scholarly journals ER Expression Associates With Poor Prognosis in Male Lung Squamous Carcinoma After Radical Resection

2021 ◽  
Author(s):  
Xue Yang ◽  
Xiangfeng Jin ◽  
Rongjian Xu ◽  
Ning An
Keyword(s):  
Poor Prognosis ◽  
Squamous Carcinoma ◽  
Radical Resection ◽  
Lung Squamous Carcinoma ◽  
Er Expression

scholarly journals ER expression associates with poor prognosis in male lung squamous carcinoma after radical resection

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Xue Yang ◽  
Xiangfeng Jin ◽  
Rongjian Xu ◽  
Zhuang Yu ◽  
Ning An
Keyword(s):  
Survival Analysis ◽  
Poor Prognosis ◽  
Disease Free Survival ◽  
Squamous Carcinoma ◽  
Radical Resection ◽  
R0 Resection ◽  
Poor Overall Survival ◽  
Male Patients ◽  
Lung Squamous Carcinoma ◽  
Public Datasets

Abstract Background Clinical options for lung squamous carcinoma (LUSC) are still quite limited. Carcinogenesis is an exceedingly complicated process involving multi-level dysregulations. Therefore, only looking into one layer of genomic dysregulation is far from sufficient. Methods We identified differentially expressed genes with consistent upstream genetic or epigenetic dysregulations in LUSC. Random walk was adopted to identify genes significantly affected by upstream abnormalities. Expression differentiation and survival analysis were conducted for these significant genes, respectively. Prognostic power of selected gene was also tested in 102 male LUSC samples through immunohistochemistry assay. Results Twelve genes were successfully retrieved from biological network, including ERα (ESRS1), EGFR, AR, ATXN1, MAPK3, PRKACA, PRKCA, SMAD4, TP53, TRAF2, UBQLN4 and YWHAG, which were closely related to sex hormone signaling pathway. Survival analysis in public datasets indicated ERα was significantly associated with a poor overall survival (OS) in male LUSC. The result of our immunohistochemistry assay also demonstrated this correlation using R0 resected tumors (n = 102, HR: 2.152, 95% CI: 1.089–4.255, p = 0.024). Although disease-free survival (DFS) difference was non-significant (n = 102, p = 0.12), the tendency of distinction was straight-forward. Cox analysis indicated ERα was the only independent prognostic factor for male patients’ OS after R0 resection (HR = 2.152, p = 0.037). Conclusion ERα was significantly related to a poor prognosis in LUSC, especially for male patients after radical surgery, confirmed by our immunohistochemistry data.

scholarly journals Invasion Types Are Associated With Poor Prognosis in Lung Squamous Carcinoma Patients

Medicine ◽  
2015 ◽  
Vol 94 (43) ◽  
pp. e1634 ◽  
Author(s):  
Yang Zhao ◽  
Hongchang Shen ◽  
Chen Qiu ◽  
Tiehong Zhang ◽  
Pingping Hu ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Squamous Carcinoma ◽  
Lung Squamous Carcinoma

scholarly journals Gastric cancer with repeated metastasis in the colonic lumen: a case report and multi-surgical experience

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110184
Author(s):  
Yi Wang ◽  
Peiqing Ma ◽  
Kan Liu ◽  
Dongkui Xu ◽  
Qian Liu
Keyword(s):  
Gastric Cancer ◽  
Gastric Carcinoma ◽  
Poor Prognosis ◽  
Partial Gastrectomy ◽  
Radical Resection ◽  
Surgical Experience ◽  
Colonic Lumen ◽  
Poorly Differentiated ◽  
Gastric Stump Carcinoma ◽  
Peritoneal Spread

Poorly differentiated gastric adenocarcinoma is commonly associated with lymph node metastasis, peritoneal spread, and liver metastasis but rarely with intraintestinal metastasis. Most patients with metastatic gastric carcinoma are unable to undergo surgical treatment and have a poor prognosis. A 42-year-old man with hunger-related abdominal pain was diagnosed as having gastric cancer. After the first surgery (distal partial gastrectomy) and the second surgery (gastric stump carcinoma (GSC) resection), the patient suffered repeated multiple intracolonic metastases and underwent three additional resection operations. The patient survived for 154 months after the first operation. In patients with gastric carcinoma that metastasizes to the colonic lumen, radical resection, if possible, can extend survival. Once patients develop extensive extraintestinal metastasis, radical resection cannot be performed, and patients often exhibit a poor prognosis.

Treating cancer-associated hypercalcaemia

1990 ◽  
Vol 28 (22) ◽  
pp. 85-87
Keyword(s):  
Cancer Patients ◽  
Poor Prognosis ◽  
Calcium Metabolism ◽  
Squamous Carcinoma ◽  
Breast Carcinomas ◽  
Prompt Treatment ◽  
New Approaches

Hypercalcaemia occurs in about 10% of cancer patients. Although it may complicate any tumour it is particularly common with myeloma, squamous carcinoma of the bronchus, and renal and breast carcinomas, probably because these tumours metastasise to bone or can produce humoral substances which affect calcium metabolism. Patients with hypercalcaemia of malignancy generally have a poor prognosis, but prompt treatment can improve many distressing symptoms. We discuss some new approaches to treatment as well as more traditional ones.

scholarly journals Identification of Potential Long Non-coding RNA Expression Quantitative Trait Methylations in Lung Adenocarcinoma and Lung Squamous Carcinoma

2020 ◽  
Vol 11 ◽  
Author(s):  
Xiaohong Wu ◽  
Yue Gao ◽  
Jianlong Bu ◽  
Lin Deng ◽  
Pinyi Zhang ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Quantitative Trait ◽  
Regulatory Networks ◽  
Squamous Carcinoma ◽  
Drug Repurposing ◽  
Cancer Pathogenesis ◽  
Non Coding Rna ◽  
Wide Range ◽  
Lung Squamous Carcinoma ◽  
Long Non Coding Rna

There are associations between DNA methylation and the expression of long non-coding RNA (lncRNA), also known as lncRNA expression quantitative trait methylations (lnc-eQTMs). Lnc-eQTMs may induce a wide range of carcinogenesis pathways. However, lnc-eQTMs have not been globally identified and studied, and their roles in lung adenocarcinoma (LUAD) and lung squamous carcinoma (LUSC) are largely unknown. In the present study, we identified some differential methylation sites located in genes of long intergenic non-coding RNAs (lincRNAs) and other types of lncRNAs in LUAD and LUSC. An integrated pipeline was established to construct two global cancer-specific regulatory networks of lnc-eQTMs in LUAD and LUSC. The associations between eQTMs showed common and specific features between LUAD and LUSC. Some lnc-eQTMs were also related with survival in LUAD- and LUSC-specific regulatory networks. Lnc-eQTMs were associated with cancer-related functions, such as lung epithelium development and vasculogenesis by functional analysis. Drug repurposing analysis revealed that these lnc-eQTMs may mediate the effects of some anesthesia-related drugs in LUAD and LUSC. In summary, the present study elucidates the roles of lnc-eQTMs in LUAD and LUSC, which could improve our understanding of lung cancer pathogenesis and facilitate treatment.

Comparative proteome analysis of human lung squamous carcinoma tissue

2006 ◽  
Vol 5 (4) ◽  
pp. 232-239 ◽  
Author(s):  
Cui Li ◽  
Can’e Tang ◽  
Chaojun Duan ◽  
Hong Yi ◽  
Zhiqiang Xiao ◽  
...  
Keyword(s):  
Human Lung ◽  
Squamous Carcinoma ◽  
Proteome Analysis ◽  
Carcinoma Tissue ◽  
Lung Squamous Carcinoma

Multidimensional Coculture System to Model Lung Squamous Carcinoma Progression

10.3791/60644 ◽  
2020 ◽  
Author(s):  
Shuang Chen ◽  
Andreas Giannakou ◽  
Jonathon Golas ◽  
Kenneth G. Geles
Keyword(s):  
Squamous Carcinoma ◽  
Model Lung ◽  
Coculture System ◽  
Lung Squamous Carcinoma
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