Prevalence of Gastrointestinal Symptoms in COVID-19 Patients and Impact of Medical Resources on Disease Transmission

Author(s):  
Muhammad Majeed ◽  
Rohit Agrawal ◽  
Yuchen Wang ◽  
Bashar M. Attar ◽  
Palak Patel ◽  
...  
2020 ◽  
Vol 7 (Supplement_1) ◽  
pp. S293-S293
Author(s):  
Bethany E Ho ◽  
Andrea P Ho ◽  
Michaela A Ho ◽  
Elizabeth C Ho

Abstract Background Patients with COVID-19 most commonly report respiratory symptoms, with a minority reporting gastrointestinal (GI) symptoms in currently available reports. Additionally, little is known about the symptoms of anosmia/hyposmia, ageusia, and dysgeusia anecdotally seen in COVID-19 patients, which may be considered both GI and sensory/neurological manifestations of infection. Methods We interviewed 7 patients via oral inquiries and a questionnaire, collecting data on subject symptoms and their durations. Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to confirm 2 of these cases. Results We report a familial cluster of 7 COVID-19 cases, 5 of whom reported sensory symptoms of anosmia/hyposmia (5/7), ageusia/hypogeusia (5/7), and/or dysgeusia (3/7). All 7 cases reported GI involvement with one or more symptom of: nausea (5/7), diarrhea (4/7), abdominal pain (3/7), anorexia (3/7), and emesis (2/7). Figure 1. Timeline of Symptoms and Exposure to Index Case in Familial COVID-19 Cluster Conclusion This frequency of GI symptoms is high relative to currently available epidemiological reports, which also infrequently report on sensory symptoms. The mechanistic underpinnings of GI and sensory symptoms in COVID-19 warrant close consideration and analysis, especially as it relates to reducing disease transmission. COVID-19 exhibits wide variation in duration, severity, and progression of symptoms, even within a familial cluster. Disclosures All Authors: No reported disclosures


2021 ◽  
Author(s):  
Tangjuan Li ◽  
Yanni Xiao

Abstract During the outbreak of emerging infectious diseases, media coverage and medical resource play important roles in affecting the disease transmission. To investigate the effects of the saturation of media coverage and limited medical resources, we proposed a mathematical model with extra compartment of media coverage and two nonlinear functions. We theoretically obtained that saturated recovery significantly contributes the occurrence of backward bifurcation and rich dynamics. Then it is reasonable to only considering nonlinear recovery, we theoretically showed that backward bifurcation can occur and multiple equilibria may coexist under certain conditions in this case. And numerical simulations reveals the rich dynamic behaviors, including forward-backward bifurcation, Hopf bifurcation, Saddle-Node bifurcation, Homoclinic bifurcation and unstable limit cycle. Comparing the system with linear recovery, where the threshold dynamic are almost completely characterized by a threshold condition called the basic reproduction number, we concluded that only saturated media impact hardly induces the complicated dynamics, while the nonlinear recovery function, associated with limitation of medical resources, may induce the coexistence of the disease-free equilibrium (DFE) and a endemic state or multiple endemic states, which means that the limitation of medical resources causes much difficulties in eliminating the infectious diseases.


2020 ◽  
Vol 41 (S1) ◽  
pp. s100-s100
Author(s):  
Carolee Estelle ◽  
Julie Trivedi ◽  
Patricia Jackson ◽  
Doramarie Arocha ◽  
Wendy Chung ◽  
...  

Background: In the setting of global warming, natural disasters are increasing in pace and scope. Although natural disasters themselves do not cause outbreaks, the breakdowns in sanitary infrastructure and the displacement of populations, often to crowded shelters, have caused outbreaks. On August 26, 2017, category 4 hurricane Harvey made landfall near Corpus Christi, Texas, causing catastrophic flooding and displacing >30,000 residents from the Southern Gulf Coast region. Dallas accepted >3,800 evacuees at the Kay Bailey Hutchison Convention Center mega-shelter for 23 days, where a medical clinic was erected in the convention center parking garage. The medical clinic uniquely included a dedicated infection prevention team composed of local volunteer infection preventionists, healthcare epidemiologists, infectious diseases providers, and health department personnel. Methods: Evacuees were housed at the Dallas mega-shelter from August 29 through September 20. The infection prevention team maintained a presence of 3–4 members during clinical operations in shifts. The team conducted an initial needs assessment upon opening of the shelter medical clinic, facilitated acquisition of adequate numbers of hand sanitizer stations, sinks with running water, portable hand-washing stations, portable toilets and showers, and cleaning products. The infection prevention team coordinated and oversaw environmental cleaning services (EVS) carried out by local hospital EVS staff. Protocols for cleaning, disinfection, communicable disease testing, isolation, and treatment were created. In addition, education and training materials for the implementation of these protocols were distributed to volunteer staff. The infection preventionists created and provided oversight of the designated isolation units for respiratory, gastrointestinal and dermatologic infections of outbreak potential. Infection prevention rounding tools were developed and executed daily in the clinic, at the on-site daycare center, dining area, and the general shelter dormitory. Vaccination for influenza was formalized under a protocol and administered at the clinic and via mobile vaccination teams in the chronic illness section of the dormitory. Results: In tota3,829 residents were housed at the mega-shelter for 23 days. Moreover, 1,560 patients were seen in 2,654 clinic visits at the shelter medical clinic. In total, 48 (19%) clinic visits were for respiratory symptoms, 228 (9%) were for dermatologic problems, and 215 (8%) were for gastrointestinal symptoms. Also, 32 patients were referred to the isolation unit within the clinic. Overall, 98 influenza vaccines were administered. There was 1 confirmed case of influenza and 1 confirmed case of norovirus. Conclusions: No known transmission of communicable diseases occurred in this long-term, natural disaster–related mega-shelter, likely attributed to having a comprehensive infection prevention team of on-site volunteers available throughout the shelter operation. This model should be considered in future large-scale shelter settings to prevent disease transmission.Disclosures: NoneFunding: None


2001 ◽  
Vol 120 (5) ◽  
pp. A642-A642 ◽  
Author(s):  
R CLOUSE ◽  
C PRAKASH ◽  
R ANDERSON ◽  
P LUSTMAN ◽  
W UNIV

1952 ◽  
Vol 20 (1) ◽  
pp. 119-128 ◽  
Author(s):  
Donald R. Smith

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