A Cohert Study of the Relationship Between c-erbB-2 and Cyclin D1 Overexpression, p53 Mutation and/or Protein Accumulation, and Risk of Progression from Benign Breast Disease to Breast Cancer; and Creation of a Bank of Benign Breast Tissue

2000 ◽  
Author(s):  
Rita A. Kandel
Keyword(s):  
Breast Cancer ◽  
Cyclin D1 ◽  
Breast Tissue ◽  
Benign Breast Disease ◽  
Breast Disease ◽  
P53 Mutation ◽  
Protein Accumulation ◽  
Benign Breast Tissue ◽  
Risk Of Progression ◽  
The Relationship

scholarly journals A Cohort Study of p53 Mutations and Protein Accumulation in Benign Breast Tissue and Subsequent Breast Cancer Risk

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Geoffrey C. Kabat ◽  
Rita A. Kandel ◽  
Andrew G. Glass ◽  
Joan G. Jones ◽  
Neal Olson ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Confidence Intervals ◽  
Breast Tissue ◽  
Benign Breast Disease ◽  
P53 Protein ◽  
Breast Disease ◽  
Genetic Alterations ◽  
Protein Accumulation ◽  
Missense Mutations ◽  
Increased Risk

Mutations in the p53 tumor suppressor gene and accumulation of its protein in breast tissue are thought to play a role in breast carcinogenesis. However, few studies have prospectively investigated the association of p53 immunopositivity and/or p53 alterations in women with benign breast disease in relation to the subsequent risk of invasive breast cancer. We carried out a case-control study nested within a large cohort of women biopsied for benign breast disease in order to address this question. After exclusions, 491 breast cancer cases and 471 controls were available for analysis. Unconditional logistic regression was used to estimate odds ratios (OR) and 95% confidence intervals (95% CI). Neither p53 immunopositivity nor genetic alterations in p53 (either missense mutations or polymorphisms) was associated with altered risk of subsequent breast cancer. However, the combination of both p53 immunopositivity and any p53 nucleotide change was associated with an approximate 5-fold nonsignificant increase in risk (adjusted OR 4.79, 95% CI 0.28–82.31) but the confidence intervals were extremely wide. Our findings raise the possibility that the combination of p53 protein accumulation and the presence of genetic alterations may identify a group at increased risk of breast cancer.

Evaluation of the expression levels of nm23-h1 mRNA in primary breast cancer, benign breast disease, axillary lymph nodes and normal breast tissue

Pathology ◽  
1994 ◽  
Vol 26 (4) ◽  
pp. 423-428 ◽  
Author(s):  
Rebecca J. Goodall ◽  
Hugh J.S. Dawkins ◽  
Peter D. Robbins ◽  
Erika Hähnel ◽  
Mohinder Sarna ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Primary Breast Cancer ◽  
Breast Tissue ◽  
Benign Breast Disease ◽  
Normal Breast Tissue ◽  
Breast Disease ◽  
Normal Breast ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph

Prostate specific antigen in breast cancer, benign breast disease and normal breast tissue

1996 ◽  
Vol 40 (2) ◽  
pp. 171-178 ◽  
Author(s):  
He Yu ◽  
Eleftherios P. Diamandis ◽  
Michael Levesque ◽  
Maurizia Giai ◽  
Riccardo Roagna ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Prostate Specific Antigen ◽  
Breast Tissue ◽  
Benign Breast Disease ◽  
Normal Breast Tissue ◽  
Specific Antigen ◽  
Breast Disease ◽  
Normal Breast

Glycolytic Enzymes in Breast Cancer, Benign Breast Disease and Normal Breast Tissue

Tumor Biology ◽  
1987 ◽  
Vol 8 (5) ◽  
pp. 251-263 ◽  
Author(s):  
A. Hennipman ◽  
J. Smits ◽  
B. van Oirschot ◽  
J.C. van Houwelingen ◽  
G. Rijksen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Tissue ◽  
Benign Breast Disease ◽  
Normal Breast Tissue ◽  
Breast Disease ◽  
Normal Breast ◽  
Glycolytic Enzymes
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