Hydrophobically Modified Chitosan Gauze for Control of Massive Hemorrhage

The antibacterial activity of N,O-acylated chitosan derivative with linoleic acid (CH_LA) was tested by disc and well diffusion, agar impregnation and microdilution methods against Staphylococcus aureus, Escherichia coli and Helicobacter pylori strains. Hydrophobically modified chitosan (HMC) was expected to exhibit enhanced antibacterial activity and specific mucin interactions. Although diffusion tests have not indicated the antibacterial potential of chitosan (CH) or CH_LA, the results of the microdilution method demonstrated that tested polymers significantly reduced the amount of living bacteria cells in different concentrations depending on the microorganism. Additionally, CH_LA was characterized by enhanced antibacterial activity compared to CH, which may suggest a different mechanism of interaction with S. aureus and H. pylori. Furthermore, the UV-VIS analysis revealed that the amphiphilic character of derivative led to strong CH_LA–mucin interactions. The study proved the high potential of CH_LA in antibacterial applications, especially for the gastrointestinal tract.

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Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery

International Journal of Nanomedicine ◽

10.2147/ijn.s166901 ◽

2018 ◽

Vol Volume 13 ◽

pp. 5837-5848 ◽

Cited By ~ 11

Author(s):

M Gulrez Zariwala ◽

Harshada Bendre ◽

Anatoliy Markiv ◽

Sebastien Farnaud ◽

Derek Renshaw ◽

...

Keyword(s):

Drug Delivery ◽

Modified Chitosan ◽

Hydrophobically Modified

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Injectable hydrogel composed of hydrophobically modified chitosan/oxidized-dextran for wound healing

Materials Science and Engineering C ◽

10.1016/j.msec.2019.109930 ◽

2019 ◽

Vol 104 ◽

pp. 109930 ◽

Cited By ~ 12

Author(s):

Xinchen Du ◽

Yujie Liu ◽

Xin Wang ◽

Hongyu Yan ◽

Lina Wang ◽

...

Keyword(s):

Wound Healing ◽

Injectable Hydrogel ◽

Oxidized Dextran ◽

Modified Chitosan ◽

Hydrophobically Modified

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Chitosan-Based Thermo-Sensitive Hydrogel Loading Oyster Peptides for Hemostasis Application

Materials ◽

10.3390/ma13215038 ◽

2020 ◽

Vol 13 (21) ◽

pp. 5038

Author(s):

Dongying Zhang ◽

Zhang Hu ◽

Lingyu Zhang ◽

Sitong Lu ◽

Fengyan Liang ◽

...

Keyword(s):

Matrix Material ◽

Safety Evaluation ◽

Massive Hemorrhage ◽

Gelatin Sponge ◽

Glycerol Phosphate ◽

Modified Chitosan ◽

The Matrix ◽

Adsorption Rates

Uncontrolled massive hemorrhage is one of the principal causes of death in trauma emergencies. By using catechol-modified chitosan (CS-C) as the matrix material and β glycerol phosphate (β-GP) as a thermo-sensitive agent, chitosan-based thermo-sensitive hydrogel loading oyster peptides (CS-C/OP/β-GP) were prepared at physiological temperature. The hemostatic performance of CS-C/OP/β-GP hydrogel was tested in vivo and in vitro, and its biological safety was evaluated. The results showed that the in vitro coagulation time and blood coagulation index of CS-C/OP/β-GP hydrogel were better than those of a commercial gelatin sponge. Notably, compared with the gelatin sponge, CS-C/OP/β-GP hydrogel showed that the platelet adhesion and erythrocyte adsorption rates were 38.98% and 95.87% higher, respectively. Additionally, the hemostasis time in mouse liver injury was shortened by 19.5%, and the mass of blood loss in the mouse tail amputation model was reduced by 18.9%. The safety evaluation results demonstrated that CS-C/OP/β-GP had no cytotoxicity to L929 cells, and the hemolysis rates were less than 5% within 1 mg/mL, suggesting good biocompatibility. In conclusion, our results indicate that CS-C/OP/β-GP is expected to be a promising dressing in the field of medical hemostasis.

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