scholarly journals Application Effects of Remimazolam and on Elderly Patients Undergoing Hip Replacement

2021 ◽  
Author(s):  
Junbao Zhang ◽  
Xin Wang ◽  
Qin Zhang ◽  
Zicheng Wang ◽  
Shoufeng Zhu
Keyword(s):  
Heart Rate ◽  
Elderly Patients ◽  
Hip Replacement ◽  
Adverse Reactions ◽  
Laryngeal Mask ◽  
Anesthesia Induction ◽  
Plasma Epinephrine ◽  
Analgesic Effects ◽  
Laryngeal Mask Insertion ◽  
Time Point

Abstract Objective To explore the anesthetic and analgesic effects of remimazolam and propofol in elderly patients undergoing hip replacement and their effects on respiratory and circulatory systems, stress and cognitive function. Methods 60 elderly patients undergoing elective hip replacement in the hospital were selected as the research subjects, and they were divided into the remimazolam group and the propofol group according to the admission sequence of patients. The remimazolam group was anesthetized with remimazolam, and the propofol group was anesthetized with propofol. The anesthesia-related indicators, perioperative pain degree [Visual Analogue Scale (VAS)], circulatory indicators [heart rate, mean arterial pressure (MAP)] before anesthesia (T0), immediately before laryngeal mask insertion (T1), at 5 min after laryngeal mask insertion (T2), at 30 min after laryngeal mask insertion (T3) and at 5 min after laryngeal mask removal (T4), stress response indicators (plasma epinephrine, norepinephrine, cortisol) before anesthesia induction and at 24 h and 72 h after surgery, cognitive function [Mini-Mental State Examination (MMSE)] and adverse reactions were compared between the two groups. Results Among the 60 enrolled patients, only 1 case was excluded due to withdrawal, thus 30 cases in the remimazolam group and 29 cases in the propofol group were included. There were statistically significant differences in the heart rate, MAP, plasma epinephrine, norepinephrine, cortisol and VAS score in the two groups from the aspects of interaction effect and time-point effect (P<0.05). The heart rate and MAP at T1, T2 and T3 in the two groups were significantly decreased compared with those at T0, but the heart rate and MAP in the remimazolam group at T1, T2 and T3 were significantly higher than those in the propofol group (P<0.05). There were no statistical differences in the anesthesia time, awakening time and extubation time between the remimazolam group and the propofol group (P>0.05). The levels of plasma epinephrine, norepinephrine and cortisol in the two groups were significantly higher at 24 h and 72 h after surgery than those before anesthesia induction, and the above levels were significantly lower in the remimazolam group than those in the propofol group (P<0.05). The VAS scores at each time point in the two groups were significantly reduced compared to before surgery, but there was no statistically significant difference between the two groups after surgery (P>0.05). The MMSE scores of the two groups were significantly lower at 1 d and 3 d after surgery compared with those before anesthesia induction, but the score in the remimazolam group was significantly higher than that in the propofol group (P<0.05). In addition, the incidence rates of adverse reactions were significantly lower in the remimazolam group compared to the propofol group (P<0.05). Conclusion Compared with propofol, remimazolam can achieve equivalent anesthetic and analgesic effects in elderly patients undergoing hip replacement. However, the latter one can significantly relieve respiratory and circulatory suppression, stress response and cognitive dysfunction, with good safety. Trial registration Clinical trial ethics committee of Hefei second people's Hospital：2021- scientific research-032 (September 6, 2021).

scholarly journals Recommended dose of sufentanil during induction of general anesthesia to avoid coughing and drastic hemodynamic fluctuations in patients undergoing surgery

2021 ◽  
Vol 49 (3) ◽  
pp. 030006052199614
Author(s):  
Ping Chen ◽  
Ping Zeng ◽  
Yuan Gong ◽  
Xiang Long
Keyword(s):  
Blood Pressure ◽  
Clinical Trial ◽  
Heart Rate ◽  
General Anesthesia ◽  
Adverse Reactions ◽  
The Other ◽  
Anesthesia Induction ◽  
Common Complication ◽  
Chest Tightness ◽  
Group I

Background Sufentanil-induced cough (SIC) is a common complication during anesthesia induction. We explored the recommended sufentanil dose that effectively avoids cough during general anesthesia using a clinical trial to analyze the effective dose (ED)50 and ED95 of sufentanil that avoids cough, hemodynamic fluctuations, and adverse reactions. Methods On the basis of sufentanil dose, 136 patients (ASA class I–II) were randomly allocated into the following groups: I, 0.1 μg/kg; II, 0.3 μg/kg; III, 0.5 μg/kg; or IV, 1.0 μg/kg. The number of coughing incidents, dizziness, panic, and chest tightness within 1 minute after sufentanil injection, and the patient’s heart rate (HR) and blood pressure 5 minutes after intubation were recorded and analyzed. Cough was assessed as follows: none, 0 times; mild, 1 to 2 times/minute; moderate, 3 to 4 times/minute; and severe, 5 times/minute or more. Results The ED50 and ED95 of cough incidence induced by intravenous sufentanil in patients during general anesthesia induction was 0.332 μg/kg and 1.423 μg/kg, respectively. The cough rate in group I was lower than the other groups. The incidence of dizziness, panic, chest tightness, hypertension, bradycardia, and tachycardia were not significantly different. Conclusions The recommended sufentanil dose during general anesthesia induction is 0.1 μg/kg.

Evaluation of the Alaris Auditory Evoked Potential Index as an Indicator of Anesthetic Depth in Preschool Children during Induction of Anesthesia with Sevoflurane and Remifentanil

2004 ◽  
Vol 101 (2) ◽  
pp. 294-298 ◽  
Author(s):  
Frank Weber ◽  
Thomas Bein ◽  
Jonny Hobbhahn ◽  
Kai Taeger
Keyword(s):  
Heart Rate ◽  
Preschool Children ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Pediatric Patients ◽  
Auditory Evoked Potential ◽  
Laryngeal Mask ◽  
Prediction Probability ◽  
Laryngeal Mask Insertion ◽  
Eye Closure

Background Autoregressive modeling with exogenous input of middle latency auditory evoked potentials (A-Line autoregressive index [AAI]) has been proposed for monitoring depth of anesthesia in adults. The aim of this study was to evaluate the performance of the AAI during induction of anesthesia with sevoflurane and remifentanil in pediatric patients. Methods Twenty preschool children were anesthetized with sevoflurane and remifentanil. AAI, heart rate, and mean arterial pressure were compared for their ability to distinguish between different hypnotic states before inhalation induction and during sevoflurane anesthesia with and without remifentanil infusion. The prediction probability was calculated for discrimination between the predefined case milestones Awake, Spontaneous Eye Closure, and insertion of a laryngeal mask airway during general anesthesia (Laryngeal Mask Insertion). Results The AAI (mean +/- SD) in Awake children was 79 +/- 10, declining to 59 +/- 22 at Spontaneous Eye Closure and 34 +/- 13 when anesthetized. AAI values significantly overlapped between anesthetic states. For the AAI, the prediction probabilities regarding the ability to discriminate the hypnotic state at the case milestones Awake versus Spontaneous Eye Closure and Awake versus Laryngeal Mask Insertion were 0.77 and 0.99, respectively. In terms of prediction probability values, heart rate and mean arterial pressure were not indicative for anesthetic states. Remifentanil did not influence the AAI. Conclusion During induction of pediatric patients with sevoflurane, the AAI is of higher value in predicting anesthetic states than hemodynamic variables and reliably differentiates between the awake and anesthetized states. However, individual AAI values demonstrate significant variability and overlap between different clinical conditions.

scholarly journals Study on Effect of Laryngeal Mask Anesthesia and Endotracheal Intubation Anesthesia on Elderly Patients Undergoing Laparoscopic Gallbladder Surgery

2020 ◽  
Vol 4 (5) ◽  
Author(s):  
Xin Wang
Keyword(s):  
Carbon Dioxide ◽  
Heart Rate ◽  
Blood Glucose ◽  
Mean Arterial Pressure ◽  
Elderly Patients ◽  
Airway Pressure ◽  
Statistical Significance ◽  
Laryngeal Mask ◽  
Gallbladder Surgery ◽  
Index Changes

Objective: To analyze the effect of laryngeal mask anesthesia and endotracheal intubation anesthesia in elderly laparoscopic gallbladder surgery. Methods: 100 subjects of the experiment came from elderly patients with gallbladder stones admitted from September 2016 to September 2019 in our hospital. There were group A and group B of 50 cases each, and were used tube anesthesia and laryngeal mask anesthesia, then comparing the anesthesia effect. Results: Statistical significance(P<0.05): Air pressure and end-respiratory carbon dioxide partial pressure index changes when immediately after insertion, immediately after removal, 3 minutes after removal; heart rate, mean arterial pressure, airway pressure, and end-expiratory carbon dioxide index changes when 3 minutes after insertion and immediately before removal; blood glucose and cortisol changes when after insertion, immediately before removal and min after removal. No statistical significance(P>0.05): Changes in heart rate, mean arterial pressure, airway pressure, and end-expiratory carbon dioxide indexes before insertion; changes in blood glucose and cortisol indexes before insertion. Conclusion: It is more ideal for elderly patients with abdominal cavity and gallbladder surgery to have laryngeal mask anesthesia, which can effectively keep blood circulation stable and have promotion value.

scholarly journals Effects of Intraoperative Dexmedetomidine Infusion on Postoperative Delirium in Elderly Patients Undergoing Total Hip Arthroplasty

2021 ◽  
Vol 105 (1-3) ◽  
pp. 328-335
Author(s):  
Chen Yan ◽  
Dai Ti-jun
Keyword(s):  
Heart Rate ◽  
Total Hip Arthroplasty ◽  
Elderly Patients ◽  
Hospital Stay ◽  
Hip Arthroplasty ◽  
Postoperative Delirium ◽  
Length Of Hospital Stay ◽  
Anesthesia Induction ◽  
Total Hip ◽  
Group D

Objective To investigate the effects of dexmedetomidine on postoperative delirium in elderly patients undergoing total hip arthroplasty. Methods A total of 100 patients, 42 male and 58 female, ages 60 to 85 years, American Society of Anesthesiologists grade I or II, who were undergoing total hip arthroplasty were randomly divided into 2 groups: a dexmedetomidine group (group D; n = 50) and a control group (group C; n = 50). Group D patients were infused with 0.3 μg · kg−1 · h−1 of dexmedetomidine from 5 minutes prior to anesthesia induction until the end of surgery. Group C patients received an equal volume of saline. Heart rate and mean arterial pressure (MAP) were recorded before anesthesia induction (T0), 1 minute before extubation (T1), and 30 minutes after extubation (T2). The Visual Analog Score (VAS) at 1, 2, and 3 days after surgery, the incidence and duration of postoperative delirium, and the length of hospital stay were recorded. Adverse reactions, such as nausea, vomiting, and lethargy, were also recorded. Results The Visual Analog Scores in the 2 groups were similar. In group D, there was no significant difference in heart rate (P = 0.232) and MAP (P = 0.056) between T0 and T1. However, in group C, heart rate significantly increased by 15.3 bpm (P = 0.000) and MAP significantly increased by 10.7 mmHg (P = 0.001) at T1 compared with those at T0. The incidence of postoperative delirium in group D (10%) was significantly lower than that in group C (26%; P = 0.037). The duration of delirium in group D (1.3 ± 0.6 days) was shorter than that in group C (3.0 ± 0.5 days; P = 0.000). The length of hospital stay in group D (13.2 ± 0.9 days) was shorter than that in group C (16.1 ± 0.7 days; P = 0.000). No significant differences were observed in adverse effects between the 2 groups. Conclusion Intravenous infusion of dexmedetomidine can not only reduce the incidence and duration of postoperative delirium, but also shorten the length of hospital stay in elderly patients undergoing total hip arthroplasty.

scholarly journals The Median Effective Dose (ED50) of cis-Atracurium for Laryngeal Mask Airway Insertion during General Anaesthesia for Patients Undergoing Urinary Surgery

2019 ◽  
Author(s):  
Xiaohua Wang ◽  
Ke Huang ◽  
Dongxu Yao ◽  
Jixiu Xue ◽  
Tianlong Wang
Keyword(s):  
Blood Pressure ◽  
Heart Rate ◽  
Laryngeal Mask Airway ◽  
Effective Dose ◽  
General Anaesthesia ◽  
Laryngeal Mask ◽  
Laryngeal Mask Airway Insertion ◽  
Sequential Method ◽  
Laryngeal Mask Insertion ◽  
Train Of Four

Abstract Background In clinical practice, the laryngeal mask airway is an easy-to-use supraglottic airway device. However, the cis- atracurium dosage for laryngeal mask insertion is not standardised. We aimed to determine the optimal dose and hypnotic median effective dose of cis- atracurium using a sequential method for successful laryngeal mask insertion when inducting general anaesthesia. Method s : The cohort study protocol is registered at clinicaltrial.gov (NCT-03358680). Twenty-three patients undergoing elective urinary surgery were sequentially administered doses (mg·kg -1 ) of cis- atracurium as follows: 0.15, 0.1, 0.07, 0.05, 0.03, and 0.02. Systolic and diastolic blood pressure, heart rate, bispectral index, and train-of-four were continuously monitored. Successful laryngeal mask insertion occurred without resistance to mouth opening, resistance to insertion, coughing, swallowing, laryngospasm/airway obstruction, and head and body movement. The main outcome was the response to laryngeal mask airway insertion: ≥16 points and <16 points indicated “satisfactory” and “unsatisfactory” responses, respectively. The median effective dose was estimated using the mean of the seven crossovers from “satisfactory” and “unsatisfactory” responses. Result s : The median effective dose of cis- atracurium was 0.0265 mg·kg -1 (95% CI 0.0236-0.0298) using the sequential method. The heart rate was decreased in the 0.05 group compared to the 0.03 group at timepoints T7, T8, and T10. The systolic blood pressure was decreased in the 0.02 group compared to the 0.05 group at timepoints T2, T3, T4. The train-of-four value was significantly lower in the 0.05 group than in the 0.03 group at timepoint T3. Conclusion s : cis- a tracurium was a good option for muscle relaxation in urinary surgery.

The Hemodynamic and Fibrinolytic Response to Low Dose Epinephrine and Phenylephrine Infusions During Total Hip Replacement Under Epidural Anesthesia

1992 ◽  
Vol 68 (04) ◽  
pp. 436-441 ◽  
Author(s):  
Nigel E Sharrock ◽  
George Go ◽  
Robert Mineo ◽  
Peter C Harpel
Keyword(s):  
Heart Rate ◽  
Deep Vein Thrombosis ◽  
Cardiac Index ◽  
Total Hip Replacement ◽  
Epidural Anesthesia ◽  
Hip Replacement ◽  
Low Dose ◽  
Total Hip ◽  
Vein Thrombosis ◽  
Deep Vein

SummaryLower rates of deep vein thrombosis have been noted following total hip replacement under epidural anesthesia in patients receiving exogenous epinephrine throughout surgery. To determine whether this is due to enhanced fibrinolysis or to circulatory effects of epinephrine, 30 patients scheduled for primary total hip replacement under epidural anesthesia were randomly assigned to receive intravenous infusions of either low dose epinephrine or phenylephrine intraoperatively. All patients received lumbar epidural anesthesia with induced hypotension and were monitored with radial artery and pulmonary artery catheters.Patients receiving low dose epinephrine infusion had maintenance of heart rate and cardiac index whereas both heart rate and cardiac index declined significantly throughout surgery in patients receiving phenylephrine (p = 0.0001 and p = 0.0001, respectively). Tissue plasminogen activator (t-PA) activity increased significantly during surgery (p <0.0005) and declined below baseline postoperatively (p <0.005) in both groups. Low dose epinephrine was not associated with any additional augmentation of fibrinolytic activity perioperatively. There were no significant differences in changes in D-Dimer, t-PA antigen, α2-plasmin inhibitor-plasmin complexes or thrombin-antithrombin III complexes perioperatively between groups receiving low dose epinephrine or phenylephrine. The reduction in deep vein thrombosis rate with low dose epinephrine is more likely mediated by a circulatory mechanism than by augmentation of fibrinolysis.

scholarly journals The Incidence of Bacteraemia following Laryngeal Mask Insertion

1992 ◽  
Vol 20 (4) ◽  
pp. 484-486 ◽  
Author(s):  
J. Brimacombe ◽  
N. Shorney ◽  
R. Swainston ◽  
G. Bapty
Keyword(s):  
Laryngeal Mask Airway ◽  
Antibiotic Prophylaxis ◽  
Laryngeal Mask ◽  
The Other ◽  
Anaerobic Culture ◽  
Culture Bottle ◽  
Oral Intubation ◽  
Skin Flora ◽  
Laryngeal Mask Insertion

The incidence of bacteraemia following insertion of the laryngeal mask airway (LMA) was investigated in one hundred fit patients. Four cultures were positive: three represented contamination with skin flora; the other was a microaerophilic streptococcus grown from an anaerobic culture bottle. Although this organism can be pathogenic, it may also represent contamination. Our findings suggest that significant bacteraemia on insertion of the LMA is uncommon and is probably no more than with oral intubation. Antibiotic prophylaxis is of doubtful benefit in these circumstances.

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