Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery

The antibacterial activity of N,O-acylated chitosan derivative with linoleic acid (CH_LA) was tested by disc and well diffusion, agar impregnation and microdilution methods against Staphylococcus aureus, Escherichia coli and Helicobacter pylori strains. Hydrophobically modified chitosan (HMC) was expected to exhibit enhanced antibacterial activity and specific mucin interactions. Although diffusion tests have not indicated the antibacterial potential of chitosan (CH) or CH_LA, the results of the microdilution method demonstrated that tested polymers significantly reduced the amount of living bacteria cells in different concentrations depending on the microorganism. Additionally, CH_LA was characterized by enhanced antibacterial activity compared to CH, which may suggest a different mechanism of interaction with S. aureus and H. pylori. Furthermore, the UV-VIS analysis revealed that the amphiphilic character of derivative led to strong CH_LA–mucin interactions. The study proved the high potential of CH_LA in antibacterial applications, especially for the gastrointestinal tract.

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Selective Modification of Chitosan to Enable the Formation of Chitosan-DNA Condensates by Electron Donator Stabilization

International Journal of Carbohydrate Chemistry ◽

10.1155/2011/146419 ◽

2011 ◽

Vol 2011 ◽

pp. 1-11 ◽

Cited By ~ 8

Author(s):

Karl E. Kador ◽

Anuradha Subramanian

Keyword(s):

Drug Delivery ◽

Gene Delivery ◽

Transfection Efficiency ◽

Protonated Form ◽

Chemical Modifications ◽

Modified Chitosan

Chitosan, a polyaminosaccharide, has been investigated for its use in the field of drug-delivery and biomaterial applications because of its natural biocompatibility and polycationic properties. Chemical modifications of chitosan have been attempted in an effort to increase the transfection efficiency with respect to gene delivery applications; however, it is unknown how these modifications affect the formation of the condensates. This study attempts to determine the effects of modification of the cationic center of chitosan on the ability to condense DNA. Specifically, electron-donating or -withdrawing groups were used as modifiers of the cationic charge on the chitosan backbone to stabilize the protonated form of chitosan, which is necessary to form condensates and increase the efficiency of the polymer to condense DNA by yielding condensates at a lower nitrogen to phosphorous (N : P) ratio. While an N : P ratio of 7 is needed to condense DNA with unmodified chitosan, phthalate-modified chitosan yielded condensates were obtained at an N : P ratio of 1.0.

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Use of Chemically Modified Chitosan and Other Natural-Origin Polymers in Tissue Engineering and Drug Delivery

Biodegradable Systems in Tissue Engineering and Regenerative Medicine ◽

10.1201/9780203491232-25 ◽

2004 ◽

pp. 345-356

Keyword(s):

Drug Delivery ◽

Tissue Engineering ◽

Natural Origin ◽

Modified Chitosan ◽

Chemically Modified

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Using Chitosan or Chitosan Derivatives in Cancer Therapy

Polysaccharides ◽

10.3390/polysaccharides2040048 ◽

2021 ◽

Vol 2 (4) ◽

pp. 795-816

Author(s):

Md Salman Shakil ◽

Kazi Mustafa Mahmud ◽

Mohammad Sayem ◽

Mahruba Sultana Niloy ◽

Sajal Kumar Halder ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Anticancer Agents ◽

Chitosan Nanoparticles ◽

Chemotherapeutic Drugs ◽

Chitosan Derivatives ◽

Drug Delivery Vehicles ◽

Modified Chitosan ◽

Therapeutic Benefits ◽

Delivery Vehicles

Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy.

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