A new atherosclerotic lesion probe based on hydrophobically modified chitosan nanoparticles functionalized by the atherosclerotic plaque targeted peptides

The antibacterial activity of N,O-acylated chitosan derivative with linoleic acid (CH_LA) was tested by disc and well diffusion, agar impregnation and microdilution methods against Staphylococcus aureus, Escherichia coli and Helicobacter pylori strains. Hydrophobically modified chitosan (HMC) was expected to exhibit enhanced antibacterial activity and specific mucin interactions. Although diffusion tests have not indicated the antibacterial potential of chitosan (CH) or CH_LA, the results of the microdilution method demonstrated that tested polymers significantly reduced the amount of living bacteria cells in different concentrations depending on the microorganism. Additionally, CH_LA was characterized by enhanced antibacterial activity compared to CH, which may suggest a different mechanism of interaction with S. aureus and H. pylori. Furthermore, the UV-VIS analysis revealed that the amphiphilic character of derivative led to strong CH_LA–mucin interactions. The study proved the high potential of CH_LA in antibacterial applications, especially for the gastrointestinal tract.

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Hydrophobically modified chitosan nanoliposomes for intestinal drug delivery

International Journal of Nanomedicine ◽

10.2147/ijn.s166901 ◽

2018 ◽

Vol Volume 13 ◽

pp. 5837-5848 ◽

Cited By ~ 11

Author(s):

M Gulrez Zariwala ◽

Harshada Bendre ◽

Anatoliy Markiv ◽

Sebastien Farnaud ◽

Derek Renshaw ◽

...

Keyword(s):

Drug Delivery ◽

Modified Chitosan ◽

Hydrophobically Modified

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Using Chitosan or Chitosan Derivatives in Cancer Therapy

Polysaccharides ◽

10.3390/polysaccharides2040048 ◽

2021 ◽

Vol 2 (4) ◽

pp. 795-816

Author(s):

Md Salman Shakil ◽

Kazi Mustafa Mahmud ◽

Mohammad Sayem ◽

Mahruba Sultana Niloy ◽

Sajal Kumar Halder ◽

...

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Anticancer Agents ◽

Chitosan Nanoparticles ◽

Chemotherapeutic Drugs ◽

Chitosan Derivatives ◽

Drug Delivery Vehicles ◽

Modified Chitosan ◽

Therapeutic Benefits ◽

Delivery Vehicles

Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy.

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