focused coping significantly moderated the effects of pain catastrophizing on pain interference. Seeking help from God helped individuals deal with chronic pain problems, as well as actively resolving difficulties. The use of these two coping styles in the Indonesian population can be useful for managing chronic pain.

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Prophylactic Effect of Memantine on Chronic Migraine Headache

Journal of Computational and Theoretical Nanoscience ◽

10.1166/jctn.2019.8606 ◽

2019 ◽

Vol 16 (12) ◽

pp. 5327-5331

Author(s):

Davood Kashipazha ◽

Sahereh Emadi

Keyword(s):

Chronic Migraine ◽

Migraine Headache ◽

Migraine Treatment ◽

Prophylactic Effect ◽

Migraine Headaches ◽

Treatment And Prevention ◽

Significant Difference ◽

High Prevalence ◽

The Mean

Given the high prevalence of migraine treatment failure and resistance to existing drugs and side effects of drugs, finding alternative therapies for refractory patients or chronic migraine is essential. Fifty four patients with migraine headaches were stochastic classified to the 2 groups: placebo and memantine. In first one, memantine is managed at a dose of 20 mg in a day, that enhanced 4 weeks to this dose, and in second group placebo was given. The severity, duration, incapacity, and frequency of migraine headache attacks were recorded at the starting of the research, and the end of first, second, third and fourth months of the study. The mean of VAS score did not have a significant difference at the beginning of the study and at the end of the first month, however here was a significant decrease in the memantine group, during the end of second, third and fourth. After 4 months of behaving, MIDAS score were 22.44±10.62 in the memantine group, when in the placebo group, this was 14.47±1.79 (p <0.0001). The outcomes shows the role of memantine on the treatment and prevention of chronic migraine headaches. In addition, the migraine headaches incidence is mainly decreased in the memantine group in comparison to placebo at the end of the research.

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Insomnia and HRQoL of Indonesians with Chronic Pain: The Role of Catastrophizing

Psychological Research on Urban Society ◽

10.7454/proust.v4i1.109 ◽

2021 ◽

Vol 4 (1) ◽

pp. 15

Author(s):

Fariza Nur Shabrina ◽

Sali Rahadi Asih

Keyword(s):

Chronic Pain ◽

Urban Population ◽

Pain Catastrophizing ◽

Mediation Analyses ◽

Mediating Role ◽

Anxiety Trait ◽

High Prevalence ◽

Related Quality ◽

Health Related

Insomnia and chronic pain share the same catastrophizing cognitive tendency. The high prevalence of insomnia and chronic pain was found in the urban population. Seeing the interaction between both in influencing individuals is imperative. Most studies in insomnia and pain are conducted in the Western population, with little to no research conducted in Indonesian urban population. As a part longitudinal chronic pain study, this research explored (a) the mediating role of pain catastrophizing in linking insomnia with health-related quality of life (HRQoL) and (b) the moderating role of anxiety trait in influencing the mediation within Indonesian adults with chronic pain. The data were gathered through self-administered online questionnaires, and the moderated-mediation analyses were conducted at the beginning phase of the longitudinal study. The results from 415 participants validated that pain catastrophizing partially mediated the relationship between insomnia and HRQoL. Furthermore, no significant moderating effect of anxiety trait was found. People with insomnia showed rumination, worry, and dysfunctional beliefs regarding their sleep, which generalized into catastrophic thoughts regarding their pain experience. This pain catastrophizing in turn influenced the HRQoL. Interventions that simultaneously target both catastrophic thoughts in insomnia and pain would prove to be beneficial in mitigating pain among Indonesian adults.

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Role of Physical Therapy in an Interdisciplinary Approach to Chronic-Pain Management

PsycEXTRA Dataset ◽

10.1037/e677392011-001 ◽

2011 ◽

Author(s):

Victoria Dorward

Keyword(s):

Chronic Pain ◽

Pain Management ◽

Physical Therapy ◽

Interdisciplinary Approach ◽

Chronic Pain Management

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Role of Ethnicity on Pain Perception, Fatigue, and Quality of Life in a Pediatric Chronic Pain Population

PsycEXTRA Dataset ◽

10.1037/e691752007-001 ◽

2007 ◽

Author(s):

Jeffrey I. Gold ◽

Trina Haselrig ◽

D. Colette Nicolaou ◽

Katharine A. Belmont

Keyword(s):

Quality Of Life ◽

Chronic Pain ◽

Pain Perception ◽

Pediatric Chronic Pain

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The role of state and trait positive affect and mindfulness in affective reactivity to pain in chronic migraine.

Health Psychology ◽

10.1037/hea0000692 ◽

2019 ◽

Vol 38 (1) ◽

pp. 94-102 ◽

Cited By ~ 2

Author(s):

Yvette Ciere ◽

Evelien Snippe ◽

Mariëlle Padberg ◽

Bram Jacobs ◽

Annemieke Visser ◽

...

Keyword(s):

Positive Affect ◽

Chronic Migraine ◽

Affective Reactivity

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High prevalence of lower extremity peripheral artery disease in type 2 diabetes patients with diabetic nephropathy and the role of netrin-1 levels

Endocrine Abstracts ◽

10.1530/endoabs.49.gp96 ◽

2017 ◽

Author(s):

Ahmet Kor ◽

Suleyman Baldane ◽

Suleyman Hilmi Ipekci ◽

Kamile Marakoglu ◽

Ali Altinok ◽

...

Keyword(s):

Type 2 Diabetes ◽

Diabetic Nephropathy ◽

Lower Extremity ◽

Peripheral Artery Disease ◽

Peripheral Artery ◽

High Prevalence ◽

Artery Disease ◽

Diabetes Patients

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Chemo- and Optogenetic Strategies for the Elucidation of Pain Pathways

The Oxford Handbook of the Neurobiology of Pain ◽

10.1093/oxfordhb/9780190860509.013.33 ◽

2019 ◽

pp. 816-832 ◽

Cited By ~ 1

Author(s):

Sascha R. A. Alles ◽

Anne-Marie Malfait ◽

Richard J. Miller

Keyword(s):

Chronic Pain ◽

Pain Response ◽

Conscious Perception ◽

Novel Therapies ◽

The Past ◽

Nociceptive Pathways ◽

Pain Pathways ◽

Technical Advances ◽

The Brain

Pain is not a simple phenomenon and, beyond its conscious perception, involves circuitry that allows the brain to provide an affective context for nociception, which can influence mood and memory. In the past decade, neurobiological techniques have been developed that allow investigators to elucidate the importance of particular groups of neurons in different aspects of the pain response, something that may have important translational implications for the development of novel therapies. Chemo- and optogenetics represent two of the most important technical advances of recent times for gaining understanding of physiological circuitry underlying complex behaviors. The use of these techniques for teasing out the role of neurons and glia in nociceptive pathways is a rapidly growing area of research. The major findings of studies focused on understanding circuitry involved in different aspects of nociception and pain are highlighted in this article. In addition, attention is drawn to the possibility of modification of chemo- and optogenetic techniques for use as potential therapies for treatment of chronic pain disorders in human patients.

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